NURIA M PASTOR-SOLER

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Alkaline pH- and cAMP-induced V-ATPase membrane accumulation is mediated by protein kinase A in epididymal clear cells
    NURIA M PASTOR-SOLER
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, A915 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15263, USA
    Am J Physiol Cell Physiol 294:C488-94. 2008
  2. pmc Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells
    Hui Li
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol Renal Physiol 299:F167-77. 2010
  3. pmc Regulation of proximal tubule vacuolar H+-ATPase by PKA and AMP-activated protein kinase
    Mohammad M Al-Bataineh
    Renal Electrolyte Div, Dept of Medicine, Scaife Hall A915, 3550 Terrace St, Pittsburgh, PA 15263
    Am J Physiol Renal Physiol 306:F981-95. 2014
  4. pmc AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells
    Rodrigo Alzamora
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol Renal Physiol 299:F1308-19. 2010
  5. pmc Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKA and AMP-activated protein kinase
    Fan Gong
    Department of Medicine, Renal Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15263, USA
    Am J Physiol Renal Physiol 298:F1162-9. 2010
  6. pmc AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells
    Kenneth R Hallows
    Renal Electrolyte Division, Dept of Medicine, Scaife A915, 3550 Terrace St, Pittsburgh, PA 15263, USA
    Am J Physiol Cell Physiol 296:C672-81. 2009
  7. pmc PKA regulates vacuolar H+-ATPase localization and activity via direct phosphorylation of the a subunit in kidney cells
    Rodrigo Alzamora
    Renal Electrolyte Division, Departments of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 285:24676-85. 2010
  8. pmc AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney
    Rodrigo Alzamora
    Renal Electrolyte Div, Dept of Medicine, S976 1 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261
    Am J Physiol Renal Physiol 305:F943-56. 2013
  9. pmc PIP5KIβ selectively modulates apical endocytosis in polarized renal epithelial cells
    Christina M Szalinski
    Renal Electrolyte Division, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 8:e53790. 2013
  10. pmc Role of the energy sensor AMP-activated protein kinase in renal physiology and disease
    Kenneth R Hallows
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Physiol Renal Physiol 298:F1067-77. 2010

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Alkaline pH- and cAMP-induced V-ATPase membrane accumulation is mediated by protein kinase A in epididymal clear cells
    NURIA M PASTOR-SOLER
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, A915 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15263, USA
    Am J Physiol Cell Physiol 294:C488-94. 2008
    ..We conclude that direct stimulation of PKA activity by cAMP is necessary and sufficient for the alkaline pH-induced accumulation of V-ATPase in clear cell apical microvilli...
  2. pmc Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells
    Hui Li
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol Renal Physiol 299:F167-77. 2010
    ....
  3. pmc Regulation of proximal tubule vacuolar H+-ATPase by PKA and AMP-activated protein kinase
    Mohammad M Al-Bataineh
    Renal Electrolyte Div, Dept of Medicine, Scaife Hall A915, 3550 Terrace St, Pittsburgh, PA 15263
    Am J Physiol Renal Physiol 306:F981-95. 2014
    ..Our results suggest that in proximal tubule the V-ATPase subcellular localization and activity are acutely coregulated via PKA downstream of hormonal signals and via AMPK downstream of metabolic stress. ..
  4. pmc AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells
    Rodrigo Alzamora
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol Renal Physiol 299:F1308-19. 2010
    ..These results indicate that AMPK inhibits KCNQ1 activity by promoting Nedd4-2-dependent channel ubiquitination and retrieval from the plasma membrane...
  5. pmc Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKA and AMP-activated protein kinase
    Fan Gong
    Department of Medicine, Renal Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15263, USA
    Am J Physiol Renal Physiol 298:F1162-9. 2010
    ..Taken together, our results suggest that in intercalated cells V-ATPase subcellular localization and therefore its activity may be coupled to acid-base status via PKA, and metabolic status via AMPK...
  6. pmc AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells
    Kenneth R Hallows
    Renal Electrolyte Division, Dept of Medicine, Scaife A915, 3550 Terrace St, Pittsburgh, PA 15263, USA
    Am J Physiol Cell Physiol 296:C672-81. 2009
    ..V-ATPase activity may be coupled to the sensing of acid-base status via PKA and to metabolic status via AMPK...
  7. pmc PKA regulates vacuolar H+-ATPase localization and activity via direct phosphorylation of the a subunit in kidney cells
    Rodrigo Alzamora
    Renal Electrolyte Division, Departments of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 285:24676-85. 2010
    ..In summary, these results indicate a novel mechanism for the regulation of V-ATPase localization and activity in kidney cells via direct PKA-dependent phosphorylation of the A subunit at Ser-175...
  8. pmc AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney
    Rodrigo Alzamora
    Renal Electrolyte Div, Dept of Medicine, S976 1 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261
    Am J Physiol Renal Physiol 305:F943-56. 2013
    ..Regulation of the V-ATPase by AMPK may couple V-ATPase activity to cellular metabolic status with potential relevance to ischemic injury in the kidney and other tissues...
  9. pmc PIP5KIβ selectively modulates apical endocytosis in polarized renal epithelial cells
    Christina M Szalinski
    Renal Electrolyte Division, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 8:e53790. 2013
    ..PtdIns(4,5)P(2) may be required to overcome specific structural constraints that limit the efficiency of apical endocytosis...
  10. pmc Role of the energy sensor AMP-activated protein kinase in renal physiology and disease
    Kenneth R Hallows
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Physiol Renal Physiol 298:F1067-77. 2010
    ..A more complete understanding of the AMPK pathway in the kidney offers potential for improved therapies for several renal diseases including diabetic nephropathy, polycystic kidney disease, and ischemia-reperfusion injury...
  11. pmc Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells
    Christine Rondanino
    Renal Electrolyte Div, Dept of Medicine, Univ of Pittsburgh School of Medicine, PA 15261, USA
    Am J Physiol Renal Physiol 301:F622-33. 2011
    ..We conclude that Gal-7 is selectively targeted to cilia and plays a key role in surface stabilization of glycoconjugates responsible for integrating cilia function with epithelial repair...
  12. pmc Shear stress-dependent regulation of apical endocytosis in renal proximal tubule cells mediated by primary cilia
    Venkatesan Raghavan
    Renal Electrolyte Division, Department of Medicine, and
    Proc Natl Acad Sci U S A 111:8506-11. 2014
    ....
  13. pmc Regulation of large-conductance Ca2+-activated K+ channels by WNK4 kinase
    Zhijian Wang
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
    Am J Physiol Cell Physiol 305:C846-53. 2013
    ..Based on these results, we propose that WNK4 provides a cellular mechanism for the coordinated regulation of two key secretory K(+) channels in the distal nephron, ROMK and BK. ..
  14. pmc Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells
    Kenneth R Hallows
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15621, USA
    J Biol Chem 284:5774-83. 2009
    ..In summary, these results suggest that sAC regulates both basal and agonist-stimulated Na(+) reabsorption in the kidney collecting duct, acting to enhance Na(+),K(+)-ATPase activity...
  15. ncbi request reprint AMP-activated protein kinase regulation of kidney tubular transport
    NURIA M PASTOR-SOLER
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Curr Opin Nephrol Hypertens 21:523-33. 2012
    ....
  16. pmc SGLT1, a novel cardiac glucose transporter, mediates increased glucose uptake in PRKAG2 cardiomyopathy
    Sanjay K Banerjee
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA 15213 2582, USA
    J Mol Cell Cardiol 49:683-92. 2010
    ..Increased AMPK activity leads to upregulation of SGLT1, which in turn mediates increased cardiac glucose uptake...
  17. pmc Epithelial transport during septic acute kidney injury
    Eric D Morrell
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, S976 1 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Nephrol Dial Transplant 29:1312-9. 2014
    ..We feel that this conceptual model resolves many of the physiologic and clinical paradoxes that septic AKI presents to practicing researchers and clinicians. ..
  18. pmc Extracorporeal therapy for dabigatran removal in the treatment of acute bleeding: a single center experience
    Tripti Singh
    Renal Electrolyte Division, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin J Am Soc Nephrol 8:1533-9. 2013
    ..This work presents five cases, in which extracorporeal therapy was performed for dabigatran removal in acutely bleeding patients...