Manisha N Patel

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi Age dependence of seizure-induced oxidative stress
    M Patel
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box C238, Denver, CO 80262, USA
    Neuroscience 118:431-7. 2003
  2. ncbi Metalloporphyrins improve the survival of Sod2-deficient neurons
    Manisha N Patel
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center Denver, CO 80262, USA
    Aging Cell 2:219-22. 2003
  3. ncbi Mitochondrial dysfunction and oxidative stress: cause and consequence of epileptic seizures
    Manisha Patel
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Free Radic Biol Med 37:1951-62. 2004
  4. ncbi Activation of NADPH oxidase and extracellular superoxide production in seizure-induced hippocampal damage
    Manisha Patel
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Neurochem 92:123-31. 2005
  5. ncbi Seizure-induced formation of isofurans: novel products of lipid peroxidation whose formation is positively modulated by oxygen tension
    Manisha Patel
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Neurochem 104:264-70. 2008
  6. ncbi Oxidative stress, mitochondrial dysfunction, and epilepsy
    Manisha N Patel
    National Jewish Medical and Research Center and University of Colorado Health Sciences Center, 1400 Jackson Street, Room K706, Denver, CO 80206, USA
    Free Radic Res 36:1139-46. 2002

Research Grants

Detail Information

Publications6

  1. ncbi Age dependence of seizure-induced oxidative stress
    M Patel
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box C238, Denver, CO 80262, USA
    Neuroscience 118:431-7. 2003
    ....
  2. ncbi Metalloporphyrins improve the survival of Sod2-deficient neurons
    Manisha N Patel
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center Denver, CO 80262, USA
    Aging Cell 2:219-22. 2003
    ..Furthermore, Sod2-deficient neuronal cultures provide a simple model system to screen the biological efficacy of mitochondrial antioxidants...
  3. ncbi Mitochondrial dysfunction and oxidative stress: cause and consequence of epileptic seizures
    Manisha Patel
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Free Radic Biol Med 37:1951-62. 2004
    ..This review focuses on the emerging role of oxidative stress and mitochondrial dysfunction both as a consequence and as a cause of epileptic seizures...
  4. ncbi Activation of NADPH oxidase and extracellular superoxide production in seizure-induced hippocampal damage
    Manisha Patel
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Neurochem 92:123-31. 2005
    ..These results suggest that seizure activity activates the membrane NADPH oxidase complex resulting in increased formation of O2*-...
  5. ncbi Seizure-induced formation of isofurans: novel products of lipid peroxidation whose formation is positively modulated by oxygen tension
    Manisha Patel
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Neurochem 104:264-70. 2008
    ..These results demonstrate seizure-induced increase in IsoF formation and its correlation with changes in hippocampal pO2 and mitochondrial dysfunction...
  6. ncbi Oxidative stress, mitochondrial dysfunction, and epilepsy
    Manisha N Patel
    National Jewish Medical and Research Center and University of Colorado Health Sciences Center, 1400 Jackson Street, Room K706, Denver, CO 80206, USA
    Free Radic Res 36:1139-46. 2002
    ..This review focuses on the emerging role of oxidative stress and mitochondrial dysfunction both as a consequence and cause of epileptic seizures...

Research Grants1

  1. Two-step therapeutic screen for mitochondrial epilepsies
    Manisha Patel; Fiscal Year: 2007
    ..This screening procedure will allow us to participate the the NINDS cooperative program designed to specifically develop candidate therapies for clinical development. ..