Anil V Parwani

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..2 translocation RCCs in adult patients with aggressive clinical course, this adult case occurring during pregnancy with a novel translocation involving chromosome 19 followed an indolent clinical course...

..Here we describe the CPCTR information management system architecture, common data element (CDE) development, query interfaces, data curation, and quality control...

..A panel of markers, including proPSA, should be performed when metastatic prostate carcinoma is in the differential diagnosis...

..abstract:..

..One year later, the patient presented with recurrent high-grade sarcoma in the soft tissue of the left chest wall. We herein present the spectrum of histological findings and molecular genotyping data...

..The National Mesothelioma Virtual Bank is an initiative which collects annotated datasets relevant to human mesothelioma to develop an enterprising biospecimen resource to fulfill researchers' need...

..The tool is a useful quality assurance instrument and its prospective nature allows for the potential prevention of some serious errors...

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..Thus, our findings demonstrate the effectiveness of this viral system for 15-LO-1 expression studies in tissues...

..Clinical management and subsequent follow-up of this patient is presented...

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..To the best of the authors' knowledge, this is the first case of 2 morphologically distinct tumors, one chromophobe renal cell carcinoma and the other primary carcinoid tumor in the same kidney...

..This study attempted to distinguish primary bladder adenocarcinoma (PBA) from metastatic colonic adenocarcinomas (MCA), which is a difficult diagnostic and clinical problem...

..FISH results, even those showing significant chromosomal abnormalities, should not alter the primarily morphology-based diagnosis of RO...

..Negative or patchy staining for basal cells and positive staining for AMACR may contribute to diagnostic difficulty in these entities...

..Differential diagnoses include intratubular germ-cell neoplasia, malignant lymphomas, and malakoplakia. Orchiectomy is currently the most appropriate therapy for this condition...

..Further exploration of 8q gain, 14q loss, MYC, HIF1A and EPAS1 (HIF2α) as molecular markers of tumor behavior and prognosis could aid in personalizing medicine for patients with clear-cell renal cell carcinoma...

..The histological and immunohistochemical findings in this study serve to broaden the morphological spectrum of urothelial carcinomas with prominent rhabdoid features and add further evidence as to their poor prognosis...

..Thus far, there have been no previous studies assessing the diagnostic utility of p63 and P501S combined together as a dual immunostain in distinguishing between these two cancers...

..Whether this complex epithelium represents entrapped or neoplastic renal tubular epithelium remains an open question...

..These cytomorphologic, immunophenotypic, and cytogenetic features were helpful for including this entity in the differential diagnosis of renal cell carcinomas...

..To date, the tumor has followed a benign course without evidence of local recurrence or metastasis...

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..Our study expands the histology described in prostate cancer to include in very rare cases with prominent pleomorphism and bizarre giant cells. This giant cell component heralds a particularly aggressive clinical outcome...

..The possibility of nephrogenic adenoma should always be in the differential diagnosis when evaluating patients with predisposed urinary tract symptoms...

..Fluorescence in situ hybridization analysis effectively separates these morphologically very similar yet genetically distinctive entities...

..Our data show that CD10 and pankeratin can be used to confirm the presence of VD in vasectomy specimens in which the epithelial histologic features are suboptimal...

..We report a relatively unusual case of PNET arising in a malignant mixed germ cell tumor in a 35-year-old man...

..With thorough training, careful validation of specific applications, and regular postsignout review of glass IHC slides (eg, quality assurance review), WSI technology can be used for IHC stain interpretation...

..At initial gross examination, the tumor mimicked a urothelial carcinoma...

..The genomic amplifications/deletions identified herein represent potential diagnostic and/or prognostic biomarkers...

..Hemangiomas of genitourinary origin are extremely rare, typically benign vascular tumors. This finding represents the first reported hemangioma within a radical prostatectomy specimen...

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..2 translocation RCC with respect to age, clinical behavior, and molecular abnormalities...

..In a patient with known primary neoplasm, the differential diagnosis of a thyroid nodule should always include a metastatic lesion along with primary neoplasia...

..Proximal, fibroma-like, and angiomatoid variants have been described. The proximal variant (with larger cells, prominent nucleoli, and rhabdoid changes) is clinically more aggressive...

..In addition to pure squamous cell carcinoma and adenosquamous cancer, other patterns may be seen. Whereas the adenocarcinoma component is typically high grade, the squamous component has a wide range of differentiation...

..In selected cases, IPOX studies were critical in arriving at the correct diagnosis...

..There has been no significant delay in case turnaround time since implementation. Further assessment of the tool's function after full departmental application is underway...

..While RCCm, CD10, and vimentin performed adequately, they were significantly less reliable than p63 with both false positives and false negatives...

..The goal of our study was to examine the expression and biological relevance of TSPO in prostate cancer and show that the commonly prescribed benzodiazepine lorazepam, a ligand for TSPO, exhibits anticancer properties...

..A rich arborizing capillary network was evident, as were a high mitosis/karyorrhexis index and foci of necrosis. The glial component consisted of pleomorphic round to oval nuclei and numerous gemistocytes embedded in a fibrillary stroma...

..Recently a case with translocation t(1;19) has been described. This article provides a brief overview of the current knowledge of mixed epithelial and stromal tumor of the kidney...

..The differential diagnosis includes medulloblastoma (in cerebellar tumors), primitive neuroectodermal tumor (in suprasellar tumors), choroid plexus carcinoma, and malignant glioma...

..In rare cases a myoepithelial carcinoma also arises in a preexisting PA, necessitating an accurate interpretation for more definitive therapy...

..Alterations of 9p21/chromosome 9 detected by fluorescence in situ hybridization can also be used for diagnostic confirmation and prognostic prediction...

..We examined the effect of Ercc1 deletion in the development of prostate cancer in a prostate recapitulation model as Ercc1 deficient mice die within four weeks of birth...

..The FLiMP mouse model should also be useful in crosses with other GEM models to further define the combinations of molecular alterations necessary for PCa progression...

..The physiopathological mechanisms making clear cell renal cell carcinoma an avid recipient of a metastatic carcinoma have been speculated upon, but are still unknown...

..To the best of our knowledge, this is the second case reported till date. We present the challenges encountered in the diagnosis of this case and review of pelvic collision tumors...

..This paper examines if tissue blocks, identified by localized computer searches at participating institutions, can be retrieved in adequate quantity and quality to support medical researchers...

..Herein, we describe the various bioinformatics tools used to support translational research at the University of Pittsburgh Medical Center...

..63%; 2 of 316 tumor spots), which further illustrates the patchy and focal presence of virion containing cells. p53 staining in these two spots was also patchy and confined to rare nuclei...

..Numerous multinucleated giant cells were observed as well. Differential diagnosis includes primary or metastatic clear-cell tumors...

..This is the first report, to our knowledge, indicating both sarcomatoid and choriocarcinomatous features in a conventional urothelial carcinoma of the bladder...

..The differential diagnosis included otherwise typical high-grade urothelial carcinoma, reactive urothelial cells and rarely large cell lymphoma. The rarity of the tumor cells may impose a diagnostic challenge in urine specimen...

..Since few malignant cases have been reported, firm criteria for malignancy have yet to be established. This review focuses on the perivascular epithelioid cell tumors-not otherwise specified subset...

..The current most generally favored treatment option for all patients who present with MPC is immediate radical cystectomy...

..A cytologic diagnosis of high-grade urothelial carcinoma in these cases leads to a timely clinical intervention for optimal patient management...

..After the FNA diagnosis of "thyroid neoplasm" was made, the patient underwent a near-total thyroidectomy, which revealed a SFT. Differential diagnosis of spindle cell lesions in thyroid is also presented...

..This ensures the pathologists make note of these findings in their reports, thereby improving the quality and uniformity of information in the pathology reports...

..the latter, although nonspecific, provides an accurate diagnosis. The differential diagnosis includes various degenerative, inflammatory/infectious, and lymphoproliferative disorders of the central nervous system...

..The aim of this study was to review our experience and the effectiveness of this novel PQAT tool in cytology...

..Both antibiotics and surgery can be treatment options depending on the patient's disease status...

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..An accurate diagnosis of these lesions as PA metastases is essential for effective, timely treatment and therapeutic design...

..36%) and 12 (3.2%), respectively (P < .001). Focused review detects a higher proportion of errors and may be more effectively used for design of error reduction initiatives...

..It is noteworthy that all of these alterations occur at the level of carcinoma in situ...

..FNA is an important tool in determining the benign nature of these lesions and excluding other causes of breast masses in this patient population, such as infections, malignant lymphoma and breast carcinoma...

..It is important to differentiate this condition from its frequent mimics, such as classic seminoma and embryonal carcinoma, because patients with spermatocytic seminoma may not require further treatment after surgery...

..In conclusion, our results suggest that that proliferative effects of estrogen in lung cancer cells is mediated primarily, if not exclusively, by the nongenomic action of ERbeta...

..To our knowledge, morphological findings of RRP have been reported rarely...

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..Stereotactic FNA of the CC of the third ventricle is an accurate and cost-effective diagnostic modality. Cytomorphology coupled with the radiologic features is sufficiently unique for the diagnosis of this rare pathologic entity...

..Although the heterotopic breast tissue on the skin along the milk line is well recognized, it has not been described to involve internal organs including the heart...

..The aim of this study was to determine if the Ventana Symphony H&E protocol can improve on the detection of prominent nucleoli in foci of prostate cancer...

..An adequate awareness of these potential sources of erroneous diagnoses, coupled with appropriate clinical findings, may result in a higher accuracy rate...

..The immunostaining pattern predominantly was focal, necessitating a careful evaluation of positive reactions on cytologic samples...

..Clinicardiologic features and anatomic location of the tumor in the brain are additionally helpful...