David Patterson

Summary

Affiliation: University of Denver
Country: USA

Publications

  1. doi request reprint Molecular genetic analysis of Down syndrome
    David Patterson
    Eleanor Roosevelt Institute, University of Denver, 2101 E Wesley Avenue, Denver, CO 80208 6600, USA
    Hum Genet 126:195-214. 2009
  2. doi request reprint Down syndrome as a model of DNA polymerase beta haploinsufficiency and accelerated aging
    David Patterson
    Eleanor Roosevelt Institute, University of Denver, Denver, CO, USA
    Mech Ageing Dev 133:133-7. 2012
  3. pmc A humanized mouse model for the reduced folate carrier
    David Patterson
    Eleanor Roosevelt Institute, Department of Biological Sciences, University of Denver, 1899 Gaylord Street, Denver, CO 80206, USA
    Mol Genet Metab 93:95-103. 2008
  4. ncbi request reprint Down syndrome and genetics - a case of linked histories
    David Patterson
    Eleanor Roosevelt Institute, Department of Biological Sciences, University of Denver, Colorado 80206, USA
    Nat Rev Genet 6:137-47. 2005
  5. ncbi request reprint Genetic mechanisms involved in the phenotype of Down syndrome
    David Patterson
    Eleanor Roosevelt Institute, University of Denver, Denver, Colorado 80206, USA
    Ment Retard Dev Disabil Res Rev 13:199-206. 2007
  6. doi request reprint Inherent properties of adenylosuccinate lyase could explain S-Ado/SAICAr ratio due to homozygous R426H and R303C mutations
    Stephen P Ray
    Department of Physics and Astronomy, University of Denver, Denver, CO, USA
    Biochim Biophys Acta 1834:1545-53. 2013
  7. ncbi request reprint The production of transgenic mice expressing human cystathionine beta-synthase to study Down syndrome
    Christine Butler
    The Eleanor Roosevelt Institute at the University of Denver, CO 80206, USA
    Behav Genet 36:429-38. 2006
  8. doi request reprint Folate metabolism and the risk of Down syndrome
    David Patterson
    Eleanor Roosevelt Institute and Departemnt of Biological Sciences, University of Denver, Colorado, USA
    Downs Syndr Res Pract 12:93-7. 2008
  9. doi request reprint Genetic and metabolomic analysis of AdeD and AdeI mutants of de novo purine biosynthesis: cellular models of de novo purine biosynthesis deficiency disorders
    Nathan Duval
    Eleanor Roosevelt Institute and Department of Biological Sciences, University of Denver, Denver, CO 80208, USA
    Mol Genet Metab 108:178-89. 2013
  10. doi request reprint Overexpression of amyloid-β protein precursor induces mitochondrial oxidative stress and activates the intrinsic apoptotic cascade
    Matthew G Bartley
    Department of Biological Sciences and the Eleanor Roosevelt Institute, University of Denver, Denver, CO, USA
    J Alzheimers Dis 28:855-68. 2012

Research Grants

  1. AUTISM AND AMPS LYASE MUTATIONS: CELL AND MOUSE MODELS
    David Patterson; Fiscal Year: 2007
  2. SOMATIC CELL GENETIC STUDIES OF DOWN SYNDROME
    David Patterson; Fiscal Year: 2002
  3. SOMATIC CELL GENETIC ANALYSIS OF PURINE SYNTHESIS
    David Patterson; Fiscal Year: 2001
  4. Proteomics for Testing Hypotheses about Down Syndrome
    David Patterson; Fiscal Year: 2007

Collaborators

Detail Information

Publications16

  1. doi request reprint Molecular genetic analysis of Down syndrome
    David Patterson
    Eleanor Roosevelt Institute, University of Denver, 2101 E Wesley Avenue, Denver, CO 80208 6600, USA
    Hum Genet 126:195-214. 2009
    ..These mouse models allow experimental approaches, including attempts at therapy, that are not possible in humans. Progress in understanding the genetic mechanisms by which trisomy of HSA21 leads to DS is the subject of this review...
  2. doi request reprint Down syndrome as a model of DNA polymerase beta haploinsufficiency and accelerated aging
    David Patterson
    Eleanor Roosevelt Institute, University of Denver, Denver, CO, USA
    Mech Ageing Dev 133:133-7. 2012
    ..As such, Down syndrome may provide a model for elucidating some of the basic mechanisms of aging...
  3. pmc A humanized mouse model for the reduced folate carrier
    David Patterson
    Eleanor Roosevelt Institute, Department of Biological Sciences, University of Denver, 1899 Gaylord Street, Denver, CO 80206, USA
    Mol Genet Metab 93:95-103. 2008
    ....
  4. ncbi request reprint Down syndrome and genetics - a case of linked histories
    David Patterson
    Eleanor Roosevelt Institute, Department of Biological Sciences, University of Denver, Colorado 80206, USA
    Nat Rev Genet 6:137-47. 2005
  5. ncbi request reprint Genetic mechanisms involved in the phenotype of Down syndrome
    David Patterson
    Eleanor Roosevelt Institute, University of Denver, Denver, Colorado 80206, USA
    Ment Retard Dev Disabil Res Rev 13:199-206. 2007
    ..In this manuscript, we describe current knowledge about these genetic complexities and their likely importance in the context of DS. We identify gaps in current knowledge and suggest priorities to fill these gaps...
  6. doi request reprint Inherent properties of adenylosuccinate lyase could explain S-Ado/SAICAr ratio due to homozygous R426H and R303C mutations
    Stephen P Ray
    Department of Physics and Astronomy, University of Denver, Denver, CO, USA
    Biochim Biophys Acta 1834:1545-53. 2013
    ....
  7. ncbi request reprint The production of transgenic mice expressing human cystathionine beta-synthase to study Down syndrome
    Christine Butler
    The Eleanor Roosevelt Institute at the University of Denver, CO 80206, USA
    Behav Genet 36:429-38. 2006
    ..They can also be used to develop therapies that target abnormalities in 1C-TS metabolism to improve cognition in persons with DS...
  8. doi request reprint Folate metabolism and the risk of Down syndrome
    David Patterson
    Eleanor Roosevelt Institute and Departemnt of Biological Sciences, University of Denver, Colorado, USA
    Downs Syndr Res Pract 12:93-7. 2008
    ..This article reviews these challenging findings and looks at where investigations can now go to resolve these issues...
  9. doi request reprint Genetic and metabolomic analysis of AdeD and AdeI mutants of de novo purine biosynthesis: cellular models of de novo purine biosynthesis deficiency disorders
    Nathan Duval
    Eleanor Roosevelt Institute and Department of Biological Sciences, University of Denver, Denver, CO 80208, USA
    Mol Genet Metab 108:178-89. 2013
    ....
  10. doi request reprint Overexpression of amyloid-β protein precursor induces mitochondrial oxidative stress and activates the intrinsic apoptotic cascade
    Matthew G Bartley
    Department of Biological Sciences and the Eleanor Roosevelt Institute, University of Denver, Denver, CO, USA
    J Alzheimers Dis 28:855-68. 2012
    ..These data indicate that overexpression of WT AβPP is sufficient to induce MOS and intrinsic apoptosis, suggesting a novel pro-oxidant role for AβPP at mitochondria which may be relevant in AD and DS disease pathologies...
  11. ncbi request reprint A tribute to Dr. Theodore T. Puck (September 24, 1916-November 6, 2005)
    Philip I Marcus
    Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut 06269, USA
    In Vitro Cell Dev Biol Anim 42:235-41. 2006
    ..In tribute to Dr. Puck, In Vitro Cellular and Developmental Biology-Animal presents invited remembrances from four colleagues whose associations with Dr. Puck spanned 51 years...
  12. ncbi request reprint Down's syndrome
    Nancy J Roizen
    Department of Pediatrics, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Lancet 361:1281-9. 2003
    ..Approaches and outcomes differ throughout the world...
  13. ncbi request reprint Uncontrolled manifold analysis of single trials during multi-finger force production by persons with and without Down syndrome
    John P Scholz
    Department of Physical Therapy and Biomechanics and Movement Science Program, University of Delaware, Newark, DE 19716, USA
    Exp Brain Res 153:45-58. 2003
    ..We conclude that the single-trial method of UCM analysis allows the analysis of hypotheses about stabilization of different performance variables by alleged multi-finger synergies in both typical individuals and individuals with DS...
  14. ncbi request reprint Methylation-mediated downregulation of the B-cell translocation gene 3 (BTG3) in breast cancer cells
    Jingwei Yu
    Department of Laboratory Medicine, University of California, San Francisco, 185 Berry Street, Suite 290, San Francisco, CA 94107, USA
    Gene Expr 14:173-82. 2008
    ..The findings are consistent with a role for an additional copy of BTG3 in the reduced incidence of breast cancer in individuals with Down syndrome...
  15. ncbi request reprint Toward a research agenda for Down syndrome
    Ira T Lott
    Department of Pediatrics, Neurology and Neurobiology, University of California, Irvine, University of California Medical Center, Orange, California, USA
    Ment Retard Dev Disabil Res Rev 13:288-9. 2007
  16. ncbi request reprint Finger coordination in persons with Down syndrome: atypical patterns of coordination and the effects of practice
    Mark L Latash
    Department of Kinesiology, Rec Hall 267, Pennsylvania State University, University Park 16802, USA
    Exp Brain Res 146:345-55. 2002
    ..Practice is an effective way of improving finger coordination in DS, particularly when using variable tasks...

Research Grants13

  1. AUTISM AND AMPS LYASE MUTATIONS: CELL AND MOUSE MODELS
    David Patterson; Fiscal Year: 2007
    ..We will then attempt to intervene with appropriate pharmacological agents to reverse the effects of ADSL deficiency, and, we hope, to other forms of autism. ..
  2. SOMATIC CELL GENETIC STUDIES OF DOWN SYNDROME
    David Patterson; Fiscal Year: 2002
    ..Their success will add greatly to our understanding of neurological development in general and of mental retardation in Down syndrome in particular. ..
  3. SOMATIC CELL GENETIC ANALYSIS OF PURINE SYNTHESIS
    David Patterson; Fiscal Year: 2001
    ....
  4. Proteomics for Testing Hypotheses about Down Syndrome
    David Patterson; Fiscal Year: 2007
    ..Understanding of the alterations in protein levels in the Ts65Dn mouse model of DS should lead to new approaches of ameliorate the cognitive and behavioral aspects of DS. ..