J Thomas Parsons

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Emerging views of integrin signaling: implications for prostate cancer
    Jill K Slack-Davis
    Department of Microbiology, University of Virginia Health Sciences System, Charlottesville, Virginia 22908, USA
    J Cell Biochem 91:41-6. 2004
  2. ncbi request reprint Shifting paradigms in tumor metastasis: challenges and opportunities
    J Thomas Parsons
    Department of Microbiology, University of Virginia Health System, Charlottesville, VA, USA
    Cancer Biol Ther 1:582-5. 2002
  3. doi request reprint Focal adhesion kinase: targeting adhesion signaling pathways for therapeutic intervention
    J Thomas Parsons
    Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Clin Cancer Res 14:627-32. 2008
  4. ncbi request reprint Focal adhesion kinase: the first ten years
    J Thomas Parsons
    Department of Microbiology, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Cell Sci 116:1409-16. 2003
  5. ncbi request reprint Src family protein tyrosine kinases: cooperating with growth factor and adhesion signaling pathways
    J T Parsons
    Department of Microbiology, Health Sciences Center, University of Virginia, Charlottesville, VA 22908, USA
    Curr Opin Cell Biol 9:187-92. 1997
  6. ncbi request reprint Integrin-dependent activation of the p70 ribosomal S6 kinase signaling pathway
    R K Malik
    Department of Pediatrics, Health Sciences Center, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 271:29785-91. 1996
  7. ncbi request reprint Integrin-mediated signalling: regulation by protein tyrosine kinases and small GTP-binding proteins
    J T Parsons
    Department of Microbiology, Health Sciences Center, University of Virginia, Charlottesville, VA 22908, USA
    Curr Opin Cell Biol 8:146-52. 1996
  8. pmc Cell adhesion: integrating cytoskeletal dynamics and cellular tension
    J Thomas Parsons
    Department of Microbiology, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Nat Rev Mol Cell Biol 11:633-43. 2010
  9. pmc Mitogen-activated protein kinase feedback phosphorylation regulates MEK1 complex formation and activation during cellular adhesion
    Scott T Eblen
    Department of Microbiology, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Mol Cell Biol 24:2308-17. 2004
  10. pmc RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility
    Tomas Vomastek
    Department of Microbiology and Cancer Center, University of Virginia Health Science Center, Charlottesville, VA 22908, USA
    Mol Cell Biol 27:8296-305. 2007

Research Grants

  1. FOCAL ADHESION KINASE SIGNALING
    J Parsons; Fiscal Year: 2000
  2. FOCAL ADHESION KINASE SIGNALING
    J Parsons; Fiscal Year: 2003
  3. Function of Cortactin, a Src Target
    J Parsons; Fiscal Year: 2005
  4. AVIAN SARCOMA VIRUS TUMOR ANTIGENS
    J Parsons; Fiscal Year: 1991

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Emerging views of integrin signaling: implications for prostate cancer
    Jill K Slack-Davis
    Department of Microbiology, University of Virginia Health Sciences System, Charlottesville, Virginia 22908, USA
    J Cell Biochem 91:41-6. 2004
    ..These pathways are likely to provide novel sites of therapeutic intervention for the treatment of prostate cancer...
  2. ncbi request reprint Shifting paradigms in tumor metastasis: challenges and opportunities
    J Thomas Parsons
    Department of Microbiology, University of Virginia Health System, Charlottesville, VA, USA
    Cancer Biol Ther 1:582-5. 2002
  3. doi request reprint Focal adhesion kinase: targeting adhesion signaling pathways for therapeutic intervention
    J Thomas Parsons
    Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Clin Cancer Res 14:627-32. 2008
    ..Targeting the pathways that mediate many of these signals has been a major goal in the effort to develop therapeutics...
  4. ncbi request reprint Focal adhesion kinase: the first ten years
    J Thomas Parsons
    Department of Microbiology, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Cell Sci 116:1409-16. 2003
    ..FAK-dependent activation of these pathways has been implicated in a diverse array of cellular processes, including cell migration, growth factor signaling, cell cycle progression and cell survival...
  5. ncbi request reprint Src family protein tyrosine kinases: cooperating with growth factor and adhesion signaling pathways
    J T Parsons
    Department of Microbiology, Health Sciences Center, University of Virginia, Charlottesville, VA 22908, USA
    Curr Opin Cell Biol 9:187-92. 1997
    ....
  6. ncbi request reprint Integrin-dependent activation of the p70 ribosomal S6 kinase signaling pathway
    R K Malik
    Department of Pediatrics, Health Sciences Center, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 271:29785-91. 1996
    ..These results indicate at least a partial requirement for FAK in the S6K activation pathway...
  7. ncbi request reprint Integrin-mediated signalling: regulation by protein tyrosine kinases and small GTP-binding proteins
    J T Parsons
    Department of Microbiology, Health Sciences Center, University of Virginia, Charlottesville, VA 22908, USA
    Curr Opin Cell Biol 8:146-52. 1996
    ..Recent evidence shows that coordinated regulation of these signalling molecules is central to the control of cell adhesion, formation of the actin cytoskeleton and activation of intracellular signalling cascades...
  8. pmc Cell adhesion: integrating cytoskeletal dynamics and cellular tension
    J Thomas Parsons
    Department of Microbiology, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Nat Rev Mol Cell Biol 11:633-43. 2010
    ..Adhesion formation and disassembly drive the migration cycle by activating Rho GTPases, which in turn regulate actin polymerization and myosin II activity, and therefore adhesion dynamics...
  9. pmc Mitogen-activated protein kinase feedback phosphorylation regulates MEK1 complex formation and activation during cellular adhesion
    Scott T Eblen
    Department of Microbiology, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Mol Cell Biol 24:2308-17. 2004
    ..We propose that activation of ERK during adhesion creates a feedback system in which ERK phosphorylates MEK1 on T292, and this in turn blocks additional S298 phosphorylation in response to integrin signaling...
  10. pmc RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility
    Tomas Vomastek
    Department of Microbiology and Cancer Center, University of Virginia Health Science Center, Charlottesville, VA 22908, USA
    Mol Cell Biol 27:8296-305. 2007
    ..We suggest that RACK1 tethers the ERK pathway core kinases and channels signals from upstream activation by integrins to downstream targets at focal adhesions...
  11. pmc PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation
    Jill K Slack-Davis
    Department of Microbiology, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Cell Biol 162:281-91. 2003
    ....
  12. pmc Matrix rigidity regulates cancer cell growth by modulating cellular metabolism and protein synthesis
    Robert W Tilghman
    Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 7:e37231. 2012
    ..Understanding how the various mechanical properties of these microenvironments affect the biology of tumor cells during disease progression is critical in identifying molecular targets for cancer therapy...
  13. ncbi request reprint Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells
    Robert W Tilghman
    Department of Microbiology, University of Virginia Health System, Charlottesville, 22908, USA
    J Cell Sci 118:2613-23. 2005
    ..These data are consistent with a role for FAK in regulating the formation of a leading edge during cell migration by coordinating integrin signaling to direct the correct spatial activation of membrane protrusion...
  14. doi request reprint FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts
    Marcin P Iwanicki
    Department of Microbiology, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Cell Sci 121:895-905. 2008
    ..These studies support a model in which FAK and PDZ-RhoGEF cooperate to induce Rho/ROCKII-dependent focal adhesion movement and trailing-edge retraction in response to LPA...
  15. ncbi request reprint FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly
    Donna J Webb
    Department of Cell Biology, UVA School of Medicine, P O Box 800732, Charlottesville, Virginia 22908 0732, USA
    Nat Cell Biol 6:154-61. 2004
    ....
  16. pmc Inhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment
    Jayme B Stokes
    Department of Surgery, University of Virginia, Charlottesville, Virginia, USA
    Mol Cancer Ther 10:2135-45. 2011
    ..These data support a role for FAK in PDA and suggest that inhibitors of FAK may contribute to efficacious treatment of patients with PDA...
  17. ncbi request reprint Mislocalization or reduced expression of Arf GTPase-activating protein ASAP1 inhibits cell spreading and migration by influencing Arf1 GTPase cycling
    Yunhao Liu
    Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Biol Chem 280:8884-92. 2005
    ..Loijens, J. C., Martin, K. H., Karginov, A. V., and Parsons, J. T. (2002) Mol. Biol. Cell. 13, 2147-2156) suggest that the recruitment of certain adhesion components such as paxillin requires dynamic GTP/GDP turnover of Arf1 GTPase...
  18. pmc A novel role for signal transducer and activator of transcription 5b (STAT5b) in beta1-integrin-mediated human breast cancer cell migration
    Teresa M Bernaciak
    Department of Microbiology, University of Virginia, 1300 Jefferson Park Avenue, Charlottesville, VA 22908, USA
    Breast Cancer Res 11:R52. 2009
    ..The contribution of STAT5b to breast cancer cell motility has not been explored. This work aims to elucidate the role of STAT5b in breast cancer cell migration...
  19. pmc Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase
    Katherine A Owen
    Department of Microbiology, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Cell Biol 179:1275-87. 2007
    ..However, the combined loss of FAK and Pyk2 had no greater effect than the loss of either molecule alone, indicating that both kinases function within the same pathway to promote invasion...
  20. pmc Differential requirement for focal adhesion kinase signaling in cancer progression in the transgenic adenocarcinoma of mouse prostate model
    Jill K Slack-Davis
    Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    Mol Cancer Ther 8:2470-7. 2009
    ....
  21. ncbi request reprint Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion
    Andrew W Kinley
    Department of Microbiology, Health Sciences Center, University of Virginia, Charlottesville, VA 22908, USA
    Curr Biol 13:384-93. 2003
    ..A key regulator of actin polymerization is Arp2/3 complex. Cortactin, an F-actin binding protein that localizes to membrane ruffles, is an activator of Arp2/3 complex...
  22. ncbi request reprint Integrin connections map: to infinity and beyond
    Karen H Martin
    Department of Microbiology, University of Virginia Health System, Box 800734, Charlottesville, VA 22908 0734, USA
    Science 296:1652-3. 2002
    ..Advances in imaging have contributed to the understanding of the dynamic nature of these cell-ECM interactions and the complexes that form at these sites and have provided insights into their regulation and signal organizing functions...
  23. ncbi request reprint Cortactin phosphorylation sites mapped by mass spectrometry
    Karen H Martin
    Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA
    J Cell Sci 119:2851-3. 2006
  24. pmc Focal adhesion kinase as a regulator of cell tension in the progression of cancer
    Robert W Tilghman
    Department of Microbiology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Semin Cancer Biol 18:45-52. 2008
    ....
  25. ncbi request reprint Cellular characterization of a novel focal adhesion kinase inhibitor
    Jill K Slack-Davis
    Department of Microbiology and Cancer Center, Health Sciences System, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 282:14845-52. 2007
    ....
  26. ncbi request reprint Identification of phosphorylation sites in betaPIX and PAK1
    Mark W Mayhew
    Department of Cell Biology, University of Virginia, Charlottesville, VA 22908, USA
    J Cell Sci 120:3911-8. 2007
  27. ncbi request reprint Disruption of FRNK expression by gene targeting of the intronic promoter within the focal adhesion kinase gene
    Haruko Hayasaka
    Department of Microbiology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Cell Biochem 102:947-54. 2007
    ..Despite the fact that ectopic expression of FRNK suppresses focal adhesion formation in cultured cells, these results suggest that endogenous FRNK is not essential for development or the formation of the mouse vasculature...
  28. pmc Matrix rigidity regulates cancer cell growth and cellular phenotype
    Robert W Tilghman
    Department of Microbiology and Cancer Center, School of Medicine, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 5:e12905. 2010
    ..However, it is unclear as to what extent cancer cells respond to changes in the mechanical properties (rigidity/stiffness) of the microenvironment and how this response varies among cancer cell lines...
  29. pmc Mass spectrometric analysis identifies a cortactin-RCC2/TD60 interaction in mitotic cells
    Pablo R Grigera
    Department of Microbiology, Immunology and Cancer Biology, University of Virginia Health System, Charlottesville, VA 22908, United States
    J Proteomics 75:2153-9. 2012
    ....
  30. pmc Focal adhesion kinase modulates activation of NF-kappaB by flow in endothelial cells
    Tobias Petzold
    Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia 22908, USA
    Am J Physiol Cell Physiol 297:C814-22. 2009
    ..FAK therefore regulates NF-kappaB phosphorylation and transcriptional activity in response to flow by a novel mechanism...
  31. ncbi request reprint Adhesion assembly, disassembly and turnover in migrating cells -- over and over and over again
    Donna J Webb
    Department of Cell Biology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Nat Cell Biol 4:E97-100. 2002
    ..Even though understanding these processes is challenging, important insights are beginning to emerge, and the technology to facilitate significant advances in this area is now in place...
  32. pmc The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly
    Yunhao Liu
    Department of Microbiology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Mol Biol Cell 13:2147-56. 2002
    ....
  33. ncbi request reprint Src family kinases, key regulators of signal transduction
    Sarah J Parsons
    Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, VA 22908 0734, USA
    Oncogene 23:7906-9. 2004
    ..In this volume, we have attempted to provide the reader with an overview of the current understanding of the function of Src family kinases in the regulation of selected cellular signaling pathways...
  34. ncbi request reprint Expression of focal adhesion kinase in normal and pathologic human prostate tissues
    Joshua D Rovin
    Department of Surgery, University of Virginia, Charlottesville 22908, USA
    Prostate 53:124-32. 2002
    ..In tumor cells, including prostate adenocarcinoma, FAK overexpression has been linked to cancer progression...
  35. pmc Breaking barriers through collaboration: the example of the Cell Migration Consortium
    Alan Rick Horwitz
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Genome Biol 3:comment2011. 2002
    ..The development and operation of this Consortium may provide useful insights for those who plan similarly large-scale, interdisciplinary approaches...
  36. ncbi request reprint FRNK, the autonomously expressed C-terminal region of focal adhesion kinase, is uniquely regulated in vascular smooth muscle: analysis of expression in transgenic mice
    Haruko Hayasaka
    Department of Microbiology, University of Virginia Health System, Charlottesville, Virginia 22908 0734, USA
    J Cell Biochem 95:1248-63. 2005
    ..Mutation of AP-1 and NF-E2 binding consensus sequences within this element abrogated enhancer activity, supporting the involvement of this promoter element in VSMC expression of FRNK...
  37. ncbi request reprint FAK phosphorylation sites mapped by mass spectrometry
    Pablo R Grigera
    Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA
    J Cell Sci 118:4931-5. 2005
  38. pmc Selective expression of an endogenous inhibitor of FAK regulates proliferation and migration of vascular smooth muscle cells
    J M Taylor
    Department of Microbiology, Health Sciences Center, University of Virginia, Charlottesville, Virginia 22908, USA
    Mol Cell Biol 21:1565-72. 2001
    ..Furthermore, increased FRNK expression following vascular injury or during development may alter the SMC phenotype by negatively regulating proliferative and migratory signals...
  39. ncbi request reprint p130Cas, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase
    M T Harte
    Department of Microbiology and Cancer Center, University of Virginia, Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Biol Chem 271:13649-55. 1996
    ..The association of p130(Cas) with pp125(FAK), a kinase which is activated upon cell adhesion, is likely to be functionally important in integrin mediated signal transduction...
  40. pmc Cas and NEDD9 Contribute to Tumor Progression through Dynamic Regulation of the Cytoskeleton
    Michael S Guerrero
    University of Virginia School of Medicine, Charlottesville, VA, USA
    Genes Cancer 3:371-81. 2012
    ..Given these roles, Cas and NEDD9 may prove to be viable candidates for use as biomarkers and therapeutic targets...
  41. ncbi request reprint Regulation of focal adhesion targeting and inhibitory functions of the FAK related protein FRNK using a novel estrogen receptor "switch"
    Karen H Martin
    Department of Microbiology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Cell Motil Cytoskeleton 51:76-88. 2002
    ..Furthermore, when cells expressing of FRNK-ER* were treated with hormone, the cells responded with a dramatic change in cell morphology, suggesting a role for FAK in the regulation of the adhesive properties of focal adhesions...
  42. ncbi request reprint Dynamin2 and cortactin regulate actin assembly and filament organization
    Dorothy A Schafer
    Department of Biology, University of Virginia, Charlottesville, VA 22904, USA
    Curr Biol 12:1852-7. 2002
    ..GTP hydrolysis altered the organization of the filaments and the lipid vesicles. We conclude that dynamin2, through an interaction with cortactin, regulates actin assembly and actin filament organization at membranes...
  43. ncbi request reprint Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho
    J M Taylor
    Department of Microbiology, Health Sciences Center, University of Virginia, Charlottesville, Virginia, USA
    J Cell Sci 112:231-42. 1999
    ..These data indicate the possibility that Graf may be an effector for Rho in certain cell types...
  44. pmc An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase
    J D Hildebrand
    Department of Microbiology, Health Sciences Center, University of Virginia, Charlottesville 22908, USA
    Mol Cell Biol 16:3169-78. 1996
    ..We suggest that Graf may function to mediate cross talk between the tyrosine kinases such as FAK and the Rho family GTPase that control steps in integrin-initiated signaling events...
  45. ncbi request reprint Characterization of graf, the GTPase-activating protein for rho associated with focal adhesion kinase. Phosphorylation and possible regulation by mitogen-activated protein kinase
    J M Taylor
    Department of Microbiology, Health Sciences Center, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 273:8063-70. 1998
    ..Based on these data we suggest that phosphorylation of Graf by MAP kinase or related kinases may be a mechanism by which growth factor signaling modulates Rho-mediated cytoskeletal changes in PC12 and perhaps other cells...
  46. ncbi request reprint Alterations in the focal adhesion kinase/Src signal transduction pathway correlate with increased migratory capacity of prostate carcinoma cells
    J K Slack
    Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA
    Oncogene 20:1152-63. 2001
    ....
  47. pmc Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains
    M D Schaller
    Department of Microbiology, University of Virginia School of Medicine, Charlottesville 22908, USA
    J Cell Biol 130:1181-7. 1995
    ....
  48. pmc pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions
    M D Schaller
    Department of Microbiology, School of Medicine, University of Virginia, Charlottesville 22908
    Proc Natl Acad Sci U S A 89:5192-6. 1992
    ..Immunofluorescence localization experiments show that pp125 is localized to focal adhesions; hence, we suggest the name focal adhesion kinase...
  49. pmc Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction
    Tomas Vomastek
    National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110 067, India
    Mol Cell Biol 28:6954-66. 2008
    ..We propose that Tpr is both a substrate and a scaffold for activated ERKs...
  50. pmc HDAC6 modulates cell motility by altering the acetylation level of cortactin
    Xiaohong Zhang
    Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Mol Cell 27:197-213. 2007
    ....
  51. ncbi request reprint Interaction of cortactin and N-WASp with Arp2/3 complex
    Alissa M Weaver
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Curr Biol 12:1270-8. 2002
    ..Cortactin and N-WASp activate Arp2/3 complex, alone or in concert. Both cortactin and N-WASp contain an acidic (A) domain that is required for Arp2/3 complex binding...
  52. pmc Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells
    Laurence Bougnères
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Cell Biol 166:225-35. 2004
    ..These results point at a major role for a Crk-cortactin complex in actin polymerization downstream of tyrosine kinase signaling...
  53. ncbi request reprint Cell migration: integrating signals from front to back
    Anne J Ridley
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London W1W 7BS, UK
    Science 302:1704-9. 2003
    ....
  54. pmc Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton
    Julie A Head
    Department of Craniofacial Biology and Cancer Center, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Mol Biol Cell 14:3216-29. 2003
    ....
  55. ncbi request reprint Fgd1, the Cdc42 GEF responsible for Faciogenital Dysplasia, directly interacts with cortactin and mAbp1 to modulate cell shape
    Peng Hou
    Department of Pediatrics and Communicable Diseases, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    Hum Mol Genet 12:1981-93. 2003
    ....
  56. ncbi request reprint Focal adhesion kinase (FAK) regulates insulin-stimulated glycogen synthesis in hepatocytes
    Danshan Huang
    UCLA Gonda Goldschmied Diabetes Center and the Research Service, West Los Angeles Veterans Administration Medical Center, Los Angeles, California 90095, USA
    J Biol Chem 277:18151-60. 2002
    ..Insulin action may be subject to regulation by the integrin signaling pathway, ensuring that these growth and differentiation-promoting pathways act in a coordinated and/or complementary manner...
  57. ncbi request reprint Involvement of the Src-cortactin pathway in podosome formation and turnover during polarization of cultured osteoclasts
    Chen Luxenburg
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Sci 119:4878-88. 2006
    ....

Research Grants22

  1. FOCAL ADHESION KINASE SIGNALING
    J Parsons; Fiscal Year: 2000
    ..abstract_text> ..
  2. FOCAL ADHESION KINASE SIGNALING
    J Parsons; Fiscal Year: 2003
    ..abstract_text> ..
  3. Function of Cortactin, a Src Target
    J Parsons; Fiscal Year: 2005
    ..Such mice, bearing a mutated form of Cortactin will allow one to directly test the role of Cortactin in mediating specific cellular functions in a cell type specific fashion. ..
  4. AVIAN SARCOMA VIRUS TUMOR ANTIGENS
    J Parsons; Fiscal Year: 1991
    ..These studies will permit us to define the structural and functional domains of pp60src and allow us to relate this information to other proteins which may be members of a family of related tyrosine protein kinases...