Kristine B Patterson

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Smallpox and the Native American
    Kristine B Patterson
    Department of Medicine, University of North Carolina at Chapel Hill, 27599 7030, USA
    Am J Med Sci 323:216-22. 2002
  2. doi request reprint Differential penetration of raltegravir throughout gastrointestinal tissue: implications for eradication and cure
    Kristine B Patterson
    University of North Carolina Department of Medicine, Chapel Hill, North Carolina 27599 7215, USA
    AIDS 27:1413-9. 2013
  3. pmc Protein binding of lopinavir and ritonavir during 4 phases of pregnancy: implications for treatment guidelines
    Kristine B Patterson
    Department of Medicine, University of North Carolina, Chapel Hill, NC 27599 7215, USA
    J Acquir Immune Defic Syndr 63:51-8. 2013
  4. pmc Darunavir, ritonavir, and etravirine pharmacokinetics in the cervicovaginal fluid and blood plasma of HIV-infected women
    Kristine Patterson
    University of North Carolina at Chapel Hill, AIDS Clinical Trials Unit, 130 Mason Farm Rd, CB 7215, Chapel Hill, NC 27599 7215, USA
    Antimicrob Agents Chemother 55:1120-2. 2011
  5. pmc Treatment responses in antiretroviral treatment-naive premenopausal and postmenopausal HIV-1-infected women: an analysis from AIDS Clinical Trials Group Studies
    Kristine B Patterson
    University of North Carolina, Chapel Hill, NC 27599 7215, USA
    Clin Infect Dis 49:473-6. 2009
  6. ncbi request reprint Frequent detection of acute HIV infection in pregnant women
    Kristine B Patterson
    School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    AIDS 21:2303-8. 2007
  7. ncbi request reprint Effects of age and sex on immunological and virological responses to initial highly active antiretroviral therapy
    K Patterson
    School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7215, USA
    HIV Med 8:406-10. 2007
  8. pmc Genital tract, cord blood, and amniotic fluid exposures of seven antiretroviral drugs during and after pregnancy in human immunodeficiency virus type 1-infected women
    Rosa F Yeh
    School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Antimicrob Agents Chemother 53:2367-74. 2009
  9. pmc Antiretroviral drug exposure in the female genital tract: implications for oral pre- and post-exposure prophylaxis
    Julie B Dumond
    School of Pharmacy, University of North Carolina at Chapel Hill, North Carolina, USA
    AIDS 21:1899-907. 2007
  10. pmc Penetration of tenofovir and emtricitabine in mucosal tissues: implications for prevention of HIV-1 transmission
    Kristine B Patterson
    University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Sci Transl Med 3:112re4. 2011

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Smallpox and the Native American
    Kristine B Patterson
    Department of Medicine, University of North Carolina at Chapel Hill, 27599 7030, USA
    Am J Med Sci 323:216-22. 2002
    ..Fortunately, they were also major beneficiaries of early vaccination programs. Thus, the arrival of smallpox and the decline of the Native American populations are inexorably linked, as the history summarized here illustrates...
  2. doi request reprint Differential penetration of raltegravir throughout gastrointestinal tissue: implications for eradication and cure
    Kristine B Patterson
    University of North Carolina Department of Medicine, Chapel Hill, North Carolina 27599 7215, USA
    AIDS 27:1413-9. 2013
    ..To investigate the concentration of the integrase strand inhibitor raltegravir (RAL) throughout gastrointestinal (GI) tissue, especially gut-associated lymphoid tissue (GALT), as an adjunct to current prevention and cure strategies...
  3. pmc Protein binding of lopinavir and ritonavir during 4 phases of pregnancy: implications for treatment guidelines
    Kristine B Patterson
    Department of Medicine, University of North Carolina, Chapel Hill, NC 27599 7215, USA
    J Acquir Immune Defic Syndr 63:51-8. 2013
    ....
  4. pmc Darunavir, ritonavir, and etravirine pharmacokinetics in the cervicovaginal fluid and blood plasma of HIV-infected women
    Kristine Patterson
    University of North Carolina at Chapel Hill, AIDS Clinical Trials Unit, 130 Mason Farm Rd, CB 7215, Chapel Hill, NC 27599 7215, USA
    Antimicrob Agents Chemother 55:1120-2. 2011
    ..The high exposures of darunavir and etravirine in cervicovaginal fluid warrant further evaluation of these drugs for use in HIV-1 prevention...
  5. pmc Treatment responses in antiretroviral treatment-naive premenopausal and postmenopausal HIV-1-infected women: an analysis from AIDS Clinical Trials Group Studies
    Kristine B Patterson
    University of North Carolina, Chapel Hill, NC 27599 7215, USA
    Clin Infect Dis 49:473-6. 2009
    ..Changes in CD4 counts or human immunodeficiency virus type 1 RNA levels were similar at 24, 48, and 96 weeks after treatment initiation. ART-naive women should respond to ART regardless of menopausal status...
  6. ncbi request reprint Frequent detection of acute HIV infection in pregnant women
    Kristine B Patterson
    School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    AIDS 21:2303-8. 2007
    ..Universal prenatal HIV antibody testing, which does not detect acute HIV, is standard for pregnant women in the United States. Unrecognized HIV acquisition during pregnancy may result in higher rates of perinatal transmission...
  7. ncbi request reprint Effects of age and sex on immunological and virological responses to initial highly active antiretroviral therapy
    K Patterson
    School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7215, USA
    HIV Med 8:406-10. 2007
    ..Currently, women comprise >50% of HIV-infected individuals worldwide. It is not known if there are differences between the sexes in the immunological and virological responses to HAART across the age strata...
  8. pmc Genital tract, cord blood, and amniotic fluid exposures of seven antiretroviral drugs during and after pregnancy in human immunodeficiency virus type 1-infected women
    Rosa F Yeh
    School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Antimicrob Agents Chemother 53:2367-74. 2009
    ..Measurement of antiretroviral exposure in maternal genital secretions, cord BP, and amniotic fluid may be needed to identify signals of subtherapeutic or supratherapeutic drug exposure...
  9. pmc Antiretroviral drug exposure in the female genital tract: implications for oral pre- and post-exposure prophylaxis
    Julie B Dumond
    School of Pharmacy, University of North Carolina at Chapel Hill, North Carolina, USA
    AIDS 21:1899-907. 2007
    ..To describe first dose and steady state antiretroviral drug exposure in the female genital tract...
  10. pmc Penetration of tenofovir and emtricitabine in mucosal tissues: implications for prevention of HIV-1 transmission
    Kristine B Patterson
    University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Sci Transl Med 3:112re4. 2011
    ..These results demonstrate the need for detailed pharmacological studies to improve the application of ART for PrEP to prevent transmission of HIV...
  11. pmc Pharmacokinetic modelling of efavirenz, atazanavir, lamivudine and tenofovir in the female genital tract of HIV-infected pre-menopausal women
    Julie B Dumond
    UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 27599 7569, USA
    Clin Pharmacokinet 51:809-22. 2012
    ..These blood plasma (BP) and cervicovaginal fluid (CVF) data were co-modelled for four antiretrovirals with varying CVF exposures...
  12. pmc Dolutegravir pharmacokinetics in the genital tract and colorectum of HIV-negative men after single and multiple dosing
    Benjamin N Greener
    University of North Carolina at Chapel Hill Eshelman School of Pharmacy, Chapel Hill, NC, USA
    J Acquir Immune Defic Syndr 64:39-44. 2013
    ..To describe first-dose and steady state pharmacokinetics (PKs) of dolutegravir (DTG) in blood plasma (BP), seminal fluid (SF), colorectal tissue (RT), and rectal mucosal fluid (RF) of healthy HIV-negative men...
  13. pmc Single- and multiple-dose pharmacokinetics of darunavir plus ritonavir and etravirine in semen and rectal tissue of HIV-negative men
    Kevin C Brown
    Division of Pharmacotherapy and Experimental Therapeutics University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC, USA
    J Acquir Immune Defic Syndr 61:138-44. 2012
    ..Defining the individual exposure of commercially available antiretroviral therapy in genital secretions and vulnerable mucosal tissues is paramount to designing future prevention interventions...
  14. pmc Dose separation does not overcome the pharmacokinetic interaction between fosamprenavir and lopinavir/ritonavir
    Amanda H Corbett
    School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Antimicrob Agents Chemother 50:2756-61. 2006
    ..67 [0.54 to 0.83] and 0.77 [0.59 to 0.99], respectively) compared to simultaneous administration. Additional investigations are warranted to determine the optimal dosing of FPV with LPV/RTV...
  15. pmc The pharmacokinetics and viral activity of tenofovir in the male genital tract
    Manoli Vourvahis
    Division of Pharmacotherapy and Experimental Therapeutics, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599 7360, USA
    J Acquir Immune Defic Syndr 47:329-33. 2008
    ..To measure tenofovir (TFV) concentrations in the male genital tract (GT) after single and multiple doses of tenofovir disoproxil fumarate (TDF) and evaluate the HIV-1 RNA response to monotherapy...
  16. pmc Single and multiple dose pharmacokinetics of maraviroc in saliva, semen, and rectal tissue of healthy HIV-negative men
    Kevin C Brown
    Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7569, USA
    J Infect Dis 203:1484-90. 2011
    ..Saliva may be of utility for noninvasively measuring adherence...
  17. pmc Maraviroc concentrates in the cervicovaginal fluid and vaginal tissue of HIV-negative women
    Julie B Dumond
    Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill Eshelman School of Pharmacy, Chapel Hill, NC 27599 7360, USA
    J Acquir Immune Defic Syndr 51:546-53. 2009
    ..To compare single- and multiple-dose maraviroc exposures in cervicovaginal fluid (CVF) and vaginal tissue (VT) with blood plasma (BP) and quantify maraviroc protein binding in CVF...
  18. doi request reprint Single and multiple dose pharmacokinetics of dolutegravir in the genital tract of HIV-negative women
    Jessica L Adams
    University of North Carolina at Chapel Hill, Eshelman School of Pharmacy, Chapel Hill, NC, USA
    Antivir Ther 18:1005-13. 2013
    ....
  19. doi request reprint Tenofovir diphosphate and emtricitabine triphosphate concentrations in blood cells compared with isolated peripheral blood mononuclear cells: a new measure of antiretroviral adherence?
    Jessica L Adams
    Department of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Acquir Immune Defic Syndr 62:260-6. 2013
    ..We compared concentrations of TFV-diphosphate (TFV-DP) and FTC-triphosphate (FTC-TP) in the upper layer packed cells (ULPCs) obtained after whole blood centrifugation to isolated PBMCs as a possible alternative marker of adherence...
  20. ncbi request reprint Lopinavir/ritonavir induces the hepatic activity of cytochrome P450 enzymes CYP2C9, CYP2C19, and CYP1A2 but inhibits the hepatic and intestinal activity of CYP3A as measured by a phenotyping drug cocktail in healthy volunteers
    Rosa F Yeh
    School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599, USA
    J Acquir Immune Defic Syndr 42:52-60. 2006
    ....
  21. pmc Elevated frequencies of micronucleated erythrocytes in infants exposed to zidovudine in utero and postpartum to prevent mother-to-child transmission of HIV
    Kristine L Witt
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Environ Mol Mutagen 48:322-9. 2007
    ..These results demonstrate that transplacentalZDV exposure is genotoxic in humans. Long-term monitoring of HIV-uninfected ZDV-exposed infants is recommended to ensure their continued health...