Nitin Patel

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi Involvement of miR-30c and miR-301a in immediate induction of plasminogen activator inhibitor-1 by placental growth factor in human pulmonary endothelial cells
    Nitin Patel
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Biochem J 434:473-82. 2011
  2. ncbi GPR158, an orphan member of G protein-coupled receptor Family C: glucocorticoid-stimulated expression and novel nuclear role
    Nitin Patel
    Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 8:e57843. 2013
  3. ncbi Placenta growth factor (PlGF), a novel inducer of plasminogen activator inhibitor-1 (PAI-1) in sickle cell disease (SCD)
    Nitin Patel
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 285:16713-22. 2010
  4. ncbi Placenta growth factor induces 5-lipoxygenase-activating protein to increase leukotriene formation in sickle cell disease
    Nitin Patel
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Blood 113:1129-38. 2009
  5. ncbi Placenta growth factor-induced early growth response 1 (Egr-1) regulates hypoxia-inducible factor-1alpha (HIF-1alpha) in endothelial cells
    Nitin Patel
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Biol Chem 285:20570-9. 2010
  6. ncbi Placenta growth factor augments endothelin-1 and endothelin-B receptor expression via hypoxia-inducible factor-1 alpha
    Nitin Patel
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Blood 112:856-65. 2008
  7. ncbi Interaction of clusterin and matrix metalloproteinase-9 and its implication for epithelial homeostasis and inflammation
    ShinWu Jeong
    USC Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Am J Pathol 180:2028-39. 2012

Collaborators

  • Catherine Madigan
  • ShinWu Jeong
  • Gabriel M Gordon
  • M Elizabeth Fini
  • Aaron Martin
  • Dolena R Ledee
  • Tatsuo Itakura

Detail Information

Publications7

  1. ncbi Involvement of miR-30c and miR-301a in immediate induction of plasminogen activator inhibitor-1 by placental growth factor in human pulmonary endothelial cells
    Nitin Patel
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Biochem J 434:473-82. 2011
    ..Finally, plasma levels of miR-30c and miR-301a were significantly down-regulated in patients with SCA compared with normal controls. These results provide a post-transcriptional regulatory mechanism of PlGF-induced PAI-1 elevation...
  2. ncbi GPR158, an orphan member of G protein-coupled receptor Family C: glucocorticoid-stimulated expression and novel nuclear role
    Nitin Patel
    Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 8:e57843. 2013
    ..Regulated paracellular permeability controls aqueous outflow facility in vivo. Since GCs stimulate GPR158 expression, the result is consistent with a role for elevation of GPR158 expression in GC-induced ocular hypertension...
  3. ncbi Placenta growth factor (PlGF), a novel inducer of plasminogen activator inhibitor-1 (PAI-1) in sickle cell disease (SCD)
    Nitin Patel
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 285:16713-22. 2010
    ..In conclusion, we identify a novel mechanism of PAI-1 elevation in SCD...
  4. ncbi Placenta growth factor induces 5-lipoxygenase-activating protein to increase leukotriene formation in sickle cell disease
    Nitin Patel
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Blood 113:1129-38. 2009
    ..Herein, we identify a mechanism of increased LT in SCD and show HIF-1alpha as a hypoxia-independent target of PlGF. These studies provide new avenues to ameliorate these complications...
  5. ncbi Placenta growth factor-induced early growth response 1 (Egr-1) regulates hypoxia-inducible factor-1alpha (HIF-1alpha) in endothelial cells
    Nitin Patel
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Biol Chem 285:20570-9. 2010
    ..This study provides a new therapeutic target, namely Egr-1, for attenuation of elevated leukotriene levels in patients with sickle cell disease and other inflammatory diseases...
  6. ncbi Placenta growth factor augments endothelin-1 and endothelin-B receptor expression via hypoxia-inducible factor-1 alpha
    Nitin Patel
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Blood 112:856-65. 2008
    ..PlGF levels are intrinsically elevated from the increased red cell turnover in SCD and in other chronic anemia (eg, thalassemia) and may contribute to inflammation and PHT seen in these diseases...
  7. ncbi Interaction of clusterin and matrix metalloproteinase-9 and its implication for epithelial homeostasis and inflammation
    ShinWu Jeong
    USC Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Am J Pathol 180:2028-39. 2012
    ....