David L Paterson

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc KPC type beta-lactamase, rural Pennsylvania
    Jonathan Pope
    Emerg Infect Dis 12:1613-4. 2006
  2. ncbi request reprint The epidemiological profile of infections with multidrug-resistant Pseudomonas aeruginosa and Acinetobacter species
    David L Paterson
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Clin Infect Dis 43:S43-8. 2006
  3. ncbi request reprint Resistance in gram-negative bacteria: Enterobacteriaceae
    David L Paterson
    Antibiotic Management Program, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Infect Control 34:S20-8; discussion S64-73. 2006
  4. ncbi request reprint The role of antimicrobial management programs in optimizing antibiotic prescribing within hospitals
    David L Paterson
    Antibiotic Management Program and Transplant Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Clin Infect Dis 42:S90-5. 2006
  5. pmc Extended-spectrum beta-lactamases: a clinical update
    David L Paterson
    Infectious Disease Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Clin Microbiol Rev 18:657-86. 2005
  6. ncbi request reprint Clinical experience with recently approved antibiotics
    David L Paterson
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Suite 3A, Falk Medical Building, 3601 5th Avenue, Pittsburgh, PA 15213, USA
    Curr Opin Pharmacol 6:486-90. 2006
  7. ncbi request reprint Resistance in gram-negative bacteria: enterobacteriaceae
    David L Paterson
    Antibiotic Management Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Med 119:S20-8; discussion S62-70. 2006
  8. pmc Genetic basis of multidrug resistance in Acinetobacter baumannii clinical isolates at a tertiary medical center in Pennsylvania
    Jennifer M Adams-Haduch
    Division of Infectious Diseases, University of Pittsburgh Medical Center, S829 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261
    Antimicrob Agents Chemother 52:3837-43. 2008
  9. doi request reprint Interspecies spread of Klebsiella pneumoniae carbapenemase gene in a single patient
    Hanna E Sidjabat
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    Clin Infect Dis 49:1736-8. 2009
  10. ncbi request reprint Antibiotic therapy for Klebsiella pneumoniae bacteremia: implications of production of extended-spectrum beta-lactamases
    David L Paterson
    Infectious Disease Section, VA Medical Center, Pittsburgh, Pennsylvania 15240, USA
    Clin Infect Dis 39:31-7. 2004

Detail Information

Publications88

  1. pmc KPC type beta-lactamase, rural Pennsylvania
    Jonathan Pope
    Emerg Infect Dis 12:1613-4. 2006
  2. ncbi request reprint The epidemiological profile of infections with multidrug-resistant Pseudomonas aeruginosa and Acinetobacter species
    David L Paterson
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Clin Infect Dis 43:S43-8. 2006
    ..Given the lack of antibiotic options to treat infection with panresistant strains, enhanced surveillance for these organisms is necessary at unit-specific, institutional, and national levels...
  3. ncbi request reprint Resistance in gram-negative bacteria: Enterobacteriaceae
    David L Paterson
    Antibiotic Management Program, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Infect Control 34:S20-8; discussion S64-73. 2006
    ..Better antibiotic stewardship and infection control are needed to prevent further spread of ESBLs and other forms of resistance in Enterobacteriaceae throughout the world...
  4. ncbi request reprint The role of antimicrobial management programs in optimizing antibiotic prescribing within hospitals
    David L Paterson
    Antibiotic Management Program and Transplant Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Clin Infect Dis 42:S90-5. 2006
    ....
  5. pmc Extended-spectrum beta-lactamases: a clinical update
    David L Paterson
    Infectious Disease Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Clin Microbiol Rev 18:657-86. 2005
    ..ESBLs represent an impressive example of the ability of gram-negative bacteria to develop new antibiotic resistance mechanisms in the face of the introduction of new antimicrobial agents...
  6. ncbi request reprint Clinical experience with recently approved antibiotics
    David L Paterson
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Suite 3A, Falk Medical Building, 3601 5th Avenue, Pittsburgh, PA 15213, USA
    Curr Opin Pharmacol 6:486-90. 2006
    ..Other new antibiotics (dalbavancin, telavancin, ceftobiprole and doripenem) are currently under clinical development and hold promise for widespread clinical use in the next decade...
  7. ncbi request reprint Resistance in gram-negative bacteria: enterobacteriaceae
    David L Paterson
    Antibiotic Management Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Med 119:S20-8; discussion S62-70. 2006
    ..Better antibiotic stewardship and infection control are needed to prevent further spread of ESBLs and other forms of resistance in Enterobacteriaceae throughout the world...
  8. pmc Genetic basis of multidrug resistance in Acinetobacter baumannii clinical isolates at a tertiary medical center in Pennsylvania
    Jennifer M Adams-Haduch
    Division of Infectious Diseases, University of Pittsburgh Medical Center, S829 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261
    Antimicrob Agents Chemother 52:3837-43. 2008
    ..Fifty-nine percent of the MDR isolates belonged to a single clonal group over the course of the study period, as demonstrated by pulsed-field gel electrophoresis...
  9. doi request reprint Interspecies spread of Klebsiella pneumoniae carbapenemase gene in a single patient
    Hanna E Sidjabat
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    Clin Infect Dis 49:1736-8. 2009
    ..Molecular typing and plasmid analysis suggested that the KPC gene was acquired by E. coli, most likely from K. pneumoniae, and was subsequently transferred to S. marcescens...
  10. ncbi request reprint Antibiotic therapy for Klebsiella pneumoniae bacteremia: implications of production of extended-spectrum beta-lactamases
    David L Paterson
    Infectious Disease Section, VA Medical Center, Pittsburgh, Pennsylvania 15240, USA
    Clin Infect Dis 39:31-7. 2004
    ..Antibiotic choice is particularly important in seriously ill patients with infections due to ESBL-producing K. pneumoniae...
  11. pmc High prevalence of metallo-beta-lactamase and 16S rRNA methylase coproduction among imipenem-resistant Pseudomonas aeruginosa isolates in Brazil
    Yohei Doi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Falk Medical Building Suite 3A, 3601 Fifth Avenue, Pittsburgh PA 15213, USA
    Antimicrob Agents Chemother 51:3388-90. 2007
    ..Of them, 57% and 75% produced SPM-1 and RmtD, respectively. Of note, 51% produced both enzymes, suggesting that their coproduction is already common in this geographic area...
  12. doi request reprint Intrapulmonary disposition of amphotericin B after aerosolized delivery of amphotericin B lipid complex (Abelcet; ABLC) in lung transplant recipients
    Shahid Husain
    Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, PA, USA
    Transplantation 90:1215-9. 2010
    ..However, no published data exist regarding the pharmacokinetic profile of amphotericin B lipid complex in lung transplant recipients...
  13. ncbi request reprint Epidemiological profile of linezolid-resistant coagulase-negative staphylococci
    Brian A Potoski
    Department of Pharmacy and Therapeutics, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Clin Infect Dis 43:165-71. 2006
    ..We investigated the risk factors for and the epidemiological profile of linezolid-resistant coagulase-negative staphylococci...
  14. pmc Outer membrane protein changes and efflux pump expression together may confer resistance to ertapenem in Enterobacter cloacae
    Dora Szabo
    Division of Infectious Diseases, University of Pittsburgh Medical Center, PA 15213, USA
    Antimicrob Agents Chemother 50:2833-5. 2006
    ..Gene transcription of OmpD and OmpF was diminished in the ertapenem-resistant isolate. An efflux pump inhibitor decreased the MICs of ertapenem in the resistant strain, suggesting a potential role of efflux pumps in ertapenem resistance...
  15. pmc Treatment outcome of bacteremia due to KPC-producing Klebsiella pneumoniae: superiority of combination antimicrobial regimens
    Zubair A Qureshi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Antimicrob Agents Chemother 56:2108-13. 2012
    ..7% (8/12). The use of combination therapy for definitive therapy appears to be associated with improved survival in bacteremia due to KPC-producing K. pneumoniae...
  16. ncbi request reprint Opportunistic infections in 547 organ transplant recipients receiving alemtuzumab, a humanized monoclonal CD-52 antibody
    Anton Y Peleg
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Clin Infect Dis 44:204-12. 2007
    ..We assessed the risks of infection in, to our knowledge, the largest cohort and broadest range of organ transplant recipients yet reported to have received alemtuzumab...
  17. ncbi request reprint Pseudomonas aeruginosa infections in the Intensive Care Unit: can the adequacy of empirical beta-lactam antibiotic therapy be improved?
    Sunil Bhat
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Int J Antimicrob Agents 30:458-62. 2007
    ..aeruginosa and the isolation of Gram-negative bacilli resistant to such antibiotics in the recent past can readily increase the adequacy of empirical antibiotic therapy for suspected P. aeruginosa infections...
  18. ncbi request reprint Control of an outbreak of infection with the hypervirulent Clostridium difficile BI strain in a university hospital using a comprehensive "bundle" approach
    Carlene A Muto
    Division of Hospital Epidemiology and Infection Control, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Clin Infect Dis 45:1266-73. 2007
    ..Forty-seven (51%) of 92 HA CD isolates in 2001 were identified as the "epidemic BI strain." A comprehensive CD infection control "bundle" was implemented to control the outbreak of CD infection...
  19. pmc Molecular epidemiology of CTX-M-producing Escherichia coli isolates at a tertiary medical center in western Pennsylvania
    Hanna E Sidjabat
    Division of Infectious Diseases, University of Pittsburgh Medical Center, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Antimicrob Agents Chemother 53:4733-9. 2009
    ..Our findings underscore the need to further investigate the epidemiology and virulence of CTX-M-producing E. coli in the United States...
  20. pmc Identification of 16S rRNA methylase-producing Acinetobacter baumannii clinical strains in North America
    Yohei Doi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Antimicrob Agents Chemother 51:4209-10. 2007
    ..Two of the isolates coproduced OXA-23 beta-lactamase and were highly resistant to carbapenems as well. The isolates were genetically closely related by pulsed-field gel electrophoresis...
  21. pmc Failure of current cefepime breakpoints to predict clinical outcomes of bacteremia caused by gram-negative organisms
    Sunil V Bhat
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Suite 3A Falk Medical Building, 3601 Fifth Avenue, Pittsburgh, PA 15213, USA
    Antimicrob Agents Chemother 51:4390-5. 2007
    ....
  22. pmc Clinical characteristics of bloodstream infections due to ampicillin-sulbactam-resistant, non-extended- spectrum-beta-lactamase-producing Escherichia coli and the role of TEM-1 hyperproduction
    Rebecca I Waltner-Toews
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Antimicrob Agents Chemother 55:495-501. 2011
    ..These results suggest high-level bla(TEM-1) expression as the predominant cause of ampicillin-sulbactam resistance and also the presence of yet-unidentified factors promoting overexpression of bla(TEM-1) in these isolates...
  23. pmc SHV-type extended-spectrum beta-lactamase production is associated with Reduced cefepime susceptibility in Enterobacter cloacae
    Dora Szabo
    Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Clin Microbiol 43:5058-64. 2005
    ..Phenotypic ESBL detection methods were generally unreliable with these E. cloacae isolates. Based on these results, pharmacokinetic, pharmacodynamic, and clinical reevaluation of cefepime breakpoints for E. cloacae may be prudent...
  24. ncbi request reprint Determination of risk factors associated with isolation of linezolid-resistant strains of vancomycin-resistant Enterococcus
    Jason M Pogue
    Department of Pharmacy and Therapeutics, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Infect Control Hosp Epidemiol 28:1382-8. 2007
    ..To identify independent risk factors associated with isolation of linezolid-resistant, vancomycin-resistant Enterococcus (VRE)...
  25. pmc Simple disk-based method for detection of Klebsiella pneumoniae carbapenemase-type beta-lactamase by use of a boronic acid compound
    Yohei Doi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    J Clin Microbiol 46:4083-6. 2008
    ..When combined with nonsusceptibility to ertapenem, the method was easy to perform and reliably differentiated isolates producing KPC-type beta-lactamases from those producing other types of beta-lactamases...
  26. doi request reprint Post-transplant colonization with non-Aspergillus molds and risk of development of invasive fungal disease in lung transplant recipients
    Fernanda P Silveira
    Department of Medicine, Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15237, USA
    J Heart Lung Transplant 27:850-5. 2008
    ..The clinical significance and risk of progression to invasive disease of the non-Aspergillus molds from the bronchoalveolar lavage (BAL) of lung transplant (LTx) recipients are not known...
  27. pmc Genetic environment of 16S rRNA methylase gene rmtD
    Yohei Doi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Falk Medical Building Suite 3A, 3601 Fifth Avenue, Pittsburgh, PA 15213, USA
    Antimicrob Agents Chemother 52:2270-2. 2008
    ..rmtD found in Klebsiella pneumoniae appeared to have been mobilized from P. aeruginosa by an IS26-mediated event...
  28. pmc Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase
    Yohei Doi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Antimicrob Agents Chemother 53:3159-61. 2009
    ..Sequencing of the bla(CMY) genes revealed two novel variants (CMY-33 and -44) with two- to four-amino-acid deletions in the H-10 helix. The deletions were responsible for 12- to 24-fold increases in the MICs of cefepime...
  29. ncbi request reprint Successful outcome of human metapneumovirus (hMPV) pneumonia in a lung transplant recipient treated with intravenous ribavirin
    Kashif Raza
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Heart Lung Transplant 26:862-4. 2007
    ..We report a case of hMPV pneumonia in a lung transplant recipient presenting with respiratory failure and sepsis syndrome. hMPV was diagnosed by polymerase chain reaction, and treated with intravenous ribavirin with a successful outcome...
  30. ncbi request reprint Acinetobacter baumannii bloodstream infection while receiving tigecycline: a cautionary report
    Anton Y Peleg
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Antimicrob Chemother 59:128-31. 2007
    ..baumannii occurring in patients receiving tigecycline for other indications. The possible mechanisms of resistance and pharmacokinetic limitations of the drug are addressed...
  31. doi request reprint Risk factors and outcome of extended-spectrum β-lactamase-producing Enterobacter cloacae bloodstream infections
    Zubair A Qureshi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Int J Antimicrob Agents 37:26-32. 2011
    ..The majority of isolates produced SHV-type ESBL, whereas two isolates produced CTX-M-type ESBL. Initial therapy with a carbapenem appears to be associated with improved clinical outcome in BSI due to ESBL-producing E. cloacae...
  32. pmc Tigecycline Efflux as a Mechanism for Nonsusceptibility in Acinetobacter baumannii
    Anton Y Peleg
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center and Harvard Medical School, 110 Francis St, LMOB Suite GB, Boston, MA 02215, USA
    Antimicrob Agents Chemother 51:2065-9. 2007
    ..These results indicate that an efflux-based mechanism plays a role in reduced tigecycline susceptibility in Acinetobacter...
  33. ncbi request reprint Parenteral and inhaled colistin for treatment of ventilator-associated pneumonia
    Peter K Linden
    1Abdominal Organ Transplant Intensive Care Unit, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    Clin Infect Dis 43:S89-94. 2006
    ..Colistin is a reasonably safe last-line therapeutic alternative for pneumonia due to multi- or panresistant P. aeruginosa or A. baumannii...
  34. pmc Infections with nontyphoidal Salmonella species producing TEM-63 or a novel TEM enzyme, TEM-131, in South Africa
    Tersia Kruger
    UPMC Division of Infectious Diseases, Suite 3A Falk Medical Building, 3601 5th Ave, Pittsburgh, PA 15213, USA
    Antimicrob Agents Chemother 48:4263-70. 2004
    ....
  35. pmc Integron-mediated multidrug resistance in a global collection of nontyphoidal Salmonella enterica isolates
    Mary G Krauland
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, Pennsylvania 15261, USA
    Emerg Infect Dis 15:388-96. 2009
    ..This study demonstrates that clonal expansion and horizontal gene transfer contribute to the global dissemination of antimicrobial drug resistance in S. enterica...
  36. ncbi request reprint Mechanisms of resistance of bacteria causing ventilator-associated pneumonia
    Dora Szabo
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Falk Medical Building, Suite 3A, 3601 5th Avenue, Pittsburgh, PA 15213, USA
    Clin Chest Med 26:75-9. 2005
    ..The ability of bacteria to develop and disseminate new mechanisms of antibiotic resistance may outstrip the availability of new antibiotic classes...
  37. pmc Coproduction of novel 16S rRNA methylase RmtD and metallo-beta-lactamase SPM-1 in a panresistant Pseudomonas aeruginosa isolate from Brazil
    Yohei Doi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Falk Medical Building Suite 3A, 3601 Fifth Avenue, Pittsburgh, PA 15213, USA
    Antimicrob Agents Chemother 51:852-6. 2007
    ..This is also the first report to document coproduction of a metallo-beta-lactamase and a 16S rRNA methylase, a combination that would severely compromise therapeutic options for the infected patients...
  38. ncbi request reprint Aspergillus galactomannan antigen in the bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in lung transplant recipients
    Shahid Husain
    Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, PA 15240, USA
    Transplantation 83:1330-6. 2007
    ..The clinical utility of Platelia Aspergillus enzyme immunoassay (EIA) for galactomannan (GM) antigen detection in bronchoalveolar lavage (BAL) for the diagnosis of invasive aspergillosis (IA) in lung transplant recipients is not known...
  39. ncbi request reprint Detection of plasmid-mediated class C beta-lactamases
    Yohei Doi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Falk Medical Building Suite 3A, 3601 Fifth Avenue, Pittsburgh, PA 15213, USA
    Int J Infect Dis 11:191-7. 2007
    ....
  40. ncbi request reprint International prospective study of Klebsiella pneumoniae bacteremia: implications of extended-spectrum beta-lactamase production in nosocomial Infections
    David L Paterson
    Veterans Affairs Medical Center, Pittsburgh, Pennsylvania 15240, USA
    Ann Intern Med 140:26-32. 2004
    ..Commonly encountered nosocomially acquired gram-negative bacteria, especially Klebsiella pneumoniae, produce extended-spectrum beta-lactamases (ESBLs) as an antibiotic resistance mechanism...
  41. ncbi request reprint Optimizing therapy for infections caused by enterobacteriaceae producing extended-spectrum beta-lactamases
    Andrea Endimiani
    Division of Infectious Diseases, University of Pittsburgh School of Medicine, 3601 5th Avenue, Pittsburgh, PA 15213, USA
    Semin Respir Crit Care Med 28:646-55. 2007
    ..In this context, clinical response to new antibiotics (e.g., tigecycline) and old antibiotics (e.g., colistin) with good in vitro activity against ESBL producers needs to be evaluated...
  42. pmc Intrapulmonary penetration of voriconazole in patients receiving an oral prophylactic regimen
    Blair Capitano
    School of Pharmacy, University of Pittsburgh, 720 Salk Hall, 3501 Terrace St, Pittsburgh, PA 15261, USA
    Antimicrob Agents Chemother 50:1878-80. 2006
    ..The ELF concentrations exceeded those of the plasma, with an average ELF-to-plasma ratio of 11 (+/-8). A strong association between plasma and ELF concentrations (r(2) = 0.95) was noted...
  43. ncbi request reprint "Collateral damage" from cephalosporin or quinolone antibiotic therapy
    David L Paterson
    Division of Infectious Disease, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Clin Infect Dis 38:S341-5. 2004
    ..Neither third-generation cephalosporins nor quinolones appear suitable for sustained use in hospitals as "workhorse" antibiotic therapy...
  44. pmc Clinical features and molecular epidemiology of CMY-type beta-lactamase-producing Escherichia coli
    Hanna E Sidjabat
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    Clin Infect Dis 48:739-44. 2009
    ..Of the several groups of plasmid-mediated AmpC beta-lactamases, CMY-type beta-lactamase is the most common in the United States...
  45. ncbi request reprint Bloodstream infections in organ transplant recipients receiving alemtuzumab: no evidence of occurrence of organisms typically associated with profound T cell depletion
    Fernanda P Silveira
    Division of Infectious Diseases, University of Pittsburgh Medical Center, 3601 Fifth Avenue Suite 3A, Falk Medical Building, Pittsburgh, PA 15213, USA
    J Infect 53:241-7. 2006
    ..We followed a cohort of 449 consecutive transplant recipients who received alemtuzumab to determine the occurrence of bloodstream infections, particularly those previously associated with decrease in CD4 positive T lymphocytes...
  46. ncbi request reprint Simkania negevensis in bronchoalveolar lavage of lung transplant recipients: a possible association with acute rejection
    Shahid Husain
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Transplantation 83:138-43. 2007
    ..The organism has been associated with community acquired pneumonia and acute exacerbation of chronic obstructive pulmonary disease. The prevalence and pathogenic potential of S. negevensis is not known in lung transplant recipients...
  47. pmc Extended-spectrum beta-lactamases in Klebsiella pneumoniae bloodstream isolates from seven countries: dominance and widespread prevalence of SHV- and CTX-M-type beta-lactamases
    David L Paterson
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Antimicrob Agents Chemother 47:3554-60. 2003
    ..pneumoniae infections...
  48. pmc Effect of a selective decontamination of the digestive tract regimen including parenteral cefepime on establishment of intestinal colonization with vancomycin-resistant Enterococcus spp. and Klebsiella pneumoniae in mice
    David L Paterson
    Division of Infectious Diseases, University of Pittsburg Medical Center, Pittsburg Pennslyvania, USA
    Antimicrob Agents Chemother 50:2537-40. 2006
    ..VRE) colonization. However, concurrent administration of subcutaneous ampicillin-sulbactam resulted in promotion of VRE...
  49. ncbi request reprint A large outbreak of Clostridium difficile-associated disease with an unexpected proportion of deaths and colectomies at a teaching hospital following increased fluoroquinolone use
    Carlene A Muto
    Division of Hospital Epidemiology and Infection Control, University of Pittsburgh Medical Center, Presbyterian Campus, Pittsburgh, Pennsylvania 15213, USA
    Infect Control Hosp Epidemiol 26:273-80. 2005
    ..difficile infections; of these, 26 resulted in colectomy and 18 resulted in death. We conducted an investigation of a large C. difficile outbreak in our hospital to identify risk factors and characterize the outbreak...
  50. pmc Diagnosis of human metapneumovirus infection in immunosuppressed lung transplant recipients and children evaluated for pertussis
    Ryan Dare
    Clinical Virology Laboratory, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Clin Microbiol 45:548-52. 2007
    ..Given our findings, infection with hMPV infection should be determined as part of the differential diagnosis of respiratory illnesses...
  51. pmc Community-associated extended-spectrum β-lactamase-producing Escherichia coli infection in the United States
    Yohei Doi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, PA 15261, USA
    Clin Infect Dis 56:641-8. 2013
    ..This epidemiologic shift has implications for the empiric management of community-associated infection when involvement of E. coli is suspected...
  52. ncbi request reprint Scedosporium prolificans brain abscess in a patient with chronic granulomatous disease: successful combination therapy with voriconazole and terbinafine
    Sunil V Bhat
    Division of Infectious Diseases, The University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
    Scand J Infect Dis 39:87-90. 2007
    ..He received therapy with both these antifungals which resulted in disappearance of the brain abscesses. This is the first reported cure of a CNS S. prolificans infection in an immunocompromised host...
  53. ncbi request reprint Changes in the spectrum and risk factors for invasive candidiasis in liver transplant recipients: prospective, multicenter, case-controlled study
    Shahid Husain
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Transplantation 75:2023-9. 2003
    ..This study determines whether the spectrum, risk factors, and outcome of invasive candidiasis in liver transplant recipients have changed...
  54. ncbi request reprint Antibiotic-resistant infections in the critically ill adult
    Fernanda Silveira
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Suite 3A, Falk Medical Building, 3601 5th Avenue, Pittsburgh, PA 15213, USA
    Clin Lab Med 24:329-41. 2004
    ..In contrast, evidence of polyclonality shifts prevention of antibiotic resistance to antibiotic management strategies...
  55. ncbi request reprint Pulmonary fungal infections
    Fernanda Silveira
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Curr Opin Pulm Med 11:242-6. 2005
    ..Invasive fungal infections of the lung have historically been associated with an extremely high mortality. This review aims to disseminate the most recent advances in the diagnosis and management of fungal infections of the lung...
  56. ncbi request reprint In vitro susceptibilities of aerobic and facultative Gram-negative bacilli isolated from patients with intra-abdominal infections worldwide: the 2003 Study for Monitoring Antimicrobial Resistance Trends (SMART)
    David L Paterson
    University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Antimicrob Chemother 55:965-73. 2005
    ....
  57. pmc Acinetobacter baumannii: emergence of a successful pathogen
    Anton Y Peleg
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center and Harvard Medical School, 110 Francis Street, LMOB Suite GB, Boston, MA 02215, USA
    Clin Microbiol Rev 21:538-82. 2008
    ....
  58. ncbi request reprint Clinical outcomes of intravenous immune globulin in severe clostridium difficile-associated diarrhea
    Paul Juang
    Department of Pharmacy and Therapeutics, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Am J Infect Control 35:131-7. 2007
    ....
  59. ncbi request reprint Measurement of adherence to antiretroviral medications
    David L Paterson
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Acquir Immune Defic Syndr 31:S103-6. 2002
    ..The authors believe that careful measurement of adherence is essential in the assessment of a patient failing to respond to antiretroviral therapy...
  60. ncbi request reprint Serious infections caused by enteric gram-negative bacilli--mechanisms of antibiotic resistance and implications for therapy of gram-negative sepsis in the transplanted patient
    David L Paterson
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Semin Respir Infect 17:260-4. 2002
    ..Antibiotic options are becoming more limited as the prevalence of resistance mechanisms in gram-negative bacilli increases...
  61. ncbi request reprint Trends in risk profiles for and mortality associated with invasive aspergillosis among liver transplant recipients
    Nina Singh
    Infectious Disease Section, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15240, USA
    Clin Infect Dis 36:46-52. 2003
    ....
  62. ncbi request reprint Distribution of Legionella species and serogroups isolated by culture in patients with sporadic community-acquired legionellosis: an international collaborative survey
    Victor L Yu
    Veterans Affairs Medical Center, Infectious Disease Section, Pittsburgh, Pennsylvania 15240, USA
    J Infect Dis 186:127-8. 2002
    ..9%) and L. bozemanii (2.4%), followed by L. micdadei, L. dumoffii, L. feeleii, L. wadsworthii, and L. anisa (2.2% combined). L. longbeachae constituted 30.4% of the community-acquired Legionella isolates in Australia and New Zealand...
  63. pmc Aspergillus infections in transplant recipients
    Nina Singh
    University of Pittsburgh Medical Center, VA Medical Center, Infectious Disease Section, University Dr C, Pittsburgh, PA 15240, USA
    Clin Microbiol Rev 18:44-69. 2005
    ....
  64. ncbi request reprint Meropenem administered as a prolonged infusion to treat serious gram-negative central nervous system infections
    Blair Capitano
    Antibiotic Management Program, Department of Pharmacy and Therapeutics, Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Pharmacotherapy 24:803-7. 2004
    ..Our experience demonstrates that dosage modification to maximize pharmacodynamic targets and bactericidal activity may be practically applied to optimize antibiotic treatment for difficult-to-treat CNS infections...
  65. doi request reprint Pre-medication practices and incidence of infusion-related reactions in patients receiving AMPHOTEC: data from the Patient Registry of Amphotericin B Cholesteryl Sulfate Complex for Injection Clinical Tolerability (PRoACT) registry
    David L Paterson
    University of Pittsburgh, Pittsburgh, PA, USA
    J Antimicrob Chemother 62:1392-400. 2008
    ..However, these studies did not permit the use of pre-medications upfront, which are now commonly used. Objectives To describe the use of pre-medications and determine the rate of IRRs in the real-world setting...
  66. ncbi request reprint Empirical antibiotic choice for the seriously ill patient: are minimization of selection of resistant organisms and maximization of individual outcome mutually exclusive?
    David L Paterson
    Antibiotic Management Program, Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Clin Infect Dis 36:1006-12. 2003
    ..Computer-assisted antibiotic prescribing in ICUs may supplement or replace such strategies in the future...
  67. ncbi request reprint Extended-spectrum beta-lactamase gram-negative sepsis following prostate biopsy: implications for use of fluoroquinolone prophylaxis
    Glenn M Cannon
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Can J Urol 14:3653-5. 2007
    ..The patient recovered with intravenous ertapenem. Fluoroquinolone resistant bacteria are increasing in prevalence. This needs to be recognized when the antibiotic choice for pre-procedure prophylaxis is made...
  68. ncbi request reprint Lack of efficacy of mupirocin in the prevention of infections with Staphylococcus aureus in liver transplant recipients and candidates
    David L Paterson
    Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Transplantation 75:194-8. 2003
    ..However, the role of decolonization with mupirocin applied intranasally for the prevention of S. aureus infections in these patients has not been determined...
  69. ncbi request reprint Peritoneal dialysis-related infections recommendations: 2005 update
    Beth Piraino
    University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Perit Dial Int 25:107-31. 2005
  70. ncbi request reprint Restrictive antibiotic policies are appropriate in intensive care units
    David L Paterson
    Antibiotic Management Program, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Crit Care Med 31:S25-8. 2003
    ..Antibiotic stewardship in concert with improved diagnostic methods may be our only hope in preventing endemic panresistant organisms...
  71. pmc Leptospirosis after recreational exposure to water in the Yaeyama islands, Japan
    Masashi Narita
    University of Pittsburgh, Internal Medicine Department, Pittsburgh, Pennsylvania 15232, USA
    Am J Trop Med Hyg 73:652-6. 2005
    ..The increasing incidence of leptospirosis related to recreational sports is an important public health problem in resort areas. A high-index of suspicion, early treatment, and prevention are crucial in this latently endemic area...
  72. ncbi request reprint A change in the epidemiology of infections due to extended-spectrum beta-lactamase-producing organisms
    Jesús Rodríguez-Baño
    Clin Infect Dis 42:935-7. 2006
  73. ncbi request reprint Looking for risk factors for the acquisition of antibiotic resistance: a 21st-century approach
    David L Paterson
    Clin Infect Dis 34:1564-7. 2002
  74. ncbi request reprint Appropriate pharmacokinetic index for outcome in Staphylococcus aureus pneumonia
    Brian A Potoski
    Chest 132:1101-2; author reply 1102-3. 2007
  75. pmc Effect of parenteral antibiotic administration on establishment of intestinal colonization in mice by Klebsiella pneumoniae strains producing extended-spectrum beta-lactamases
    Claudia K Hoyen
    Pediatric Infectious Diseases, Rainbow Babies and Childrens Hospital, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 47:3610-2. 2003
    ....
  76. ncbi request reprint Linezolid: the first oxazolidinone antimicrobial
    David L Paterson
    Ann Intern Med 139:863-4. 2003
  77. pmc Analysis of antibiotic resistance genes in multidrug-resistant Acinetobacter sp. isolates from military and civilian patients treated at the Walter Reed Army Medical Center
    Kristine M Hujer
    Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 50:4114-23. 2006
    ..from the WRAMC. Identifying genes associated with the MDR phenotype and defining patterns of transmission serve as a starting point for devising strategies to limit the clinical impact of these serious infections...
  78. pmc Acquisition of rectal colonization by vancomycin-resistant Enterococcus among intensive care unit patients treated with piperacillin-tazobactam versus those receiving cefepime-containing antibiotic regimens
    David L Paterson
    Royal Brisbane and Women s Hospital, University of Queensland, Brisbane, Australia
    Antimicrob Agents Chemother 52:465-9. 2008
    ..Although piperacillin-tazobactam inhibits the establishment of VRE colonization in mice when exposure occurs during treatment, our data suggest that this agent may not prevent the acquisition of VRE in patients...
  79. pmc Setting and revising antibacterial susceptibility breakpoints
    John Turnidge
    Division of Laboratory Medicine, Women s and Children s Hospital, 72 King William Rd, North Adelaide, South Australia, Australia
    Clin Microbiol Rev 20:391-408, table of contents. 2007
    ..Breakpoint-setting organizations may also play a role in developing phenotypic tests for detection of resistance mechanisms, as this information may complement use of the breakpoint in some circumstances...
  80. doi request reprint Community-acquired extended-spectrum beta-lactamase producers, United States
    Yohei Doi
    Emerg Infect Dis 13:1121-3. 2007
  81. pmc Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil
    Doroti de Oliveira Garcia
    Instituto Adolfo Lutz, Sao Paulo, Brazil
    Antimicrob Agents Chemother 52:1790-3. 2008
    ..Of the 10 pulsotypes identified during the outbreak and follow-up periods, nine produced CTX-M-2 or its new variant CTX-M-59 and one produced SHV-5. bla(CTX-M-2/59) genes were located on closely related plasmids that were transferable...
  82. pmc High prevalence of CTX-M-15-producing Klebsiella pneumoniae among inpatients and outpatients with urinary tract infection in Southern India
    - Muzaheed
    J Antimicrob Chemother 61:1393-4. 2008
  83. pmc Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans
    Yohei Doi
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté deMédecine Paris Sud, Universite Paris XI, 94275 K Bicêtre, France
    Antimicrob Agents Chemother 52:1952-6. 2008
    ..xylosoxidans strains tested (n = 5), indicating that this beta-lactamase is naturally occurring in that species. Induction experiments with imipenem and cefoxitin did not show inducibility of bla(OXA-114) expression...
  84. ncbi request reprint Returning to the pre-antibiotic era in the critically ill: the XDR problem
    David L Paterson
    Crit Care Med 35:1789-91. 2007
  85. pmc Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae isolates possessing blaKPC in the United States
    Andrea Endimiani
    Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 52:2680-2. 2008
    ..One isolate carried the bla(KPC-3) and qnrB19 genes on the same conjugative plasmid, whereas another carried the bla(KPC-3) and qnrA1 genes on separate plasmids...
  86. doi request reprint Health care-associated pneumonia: identification and initial management in the ED
    Fredrick M Abrahamian
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Am J Emerg Med 26:1-11. 2008
    ..The aim of this article is to create awareness of the entity known as HCAP and to provide knowledge of its identification and initial management in the emergency department...
  87. ncbi request reprint In vitro susceptibilities of Escherichia coli isolated from patients with intra-abdominal infections worldwide in 2002-2004: results from SMART (Study for Monitoring Antimicrobial Resistance Trends)
    Grant V Bochicchio
    University of Maryland Medical System, Baltimore, Maryland, USA
    Surg Infect (Larchmt) 7:537-45. 2006
    ..Escherichia coli has been by far the most frequently isolated species...
  88. pmc Escherichia coli isolate coproducing 16S rRNA Methylase and CTX-M-type extended-spectrum beta-lactamase isolated from an outpatient in the United States
    Yohei Doi
    Antimicrob Agents Chemother 52:1204-5. 2008