C Lowell Parsons

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Pentosanpolysulfate coating of silicone reduces encrustation
    P Zupkas
    Division of Urology, University of California, San Diego, and Veterans Affairs Medical Center, USA
    J Endourol 14:483-8. 2000
  2. ncbi request reprint Intravesical ethanol as quantitative measure of bladder hyperpermeability
    M Monga
    Division of Urology, University of California, San Diego 92103 8897, USA
    J Endourol 15:641-4. 2001
  3. ncbi request reprint Estrogenic regulation of HSP90 kD synthesis in rat urinary bladder
    P C Stein
    Division of Urology, University of California, San Diego Medical Center, 92103 8897, USA
    Urol Res 29:338-44. 2001
  4. ncbi request reprint Interstitial cystitis: epidemiology and clinical presentation
    C Lowell Parsons
    Division of Urology, UCSD Medical Center, San Diego, California 92103 8897, USA
    Clin Obstet Gynecol 45:242-9. 2002
  5. ncbi request reprint Urology practice patterns after residency training in laparoscopy
    Brian F Shay
    Division of Urology, University of California at San Diego, San Diego, California, USA
    J Endourol 16:251-6. 2002
  6. ncbi request reprint The prevalence of interstitial cystitis in gynecologic patients with pelvic pain, as detected by intravesical potassium sensitivity
    C Lowell Parsons
    Division of Urology, University of California San Diego Medical Center, 92103 8897, USA
    Am J Obstet Gynecol 187:1395-400. 2002
  7. ncbi request reprint Advances in the treatment of interstitial cystitis
    C Lowell Parsons
    Division of Urology 8897, University of California San Diego Medical Center, San Diego, CA 92103 8897, USA
    Expert Opin Pharmacother 7:411-9. 2006
  8. ncbi request reprint The role of the urinary epithelium in the pathogenesis of interstitial cystitis/prostatitis/urethritis
    C Lowell Parsons
    Division of Urology, Department of Surgery, University of California, San Diego Medical Center, University of California, San Diego, San Diego, California 92103 8897, USA
    Urology 69:9-16. 2007
  9. ncbi request reprint Increased prevalence of interstitial cystitis: previously unrecognized urologic and gynecologic cases identified using a new symptom questionnaire and intravesical potassium sensitivity
    C Lowell Parsons
    Division of Urology, University of California, San Diego, Medical Center, San Diego, California 92103 8897, USA
    Urology 60:573-8. 2002
  10. ncbi request reprint Defective Tamm-Horsfall protein in patients with interstitial cystitis
    C Lowell Parsons
    Division of Urology, University of California San Diego Medical Center, San Diego 92103 8897, USA
    J Urol 178:2665-70. 2007

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Pentosanpolysulfate coating of silicone reduces encrustation
    P Zupkas
    Division of Urology, University of California, San Diego, and Veterans Affairs Medical Center, USA
    J Endourol 14:483-8. 2000
    ....
  2. ncbi request reprint Intravesical ethanol as quantitative measure of bladder hyperpermeability
    M Monga
    Division of Urology, University of California, San Diego 92103 8897, USA
    J Endourol 15:641-4. 2001
    ..We evaluated the intravesical instillation of ethanol as a quantitative measure of bladder hyperpermeability in an experimental model in male New Zealand White rabbits...
  3. ncbi request reprint Estrogenic regulation of HSP90 kD synthesis in rat urinary bladder
    P C Stein
    Division of Urology, University of California, San Diego Medical Center, 92103 8897, USA
    Urol Res 29:338-44. 2001
    ..These findings may be relevant in the etiology and pathobiology of interstitial cystitis and menopausal voiding dysfunctions since the bladder is enriched with estrogenic receptors and is under estrogenic influence...
  4. ncbi request reprint Interstitial cystitis: epidemiology and clinical presentation
    C Lowell Parsons
    Division of Urology, UCSD Medical Center, San Diego, California 92103 8897, USA
    Clin Obstet Gynecol 45:242-9. 2002
  5. ncbi request reprint Urology practice patterns after residency training in laparoscopy
    Brian F Shay
    Division of Urology, University of California at San Diego, San Diego, California, USA
    J Endourol 16:251-6. 2002
    ..Although the impact of laparoscopic training courses has been examined, the impact of residency training in laparoscopy on subsequent urology practice patterns has not been assessed...
  6. ncbi request reprint The prevalence of interstitial cystitis in gynecologic patients with pelvic pain, as detected by intravesical potassium sensitivity
    C Lowell Parsons
    Division of Urology, University of California San Diego Medical Center, 92103 8897, USA
    Am J Obstet Gynecol 187:1395-400. 2002
    ..The purpose of this study was to determine the prevalence of interstitial cystitis in a large number of gynecologic patients with pelvic pain versus control subjects, as indicated by a positive result on a potassium sensitivity test...
  7. ncbi request reprint Advances in the treatment of interstitial cystitis
    C Lowell Parsons
    Division of Urology 8897, University of California San Diego Medical Center, San Diego, CA 92103 8897, USA
    Expert Opin Pharmacother 7:411-9. 2006
    ..Intravesical therapeutic solutions are new and promising adjunctive therapies that can offer immediate symptom relief during symptom flares, and for patients who are just beginning medical therapy...
  8. ncbi request reprint The role of the urinary epithelium in the pathogenesis of interstitial cystitis/prostatitis/urethritis
    C Lowell Parsons
    Division of Urology, Department of Surgery, University of California, San Diego Medical Center, University of California, San Diego, San Diego, California 92103 8897, USA
    Urology 69:9-16. 2007
    ..A name such as lower urinary dysfunctional epithelium would incorporate all of these diseases under a single pathophysiologic process. As a result of these discoveries, a new paradigm for diagnosis and treatment is emerging...
  9. ncbi request reprint Increased prevalence of interstitial cystitis: previously unrecognized urologic and gynecologic cases identified using a new symptom questionnaire and intravesical potassium sensitivity
    C Lowell Parsons
    Division of Urology, University of California, San Diego, Medical Center, San Diego, California 92103 8897, USA
    Urology 60:573-8. 2002
    ....
  10. ncbi request reprint Defective Tamm-Horsfall protein in patients with interstitial cystitis
    C Lowell Parsons
    Division of Urology, University of California San Diego Medical Center, San Diego 92103 8897, USA
    J Urol 178:2665-70. 2007
    ..In patients with interstitial cystitis this protective effect is decreased. We hypothesized that a difference in Tamm-Horsfall protein in patients with interstitial cystitis exists that may be involved in disease pathogenesis...
  11. doi request reprint Alkalinized lidocaine and heparin provide immediate relief of pain and urgency in patients with interstitial cystitis
    C Lowell Parsons
    Division of Urology, University of California San Diego, San Diego, CA 92103, USA
    J Sex Med 9:207-12. 2012
    ..This combination has also been reported to relieve pain associated with sex in patients with IC...
  12. ncbi request reprint Toxic factors in human urine that injure urothelium
    Mahadevan Rajasekaran
    Division of Urology, University of California San Diego Medical Center, San Diego, CA 92103 8897, USA
    Int J Urol 13:409-14. 2006
    ....
  13. ncbi request reprint Abnormal urinary potassium metabolism in patients with interstitial cystitis
    C Lowell Parsons
    Division of Surgery Urology, University of California San Diego Medical Center, San Diego 92103 8897, USA
    J Urol 173:1182-5. 2005
    ..This study tested these hypotheses...
  14. ncbi request reprint Quantifying symptoms in men with interstitial cystitis/prostatitis, and its correlation with potassium-sensitivity testing
    C Lowell Parsons
    Division of Surgery Urology, University of California San Diego Medical Center, 200 West Arbor Drive, San Diego, CA 92103 8897, USA
    BJU Int 95:86-90. 2005
    ..To determine whether men previously diagnosed with prostatitis also have pathology originating in the bladder...
  15. doi request reprint Abnormal glycosylation of Tamm-Horsfall protein in patients with interstitial cystitis
    Sulabha P Argade
    Division of Urology, University of California, San Diego Medical Center, San Diego, CA 92103 8897, USA
    BJU Int 103:1085-9. 2009
    ..To confirm abnormal glycosylation of Tamm-Horsfall protein (THP) in patients with interstitial cystitis (IC)...
  16. ncbi request reprint Prostatitis, interstitial cystitis, chronic pelvic pain, and urethral syndrome share a common pathophysiology: lower urinary dysfunctional epithelium and potassium recycling
    C Lowell Parsons
    Division of Urology, Department of Surgery, University of California, San Diego, Medical Center, 92103 8897, USA
    Urology 62:976-82. 2003
  17. ncbi request reprint Intravesical ethanol test: an ineffective measure of bladder hyperpermeability
    Zachary Gordon
    Division of Urology, University of California, San Diego, School of Medicine, San Diego, California, USA
    Urology 61:555-7. 2003
    ..To evaluate the intravesical ethanol test as a quantitative measure of bladder hyperpermeability in patients with interstitial cystitis...
  18. ncbi request reprint Diagnosing chronic pelvic pain of bladder origin
    C Lowell Parsons
    Division of Urology, Department of Surgery, University of California San Diego Medical Center, San Diego, USA
    J Reprod Med 49:235-42. 2004
    ..IC can be treated very successfully in the majority of cases...
  19. doi request reprint A multi-site study confirms abnormal glycosylation in the Tamm-Horsfall protein of patients with interstitial cystitis
    C Lowell Parsons
    Division of Urology, University of California San Diego, San Diego, USA
    J Urol 186:112-6. 2011
    ..We confirm the single site observation of decreased sialylation and abnormal glycosylation of Tamm-Horsfall protein in patients with interstitial cystitis compared to control subjects...
  20. ncbi request reprint Current strategies for managing interstitial cystitis
    C Lowell Parsons
    Division of Urology, UCSD Medical Center, San Diego, CA 92103 8897, USA
    Expert Opin Pharmacother 5:287-93. 2004
    ..Preliminary results indicate this therapeutic solution provides immediate temporary relief of symptoms...
  21. ncbi request reprint Effect of pentosan polysulfate therapy on intravesical potassium sensitivity
    C Lowell Parsons
    Division of Urology, University of California, San Diego, Medical Center, San Diego, California 92103 8897, USA
    Urology 59:329-33. 2002
    ..Most individuals with IC appear to have an abnormally permeable epithelium that allows urinary solutes such as potassium to penetrate to the bladder interstitium, provoking symptoms...
  22. ncbi request reprint Role of sialic acid in urinary cytoprotective activity of Tamm-Horsfall protein
    C Lowell Parsons
    Division of Urology, University of California, San Diego, Medical Center, San Diego, California 92103 8897, USA
    Urology 69:577-81. 2007
    ..This study investigated the effect of desialylation on the cytoprotective activity of THP...
  23. doi request reprint Tamm-Horsfall protein-associated nucleotides in patients with interstitial cystitis
    Sulabha Argade
    Division of Urology, University of California UC San Diego Health System, San Diego, CA 92103 8897, USA
    BJU Int 111:811-9. 2013
    ..The current study provides additional evidence of our earlier finding that THP is abnormal in IC patients. This can adversely affect THP's protective function, and suggests that THP plays a role in the pathogenesis of the disease...
  24. ncbi request reprint Successful downregulation of bladder sensory nerves with combination of heparin and alkalinized lidocaine in patients with interstitial cystitis
    C Lowell Parsons
    Division of Urology, University of California, San Diego, Medical Center, San Diego, California 92103 8897, USA
    Urology 65:45-8. 2005
    ..To test the efficacy of a new intravesical therapeutic solution in relieving urgency/frequency and pain in interstitial cystitis (IC)...
  25. ncbi request reprint Urine-induced apoptosis in cultured bladder urothelial cells
    Paul C Stein
    Division of Urology, University of California, San Diego Medical Center, USA
    Adv Exp Med Biol 539:585-98. 2003
  26. ncbi request reprint Tamm-Horsfall protein protects urothelial permeability barrier
    Paul Stein
    Division of Urology, University of California, Medical Center, San Diego, California 92103 8897, USA
    Urology 66:903-7. 2005
    ..THP may sequester and subsequently neutralize these toxic urinary cations...
  27. ncbi request reprint Intravesical potassium sensitivity in patients with prostatitis
    C Lowell Parsons
    Division of Urology, University of California San Diego Medical Center, San Diego, CA 92103, USA
    J Urol 168:1054-7. 2002
    ..We used the potassium sensitivity test for the presence of epithelial dysfunction in men with diagnosed prostatitis...
  28. ncbi request reprint Argument for the use of the potassium sensitivity test in the diagnosis of interstitial cystitis. For
    C Lowell Parsons
    Division of Urology, University of California San Diego Medical Center, 200 West Arbor Drive, San Diego, CA 92103 8897, USA
    Int Urogynecol J Pelvic Floor Dysfunct 16:430-1. 2005
  29. ncbi request reprint Prevalence of interstitial cystitis in young women
    C Lowell Parsons
    Division of Urology, University of California, San Diego, Medical Center, San Diego, California 92103 8897, USA
    Urology 64:866-70. 2004
    ..To test this hypothesis, we used a validated IC symptom questionnaire and intravesical potassium sensitivity testing (PST), history, and physical examination to determine the prevalence of IC in a fixed population of young women...
  30. ncbi request reprint Improvement in sexual functioning in patients with interstitial cystitis/painful bladder syndrome
    J Curtis Nickel
    Queen s University Urology, Kingston, Ontario, Canada
    J Sex Med 5:394-9. 2008
    ..Sexual functioning is one of the strongest predictors of poorer quality of life (QOL) in patients diagnosed with interstitial cystitis/painful bladder syndrome (IC/PBS)...
  31. ncbi request reprint Multimodal therapy for interstitial cystitis
    Jeffrey R Dell
    Institute for Female Pelvic Medicine, Urogynecology and Reconstructive Pelvic Surgery, Obstetrics and Gynecology Consultants, P C, Knoxville, Tennessee 37923, USA
    J Reprod Med 49:243-52. 2004
    ..Acute and chronic pain associated with IC can now be effectively managed using a multimodal approach with PPS as the basis...
  32. ncbi request reprint Misleading report of massive bleeding in a patient taking pentosan polysulfate
    C Lowell Parsons
    Arch Intern Med 163:119; authors reply 119-20. 2003
  33. ncbi request reprint The emerging presence of interstitial cystitis in gynecologic patients with chronic pelvic pain
    Edward J Stanford
    Center for Advanced Pelvic Surgery and Medicine, Belleville Memorial Hospital, Belleville, Illinois 62801, USA
    Urology 69:53-9. 2007
    ..By determining whether the pain is of bladder origin, the physician can more successfully treat the patient with CPP...
  34. ncbi request reprint Contemporary clinical presentation of interstitial cystitis
    Joel M H Teichman
    Division of Urology, University of British Columbia, Vancouver, British Columbia, Canada
    Urology 69:41-7. 2007
    ..Overall, published reports in the literature indicate that the clinical presentation of IC is variable. IC is readily suggested by history, physical examination, and voiding diary findings...
  35. ncbi request reprint Re: Interstitial cystitis versus detrusor overactivity: a comparative, randomized, controlled study of cystometry using saline and 0.3 m potassium chloride. J. Philip, S. Willmott and P. Irwin. J Urol, 175: 566-571, 2006
    C Lowell Parsons
    J Urol 176:1253-4; author reply 1254. 2006
  36. ncbi request reprint MN-001, a novel oral anti-inflammatory agent, suppresses bladder hyperactivity in a rat model
    Mahadevan Rajasekaran
    Urology Research Laboratory, Veterans Medical Research Foundation, La Jolla, CA, USA
    BJU Int 98:430-4. 2006
    ..To evaluate the effects of MN-001, a novel orally active anti-inflammatory agent, in suppressing the bladder hyperactivity resulting from ovalbumin (OA)-induced mast-cell stimulation in a rat model...
  37. ncbi request reprint Interstitial cystitis: a chronic disease with ever-increasing recognition and prevalence
    C Lowell Parsons
    J Urol 173:6. 2005
  38. ncbi request reprint Randomized, double-blind, dose-ranging study of pentosan polysulfate sodium for interstitial cystitis
    J Curtis Nickel
    Department of Urology, Queens University, Kingston General Hospital, Kingston, Ontario, Canada
    Urology 65:654-8. 2005
    ..To compare the current recommended dose of pentosan polysulfate sodium (PPS) with doses two to three times higher...
  39. ncbi request reprint The historical origins of interstitial cystitis
    J Kellogg Parsons
    Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Urol 171:20-2. 2004
    ..We identify early descriptions of interstitial cystitis and trace its evolution as a clinical entity during the 19th century...
  40. ncbi request reprint Interstitial cystitis: a primary care perspective
    Matt Rosenberg
    Mid Michigan Health Centers, Jackson, MI, USA
    Cleve Clin J Med 72:698-704. 2005
    ..Its diagnosis is straightforward, and effective therapies are available. Physicians should keep the diagnosis of interstitial cystitis in mind for all patients presenting with pelvic pain or urinary symptoms...