Robert F Pass

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint Congenital cytomegalovirus infection and hearing loss
    Robert F Pass
    Department of Pediatrics, University of Alabama at Birmingham, Children s Hospital, 1600 7th Avenue South, CHB 309, Birmingham, AL 35233, USA
    Herpes 12:50-5. 2005
  2. ncbi request reprint Development of cytomegalovirus vaccines: prospects for prevention of congenital CMV infection
    Robert F Pass
    Department of Pediatrics, University of Alabama School of Medicine, Birmingham, USA
    Semin Pediatr Infect Dis 13:196-204. 2002
  3. pmc Development and evidence for efficacy of CMV glycoprotein B vaccine with MF59 adjuvant
    Robert F Pass
    Department of Pediatrics, University of Alabama at Birmingham, USA
    J Clin Virol 46:S73-6. 2009
  4. pmc Vaccine prevention of maternal cytomegalovirus infection
    Robert F Pass
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham 35233, USA
    N Engl J Med 360:1191-9. 2009
  5. ncbi request reprint Congenital cytomegalovirus infection following first trimester maternal infection: symptoms at birth and outcome
    Robert F Pass
    Department of Pediatrics, University of Alabama at Birmingham, USA
    J Clin Virol 35:216-20. 2006
  6. ncbi request reprint Hearing loss in children with congenital cytomegalovirus infection born to mothers with preexisting immunity
    Shannon A Ross
    Department of Pediatrics, University of Alabama at Birmingham, 35233, USA
    J Pediatr 148:332-6. 2006
  7. pmc Neurodevelopmental outcomes following ganciclovir therapy in symptomatic congenital cytomegalovirus infections involving the central nervous system
    Sara E Oliver
    Department of Pediatrics, University of Alabama at Birmingham, United States
    J Clin Virol 46:S22-6. 2009
  8. ncbi request reprint Detection of cytomegalovirus infection during a vaccine clinical trial in healthy young women: seroconversion and viral shedding
    Changpin Zhang
    Department of Pediatrics, UAB School of Medicine, Birmingham, AL 35233, USA
    J Clin Virol 35:338-42. 2006
  9. ncbi request reprint Maternal immunity and prevention of congenital cytomegalovirus infection
    Karen B Fowler
    Department of Pediatrics, University of Alabama, Birmingham, USA
    JAMA 289:1008-11. 2003
  10. ncbi request reprint Congenital cytomegalovirus infection: association between virus burden in infancy and hearing loss
    Suresh B Boppana
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    J Pediatr 146:817-23. 2005

Research Grants

  1. SOUTHEAST PEDIATRIC AIDS CLINICAL TRIALS UNIT
    Robert Pass; Fiscal Year: 2004
  2. CMV Subunit Vaccine in Young Women at Risk
    Robert Pass; Fiscal Year: 2007

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Congenital cytomegalovirus infection and hearing loss
    Robert F Pass
    Department of Pediatrics, University of Alabama at Birmingham, Children s Hospital, 1600 7th Avenue South, CHB 309, Birmingham, AL 35233, USA
    Herpes 12:50-5. 2005
    ..Antiviral treatment that could improve hearing outcome, with a safety profile suitable for use in minimally ill infants, would clearly increase the benefit of universal screening for congenital CMV infection...
  2. ncbi request reprint Development of cytomegalovirus vaccines: prospects for prevention of congenital CMV infection
    Robert F Pass
    Department of Pediatrics, University of Alabama School of Medicine, Birmingham, USA
    Semin Pediatr Infect Dis 13:196-204. 2002
    ..At least 4 CMV vaccines are in clinical trials, and advances in biotechnology are paving the way for additional novel vaccines...
  3. pmc Development and evidence for efficacy of CMV glycoprotein B vaccine with MF59 adjuvant
    Robert F Pass
    Department of Pediatrics, University of Alabama at Birmingham, USA
    J Clin Virol 46:S73-6. 2009
    ..This review briefly considers the rationale for gB as a vaccine antigen, the history of this CMV gB vaccine and the data supporting vaccine efficacy...
  4. pmc Vaccine prevention of maternal cytomegalovirus infection
    Robert F Pass
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham 35233, USA
    N Engl J Med 360:1191-9. 2009
    ..Congenital infection with cytomegalovirus (CMV) is an important cause of hearing, cognitive, and motor impairments in newborns...
  5. ncbi request reprint Congenital cytomegalovirus infection following first trimester maternal infection: symptoms at birth and outcome
    Robert F Pass
    Department of Pediatrics, University of Alabama at Birmingham, USA
    J Clin Virol 35:216-20. 2006
    ..The relationship between gestational age at time of maternal cytomegalovirus (CMV) infection and outcome of fetal infection is not well defined because the timing of maternal infection is usually not known...
  6. ncbi request reprint Hearing loss in children with congenital cytomegalovirus infection born to mothers with preexisting immunity
    Shannon A Ross
    Department of Pediatrics, University of Alabama at Birmingham, 35233, USA
    J Pediatr 148:332-6. 2006
    ..To define hearing outcomes in children with congenital cytomegalovirus (CMV) infection born to mothers with non-primary CMV infection...
  7. pmc Neurodevelopmental outcomes following ganciclovir therapy in symptomatic congenital cytomegalovirus infections involving the central nervous system
    Sara E Oliver
    Department of Pediatrics, University of Alabama at Birmingham, United States
    J Clin Virol 46:S22-6. 2009
    ..Ganciclovir protects against hearing deterioration in infants with symptomatic congenital cytomegalovirus (CMV) disease involving the central nervous system (CNS)...
  8. ncbi request reprint Detection of cytomegalovirus infection during a vaccine clinical trial in healthy young women: seroconversion and viral shedding
    Changpin Zhang
    Department of Pediatrics, UAB School of Medicine, Birmingham, AL 35233, USA
    J Clin Virol 35:338-42. 2006
    ..Previous study showed that this method detected the antibody response to infection and was negative with vaccine induced immunity...
  9. ncbi request reprint Maternal immunity and prevention of congenital cytomegalovirus infection
    Karen B Fowler
    Department of Pediatrics, University of Alabama, Birmingham, USA
    JAMA 289:1008-11. 2003
    ..Vaccine development to prevent congenital cytomegalovirus (CMV) infection has been impeded by the uncertainty over whether maternal immunity protects the fetus...
  10. ncbi request reprint Congenital cytomegalovirus infection: association between virus burden in infancy and hearing loss
    Suresh B Boppana
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    J Pediatr 146:817-23. 2005
    ..To determine the relationship between the virus burden in infancy and hearing loss in congenital CMV infection...
  11. ncbi request reprint Human cytomegalovirus-encoded alpha -chemokines exhibit high sequence variability in congenitally infected newborns
    Ravit Arav-Boger
    Division of Infectious Diseases, Department of Pediatrics, Johns Hopkins Hospital, and Molecular Virology Laboratories, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Infect Dis 193:788-91. 2006
    ..Unlike our findings for the contiguous UL144 gene, no specific UL146 or UL147 genotype was associated with disease outcome...
  12. pmc Polymorphisms in Toll-like receptor genes influence antibody responses to cytomegalovirus glycoprotein B vaccine
    Ravit Arav-Boger
    Department of Pediatrics, Division of Infectious Diseases, Johns Hopkins Hospital, Baltimore, Maryland 21287 4933, USA
    BMC Res Notes 5:140. 2012
    ..A clinical trial of CMV glycoprotein B (gB) vaccine in young women showed promising efficacy. Improved understanding of the basis for prevention of CMV infection is essential for developing improved vaccines...
  13. ncbi request reprint Detection of cytomegalovirus infection during clinical trials of glycoprotein B vaccine
    Changpin Zhang
    Department of Pediatrics, UAB School of Medicine, Children s Hospital CHB 309, 1600 7th Avenue South, Birmingham, AL 35233, USA
    Vaccine 23:507-10. 2004
    ..One subject who acquired CMV during a vaccine trial was easily identified by gB-absorbed CMV IgG results. The gB-absorbed CMV IgG antibody assay is a promising approach for screening CMV gB vaccine trial participants for CMV infection...
  14. ncbi request reprint Interval between births and risk of congenital cytomegalovirus infection
    Karen B Fowler
    Department of Pediatrics, School of Medicine, University of Alabama at Birmingham, Birmingham, USA
    Clin Infect Dis 38:1035-7. 2004
    ..However, the risk of transmission remained elevated for women with delivery intervals of 25-48 months and for those with delivery intervals >48 months apart...
  15. pmc Enzyme-linked immunosorbent assay for measurement of cytomegalovirus glycoprotein B antibody in serum
    Daniel J Hackett
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Clin Vaccine Immunol 17:836-9. 2010
    ..This ELISA gives accurate and reproducible results for the relative quantity of anti-CMV gB IgG in serum over a wide range of antibody levels...
  16. ncbi request reprint Diagnosis and management of cytomegalovirus infection in the newborn
    Ravit Arav-Boger
    Department of Pediatrics, Johns Hopkins University Hospital, USA
    Pediatr Ann 31:719-25. 2002
  17. ncbi request reprint Predictors of hearing loss in children with symptomatic congenital cytomegalovirus infection
    Lisa B Rivera
    Department of Pediatrics, University of Alabama School of Medicine, Birmingham, Alabama 35233, USA
    Pediatrics 110:762-7. 2002
    ..The purpose of this study was to identify indicators present in the newborn period that have predictive value for the development of hearing loss in children with symptomatic congenital CMV infection...
  18. ncbi request reprint Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial
    David W Kimberlin
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    J Pediatr 143:16-25. 2003
    ..To evaluate the efficacy and safety of ganciclovir therapy in neonates with congenital cytomegalovirus (CMV) disease...
  19. ncbi request reprint Risk factors for congenital cytomegalovirus infection in the offspring of young women: exposure to young children and recent onset of sexual activity
    Karen B Fowler
    Department of Pediatrics, University of Alabama, Birmingham, Alabama, USA
    Pediatrics 118:e286-92. 2006
    ..Our objective with this study was to investigate whether maternal cytomegalovirus exposure through young children and by sexual activity increases the risk for congenital cytomegalovirus infection in their offspring...
  20. pmc Glycoprotein B vaccine is capable of boosting both antibody and CD4 T-cell responses to cytomegalovirus in chronically infected women
    Steffanie Sabbaj
    Department of Medicine, University of Alabama at Birmingham, AL 35294, USA
    J Infect Dis 203:1534-41. 2011
    ..These data suggest that this vaccine is capable of boosting immunity in a population of CMV-infected women and warrants additional evaluation to determine whether these boosted responses may prevent mother to child transmission of CMV...
  21. ncbi request reprint Polymorphisms of the cytomegalovirus (CMV)-encoded tumor necrosis factor-alpha and beta-chemokine receptors in congenital CMV disease
    Ravit Arav-Boger
    Department of Pediatrics, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Park 256, 600 N Wolfe Street, Baltimore, MD 21287, USA
    J Infect Dis 186:1057-64. 2002
    ..Other CMV polymorphisms should be further evaluated for potential relevance to neonatal infection, transplantation, and acquired immunodeficiency syndrome-associated CMV diseases...
  22. ncbi request reprint Cytomegalovirus infection
    Robert F Pass
    UAB School of Medicine, Birmingham, AL, USA
    Pediatr Rev 23:163-70. 2002
  23. doi request reprint Increased mtDNA levels without change in mitochondrial enzymes in peripheral blood mononuclear cells of infants born to HIV-infected mothers on antiretroviral therapy
    Grace A McComsey
    Case Western Reserve University, Cleveland, Ohio 44106, USA
    HIV Clin Trials 9:126-36. 2008
    ..The effects of gestational nucleoside reverse transcriptase inhibitors (NRTIs) on mitochondrial DNA (mtDNA) are controversial. The effects of mtDNA depletion on mitochondrial function have not been assessed...
  24. ncbi request reprint Congenital cytomegalovirus infection: impairment and immunization
    Robert F Pass
    J Infect Dis 195:767-9. 2007
  25. ncbi request reprint Seroprevalence of cytomegalovirus infection in the United States, 1988-1994
    Stephanie A S Staras
    Department of Epidemiology, Emory University, Atlanta, GA 30322, USA
    Clin Infect Dis 43:1143-51. 2006
    ..However, there are no nationwide estimates of CMV seroprevalence among pregnant women or the overall population of the United States...
  26. ncbi request reprint Umbilical cord blood transplantation and cytomegalovirus: Posttransplantation infection and donor screening
    Maria S Albano
    National Cord Blood Program, New York Blood Center, 310 E 67 St, New York, NY 10021, USA
    Blood 108:4275-82. 2006
    ..Saliva culture for CMV had both false-positive and -negative results. CB-PCR was a useful alternative for detecting CMV in CB donors...
  27. doi request reprint Influence of sexual activity on cytomegalovirus seroprevalence in the United States, 1988-1994
    Stephanie A S Staras
    Department of Epidemiology and Health Policy Research, School of Medicine, University of Florida, Gainesville, Florida, USA sasehpr ufl edu
    Sex Transm Dis 35:472-9. 2008
    ..Sexual and nonsexual transmission of cytomegalovirus (CMV) occurs, but the frequency of sexual transmission in the general population of the United States is unknown...
  28. ncbi request reprint Of oysters and man
    Robert F Pass
    Herpes 10:3. 2003
  29. ncbi request reprint A key role for adolescents in the epidemiology of cytomegalovirus and genital herpes infections
    Robert F Pass
    Clin Infect Dis 39:1439-40. 2004

Research Grants3

  1. SOUTHEAST PEDIATRIC AIDS CLINICAL TRIALS UNIT
    Robert Pass; Fiscal Year: 2004
    ..Leaders of the ATN, HPTN and HVTN serve as co-investigators or consultants for this application. Southeast PACTU is committed to the Scientific Agenda of the PACTG and eager to continue contributing to the Group. ..
  2. CMV Subunit Vaccine in Young Women at Risk
    Robert Pass; Fiscal Year: 2007
    ....