Research Topics
| C Lowell ParsonsSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Pentosanpolysulfate coating of silicone reduces encrustationP Zupkas
Division of Urology, University of California, San Diego, and Veterans Affairs Medical Center, USA
J Endourol 14:483-8. 2000....- Intravesical ethanol as quantitative measure of bladder hyperpermeabilityM Monga
Division of Urology, University of California, San Diego 92103 8897, USA
J Endourol 15:641-4. 2001..We evaluated the intravesical instillation of ethanol as a quantitative measure of bladder hyperpermeability in an experimental model in male New Zealand White rabbits... - Estrogenic regulation of HSP90 kD synthesis in rat urinary bladderP C Stein
Division of Urology, University of California, San Diego Medical Center, 92103 8897, USA
Urol Res 29:338-44. 2001..These findings may be relevant in the etiology and pathobiology of interstitial cystitis and menopausal voiding dysfunctions since the bladder is enriched with estrogenic receptors and is under estrogenic influence... - Interstitial cystitis: epidemiology and clinical presentationC Lowell Parsons
Division of Urology, UCSD Medical Center, San Diego, California 92103-8897, USA
Clin Obstet Gynecol 45:242-9. 2002 - Urology practice patterns after residency training in laparoscopyBrian F Shay
Division of Urology, University of California at San Diego, San Diego, California, USA
J Endourol 16:251-6. 2002..Although the impact of laparoscopic training courses has been examined, the impact of residency training in laparoscopy on subsequent urology practice patterns has not been assessed... - The prevalence of interstitial cystitis in gynecologic patients with pelvic pain, as detected by intravesical potassium sensitivityC Lowell Parsons
Division of Urology, University of California San Diego Medical Center, 92103 8897, USA
Am J Obstet Gynecol 187:1395-400. 2002..The purpose of this study was to determine the prevalence of interstitial cystitis in a large number of gynecologic patients with pelvic pain versus control subjects, as indicated by a positive result on a potassium sensitivity test... - The role of the urinary epithelium in the pathogenesis of interstitial cystitis/prostatitis/urethritisC Lowell Parsons
Division of Urology, Department of Surgery, University of California, San Diego Medical Center, University of California, San Diego, San Diego, California 92103 8897, USA
Urology 69:9-16. 2007..A name such as lower urinary dysfunctional epithelium would incorporate all of these diseases under a single pathophysiologic process. As a result of these discoveries, a new paradigm for diagnosis and treatment is emerging... - Advances in the treatment of interstitial cystitisC Lowell Parsons
Division of Urology 8897, University of California San Diego Medical Center, San Diego, CA 92103 8897, USA
Expert Opin Pharmacother 7:411-9. 2006..Intravesical therapeutic solutions are new and promising adjunctive therapies that can offer immediate symptom relief during symptom flares, and for patients who are just beginning medical therapy... - Increased prevalence of interstitial cystitis: previously unrecognized urologic and gynecologic cases identified using a new symptom questionnaire and intravesical potassium sensitivityC Lowell Parsons
Division of Urology, University of California, San Diego, Medical Center, San Diego, California 92103-8897, USA
Urology 60:573-8. 2002..Use of the PUF alone may prove to be an accurate method for detecting IC. The IC prevalence may be as high as 1 in 4.5 women... - Defective Tamm-Horsfall protein in patients with interstitial cystitisC Lowell Parsons
Division of Urology, University of California San Diego Medical Center, San Diego 92103 8897, USA
J Urol 178:2665-70. 2007..In patients with interstitial cystitis this protective effect is decreased. We hypothesized that a difference in Tamm-Horsfall protein in patients with interstitial cystitis exists that may be involved in disease pathogenesis... 
Alkalinized lidocaine and heparin provide immediate relief of pain and urgency in patients with interstitial cystitisC Lowell Parsons
Division of Urology, University of California San Diego, San Diego, CA 92103, USA
J Sex Med 9:207-12. 2012..This combination has also been reported to relieve pain associated with sex in patients with IC...- Toxic factors in human urine that injure urotheliumMahadevan Rajasekaran
Division of Urology, University of California San Diego Medical Center, San Diego, CA 92103-8897, USA
Int J Urol 13:409-14. 2006..Pentosan polysulfate neutralizes the toxic factor, attenuates urothelial damage, and suppresses potassium-mediated bladder hyperactivity... - Abnormal urinary potassium metabolism in patients with interstitial cystitisC Lowell Parsons
Division of Surgery Urology, University of California San Diego Medical Center, San Diego 92103 8897, USA
J Urol 173:1182-5. 2005..This study tested these hypotheses... - Quantifying symptoms in men with interstitial cystitis/prostatitis, and its correlation with potassium-sensitivity testingC Lowell Parsons
Division of Surgery Urology, University of California San Diego Medical Center, 200 West Arbor Drive, San Diego, CA 92103 8897, USA
BJU Int 95:86-90. 2005..To determine whether men previously diagnosed with prostatitis also have pathology originating in the bladder... - Abnormal glycosylation of Tamm-Horsfall protein in patients with interstitial cystitisSulabha P Argade
Division of Urology, University of California, San Diego Medical Center, San Diego, CA 92103 8897, USA
BJU Int 103:1085-9. 2009..To confirm abnormal glycosylation of Tamm-Horsfall protein (THP) in patients with interstitial cystitis (IC)... - Prostatitis, interstitial cystitis, chronic pelvic pain, and urethral syndrome share a common pathophysiology: lower urinary dysfunctional epithelium and potassium recyclingC Lowell Parsons
Division of Urology, Department of Surgery, University of California, San Diego, Medical Center, 92103-8897, USA
Urology 62:976-82. 2003 - Intravesical ethanol test: an ineffective measure of bladder hyperpermeabilityZachary Gordon
Division of Urology, University of California, San Diego, School of Medicine, San Diego, California, USA
Urology 61:555-7. 2003..CONCLUSIONS: The intravesical ethanol test did not prove to be a useful clinical adjunct in the diagnosis and management of interstitial cystitis. The evaluation of higher concentrations of ethanol may be warranted... - Diagnosing chronic pelvic pain of bladder originC Lowell Parsons
Division of Urology, Department of Surgery, University of California San Diego Medical Center, San Diego, USA
J Reprod Med 49:235-42. 2004..IC can be treated very successfully in the majority of cases... - Current strategies for managing interstitial cystitisC Lowell Parsons
Division of Urology, UCSD Medical Center, San Diego, CA 92103 8897, USA
Expert Opin Pharmacother 5:287-93. 2004..Preliminary results indicate this therapeutic solution provides immediate temporary relief of symptoms... - Role of sialic acid in urinary cytoprotective activity of Tamm-Horsfall proteinC Lowell Parsons
Division of Urology, University of California, San Diego, Medical Center, San Diego, California 92103 8897, USA
Urology 69:577-81. 2007..This study investigated the effect of desialylation on the cytoprotective activity of THP... - A multi-site study confirms abnormal glycosylation in the Tamm-Horsfall protein of patients with interstitial cystitisC Lowell Parsons
Division of Urology, University of California San Diego, San Diego, USA
J Urol 186:112-6. 2011..We confirm the single site observation of decreased sialylation and abnormal glycosylation of Tamm-Horsfall protein in patients with interstitial cystitis compared to control subjects... - Effect of pentosan polysulfate therapy on intravesical potassium sensitivityC Lowell Parsons
Division of Urology, University of California, San Diego, Medical Center, San Diego, California 92103-8897, USA
Urology 59:329-33. 2002..PST appears to be a valid indicator of epithelial abnormality and a reliable test in the diagnosis of IC... - Tamm-Horsfall protein protects urothelial permeability barrierPaul Stein
Division of Urology, University of California, Medical Center, San Diego, California 92103-8897, USA
Urology 66:903-7. 2005..THP appears to neutralize the LMW fraction electrostatically and attenuate urothelial damage, resulting in suppression of potassium chloride-mediated bladder hyperactivity... - Argument for the use of the potassium sensitivity test in the diagnosis of interstitial cystitis. ForC Lowell Parsons
Division of Urology, University of California San Diego Medical Center, 200 West Arbor Drive, San Diego, CA 92103-8897, USA
Int Urogynecol J Pelvic Floor Dysfunct 16:430-1. 2005 - Intravesical potassium sensitivity in patients with prostatitisC Lowell Parsons
Division of Urology, University of California San Diego Medical Center, San Diego, CA 92103, USA
J Urol 168:1054-7. 2002..We suggest reclassifying the prostatitis-interstitial cystitis disease process as lower urinary dysfunctional epithelium... - Successful downregulation of bladder sensory nerves with combination of heparin and alkalinized lidocaine in patients with interstitial cystitisC Lowell Parsons
Division of Urology, University of California, San Diego, Medical Center, San Diego, California 92103 8897, USA
Urology 65:45-8. 2005..To test the efficacy of a new intravesical therapeutic solution in relieving urgency/frequency and pain in interstitial cystitis (IC)... - Urine-induced apoptosis in cultured bladder urothelial cellsPaul C Stein
Division of Urology, University of California, San Diego Medical Center, USA
Adv Exp Med Biol 539:585-98. 2003 - Prevalence of interstitial cystitis in young womenC Lowell Parsons
Division of Urology, University of California, San Diego, Medical Center, San Diego, California 92103-8897, USA
Urology 64:866-70. 2004..5 million to perhaps 25 to 30 million women and that IC is highly prevalent in young women. Screening for IC-specific symptoms is a useful method for identifying undiagnosed IC cases... - Tamm-Horsfall protein-associated nucleotides in patients with interstitial cystitisSulabha Argade
Division of Urology, University of California UC San Diego Health System, San Diego, CA, USA
BJU Int 111:811-9. 2013..The current study provides additional evidence of our earlier finding that THP is abnormal in IC patients. This can adversely affect THP's protective function, and suggests that THP plays a role in the pathogenesis of the disease... - Misleading report of massive bleeding in a patient taking pentosan polysulfateC Lowell Parsons
Arch Intern Med 163:119; authors reply 119-20. 2003 - Improvement in sexual functioning in patients with interstitial cystitis/painful bladder syndromeJ Curtis Nickel
Queen s University Urology, Kingston, Ontario, Canada
J Sex Med 5:394-9. 2008..Sexual functioning is one of the strongest predictors of poorer quality of life (QOL) in patients diagnosed with interstitial cystitis/painful bladder syndrome (IC/PBS)... - Multimodal therapy for interstitial cystitisJeffrey R Dell
Institute for Female Pelvic Medicine, Urogynecology and Reconstructive Pelvic Surgery, Obstetrics and Gynecology Consultants, P.C, Knoxville, Tennessee 37923, USA
J Reprod Med 49:243-52. 2004..Acute and chronic pain associated with IC can now be effectively managed using a multimodal approach with PPS as the basis... - The emerging presence of interstitial cystitis in gynecologic patients with chronic pelvic painEdward J Stanford
Center for Advanced Pelvic Surgery and Medicine, Belleville Memorial Hospital, Belleville, Illinois 62801, USA
Urology 69:53-9. 2007..By determining whether the pain is of bladder origin, the physician can more successfully treat the patient with CPP... - Contemporary clinical presentation of interstitial cystitisJoel M H Teichman
Division of Urology, University of British Columbia, Vancouver, British Columbia, Canada
Urology 69:41-7. 2007..Overall, published reports in the literature indicate that the clinical presentation of IC is variable. IC is readily suggested by history, physical examination, and voiding diary findings... - Re: Interstitial cystitis versus detrusor overactivity: a comparative, randomized, controlled study of cystometry using saline and 0.3 m potassium chloride. J. Philip, S. Willmott and P. Irwin. J Urol, 175: 566-571, 2006C Lowell Parsons
J Urol 176:1253-4; author reply 1254. 2006 - MN-001, a novel oral anti-inflammatory agent, suppresses bladder hyperactivity in a rat modelMahadevan Rajasekaran
Urology Research Laboratory, Veterans Medical Research Foundation, La Jolla, CA, USA
BJU Int 98:430-4. 2006..MN-001 might have a role in managing mast cell activity and the associated bladder symptoms in patients with interstitial cystitis... - Interstitial cystitis: a chronic disease with ever-increasing recognition and prevalenceC Lowell Parsons
J Urol 173:6. 2005 - Randomized, double-blind, dose-ranging study of pentosan polysulfate sodium for interstitial cystitisJ Curtis Nickel
Department of Urology, Queens University, Kingston General Hospital, Kingston, Ontario, Canada
Urology 65:654-8. 2005..To compare the current recommended dose of pentosan polysulfate sodium (PPS) with doses two to three times higher... - The historical origins of interstitial cystitisJ Kellogg Parsons
Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
J Urol 171:20-2. 2004..We identify early descriptions of interstitial cystitis and trace its evolution as a clinical entity during the 19th century... - Interstitial cystitis: a primary care perspectiveMatt Rosenberg
Mid Michigan Health Centers, Jackson, MI, USA
Cleve Clin J Med 72:698-704. 2005..Its diagnosis is straightforward, and effective therapies are available. Physicians should keep the diagnosis of interstitial cystitis in mind for all patients presenting with pelvic pain or urinary symptoms...