Research Topics
Genomes and GenesSpecies | Freda PattersonSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Intention to quit smoking: role of personal and family member cancer diagnosisFreda Patterson
Center for Health Behavior Research, School of Medicine, University of Pennsylvania, 802 Blockley Hall, Philadelphia, PA 19104, USA
Health Educ Res 25:792-802. 2010..An adequately powered, controlled trial is needed to fully evaluate this hypothesis...
Role of functional genetic variation in the dopamine D2 receptor (DRD2) in response to bupropion and nicotine replacement therapy for tobacco dependence: results of two randomized clinical trialsCaryn Lerman
Department of Psychiatry and Abramson Cancer Center, Tobacco Use Research Center, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuropsychopharmacology 31:231-42. 2006..Study findings require confirmation in additional larger samples before they are applied in practice...
Working memory deficits predict short-term smoking resumption following brief abstinenceFreda Patterson
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
Drug Alcohol Depend 106:61-4. 2010....
Recurrent event analysis of lapse and recovery in a smoking cessation clinical trial using bupropionE Paul Wileyto
University of Pennsylvania, Tobacco Use Research Center, Philadelphia, PA 19104 3309, USA
Nicotine Tob Res 7:257-68. 2005..Further research disentangling lapse and recovery events from summary abstinence measures is needed to help us develop interventions that take advantage of bupropion at its best and that compensate where it is weak...
Genetic variation in mu-opioid-receptor-interacting proteins and smoking cessation in a nicotine replacement therapy trialRiju Ray
Department of Pharmacology, and Transdisciplinary Tobacco Use Research Center, University of Pennsylvania, Philadelphia, PA, USA
Nicotine Tob Res 9:1237-41. 2007....
Increase in anger symptoms after smoking cessation predicts relapseFreda Patterson
Transdisciplinary Tobacco Use Research Center, University of Pennsylvania, Philadelphia, PA 19104, USA
Drug Alcohol Depend 95:173-6. 2008..001). These data suggest that anger may be an important withdrawal symptom that influences liability to relapse. Future studies are needed to evaluate treatment strategies that effectively help smokers reduce and manage post-quit anger...
A novel recruitment message to increase enrollment into a smoking cessation treatment program: preliminary results from a randomized trialRobert A Schnoll
Department of Psychiatry, University of Pennsylvania, Philadelphia, 19104, USA
Health Commun 26:735-42. 2011..A larger clinical trial to evaluate a genetic prime message for improving recruitment into smoking cessation programs is warranted...
Mouse model predicts effects of smoking and varenicline on event-related potentials in humansNoam D Rudnick
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Nicotine Tob Res 12:589-97. 2010..Nicotine alters auditory event-related potentials (ERPs) in rodents and humans and is an effective treatment for smoking cessation. Less is known about the effects of the partial nicotine agonist varenicline on ERPs...
Nicotine metabolic rate predicts successful smoking cessation with transdermal nicotine: a validation studyRobert A Schnoll
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Pharmacol Biochem Behav 92:6-11. 2009..38, t[355]=-3.09, p<.05). These data support the value of the 3-HC/cotinine ratio as a biomarker to predict success with transdermal nicotine for smoking cessation...
Do small lapses predict relapse to smoking behavior under bupropion treatment?Paul Wileyto
University of Pennsylvania, Philadelphia, PA 19104 3309, USA
Nicotine Tob Res 6:357-66. 2004....
Varenicline improves mood and cognition during smoking abstinenceFreda Patterson
Department of Psychiatry, University of Pennsylvania, University of Pittsburgh Medical Center, 3811 O Hara St, Pittsburgh, PA 15213, USA
Biol Psychiatry 65:144-9. 2009..Varenicline, a partial agonist at the alpha4beta2 nAChRs, is a new, efficacious medication for nicotine dependence. Its effects on the affective and cognitive dimensions of nicotine withdrawal have yet to be well characterized...
Nicotine metabolite ratio predicts efficacy of transdermal nicotine for smoking cessationCaryn Lerman
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Clin Pharmacol Ther 79:600-8. 2006..This study evaluated the utility of the 3-HC/cotinine ratio as a predictor of the efficacy of nicotine replacement therapy as an aid for smoking cessation...
Convergent evidence that choline acetyltransferase gene variation is associated with prospective smoking cessation and nicotine dependenceRiju Ray
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
Neuropsychopharmacology 35:1374-82. 2010..Additional sequencing and characterization of ChAT may reveal functional variants that contribute to nicotine dependence and smoking cessation...
Treating tobacco dependence in womenRobert A Schnoll
The Transdisciplinary Tobacco Use Research Center, Department of Psychiatry, and Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA
J Womens Health (Larchmt) 16:1211-8. 2007..Greater attention to the unique needs of female smokers may allow healthcare providers to optimize delivery of pharmacotherapy and behavioral counseling to aid their female patients to quit smoking...
Naltrexone reduces the relative reinforcing value of nicotine in a cigarette smoking choice paradigmMargaret Rukstalis
Tobacco Use Research Center, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, USA
Psychopharmacology (Berl) 180:41-8. 2005..Naltrexone and bupropion have been shown to alter ad lib smoking behavior; however, medication effects on nicotine reward in a cigarette choice paradigm have yet to be investigated...
Cost-effectiveness of pharmacogenetic testing to tailor smoking-cessation treatmentD F Heitjan
Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
Pharmacogenomics J 8:391-9. 2008....
Changes in food reward following smoking cessation: a pharmacogenetic investigationCaryn Lerman
Department of Psychiatry, Abramson Cancer Center, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, USA
Psychopharmacology (Berl) 174:571-7. 2004..Despite the high prevalence and public health significance of weight gain following smoking cessation, little is known about the underlying bio-behavioral mechanisms or effective therapies...
Effectiveness of extended-duration transdermal nicotine therapy: a randomized trialRobert A Schnoll
Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, USA
Ann Intern Med 152:144-51. 2010..Tobacco dependence is a chronic, relapsing condition that may require extended treatment...
Predictors of attendance in a randomized clinical trial of nicotine replacement therapy with behavioral counselingFreda Patterson
University of Pennsylvania, Transdisciplinary Tobacco Use Research Center, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, USA
Drug Alcohol Depend 72:123-31. 2003..Additional research in this area would also be valuable to evaluate strategies to promote attendance in these high-risk groups...
Increases in hyperactive-impulsive symptoms predict relapse among smokers in nicotine replacement therapyMargaret Rukstalis
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
J Subst Abuse Treat 28:297-304. 2005....
Reduced nicotine reward in obesity: cross-comparison in human and mouseJulie A Blendy
Department of Pharmacology, 125 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
Psychopharmacology (Berl) 180:306-15. 2005..Tobacco use and obesity lead to significant morbidity and mortality...
Treating tobacco dependence: state of the science and new directionsCaryn Lerman
Tobacco Use Research Center, 3535 Market St, Suite 4100, Philadelphia, PA 19104, USA
J Clin Oncol 23:311-23. 2005..These discoveries could someday help practitioners to individualize the type, dosage, and duration of tobacco dependence treatment based on genotype, and maximize the efficacy...
Individualizing nicotine replacement therapy for the treatment of tobacco dependence: a randomized trialCaryn Lerman
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Ann Intern Med 140:426-33. 2004..CONCLUSIONS: Ethnicity, weight, and level of nicotine dependence may help identify smokers who have greater or lesser abstinence rates with either transdermal or nasal spray nicotine...
Translating basic science to improve pharmacotherapy for nicotine dependenceJennifer M Phillips
University of Pennsylvania, Philadelphia, Pennsylvania, USA
Nicotine Tob Res 9:S583-98. 2007....
Smoking topography predicts abstinence following treatment with nicotine replacement therapyAndrew A Strasser
Transdisciplinary Tobacco Use Research Center, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19104 3309, USA
Cancer Epidemiol Biomarkers Prev 13:1800-4. 2004..A secondary objective was to determine the relationship of smoking topography to carbon monoxide (CO) exposure...
Sex heterogeneity in pharmacogenetic smoking cessation clinical trialsRobert A Schnoll
Department of Psychiatry and Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA
Drug Alcohol Depend 104:S94-9. 2009..We conclude this paper with a summary and a brief discussion of the major caveats of this literature and priorities for future research...
Neighborhood safety as a correlate of tobacco use in a sample of urban, pregnant womenFreda Patterson
Department of Public Health, Temple University, Philadelphia, PA 19122, USA
Addict Behav 37:1132-7. 2012..This study examined the effects of self-reported neighborhood violence and perceived safety on tobacco use in a sample of low-income, pregnant women...
Neural substrates of abstinence-induced cigarette cravings in chronic smokersZe Wang
Department of Neurology, Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 27:14035-40. 2007..These data suggest that increased activation in the brain's visuospatial and reward circuitry underlies abstinence-induced cravings to smoke, and thereby, may be important in relapse...
Individual differences in nicotine intake per cigaretteFreda Patterson
Abramson Cancer Center and Department of Psychiatry, University of Pennsylvania Health Sciences and the Annenberg Public Policy Center, Philadelphia, Pennsylvania 19104, USA
Cancer Epidemiol Biomarkers Prev 12:468-71. 2003..Future research on individual differences in nicotine boost is warranted to clarify the role of psychological, physiological, and cigarette-related determinants...
Effecting behavior change: awareness of family historyJanet Audrain-McGovern
Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, USA
Am J Prev Med 24:183-9. 2003....
Effects of reproductive history on symptoms of menopause: a brief reportDeborah B Nelson
Department of Public Health and Obstetrics and Gynecology, Temple University, Philadelphia, PA, USA
Menopause 18:1143-8. 2011..The aim of this study was to examine the relationship between reproductive history and menopausal symptoms among urban women...
Cigarette smoking practices among American college students: review and future directionsFreda Patterson
Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
J Am Coll Health 52:203-10. 2004..Such information could inform the development of smoking prevention and cessation interventions targeted to the college student population...
Identifying and characterizing adolescent smoking trajectoriesJanet Audrain-McGovern
Department of Psychiatry and Abramson Cancer Center, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, USA
Cancer Epidemiol Biomarkers Prev 13:2023-34. 2004..Adolescent smoking prevention and intervention programs will need to consider this heterogeneity and tailor or enhance attention to risk and protective factors depending on the subpopulation...
Gender differences in smoking cessation in a placebo-controlled trial of bupropion with behavioral counselingBradley N Collins
University of Pennsylvania, Tabacco Research Center, Philadelphia, PA 19104, USA
Nicotine Tob Res 6:27-37. 2004..These results suggest that bupropion treatment may reduce the gender disparity in prolonged abstinence rates among lighter smokers...
