Dorothy L Patton

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Significant reduction in inflammatory response in the macaque model of chlamydial pelvic inflammatory disease with azithromycin treatment
    Dorothy L Patton
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    J Infect Dis 192:129-35. 2005
  2. ncbi request reprint Safety and efficacy evaluations for vaginal and rectal use of BufferGel in the macaque model
    D L Patton
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    Sex Transm Dis 31:290-6. 2004
  3. ncbi request reprint Macaca fascicularis vs. Macaca nemestrina as a model for topical microbicide safety studies
    Dorothy L Patton
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195, USA
    J Med Primatol 33:105-8. 2004
  4. ncbi request reprint Vaginal and rectal topical microbicide development: safety and efficacy of 1.0% Savvy (C31G) in the pigtailed macaque
    Dorothy L Patton
    University of Washington, Seattle, WA 98195 6460, USA
    Sex Transm Dis 33:691-5. 2006
  5. ncbi request reprint Lactobacillus crispatus capsules: single-use safety study in the Macaca nemestrina model
    Dorothy L Patton
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    Sex Transm Dis 30:568-70. 2003
  6. ncbi request reprint Rectal applications of nonoxynol-9 cause tissue disruption in a monkey model
    Dorothy L Patton
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    Sex Transm Dis 29:581-7. 2002
  7. pmc Preclinical safety and efficacy assessments of dendrimer-based (SPL7013) microbicide gel formulations in a nonhuman primate model
    D L Patton
    Department of Obstetrics and Gynecology, Box 356460, University of Washington, Seattle, WA 98195 6460, USA
    Antimicrob Agents Chemother 50:1696-700. 2006
  8. ncbi request reprint Development of a nonhuman primate model for Trichomonas vaginalis infection
    Dorothy L Patton
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    Sex Transm Dis 33:743-6. 2006
  9. pmc Preclinical safety assessments of UC781 anti-human immunodeficiency virus topical microbicide formulations
    D L Patton
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195 6460, USA
    Antimicrob Agents Chemother 51:1608-15. 2007
  10. doi request reprint A summary of preclinical topical microbicide vaginal safety and chlamydial efficacy evaluations in a pigtailed macaque model
    Dorothy L Patton
    Department of Obstetrics and Gynecology, Box 356460, University of Washington, Seattle, WA 98195 6460, USA
    Sex Transm Dis 35:889-97. 2008

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Significant reduction in inflammatory response in the macaque model of chlamydial pelvic inflammatory disease with azithromycin treatment
    Dorothy L Patton
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    J Infect Dis 192:129-35. 2005
    ..Azithromycin treatment dramatically reduced the inflammatory response and was highly effective in eradicating C. trachomatis from the lower and upper reproductive tract (12/12), compared with doxycycline (7/12) and placebo (3/21)...
  2. ncbi request reprint Safety and efficacy evaluations for vaginal and rectal use of BufferGel in the macaque model
    D L Patton
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    Sex Transm Dis 31:290-6. 2004
    ..The nonhuman primate model allows for safety and efficacy testing of topical microbicide products...
  3. ncbi request reprint Macaca fascicularis vs. Macaca nemestrina as a model for topical microbicide safety studies
    Dorothy L Patton
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195, USA
    J Med Primatol 33:105-8. 2004
    ..Thus, the M. fascicularis may not be useful for vaginally applied topical microbicide safety studies yet adequate for assessing safety of rectally applied topical microbicide products...
  4. ncbi request reprint Vaginal and rectal topical microbicide development: safety and efficacy of 1.0% Savvy (C31G) in the pigtailed macaque
    Dorothy L Patton
    University of Washington, Seattle, WA 98195 6460, USA
    Sex Transm Dis 33:691-5. 2006
    ..A 1.0% gel formulation of C31G, a surfactant, has been shown to have in vitro antiviral and antibacterial activity...
  5. ncbi request reprint Lactobacillus crispatus capsules: single-use safety study in the Macaca nemestrina model
    Dorothy L Patton
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    Sex Transm Dis 30:568-70. 2003
    ..Lactobacillus crispatus is a part of the normal vaginal microflora of humans...
  6. ncbi request reprint Rectal applications of nonoxynol-9 cause tissue disruption in a monkey model
    Dorothy L Patton
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    Sex Transm Dis 29:581-7. 2002
    ..Efforts to develop topical microbicide products have all but ignored evaluation for rectal use...
  7. pmc Preclinical safety and efficacy assessments of dendrimer-based (SPL7013) microbicide gel formulations in a nonhuman primate model
    D L Patton
    Department of Obstetrics and Gynecology, Box 356460, University of Washington, Seattle, WA 98195 6460, USA
    Antimicrob Agents Chemother 50:1696-700. 2006
    ..However, a single intravaginal application of the 3% (wt/wt) SPL7013 gel did not provide protection from the acquisition of cervical chlamydial infection...
  8. ncbi request reprint Development of a nonhuman primate model for Trichomonas vaginalis infection
    Dorothy L Patton
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    Sex Transm Dis 33:743-6. 2006
    ..An animal model of T. vaginalis infection would enable scientists to further investigate trichomoniasis...
  9. pmc Preclinical safety assessments of UC781 anti-human immunodeficiency virus topical microbicide formulations
    D L Patton
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195 6460, USA
    Antimicrob Agents Chemother 51:1608-15. 2007
    ..1% UC781 formulation. These results provide additional support for the continued development of UC781 formulations as anti-HIV microbicides...
  10. doi request reprint A summary of preclinical topical microbicide vaginal safety and chlamydial efficacy evaluations in a pigtailed macaque model
    Dorothy L Patton
    Department of Obstetrics and Gynecology, Box 356460, University of Washington, Seattle, WA 98195 6460, USA
    Sex Transm Dis 35:889-97. 2008
    ....
  11. pmc A summary of preclinical topical microbicide rectal safety and efficacy evaluations in a pigtailed macaque model
    Dorothy L Patton
    Department of Obstetrics and Gynecology, Box 356460, University of Washington, Seattle, WA 98195 6460, USA
    Sex Transm Dis 36:350-6. 2009
    ..As it is likely that commercial products developed for vaginal use will also be used rectally, there is a clear need to assess the safety and efficacy of candidate microbicide products specifically in the rectal compartment...
  12. ncbi request reprint The pig-tailed macaque rectal model: microflora and chlamydial infection
    D L Patton
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195-6460, USA
    Sex Transm Dis 28:363-6. 2001
    ..Furthermore, such products can be evaluated for protection against rectal chlamydial infection in this model...
  13. pmc Feasibility of LNG-IUS in a baboon model
    Jason D Bell
    Program on Women s Healthcare Effectiveness Research, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI 48109, USA
    Contraception 87:380-4. 2013
    ..This study sought to determine whether human-use IUDs could be seated correctly in the uterus of the baboon...
  14. pmc Pigtailed macaque model refinement: topical microbicide safety in the presence of coitus
    Yvonne T Cosgrove Sweeney
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA
    J Med Primatol 40:327-34. 2011
    ..Inclusion of sexual activity in the macaque model for topical microbicide safety evaluation would more closely mimic human use of topical microbicides and provide a more rigorous safety assessment...
  15. pmc Heat shock protein 60 is the major antigen which stimulates delayed-type hypersensitivity reaction in the macaque model of Chlamydia trachomatis salpingitis
    Anne B Lichtenwalner
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    Infect Immun 72:1159-61. 2004
    ....
  16. pmc Repeated Chlamydia trachomatis infection of Macaca nemestrina fallopian tubes produces a Th1-like cytokine response associated with fibrosis and scarring
    W C Van Voorhis
    Department of Medicine, University of Washington, Seattle 98195, USA
    Infect Immun 65:2175-82. 1997
    ....
  17. pmc Evidence of genetic susceptibility to Chlamydia trachomatis-induced pelvic inflammatory disease in the pig-tailed macaque
    A B Lichtenwalner
    Department of Obstetrics and Gynecology, University of Washington, Seattle 98195 6460, USA
    Infect Immun 65:2250-3. 1997
    ....
  18. pmc Killing of Chlamydia trachomatis by novel antimicrobial lipids adapted from compounds in human breast milk
    M F Lampe
    University of Washington, Seattle 98195, USA
    Antimicrob Agents Chemother 42:1239-44. 1998
    ..trachomatis. Further efficacy and toxicity studies with these lipids and assessment of their activity against other sexually transmitted disease pathogens are in progress...
  19. ncbi request reprint Influence of the normal menstrual cycle on vaginal tissue, discharge, and microflora
    D A Eschenbach
    Department of Obstetrics University of Washington, Seattle, WA 98195 6460, USA
    Clin Infect Dis 30:901-7. 2000
    ....
  20. ncbi request reprint Vaginal myeloperoxidase and flora in the pig-tailed macaque
    A B Lichtenwalner
    Department of Comparative Medicine and Regional Primate Research Center, University of Washington, Seattle 98195 7330, USA
    J Med Primatol 29:36-41. 2000
    ..MPO treatment did not reduce vaginal H2O2-producing organisms, and vaginal MPO levels tended to increase at 4 hours in treated animals. Vaginal/cervical colposcopic changes were not detected in either group...
  21. ncbi request reprint Effects of oral contraceptive pill use on vaginal flora and vaginal epithelium
    D A Eschenbach
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA
    Contraception 62:107-12. 2000
    ..04). The results indicate minimal effect of OC use on the vaginal epithelium and vaginal and cervical discharge, and a small effect on vaginal flora...
  22. ncbi request reprint Effects of vaginal intercourse with and without a condom on vaginal flora and vaginal epithelium
    D A Eschenbach
    Dept of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195 6460, USA
    J Infect Dis 183:913-8. 2001
    ..coli (P=.06) and a significant increase in other enteric gram-negative rods (P=.001) after intercourse. Intercourse was not associated with gross, colposcopic, or histologic vaginal epithelial abnormalities...
  23. pmc Persistence, immune response, and antigenic variation of Mycoplasma genitalium in an experimentally infected pig-tailed macaque (Macaca nemestrina)
    Gwendolyn E Wood
    Department of Medicine, Division of Infectious Diseases, University of Washington, Seattle, Washington, USA
    Infect Immun 81:2938-51. 2013
    ..Together these results suggest that the pig-tailed macaque is a suitable model to study M. genitalium pathogenesis, antibody-mediated selection of antigenic variants in vivo, and immune escape. ..
  24. pmc Nonhuman primate models used to study pelvic inflammatory disease caused by Chlamydia trachomatis
    Jason D Bell
    Department of Obstetrics and Gynecology, University of Michigan, 1500 East Medical Center Drive, L4510, Ann Arbor, MI 48109, USA
    Infect Dis Obstet Gynecol 2011:675360. 2011
    ..This paper explores historical and contemporary aspects of NHP modeling of chlamydial PID, with an emphasis on advantages and limitations of this approach and future directions for this research...
  25. pmc The effects of a single cervical inoculation of Chlamydia trachomatis on the female reproductive tract of the baboon (Papio anubis)
    Jason D Bell
    Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI 48109, USA
    J Infect Dis 204:1305-12. 2011
    ..We sought to determine if the baboon could become infected with a single cervical inoculation of Chlamydia trachomatis...
  26. pmc Relationship of vaginal bacteria and inflammation with conception and early pregnancy loss following in-vitro fertilization
    Linda O Eckert
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98104, USA
    Infect Dis Obstet Gynecol 11:11-7. 2003
    ..The aim of this study was investigate the impact of vaginal flora and vaginal inflammation on conception and early pregnancy loss following in-vitro fertilization (IVF)...
  27. ncbi request reprint Association between Chlamydia trachomatis and abnormal uterine bleeding
    Miklos Toth
    Department of Ob Gyn, Hill Hospital, New York, NY, USA
    Am J Reprod Immunol 57:361-6. 2007
    ..The purpose was to identify distinct inflammatory markers in endometrial tissues of women with abnormal uterine bleeding (AUB) and Chlamydia trachomatis infection...
  28. ncbi request reprint Application of optical coherence tomography for monitoring changes in cervicovaginal epithelial morphology in macaques: potential for assessment of microbicide safety
    Kathleen L Vincent
    University of Texas Medical Branch, Galveston, Texas 77555 0319, USA
    Sex Transm Dis 35:269-75. 2008
    ..Optical coherence tomography (OCT), a high-resolution, in-depth cross-sectional imaging modality, was utilized in conjunction with colposcopy to assess induced cervicovaginal epithelial changes that may predict product safety...
  29. ncbi request reprint The role of Chlamydia pneumoniae in the etiology of acne rosacea: response to the use of oral azithromycin
    Adolfo Fernandez-Obregon
    Hudson Dermatology and Skin Cancer Center, Hoboken, New Jersey, USA
    Cutis 79:163-7. 2007
    ..These preliminary data suggest the need for further investigation with clinical trials to study long-term tolerability and efficacy and also strongly implicate C pneumoniae in the pathogenesis of acne rosacea...

Research Grants10

  1. LOCAL IMMUNE RESPONSE IN CHLAMYDIA SALPINGITIS
    Dorothy Patton; Fiscal Year: 2003
    ..trachomatis- induced PID. If one chlamydial antigen is the major cause of the DTH response in PID, diagnostic or immunomodulatory efforts can be directed towards that antigen. ..
  2. Improved Macaque Safety Model for Topical Microbicides: Post-coital Assessments
    Dorothy Patton; Fiscal Year: 2007
    ..In addition, we will collect parallel assessments, when mating has occurred with a placebo gel (HEC universal placebo) in place. These studies will provide urgently needed data regarding topical microbicide use with coital activity. ..