Kristine B Patterson
Affiliation: University of North Carolina
- Smallpox and the Native AmericanKristine B Patterson
Department of Medicine, University of North Carolina at Chapel Hill, 27599 7030, USA
Am J Med Sci 323:216-22. 2002..Fortunately, they were also major beneficiaries of early vaccination programs. Thus, the arrival of smallpox and the decline of the Native American populations are inexorably linked, as the history summarized here illustrates...
- Darunavir, ritonavir, and etravirine pharmacokinetics in the cervicovaginal fluid and blood plasma of HIV-infected womenKristine Patterson
University of North Carolina at Chapel Hill, AIDS Clinical Trials Unit, 130 Mason Farm Rd, CB 7215, Chapel Hill, NC 27599 7215, USA
Antimicrob Agents Chemother 55:1120-2. 2011..The high exposures of darunavir and etravirine in cervicovaginal fluid warrant further evaluation of these drugs for use in HIV-1 prevention...
- Treatment responses in antiretroviral treatment-naive premenopausal and postmenopausal HIV-1-infected women: an analysis from AIDS Clinical Trials Group StudiesKristine B Patterson
University of North Carolina, Chapel Hill, NC 27599 7215, USA
Clin Infect Dis 49:473-6. 2009..Changes in CD4 counts or human immunodeficiency virus type 1 RNA levels were similar at 24, 48, and 96 weeks after treatment initiation. ART-naive women should respond to ART regardless of menopausal status...
- Effects of age and sex on immunological and virological responses to initial highly active antiretroviral therapyK Patterson
School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7215, USA
HIV Med 8:406-10. 2007..Currently, women comprise >50% of HIV-infected individuals worldwide. It is not known if there are differences between the sexes in the immunological and virological responses to HAART across the age strata...
- Frequent detection of acute HIV infection in pregnant womenKristine B Patterson
School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
AIDS 21:2303-8. 2007..Universal prenatal HIV antibody testing, which does not detect acute HIV, is standard for pregnant women in the United States. Unrecognized HIV acquisition during pregnancy may result in higher rates of perinatal transmission...
- Genital tract, cord blood, and amniotic fluid exposures of seven antiretroviral drugs during and after pregnancy in human immunodeficiency virus type 1-infected womenRosa F Yeh
School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Antimicrob Agents Chemother 53:2367-74. 2009..Measurement of antiretroviral exposure in maternal genital secretions, cord BP, and amniotic fluid may be needed to identify signals of subtherapeutic or supratherapeutic drug exposure...
- Single- and multiple-dose pharmacokinetics of darunavir plus ritonavir and etravirine in semen and rectal tissue of HIV-negative menKevin C Brown
Division of Pharmacotherapy and Experimental Therapeutics University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC, USA
J Acquir Immune Defic Syndr 61:138-44. 2012..Defining the individual exposure of commercially available antiretroviral therapy in genital secretions and vulnerable mucosal tissues is paramount to designing future prevention interventions...
- Antiretroviral drug exposure in the female genital tract: implications for oral pre- and post-exposure prophylaxisJulie B Dumond
School of Pharmacy, University of North Carolina at Chapel Hill, North Carolina, USA
AIDS 21:1899-907. 2007..To describe first dose and steady state antiretroviral drug exposure in the female genital tract...
- Penetration of tenofovir and emtricitabine in mucosal tissues: implications for prevention of HIV-1 transmissionKristine B Patterson
University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Sci Transl Med 3:112re4. 2011..These results demonstrate the need for detailed pharmacological studies to improve the application of ART for PrEP to prevent transmission of HIV...
- Dose separation does not overcome the pharmacokinetic interaction between fosamprenavir and lopinavir/ritonavirAmanda H Corbett
School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Antimicrob Agents Chemother 50:2756-61. 2006..67 [0.54 to 0.83] and 0.77 [0.59 to 0.99], respectively) compared to simultaneous administration. Additional investigations are warranted to determine the optimal dosing of FPV with LPV/RTV...
- The pharmacokinetics and viral activity of tenofovir in the male genital tractManoli Vourvahis
Division of Pharmacotherapy and Experimental Therapeutics, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599 7360, USA
J Acquir Immune Defic Syndr 47:329-33. 2008..To measure tenofovir (TFV) concentrations in the male genital tract (GT) after single and multiple doses of tenofovir disoproxil fumarate (TDF) and evaluate the HIV-1 RNA response to monotherapy...
- Maraviroc concentrates in the cervicovaginal fluid and vaginal tissue of HIV-negative womenJulie B Dumond
Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill Eshelman School of Pharmacy, Chapel Hill, NC 27599 7360, USA
J Acquir Immune Defic Syndr 51:546-53. 2009..To compare single- and multiple-dose maraviroc exposures in cervicovaginal fluid (CVF) and vaginal tissue (VT) with blood plasma (BP) and quantify maraviroc protein binding in CVF...
- Single and multiple dose pharmacokinetics of maraviroc in saliva, semen, and rectal tissue of healthy HIV-negative menKevin C Brown
Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7569, USA
J Infect Dis 203:1484-90. 2011..Saliva may be of utility for noninvasively measuring adherence...
- Pharmacokinetic modelling of efavirenz, atazanavir, lamivudine and tenofovir in the female genital tract of HIV-infected pre-menopausal womenJulie B Dumond
UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 27599 7569, USA
Clin Pharmacokinet 51:809-22. 2012..These blood plasma (BP) and cervicovaginal fluid (CVF) data were co-modelled for four antiretrovirals with varying CVF exposures...
- Lopinavir/ritonavir induces the hepatic activity of cytochrome P450 enzymes CYP2C9, CYP2C19, and CYP1A2 but inhibits the hepatic and intestinal activity of CYP3A as measured by a phenotyping drug cocktail in healthy volunteersRosa F Yeh
School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599, USA
J Acquir Immune Defic Syndr 42:52-60. 2006..Doses of concomitant CYP3A substrates should be reduced when combined with LPV/r, although intravenously administered compounds may require less of a relative dose reduction than orally administered compounds...
- Elevated frequencies of micronucleated erythrocytes in infants exposed to zidovudine in utero and postpartum to prevent mother-to-child transmission of HIVKristine L Witt
National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
Environ Mol Mutagen 48:322-9. 2007..These results demonstrate that transplacentalZDV exposure is genotoxic in humans. Long-term monitoring of HIV-uninfected ZDV-exposed infants is recommended to ensure their continued health...