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Genomes and Genes | David L PatersonSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
The epidemiological profile of infections with multidrug-resistant Pseudomonas aeruginosa and Acinetobacter speciesDavid L Paterson
Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Clin Infect Dis 43:S43-8. 2006..Given the lack of antibiotic options to treat infection with panresistant strains, enhanced surveillance for these organisms is necessary at unit-specific, institutional, and national levels...
Extended-spectrum beta-lactamases: a clinical updateDavid L Paterson
Infectious Disease Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Clin Microbiol Rev 18:657-86. 2005..ESBLs represent an impressive example of the ability of gram-negative bacteria to develop new antibiotic resistance mechanisms in the face of the introduction of new antimicrobial agents...- The role of antimicrobial management programs in optimizing antibiotic prescribing within hospitalsDavid L Paterson
Antibiotic Management Program and Transplant Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Clin Infect Dis 42:S90-5. 2006.... - Resistance in gram-negative bacteria: enterobacteriaceaeDavid L Paterson
Antibiotic Management Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Am J Med 119:S20-8; discussion S62-70. 2006..Better antibiotic stewardship and infection control are needed to prevent further spread of ESBLs and other forms of resistance in Enterobacteriaceae throughout the world... - Resistance in gram-negative bacteria: EnterobacteriaceaeDavid L Paterson
Antibiotic Management Program, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Am J Infect Control 34:S20-8; discussion S64-73. 2006..Better antibiotic stewardship and infection control are needed to prevent further spread of ESBLs and other forms of resistance in Enterobacteriaceae throughout the world... - Clinical experience with recently approved antibioticsDavid L Paterson
Division of Infectious Diseases, University of Pittsburgh Medical Center, Suite 3A, Falk Medical Building, 3601 5th Avenue, Pittsburgh, PA 15213, USA
Curr Opin Pharmacol 6:486-90. 2006..Other new antibiotics (dalbavancin, telavancin, ceftobiprole and doripenem) are currently under clinical development and hold promise for widespread clinical use in the next decade... 
Interspecies spread of Klebsiella pneumoniae carbapenemase gene in a single patientHanna E Sidjabat
Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
Clin Infect Dis 49:1736-8. 2009..Molecular typing and plasmid analysis suggested that the KPC gene was acquired by E. coli, most likely from K. pneumoniae, and was subsequently transferred to S. marcescens...- Genetic basis of multidrug resistance in Acinetobacter baumannii clinical isolates at a tertiary medical center in PennsylvaniaJennifer M Adams-Haduch
Division of Infectious Diseases, University of Pittsburgh Medical Center, S829 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261
Antimicrob Agents Chemother 52:3837-43. 2008..Fifty-nine percent of the MDR isolates belonged to a single clonal group over the course of the study period, as demonstrated by pulsed-field gel electrophoresis... - Antibiotic therapy for Klebsiella pneumoniae bacteremia: implications of production of extended-spectrum beta-lactamasesDavid L Paterson
Infectious Disease Section, VA Medical Center, Pittsburgh, Pennsylvania 15240, USA
Clin Infect Dis 39:31-7. 2004..Antibiotic choice is particularly important in seriously ill patients with infections due to ESBL-producing K. pneumoniae... - Intrapulmonary disposition of amphotericin B after aerosolized delivery of amphotericin B lipid complex (Abelcet; ABLC) in lung transplant recipientsShahid Husain
Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, PA, USA
Transplantation 90:1215-9. 2010..However, no published data exist regarding the pharmacokinetic profile of amphotericin B lipid complex in lung transplant recipients... - High prevalence of metallo-beta-lactamase and 16S rRNA methylase coproduction among imipenem-resistant Pseudomonas aeruginosa isolates in BrazilYohei Doi
Division of Infectious Diseases, University of Pittsburgh Medical Center, Falk Medical Building Suite 3A, 3601 Fifth Avenue, Pittsburgh PA 15213, USA
Antimicrob Agents Chemother 51:3388-90. 2007..Of them, 57% and 75% produced SPM-1 and RmtD, respectively. Of note, 51% produced both enzymes, suggesting that their coproduction is already common in this geographic area... - Treatment outcome of bacteremia due to KPC-producing Klebsiella pneumoniae: superiority of combination antimicrobial regimensZubair A Qureshi
Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Antimicrob Agents Chemother 56:2108-13. 2012..7% (8/12). The use of combination therapy for definitive therapy appears to be associated with improved survival in bacteremia due to KPC-producing K. pneumoniae... - Epidemiological profile of linezolid-resistant coagulase-negative staphylococciBrian A Potoski
Department of Pharmacy and Therapeutics, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Clin Infect Dis 43:165-71. 2006..The potential for a parallel scenario involving clonal dissemination followed by selection of linezolid-resistant methicillin-resistant Staphylococcus aureus is a real possibility... - Opportunistic infections in 547 organ transplant recipients receiving alemtuzumab, a humanized monoclonal CD-52 antibodyAnton Y Peleg
Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Clin Infect Dis 44:204-12. 2007..We assessed the risks of infection in, to our knowledge, the largest cohort and broadest range of organ transplant recipients yet reported to have received alemtuzumab... - Pseudomonas aeruginosa infections in the Intensive Care Unit: can the adequacy of empirical beta-lactam antibiotic therapy be improved?Sunil Bhat
Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Int J Antimicrob Agents 30:458-62. 2007..aeruginosa and the isolation of Gram-negative bacilli resistant to such antibiotics in the recent past can readily increase the adequacy of empirical antibiotic therapy for suspected P. aeruginosa infections... - Control of an outbreak of infection with the hypervirulent Clostridium difficile BI strain in a university hospital using a comprehensive "bundle" approachCarlene A Muto
Division of Hospital Epidemiology and Infection Control, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Clin Infect Dis 45:1266-73. 2007..Forty-seven (51%) of 92 HA CD isolates in 2001 were identified as the "epidemic BI strain." A comprehensive CD infection control "bundle" was implemented to control the outbreak of CD infection... - Identification of 16S rRNA methylase-producing Acinetobacter baumannii clinical strains in North AmericaYohei Doi
Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Antimicrob Agents Chemother 51:4209-10. 2007..Two of the isolates coproduced OXA-23 beta-lactamase and were highly resistant to carbapenems as well. The isolates were genetically closely related by pulsed-field gel electrophoresis... - Failure of current cefepime breakpoints to predict clinical outcomes of bacteremia caused by gram-negative organismsSunil V Bhat
Division of Infectious Diseases, University of Pittsburgh Medical Center, Suite 3A Falk Medical Building, 3601 Fifth Avenue, Pittsburgh, PA 15213, USA
Antimicrob Agents Chemother 51:4390-5. 2007.... - Outer membrane protein changes and efflux pump expression together may confer resistance to ertapenem in Enterobacter cloacaeDora Szabo
Division of Infectious Diseases, University of Pittsburgh Medical Center, PA 15213, USA
Antimicrob Agents Chemother 50:2833-5. 2006..Gene transcription of OmpD and OmpF was diminished in the ertapenem-resistant isolate. An efflux pump inhibitor decreased the MICs of ertapenem in the resistant strain, suggesting a potential role of efflux pumps in ertapenem resistance... - Clinical characteristics of bloodstream infections due to ampicillin-sulbactam-resistant, non-extended- spectrum-beta-lactamase-producing Escherichia coli and the role of TEM-1 hyperproductionRebecca I Waltner-Toews
Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
Antimicrob Agents Chemother 55:495-501. 2011..These results suggest high-level bla(TEM-1) expression as the predominant cause of ampicillin-sulbactam resistance and also the presence of yet-unidentified factors promoting overexpression of bla(TEM-1) in these isolates... - Molecular epidemiology of CTX-M-producing Escherichia coli isolates at a tertiary medical center in western PennsylvaniaHanna E Sidjabat
Division of Infectious Diseases, University of Pittsburgh Medical Center, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Antimicrob Agents Chemother 53:4733-9. 2009..Our findings underscore the need to further investigate the epidemiology and virulence of CTX-M-producing E. coli in the United States... - Successful outcome of human metapneumovirus (hMPV) pneumonia in a lung transplant recipient treated with intravenous ribavirinKashif Raza
Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
J Heart Lung Transplant 26:862-4. 2007..We report a case of hMPV pneumonia in a lung transplant recipient presenting with respiratory failure and sepsis syndrome. hMPV was diagnosed by polymerase chain reaction, and treated with intravenous ribavirin with a successful outcome... - Genetic environment of 16S rRNA methylase gene rmtDYohei Doi
Division of Infectious Diseases, University of Pittsburgh Medical Center, Falk Medical Building Suite 3A, 3601 Fifth Avenue, Pittsburgh, PA 15213, USA
Antimicrob Agents Chemother 52:2270-2. 2008..rmtD found in Klebsiella pneumoniae appeared to have been mobilized from P. aeruginosa by an IS26-mediated event... - Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamaseYohei Doi
Division of Infectious Diseases, University of Pittsburgh Medical Center, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Antimicrob Agents Chemother 53:3159-61. 2009..Sequencing of the bla(CMY) genes revealed two novel variants (CMY-33 and -44) with two- to four-amino-acid deletions in the H-10 helix. The deletions were responsible for 12- to 24-fold increases in the MICs of cefepime... - Simple disk-based method for detection of Klebsiella pneumoniae carbapenemase-type beta-lactamase by use of a boronic acid compoundYohei Doi
Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
J Clin Microbiol 46:4083-6. 2008..When combined with nonsusceptibility to ertapenem, the method was easy to perform and reliably differentiated isolates producing KPC-type beta-lactamases from those producing other types of beta-lactamases... - Determination of risk factors associated with isolation of linezolid-resistant strains of vancomycin-resistant EnterococcusJason M Pogue
Department of Pharmacy and Therapeutics, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Infect Control Hosp Epidemiol 28:1382-8. 2007..To identify independent risk factors associated with isolation of linezolid-resistant, vancomycin-resistant Enterococcus (VRE)... - Post-transplant colonization with non-Aspergillus molds and risk of development of invasive fungal disease in lung transplant recipientsFernanda P Silveira
Department of Medicine, Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15237, USA
J Heart Lung Transplant 27:850-5. 2008..The clinical significance and risk of progression to invasive disease of the non-Aspergillus molds from the bronchoalveolar lavage (BAL) of lung transplant (LTx) recipients are not known... - Risk factors and outcome of extended-spectrum β-lactamase-producing Enterobacter cloacae bloodstream infectionsZubair A Qureshi
Division of Infectious Diseases, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Int J Antimicrob Agents 37:26-32. 2011..The majority of isolates produced SHV-type ESBL, whereas two isolates produced CTX-M-type ESBL. Initial therapy with a carbapenem appears to be associated with improved clinical outcome in BSI due to ESBL-producing E. cloacae... - Acinetobacter baumannii bloodstream infection while receiving tigecycline: a cautionary reportAnton Y Peleg
Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
J Antimicrob Chemother 59:128-31. 2007..baumannii occurring in patients receiving tigecycline for other indications. The possible mechanisms of resistance and pharmacokinetic limitations of the drug are addressed... - Tigecycline Efflux as a Mechanism for Nonsusceptibility in Acinetobacter baumanniiAnton Y Peleg
Division of Infectious Diseases, Beth Israel Deaconess Medical Center and Harvard Medical School, 110 Francis St, LMOB Suite GB, Boston, MA 02215, USA
Antimicrob Agents Chemother 51:2065-9. 2007..These results indicate that an efflux-based mechanism plays a role in reduced tigecycline susceptibility in Acinetobacter... - Parenteral and inhaled colistin for treatment of ventilator-associated pneumoniaPeter K Linden
1Abdominal Organ Transplant Intensive Care Unit, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
Clin Infect Dis 43:S89-94. 2006..Colistin is a reasonably safe last-line therapeutic alternative for pneumonia due to multi- or panresistant P. aeruginosa or A. baumannii... - SHV-type extended-spectrum beta-lactamase production is associated with Reduced cefepime susceptibility in Enterobacter cloacaeDora Szabo
Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Clin Microbiol 43:5058-64. 2005..Phenotypic ESBL detection methods were generally unreliable with these E. cloacae isolates. Based on these results, pharmacokinetic, pharmacodynamic, and clinical reevaluation of cefepime breakpoints for E. cloacae may be prudent... - International prospective study of Klebsiella pneumoniae bacteremia: implications of extended-spectrum beta-lactamase production in nosocomial InfectionsDavid L Paterson
Veterans Affairs Medical Center, Pittsburgh, Pennsylvania 15240, USA
Ann Intern Med 140:26-32. 2004..CONCLUSIONS: Production of ESBLs by Klebsiella pneumoniae is a widespread nosocomial problem. Appropriate infection control and antibiotic management strategies are needed to stem the spread of this emerging form of resistance... - Mechanisms of resistance of bacteria causing ventilator-associated pneumoniaDora Szabo
Division of Infectious Diseases, University of Pittsburgh Medical Center, Falk Medical Building, Suite 3A, 3601 5th Avenue, Pittsburgh, PA 15213, USA
Clin Chest Med 26:75-9. 2005..The ability of bacteria to develop and disseminate new mechanisms of antibiotic resistance may outstrip the availability of new antibiotic classes... - Integron-mediated multidrug resistance in a global collection of nontyphoidal Salmonella enterica isolatesMary G Krauland
Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, Pennsylvania 15261, USA
Emerg Infect Dis 15:388-96. 2009..This study demonstrates that clonal expansion and horizontal gene transfer contribute to the global dissemination of antimicrobial drug resistance in S. enterica... - Aspergillus galactomannan antigen in the bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in lung transplant recipientsShahid Husain
Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, PA 15240, USA
Transplantation 83:1330-6. 2007..The clinical utility of Platelia Aspergillus enzyme immunoassay (EIA) for galactomannan (GM) antigen detection in bronchoalveolar lavage (BAL) for the diagnosis of invasive aspergillosis (IA) in lung transplant recipients is not known... - Detection of plasmid-mediated class C beta-lactamasesYohei Doi
Division of Infectious Diseases, University of Pittsburgh Medical Center, Falk Medical Building Suite 3A, 3601 Fifth Avenue, Pittsburgh, PA 15213, USA
Int J Infect Dis 11:191-7. 2007.... - Coproduction of novel 16S rRNA methylase RmtD and metallo-beta-lactamase SPM-1 in a panresistant Pseudomonas aeruginosa isolate from BrazilYohei Doi
Division of Infectious Diseases, University of Pittsburgh Medical Center, Falk Medical Building Suite 3A, 3601 Fifth Avenue, Pittsburgh, PA 15213, USA
Antimicrob Agents Chemother 51:852-6. 2007..This is also the first report to document coproduction of a metallo-beta-lactamase and a 16S rRNA methylase, a combination that would severely compromise therapeutic options for the infected patients... - Infections with nontyphoidal Salmonella species producing TEM-63 or a novel TEM enzyme, TEM-131, in South AfricaTersia Kruger
UPMC Division of Infectious Diseases, Suite 3A Falk Medical Building, 3601 5th Ave, Pittsburgh, PA 15213, USA
Antimicrob Agents Chemother 48:4263-70. 2004.... - Optimizing therapy for infections caused by enterobacteriaceae producing extended-spectrum beta-lactamasesAndrea Endimiani
Division of Infectious Diseases, University of Pittsburgh School of Medicine, 3601 5th Avenue, Pittsburgh, PA 15213, USA
Semin Respir Crit Care Med 28:646-55. 2007..In this context, clinical response to new antibiotics (e.g., tigecycline) and old antibiotics (e.g., colistin) with good in vitro activity against ESBL producers needs to be evaluated... - Clinical features and molecular epidemiology of CMY-type beta-lactamase-producing Escherichia coliHanna E Sidjabat
Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
Clin Infect Dis 48:739-44. 2009..Of the several groups of plasmid-mediated AmpC beta-lactamases, CMY-type beta-lactamase is the most common in the United States... - Intrapulmonary penetration of voriconazole in patients receiving an oral prophylactic regimenBlair Capitano
School of Pharmacy, University of Pittsburgh, 720 Salk Hall, 3501 Terrace St, Pittsburgh, PA 15261, USA
Antimicrob Agents Chemother 50:1878-80. 2006..The ELF concentrations exceeded those of the plasma, with an average ELF-to-plasma ratio of 11 (+/-8). A strong association between plasma and ELF concentrations (r(2) = 0.95) was noted... - "Collateral damage" from cephalosporin or quinolone antibiotic therapyDavid L Paterson
Division of Infectious Disease, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Clin Infect Dis 38:S341-5. 2004..Neither third-generation cephalosporins nor quinolones appear suitable for sustained use in hospitals as "workhorse" antibiotic therapy... - Bloodstream infections in organ transplant recipients receiving alemtuzumab: no evidence of occurrence of organisms typically associated with profound T cell depletionFernanda P Silveira
Division of Infectious Diseases, University of Pittsburgh Medical Center, 3601 Fifth Avenue Suite 3A, Falk Medical Building, Pittsburgh, PA 15213, USA
J Infect 53:241-7. 2006.... - Simkania negevensis in bronchoalveolar lavage of lung transplant recipients: a possible association with acute rejectionShahid Husain
Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Transplantation 83:138-43. 2007..The organism has been associated with community acquired pneumonia and acute exacerbation of chronic obstructive pulmonary disease. The prevalence and pathogenic potential of S. negevensis is not known in lung transplant recipients... - Effect of a selective decontamination of the digestive tract regimen including parenteral cefepime on establishment of intestinal colonization with vancomycin-resistant Enterococcus spp. and Klebsiella pneumoniae in miceDavid L Paterson
Division of Infectious Diseases, University of Pittsburg Medical Center, Pittsburg Pennslyvania, USA
Antimicrob Agents Chemother 50:2537-40. 2006..VRE) colonization. However, concurrent administration of subcutaneous ampicillin-sulbactam resulted in promotion of VRE... - Extended-spectrum beta-lactamases in Klebsiella pneumoniae bloodstream isolates from seven countries: dominance and widespread prevalence of SHV- and CTX-M-type beta-lactamasesDavid L Paterson
Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Antimicrob Agents Chemother 47:3554-60. 2003..pneumoniae infections... - In vitro susceptibilities of aerobic and facultative Gram-negative bacilli isolated from patients with intra-abdominal infections worldwide: the 2003 Study for Monitoring Antimicrobial Resistance Trends (SMART)David L Paterson
University of Pittsburgh Medical Center, Pittsburgh, PA, USA
J Antimicrob Chemother 55:965-73. 2005..The carbapenems ertapenem, meropenem and imipenem are highly active in vitro against Enterobacteriaceae isolated from intra-abdominal sites, including organisms that produce ESBLs... - Scedosporium prolificans brain abscess in a patient with chronic granulomatous disease: successful combination therapy with voriconazole and terbinafineSunil V Bhat
Division of Infectious Diseases, The University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Scand J Infect Dis 39:87-90. 2007..He received therapy with both these antifungals which resulted in disappearance of the brain abscesses. This is the first reported cure of a CNS S. prolificans infection in an immunocompromised host... - Changes in the spectrum and risk factors for invasive candidiasis in liver transplant recipients: prospective, multicenter, case-controlled studyShahid Husain
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Transplantation 75:2023-9. 2003..Routine use of antifungal prophylaxis warrants concern given the emergence of non-albicans Candida spp. as significant pathogens after liver transplantation and higher mortality in patients with these infections... - Clinical outcomes of intravenous immune globulin in severe clostridium difficile-associated diarrheaPaul Juang
Department of Pharmacy and Therapeutics, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Am J Infect Control 35:131-7. 2007.... - Pulmonary fungal infectionsFernanda Silveira
Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Curr Opin Pulm Med 11:242-6. 2005..Immense advances in the last 2-3 years are sure to improve outcome. Well-designed multicenter evaluations are still necessary, however, to optimize management as management options widen... - Acinetobacter baumannii: emergence of a successful pathogenAnton Y Peleg
Division of Infectious Diseases, Beth Israel Deaconess Medical Center and Harvard Medical School, 110 Francis Street, LMOB Suite GB, Boston, MA 02215, USA
Clin Microbiol Rev 21:538-82. 2008.... - Antibiotic-resistant infections in the critically ill adultFernanda Silveira
Division of Infectious Diseases, University of Pittsburgh Medical Center, Suite 3A, Falk Medical Building, 3601 5th Avenue, Pittsburgh, PA 15213, USA
Clin Lab Med 24:329-41. 2004..In contrast, evidence of polyclonality shifts prevention of antibiotic resistance to antibiotic management strategies... - Measurement of adherence to antiretroviral medicationsDavid L Paterson
Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
J Acquir Immune Defic Syndr 31:S103-6. 2002..The authors believe that careful measurement of adherence is essential in the assessment of a patient failing to respond to antiretroviral therapy... - Serious infections caused by enteric gram-negative bacilli--mechanisms of antibiotic resistance and implications for therapy of gram-negative sepsis in the transplanted patientDavid L Paterson
Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Semin Respir Infect 17:260-4. 2002..Antibiotic options are becoming more limited as the prevalence of resistance mechanisms in gram-negative bacilli increases... - Trends in risk profiles for and mortality associated with invasive aspergillosis among liver transplant recipientsNina Singh
Infectious Disease Section, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15240, USA
Clin Infect Dis 36:46-52. 2003.... - Distribution of Legionella species and serogroups isolated by culture in patients with sporadic community-acquired legionellosis: an international collaborative surveyVictor L Yu
Veterans Affairs Medical Center, Infectious Disease Section, Pittsburgh, Pennsylvania 15240, USA
J Infect Dis 186:127-8. 2002..9%) and L. bozemanii (2.4%), followed by L. micdadei, L. dumoffii, L. feeleii, L. wadsworthii, and L. anisa (2.2% combined). L. longbeachae constituted 30.4% of the community-acquired Legionella isolates in Australia and New Zealand... - Extended-spectrum beta-lactamase gram-negative sepsis following prostate biopsy: implications for use of fluoroquinolone prophylaxisGlenn M Cannon
Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Can J Urol 14:3653-5. 2007..The patient recovered with intravenous ertapenem. Fluoroquinolone resistant bacteria are increasing in prevalence. This needs to be recognized when the antibiotic choice for pre-procedure prophylaxis is made... - Diagnosis of human metapneumovirus infection in immunosuppressed lung transplant recipients and children evaluated for pertussisRyan Dare
Clinical Virology Laboratory, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
J Clin Microbiol 45:548-52. 2007..Given our findings, infection with hMPV infection should be determined as part of the differential diagnosis of respiratory illnesses... - Pre-medication practices and incidence of infusion-related reactions in patients receiving AMPHOTEC: data from the Patient Registry of Amphotericin B Cholesteryl Sulfate Complex for Injection Clinical Tolerability (PRoACT) registryDavid L Paterson
University of Pittsburgh, Pittsburgh, PA, USA
J Antimicrob Chemother 62:1392-400. 2008..However, these studies did not permit the use of pre-medications upfront, which are now commonly used. Objectives To describe the use of pre-medications and determine the rate of IRRs in the real-world setting... - Aspergillus infections in transplant recipientsNina Singh
University of Pittsburgh Medical Center, VA Medical Center, Infectious Disease Section, University Dr C, Pittsburgh, PA 15240, USA
Clin Microbiol Rev 18:44-69. 2005.... - Meropenem administered as a prolonged infusion to treat serious gram-negative central nervous system infectionsBlair Capitano
Antibiotic Management Program, Department of Pharmacy and Therapeutics, Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Pharmacotherapy 24:803-7. 2004..Our experience demonstrates that dosage modification to maximize pharmacodynamic targets and bactericidal activity may be practically applied to optimize antibiotic treatment for difficult-to-treat CNS infections... - Empirical antibiotic choice for the seriously ill patient: are minimization of selection of resistant organisms and maximization of individual outcome mutually exclusive?David L Paterson
Antibiotic Management Program, Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Clin Infect Dis 36:1006-12. 2003..Computer-assisted antibiotic prescribing in ICUs may supplement or replace such strategies in the future... - A large outbreak of Clostridium difficile-associated disease with an unexpected proportion of deaths and colectomies at a teaching hospital following increased fluoroquinolone useCarlene A Muto
Division of Hospital Epidemiology and Infection Control, University of Pittsburgh Medical Center, Presbyterian Campus, Pittsburgh, Pennsylvania 15213, USA
Infect Control Hosp Epidemiol 26:273-80. 2005..difficile infections; of these, 26 resulted in colectomy and 18 resulted in death. We conducted an investigation of a large C. difficile outbreak in our hospital to identify risk factors and characterize the outbreak... - Lack of efficacy of mupirocin in the prevention of infections with Staphylococcus aureus in liver transplant recipients and candidatesDavid L Paterson
Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Transplantation 75:194-8. 2003..aureus. No isolate was found to be mupirocin resistant. CONCLUSION: Elimination of S. aureus nasal carriage by mupirocin did not prevent S. aureus infections in patients in our liver transplant unit... - Peritoneal dialysis-related infections recommendations: 2005 updateBeth Piraino
University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Perit Dial Int 25:107-31. 2005 - Restrictive antibiotic policies are appropriate in intensive care unitsDavid L Paterson
Antibiotic Management Program, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Crit Care Med 31:S25-8. 2003..Antibiotic stewardship in concert with improved diagnostic methods may be our only hope in preventing endemic panresistant organisms... - Leptospirosis after recreational exposure to water in the Yaeyama islands, JapanMasashi Narita
University of Pittsburgh, Internal Medicine Department, Pittsburgh, Pennsylvania 15232, USA
Am J Trop Med Hyg 73:652-6. 2005..The increasing incidence of leptospirosis related to recreational sports is an important public health problem in resort areas. A high-index of suspicion, early treatment, and prevention are crucial in this latently endemic area... - Linezolid: the first oxazolidinone antimicrobialDavid L Paterson
Ann Intern Med 139:863-4. 2003 - Effect of parenteral antibiotic administration on establishment of intestinal colonization in mice by Klebsiella pneumoniae strains producing extended-spectrum beta-lactamasesClaudia K Hoyen
Pediatric Infectious Diseases, Rainbow Babies and Childrens Hospital, Cleveland, Ohio 44106, USA
Antimicrob Agents Chemother 47:3610-2. 2003.... - Looking for risk factors for the acquisition of antibiotic resistance: a 21st-century approachDavid L Paterson
Clin Infect Dis 34:1564-7. 2002 - A change in the epidemiology of infections due to extended-spectrum beta-lactamase-producing organismsJesús Rodríguez-Baño
Clin Infect Dis 42:935-7. 2006 - Analysis of antibiotic resistance genes in multidrug-resistant Acinetobacter sp. isolates from military and civilian patients treated at the Walter Reed Army Medical CenterKristine M Hujer
Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
Antimicrob Agents Chemother 50:4114-23. 2006..from the WRAMC. Identifying genes associated with the MDR phenotype and defining patterns of transmission serve as a starting point for devising strategies to limit the clinical impact of these serious infections... - Health care-associated pneumonia: identification and initial management in the EDFredrick M Abrahamian
David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Am J Emerg Med 26:1-11. 2008..The aim of this article is to create awareness of the entity known as HCAP and to provide knowledge of its identification and initial management in the emergency department... - Appropriate pharmacokinetic index for outcome in Staphylococcus aureus pneumoniaBrian A Potoski
Chest 132:1101-2; author reply 1102-3. 2007 - Setting and revising antibacterial susceptibility breakpointsJohn Turnidge
Division of Laboratory Medicine, Women s and Children s Hospital, 72 King William Rd, North Adelaide, South Australia, Australia
Clin Microbiol Rev 20:391-408, table of contents. 2007..Breakpoint-setting organizations may also play a role in developing phenotypic tests for detection of resistance mechanisms, as this information may complement use of the breakpoint in some circumstances... - Returning to the pre-antibiotic era in the critically ill: the XDR problemDavid L Paterson
Crit Care Med 35:1789-91. 2007 - In vitro susceptibilities of Escherichia coli isolated from patients with intra-abdominal infections worldwide in 2002-2004: results from SMART (Study for Monitoring Antimicrobial Resistance Trends)Grant V Bochicchio
University of Maryland Medical System, Baltimore, Maryland, USA
Surg Infect (Larchmt) 7:537-45. 2006..coli isolated from intraabdominal infections is not inconsequential, especially in the Asia/Pacific region. The carbapenems and amikacin were consistently active in vitro against E. coli isolates worldwide, including ESBL-producers... - Acquisition of rectal colonization by vancomycin-resistant Enterococcus among intensive care unit patients treated with piperacillin-tazobactam versus those receiving cefepime-containing antibiotic regimensDavid L Paterson
Royal Brisbane and Women s Hospital, University of Queensland, Brisbane, Australia
Antimicrob Agents Chemother 52:465-9. 2008..Although piperacillin-tazobactam inhibits the establishment of VRE colonization in mice when exposure occurs during treatment, our data suggest that this agent may not prevent the acquisition of VRE in patients... - KPC type beta-lactamase, rural PennsylvaniaJonathan Pope
Emerg Infect Dis 12:1613-4. 2006 - Escherichia coli isolate coproducing 16S rRNA Methylase and CTX-M-type extended-spectrum beta-lactamase isolated from an outpatient in the United StatesYohei Doi
Antimicrob Agents Chemother 52:1204-5. 2008 - Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in BrazilDoroti de Oliveira Garcia
Instituto Adolfo Lutz, Sao Paulo, Brazil
Antimicrob Agents Chemother 52:1790-3. 2008..Of the 10 pulsotypes identified during the outbreak and follow-up periods, nine produced CTX-M-2 or its new variant CTX-M-59 and one produced SHV-5. bla(CTX-M-2/59) genes were located on closely related plasmids that were transferable... - High prevalence of CTX-M-15-producing Klebsiella pneumoniae among inpatients and outpatients with urinary tract infection in Southern IndiaYohei Doi
J Antimicrob Chemother 61:1393-4. 2008 - Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidansYohei Doi
Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté deMédecine Paris Sud, Universite Paris XI, 94275 K Bicêtre, France
Antimicrob Agents Chemother 52:1952-6. 2008..xylosoxidans strains tested (n = 5), indicating that this beta-lactamase is naturally occurring in that species. Induction experiments with imipenem and cefoxitin did not show inducibility of bla(OXA-114) expression... - Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae isolates possessing blaKPC in the United StatesAndrea Endimiani
Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
Antimicrob Agents Chemother 52:2680-2. 2008..One isolate carried the bla(KPC-3) and qnrB19 genes on the same conjugative plasmid, whereas another carried the bla(KPC-3) and qnrA1 genes on separate plasmids... - Community-acquired extended-spectrum beta-lactamase producers, United StatesYohei Doi
Emerg Infect Dis 13:1121-3. 2007