Research Topics
| Robert F PassSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
Research Grants
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Detail Information
Publications
Congenital cytomegalovirus infection and hearing lossRobert F Pass
Department of Pediatrics, University of Alabama at Birmingham, Children s Hospital, 1600 7th Avenue South, CHB 309, Birmingham, AL 35233, USA
Herpes 12:50-5. 2005..Antiviral treatment that could improve hearing outcome, with a safety profile suitable for use in minimally ill infants, would clearly increase the benefit of universal screening for congenital CMV infection...- Development of cytomegalovirus vaccines: prospects for prevention of congenital CMV infectionRobert F Pass
Department of Pediatrics, University of Alabama School of Medicine, Birmingham, USA
Semin Pediatr Infect Dis 13:196-204. 2002..At least 4 CMV vaccines are in clinical trials, and advances in biotechnology are paving the way for additional novel vaccines... 
Development and evidence for efficacy of CMV glycoprotein B vaccine with MF59 adjuvantRobert F Pass
Department of Pediatrics, University of Alabama at Birmingham, USA
J Clin Virol 46:S73-6. 2009..This review briefly considers the rationale for gB as a vaccine antigen, the history of this CMV gB vaccine and the data supporting vaccine efficacy...- Vaccine prevention of maternal cytomegalovirus infectionRobert F Pass
Department of Pediatrics, University of Alabama at Birmingham, Birmingham 35233, USA
N Engl J Med 360:1191-9. 2009..Congenital infection with cytomegalovirus (CMV) is an important cause of hearing, cognitive, and motor impairments in newborns... - Congenital cytomegalovirus infection following first trimester maternal infection: symptoms at birth and outcomeRobert F Pass
Department of Pediatrics, University of Alabama at Birmingham, USA
J Clin Virol 35:216-20. 2006..The relationship between gestational age at time of maternal cytomegalovirus (CMV) infection and outcome of fetal infection is not well defined because the timing of maternal infection is usually not known... - Hearing loss in children with congenital cytomegalovirus infection born to mothers with preexisting immunityShannon A Ross
Department of Pediatrics, University of Alabama at Birmingham, 35233, USA
J Pediatr 148:332-6. 2006..To define hearing outcomes in children with congenital cytomegalovirus (CMV) infection born to mothers with non-primary CMV infection... - Neurodevelopmental outcomes following ganciclovir therapy in symptomatic congenital cytomegalovirus infections involving the central nervous systemSara E Oliver
Department of Pediatrics, University of Alabama at Birmingham, United States
J Clin Virol 46:S22-6. 2009..Ganciclovir protects against hearing deterioration in infants with symptomatic congenital cytomegalovirus (CMV) disease involving the central nervous system (CNS)... - Human cytomegalovirus-encoded alpha -chemokines exhibit high sequence variability in congenitally infected newbornsRavit Arav-Boger
Division of Infectious Diseases, Department of Pediatrics, Johns Hopkins Hospital, and Molecular Virology Laboratories, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Infect Dis 193:788-91. 2006..Unlike our findings for the contiguous UL144 gene, no specific UL146 or UL147 genotype was associated with disease outcome... - Detection of cytomegalovirus infection during a vaccine clinical trial in healthy young women: seroconversion and viral sheddingChangpin Zhang
Department of Pediatrics, UAB School of Medicine, Birmingham, AL 35233, USA
J Clin Virol 35:338-42. 2006..Previous study showed that this method detected the antibody response to infection and was negative with vaccine induced immunity... - Maternal immunity and prevention of congenital cytomegalovirus infectionKaren B Fowler
Department of Pediatrics, University of Alabama, Birmingham, USA
JAMA 289:1008-11. 2003..Vaccine development to prevent congenital cytomegalovirus (CMV) infection has been impeded by the uncertainty over whether maternal immunity protects the fetus... - Congenital cytomegalovirus infection: association between virus burden in infancy and hearing lossSuresh B Boppana
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
J Pediatr 146:817-23. 2005..To determine the relationship between the virus burden in infancy and hearing loss in congenital CMV infection... - Polymorphisms in Toll-like receptor genes influence antibody responses to cytomegalovirus glycoprotein B vaccineRavit Arav-Boger
Department of Pediatrics, Division of Infectious Diseases, Johns Hopkins Hospital, Baltimore, Maryland 21287 4933, USA
BMC Res Notes 5:140. 2012..A clinical trial of CMV glycoprotein B (gB) vaccine in young women showed promising efficacy. Improved understanding of the basis for prevention of CMV infection is essential for developing improved vaccines... - Detection of cytomegalovirus infection during clinical trials of glycoprotein B vaccineChangpin Zhang
Department of Pediatrics, UAB School of Medicine, Children's Hospital CHB 309, 1600 7th Avenue South, Birmingham, AL 35233, USA
Vaccine 23:507-10. 2004..One subject who acquired CMV during a vaccine trial was easily identified by gB-absorbed CMV IgG results. The gB-absorbed CMV IgG antibody assay is a promising approach for screening CMV gB vaccine trial participants for CMV infection... - Interval between births and risk of congenital cytomegalovirus infectionKaren B Fowler
Department of Pediatrics, School of Medicine, University of Alabama at Birmingham, Birmingham, USA
Clin Infect Dis 38:1035-7. 2004..However, the risk of transmission remained elevated for women with delivery intervals of 25-48 months and for those with delivery intervals >48 months apart... - Enzyme-linked immunosorbent assay for measurement of cytomegalovirus glycoprotein B antibody in serumDaniel J Hackett
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
Clin Vaccine Immunol 17:836-9. 2010..This ELISA gives accurate and reproducible results for the relative quantity of anti-CMV gB IgG in serum over a wide range of antibody levels... - Diagnosis and management of cytomegalovirus infection in the newbornRavit Arav-Boger
Department of Pediatrics, Johns Hopkins University Hospital, USA
Pediatr Ann 31:719-25. 2002 - Predictors of hearing loss in children with symptomatic congenital cytomegalovirus infectionLisa B Rivera
Department of Pediatrics, University of Alabama School of Medicine, Birmingham, Alabama 35233, USA
Pediatrics 110:762-7. 2002..However, it was not possible to identify factors that are independently predictive of the development of progressive hearing loss... - Risk factors for congenital cytomegalovirus infection in the offspring of young women: exposure to young children and recent onset of sexual activityKaren B Fowler
Department of Pediatrics, University of Alabama, Birmingham, Alabama, USA
Pediatrics 118:e286-92. 2006..Our objective with this study was to investigate whether maternal cytomegalovirus exposure through young children and by sexual activity increases the risk for congenital cytomegalovirus infection in their offspring... - Glycoprotein B vaccine is capable of boosting both antibody and CD4 T-cell responses to cytomegalovirus in chronically infected womenSteffanie Sabbaj
Department of Medicine, University of Alabama at Birmingham, AL 35294, USA
J Infect Dis 203:1534-41. 2011..These data suggest that this vaccine is capable of boosting immunity in a population of CMV-infected women and warrants additional evaluation to determine whether these boosted responses may prevent mother to child transmission of CMV... - Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trialDavid W Kimberlin
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
J Pediatr 143:16-25. 2003..To evaluate the efficacy and safety of ganciclovir therapy in neonates with congenital cytomegalovirus (CMV) disease... - Polymorphisms of the cytomegalovirus (CMV)-encoded tumor necrosis factor-alpha and beta-chemokine receptors in congenital CMV diseaseRavit Arav-Boger
Department of Pediatrics, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Park 256, 600 N Wolfe Street, Baltimore, MD 21287, USA
J Infect Dis 186:1057-64. 2002..Other CMV polymorphisms should be further evaluated for potential relevance to neonatal infection, transplantation, and acquired immunodeficiency syndrome-associated CMV diseases... - Cytomegalovirus infectionRobert F Pass
UAB School of Medicine, Birmingham, AL, USA
Pediatr Rev 23:163-70. 2002 
Increased mtDNA levels without change in mitochondrial enzymes in peripheral blood mononuclear cells of infants born to HIV-infected mothers on antiretroviral therapyGrace A McComsey
Case Western Reserve University, Cleveland, Ohio 44106, USA
HIV Clin Trials 9:126-36. 2008..The effects of gestational nucleoside reverse transcriptase inhibitors (NRTIs) on mitochondrial DNA (mtDNA) are controversial. The effects of mtDNA depletion on mitochondrial function have not been assessed...- Congenital cytomegalovirus infection: impairment and immunizationRobert F Pass
J Infect Dis 195:767-9. 2007 - Seroprevalence of cytomegalovirus infection in the United States, 1988-1994Stephanie A S Staras
Department of Epidemiology, Emory University, Atlanta, GA 30322, USA
Clin Infect Dis 43:1143-51. 2006..However, there are no nationwide estimates of CMV seroprevalence among pregnant women or the overall population of the United States... - Umbilical cord blood transplantation and cytomegalovirus: Posttransplantation infection and donor screeningMaria S Albano
National Cord Blood Program, New York Blood Center, 310 E 67 St, New York, NY 10021, USA
Blood 108:4275-82. 2006..Saliva culture for CMV had both false-positive and -negative results. CB-PCR was a useful alternative for detecting CMV in CB donors... - Influence of sexual activity on cytomegalovirus seroprevalence in the United States, 1988-1994Stephanie A S Staras
Department of Epidemiology and Health Policy Research, School of Medicine, University of Florida, Gainesville, Florida, USA sasehpr ufl edu
Sex Transm Dis 35:472-9. 2008..Sexual and nonsexual transmission of cytomegalovirus (CMV) occurs, but the frequency of sexual transmission in the general population of the United States is unknown... - Of oysters and manRobert F Pass
Herpes 10:3. 2003 - A key role for adolescents in the epidemiology of cytomegalovirus and genital herpes infectionsRobert F Pass
Clin Infect Dis 39:1439-40. 2004
Research Grants
- SOUTHEAST PEDIATRIC AIDS CLINICAL TRIALS UNITRobert Pass; Fiscal Year: 2004..Leaders of the ATN, HPTN and HVTN serve as co-investigators or consultants for this application. Southeast PACTU is committed to the Scientific Agenda of the PACTG and eager to continue contributing to the Group. ..
- CMV Subunit Vaccine in Young Women at RiskRobert Pass; Fiscal Year: 2007....