Andrew T Parsa

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Giant thoracic schwannoma presenting with abrupt onset of abdominal pain: a case report
    Isaac Yang
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA
    J Med Case Reports 3:88. 2009
  2. pmc Endocrinologic, neurologic, and visual morbidity after treatment for craniopharyngioma
    Michael E Sughrue
    Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Ave, San Francisco, CA 94117, USA
    J Neurooncol 101:463-76. 2011
  3. pmc Overexpression of CD97 confers an invasive phenotype in glioblastoma cells and is associated with decreased survival of glioblastoma patients
    Michael Safaee
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA
    PLoS ONE 8:e62765. 2013
  4. pmc Factors associated with preservation of facial nerve function after surgical resection of vestibular schwannoma
    Orin Bloch
    Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Ave, San Francisco, CA 94143, USA
    J Neurooncol 102:281-6. 2011
  5. pmc Factors influencing overall survival rates for patients with pineocytoma
    Aaron J Clark
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA 94117, USA
    J Neurooncol 100:255-60. 2010
  6. pmc Overexpression of calcium-permeable glutamate receptors in glioblastoma derived brain tumor initiating cells
    Michael C Oh
    Department of Neurological Surgery, University of California San Francisco, United States of America
    PLoS ONE 7:e47846. 2012
  7. pmc Na⁺/K⁺-ATPase β2-subunit (AMOG) expression abrogates invasion of glioblastoma-derived brain tumor-initiating cells
    Matthew Z Sun
    Corresponding Author Andrew T Parsa, MD, PhD, Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA 94117
    Neuro Oncol 15:1518-31. 2013
  8. pmc Choroid plexus papillomas: advances in molecular biology and understanding of tumorigenesis
    Michael Safaee
    Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Ave, San Francisco, CA 94117, USA
    Neuro Oncol 15:255-67. 2013
  9. pmc Supratentorial hemangioblastoma: clinical features, prognosis, and predictive value of location for von Hippel-Lindau disease
    Steven A Mills
    Department of Neurological Surgery, University of California, San Francisco, CA, USA
    Neuro Oncol 14:1097-104. 2012
  10. pmc Immunological considerations of modern animal models of malignant primary brain tumors
    Michael E Sughrue
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, California, USA
    J Transl Med 7:84. 2009

Research Grants

Detail Information

Publications127 found, 100 shown here

  1. pmc Giant thoracic schwannoma presenting with abrupt onset of abdominal pain: a case report
    Isaac Yang
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA
    J Med Case Reports 3:88. 2009
    ..We report the case of a patient with a giant thoracic schwannoma presenting unusually with acute abdominal pain and with delayed neurological impairment...
  2. pmc Endocrinologic, neurologic, and visual morbidity after treatment for craniopharyngioma
    Michael E Sughrue
    Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Ave, San Francisco, CA 94117, USA
    J Neurooncol 101:463-76. 2011
    ..4%, P = 0.11). Given the difficulty in obtaining class 1 data regarding the treatment of this tumor, this study can serve as an estimate of expected outcomes for these patients, and guide decision making until these data are available...
  3. pmc Overexpression of CD97 confers an invasive phenotype in glioblastoma cells and is associated with decreased survival of glioblastoma patients
    Michael Safaee
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA
    PLoS ONE 8:e62765. 2013
    ..This phenotype may explain the discrepancy in survival between high and low CD97-expressing tumors. This data provides impetus for further studies to determine its viability as a therapeutic target in the treatment of GBM...
  4. pmc Factors associated with preservation of facial nerve function after surgical resection of vestibular schwannoma
    Orin Bloch
    Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Ave, San Francisco, CA 94143, USA
    J Neurooncol 102:281-6. 2011
    ..Residual disease can be followed and controlled with radiosurgery if interval growth is noted...
  5. pmc Factors influencing overall survival rates for patients with pineocytoma
    Aaron J Clark
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA 94117, USA
    J Neurooncol 100:255-60. 2010
    ..Gross total resection is the most appropriate treatment for pineocytoma. The potential benefit of conventional radiotherapy for the treatment of these lesions is unproven, and little evidence supports its use at present...
  6. pmc Overexpression of calcium-permeable glutamate receptors in glioblastoma derived brain tumor initiating cells
    Michael C Oh
    Department of Neurological Surgery, University of California San Francisco, United States of America
    PLoS ONE 7:e47846. 2012
    ..Our findings raise the possibility that glutamate secretion in the GBM tumor microenvironment may stimulate brain tumor derived cancer stem cells...
  7. pmc Na⁺/K⁺-ATPase β2-subunit (AMOG) expression abrogates invasion of glioblastoma-derived brain tumor-initiating cells
    Matthew Z Sun
    Corresponding Author Andrew T Parsa, MD, PhD, Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA 94117
    Neuro Oncol 15:1518-31. 2013
    ....
  8. pmc Choroid plexus papillomas: advances in molecular biology and understanding of tumorigenesis
    Michael Safaee
    Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Ave, San Francisco, CA 94117, USA
    Neuro Oncol 15:255-67. 2013
    ..Improving our understanding of the molecular biology, genetics, and oncogenic pathways associated with this tumor will allow for the development of targeted therapies and improved outcomes for patients with this disease...
  9. pmc Supratentorial hemangioblastoma: clinical features, prognosis, and predictive value of location for von Hippel-Lindau disease
    Steven A Mills
    Department of Neurological Surgery, University of California, San Francisco, CA, USA
    Neuro Oncol 14:1097-104. 2012
    ..Von Hippel-Lindau disease is positively correlated with supratentorial hemangioblastoma when compared with non-supratentorial CNS hemangioblastomas, particularly when present in the sellar/suprasellar region...
  10. pmc Immunological considerations of modern animal models of malignant primary brain tumors
    Michael E Sughrue
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, California, USA
    J Transl Med 7:84. 2009
    ..As this review demonstrates, many of these models have inherent immune system limitations, and the impact of these limitations on studies on the influence of pre-clinical therapeutics testing warrants further attention...
  11. pmc Primary gliosarcoma: key clinical and pathologic distinctions from glioblastoma with implications as a unique oncologic entity
    Seunggu J Han
    Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Ave, San Francisco, CA 94117, USA
    J Neurooncol 96:313-20. 2010
    ..Clinical and pathologic characteristics distinct from GBM suggest that they may warrant specific treatment, separate from conventional GBM therapy...
  12. pmc The complement cascade as a mediator of tissue growth and regeneration
    Martin J Rutkowski
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA 94143, USA
    Inflamm Res 59:897-905. 2010
    ..Here, we describe the complement cascade as a mediator of tissue growth and regeneration...
  13. ncbi request reprint Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma
    Andrew T Parsa
    Department of Neurological Surgery, University of California San Francisco, 505 Parnassus Avenue, M 779, San Francisco, California 94143, USA
    Nat Med 13:84-8. 2007
    ..These data identify a previously unrecognized mechanism linking loss of the tumor suppressor PTEN with immunoresistance, mediated in part by B7-H1...
  14. ncbi request reprint Spinal cord and intradural-extraparenchymal spinal tumors: current best care practices and strategies
    Andrew T Parsa
    Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
    J Neurooncol 69:291-318. 2004
    ..Advances in many disciplines including neuroradiology, neurosurgery, neurooncology, and neuropathology have contributed to expediting diagnosis and improving outcomes...
  15. ncbi request reprint Autologous adjuvant linked fibroblasts induce anti-glioma immunity: implications for development of a glioma vaccine
    Andrew T Parsa
    Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
    J Neurooncol 64:77-87. 2003
    ..In this study we describe an in vitro model of active immunotherapy using autologous fibroblasts as immunogen. Correlative results from glioma patients immunized with autologous fibroblasts are also described...
  16. ncbi request reprint Prognostic significance of intracranial dissemination of glioblastoma multiforme in adults
    Andrew T Parsa
    Department of Neurological Surgery, School of Medicine, University of California at San Francisco, California 94143, USA
    J Neurosurg 102:622-8. 2005
    ..The objective in the present study was to assess the prognostic significance of disseminated intracranial GBM in adults at presentation and at the time of tumor progression...
  17. pmc A novel PTEN-dependent link to ubiquitination controls FLIPS stability and TRAIL sensitivity in glioblastoma multiforme
    Amith Panner
    Brain Tumor Research Center, Department of Neurological Surgery and University of California San Francisco Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94158 9001, USA
    Cancer Res 69:7911-6. 2009
    ..These results define the PTEN-Akt-AIP4 pathway as a key regulator of FLIP(S) ubiquitination, FLIP(S) stability, and TRAIL sensitivity and also define a novel link between PTEN and the ubiquitin-mediated control of protein stability...
  18. pmc Gamma interferon-mediated superinduction of B7-H1 in PTEN-deficient glioblastoma: a paradoxical mechanism of immune evasion
    Seunggu J Han
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94117, USA
    Neuroreport 20:1597-602. 2009
    ..The combination of PTEN loss and gamma-interferon exposure in glioblastoma patients results in an exceptionally immunoresistant phenotype that may negate adaptive immunity through induction of T-cell apoptosis...
  19. doi request reprint Impact of extent of resection for recurrent glioblastoma on overall survival: clinical article
    Orin Bloch
    Department of Neurological Surgery, University of California, San Francisco, California 94143 0112, USA
    J Neurosurg 117:1032-8. 2012
    ..In this study the authors investigate the impact of EOR at initial and repeat resection of GBM on overall survival...
  20. doi request reprint Neurosurgical management and prognosis of patients with glioblastoma that progresses during bevacizumab treatment
    Aaron J Clark
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 70:361-70. 2012
    ..The management and prognosis of glioblastoma patients after Stupp protocol treatment and progression during bevacizumab (BV) treatment remain undefined...
  21. doi request reprint Management of recurrent intracranial hemangiopericytoma
    Martin J Rutkowski
    Brain Tumor Research Center, Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA
    J Clin Neurosci 18:1500-4. 2011
    ..This multimodality approach also appears to outperform GKS in extending time to second recurrence. Accordingly, when safe and feasible, surgical resection of recurrent HPC with adjuvant EBRT should be the first steps in management...
  22. pmc Implications for immunotherapy of tumor-mediated T-cell apoptosis associated with loss of the tumor suppressor PTEN in glioblastoma
    James S Waldron
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94123, USA
    J Clin Neurosci 17:1543-7. 2010
    ..In addition, our results raise the possibility of combining T-cell based immunotherapy protocols with clinical inhibitors of the PI3K/Akt/mTOR pathway...
  23. pmc Differentiation of recurrent glioblastoma multiforme from radiation necrosis after external beam radiation therapy with dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging
    Ramon F Barajas
    Department of Radiology, Neuroradiology Section, University of California, San Francisco, CA 94143, USA
    Radiology 253:486-96. 2009
    ....
  24. doi request reprint Secondary gliosarcoma after diagnosis of glioblastoma: clinical experience with 30 consecutive patients
    Seunggu J Han
    Department of Neurological Surgery, University of California, San Francisco, California 94117, USA
    J Neurosurg 112:990-6. 2010
    ..The authors present a large series of histologically confirmed SGSs, with follow-up to describe the clinical and radiological presentation, pathological diagnosis, and treatment outcomes...
  25. doi request reprint Results with judicious modern neurosurgical management of parasagittal and falcine meningiomas. Clinical article
    Michael E Sughrue
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California, USA
    J Neurosurg 114:731-7. 2011
    ..The present study aims to address surgical outcomes in a focused cohort of these patients for which there is not clinical equipoise between radiosurgery and transcranial resection...
  26. doi request reprint The relevance of Simpson Grade I and II resection in modern neurosurgical treatment of World Health Organization Grade I meningiomas
    Michael E Sughrue
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurosurg 113:1029-35. 2010
    ....
  27. doi request reprint A comprehensive analysis of hearing preservation after radiosurgery for vestibular schwannoma
    Isaac Yang
    Department of Neurological Surgery, University of California at San Francisco, California 94117, USA
    J Neurosurg 112:851-9. 2010
    ..Their aim was to objectively characterize the prognostic factors that contribute to hearing preservation after GKS, as well as methodically summarize the reported literature describing hearing preservation after GKS for VS...
  28. doi request reprint Disseminated progression of glioblastoma after treatment with bevacizumab
    Orin Bloch
    Department of Neurological Surgery, Brain Tumor Research Center, University of California, San Francisco, CA 94143 0112, USA
    Clin Neurol Neurosurg 115:1795-801. 2013
    ..We have reviewed our institutional experience with bevacizumab for GBM to evaluate the prognostic factors and outcomes of patients with disseminated progression...
  29. doi request reprint Outcome and survival following primary and repeat surgery for World Health Organization Grade III meningiomas
    Michael E Sughrue
    Brain Tumor Research Center, Department of Neurological Surgery, University of California at San Francisco, California 94143, USA
    J Neurosurg 113:202-9. 2010
    ..The authors present the largest case series to date dealing with these tumors, providing analysis of 63 patients...
  30. pmc MIB-1 labeling index predicts recurrence in intraventricular central neurocytomas
    Gurvinder Kaur
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA 94143, USA
    J Clin Neurosci 20:89-93. 2013
    ..Thus, in patients with CN who were treated with STR, histology demonstrating a MIB-1 labeling index >4% can be a clinically useful prognostic indicator and can help guide adjuvant treatment...
  31. doi request reprint Prognosis by tumor location for pediatric spinal cord ependymomas
    Michael C Oh
    Departments of Neurological Surgery, University of California, San Francisco, CA 94117, USA
    J Neurosurg Pediatr 11:282-8. 2013
    ..A comprehensive literature review was performed to determine whether a tumor location along the spinal cord is prognostically significant in children undergoing surgery for spinal cord ependymomas...
  32. pmc Regional variation in histopathologic features of tumor specimens from treatment-naive glioblastoma correlates with anatomic and physiologic MR Imaging
    Ramon F Barajas
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158 2330, USA
    Neuro Oncol 14:942-54. 2012
    ..Image-guided tissue acquisition and assessment of residual tumor from treatment-naive GBM should be guided by DSC in CE regions and by DWI in NE regions...
  33. doi request reprint Surgical technique of temporary arterial occlusion in the operative management of spinal hemangioblastomas
    Aaron J Clark
    Department of Neurological Surgery, University of California, San Francisco, California, USA
    World Neurosurg 74:200-5. 2010
    ..Although benign, their highly vascular nature makes resection challenging. A major difficulty involves intraoperative differentiation of vessels supplying the tumor from those supplying the spinal cord...
  34. doi request reprint Facial nerve preservation after vestibular schwannoma Gamma Knife radiosurgery
    Isaac Yang
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA 94143, USA
    J Neurooncol 93:41-8. 2009
    ..In this study, we report the results of an objective analysis of reported facial nerve outcomes after the treatment of vestibular schwannomas with Gamma Knife radiosurgery...
  35. doi request reprint Craniopharyngioma: a comparison of tumor control with various treatment strategies
    Isaac Yang
    Department of Neurological Surgery, University of California, San Francisco, California, USA
    Neurosurg Focus 28:E5. 2010
    ..Here, the authors summarize the published literature regarding rates of tumor control with various treatment modalities for craniopharyngiomas...
  36. doi request reprint Clinical characteristics and outcomes for a modern series of primary gliosarcoma patients
    Seunggu J Han
    Department of Neurological Surgery, University of California, San Francisco, CA, USA
    Cancer 116:1358-66. 2010
    ..In the current study, the authors present a modern series of confirmed PGS cases treated in the era of magnetic resonance imaging (MRI), after the accepted glioblastoma management of resection, radiation, and temozolomide...
  37. pmc mTOR-independent translational control of the extrinsic cell death pathway by RalA
    Amith Panner
    UCSF Cancer Center, 2340 Sutter St, Rm N219, San Francisco, CA 94115 0875, USA
    Mol Cell Biol 26:7345-57. 2006
    ....
  38. doi request reprint Epidermal growth factor module-containing mucin-like receptor 2 is a newly identified adhesion G protein-coupled receptor associated with poor overall survival and an invasive phenotype in glioblastoma
    Martin J Rutkowski
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, 505 Parnassus Ave, San Francisco, CA 94143, USA
    J Neurooncol 105:165-71. 2011
    ..The invasive phenotype conferred by EMR2 correlates with clinical data demonstrating poor survival in glioblastoma patients who express high levels of EMR2 in their tumor...
  39. pmc Adjuvant radiotherapy delays recurrence following subtotal resection of spinal cord ependymomas
    Michael C Oh
    Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Ave, San Francisco, CA 94117, USA
    Neuro Oncol 15:208-15. 2013
    ..We performed a comprehensive review of the literature to evaluate whether adjuvant radiotherapy after subtotal resection (STR) has any benefit...
  40. doi request reprint A systematic review of treatment outcomes in pediatric patients with intracranial ependymomas
    Tene A Cage
    Department of Neurological Surgery, University of California San Francisco, CA 94143, USA
    J Neurosurg Pediatr 11:673-81. 2013
    ....
  41. doi request reprint Intracranial hemangiopericytoma: clinical experience and treatment considerations in a modern series of 40 adult patients
    Martin J Rutkowski
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, California, USA
    Cancer 118:1628-36. 2012
    ..Intracranial hemangiopericytoma (HPC) is a malignant meningothelial tumor. Because of its rarity, few guidelines exist for optimal management...
  42. ncbi request reprint Lack of B7 expression, not human leukocyte antigen expression, facilitates immune evasion by human malignant gliomas
    Richard C E Anderson
    Department of Neurological Surgery, The Neurological Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Neurosurgery 60:1129-36; discussion 1136. 2007
    ..Lack of human leukocyte antigens and costimulatory molecules have been suggested as mechanisms by which human malignant gliomas avoid immune recognition and elimination...
  43. doi request reprint Non-audiofacial morbidity after Gamma Knife surgery for vestibular schwannoma
    Michael E Sughrue
    Department of Neurological Surgery, University of California, San Francisco, California 94117, USA
    Neurosurg Focus 27:E4. 2009
    ..For this reason, the authors conducted a systematic review of the literature for non-audiofacial-related morbidity after the treatment of vestibular schwannoma with radiosurgery...
  44. doi request reprint A meta-analysis of tumor control rates and treatment-related morbidity for patients with glomus jugulare tumors
    Michael E Ivan
    Department of Neurological Surgery, University of California, San Francisco, California, USA
    J Neurosurg 114:1299-305. 2011
    ..In this study, the authors assessed data collected from 869 patients with glomus jugulare tumors from the published literature to identify treatment variables that impacted clinical outcomes and tumor control rates...
  45. ncbi request reprint The value of intraoperative facial nerve electromyography in predicting facial nerve function after vestibular schwannoma surgery
    Michael E Sughrue
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA 94143, USA
    J Clin Neurosci 17:849-52. 2010
    ..In conclusion, while facial nerve EMG is a critical adjunct for locating the facial nerve intraoperatively, its predictive value for facial nerve function remains to be determined...
  46. doi request reprint Extent of resection and the long-term durability of vestibular schwannoma surgery
    Michael E Sughrue
    Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurosurg 114:1218-23. 2011
    ..In this prospective study, the authors evaluated 772 patients who underwent microsurgical resection of VSs to analyze the association between total tumor resection and the tumor recurrence rate...
  47. doi request reprint Impact of bevacizumab chemotherapy on craniotomy wound healing
    Aaron J Clark
    Department of Neurological Surgery, University of California, San Francisco, California 94143 0112, USA
    J Neurosurg 114:1609-16. 2011
    ..Phase II trials reported 4%-6% impaired wound healing for bevacizumab initiated postoperatively. The effect of preoperative bevacizumab on subsequent craniotomy healing has not been addressed...
  48. doi request reprint Risk factors for the development of serious medical complications after resection of meningiomas. Clinical article
    Michael E Sughrue
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California, USA
    J Neurosurg 114:697-704. 2011
    ..The authors performed a review of 834 patients who underwent craniotomy for meningioma at their institution and analyzed the rate of major cardiac, pulmonary, renal, and hepatic complications...
  49. doi request reprint Tumor control after surgery and radiotherapy for pineocytoma
    Aaron J Clark
    Department of Neurological Surgery, University of California, San Francisco, California 94117, USA
    J Neurosurg 113:319-24. 2010
    ..Therefore, the authors performed a systematic review of the literature on tumor control after surgery for pineocytoma to determine the relative benefits of aggressive resection and postoperative adjuvant radiotherapy...
  50. doi request reprint A critical evaluation of cystic features in primary glioblastoma as a prognostic factor for survival
    Gurvinder Kaur
    Department of Neurological Surgery, University of California, San Francisco, California, USA
    J Neurosurg 115:754-9. 2011
    ....
  51. doi request reprint Complement and the central nervous system: emerging roles in development, protection and regeneration
    Martin J Rutkowski
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA 94143, USA
    Immunol Cell Biol 88:781-6. 2010
    ....
  52. doi request reprint Modern surgical outcomes following surgery for sphenoid wing meningiomas
    Michael E Sughrue
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurosurg 119:86-93. 2013
    ..The authors review their experience with resection of sphenoid wing meningiomas at a single center, to examine whether this classification predicts clinical presentation and postsurgical outcome...
  53. pmc Soluble factors secreted by glioblastoma cell lines facilitate recruitment, survival, and expansion of regulatory T cells: implications for immunotherapy
    Courtney A Crane
    Brain Tumor Research Center, Department of Neurological Surgery, Comprehensive Cancer Center, University of California, San Francisco, California 94143, USA
    Neuro Oncol 14:584-95. 2012
    ....
  54. pmc Functional mapping-guided resection of low-grade gliomas in eloquent areas of the brain: improvement of long-term survival. Clinical article
    Edward F Chang
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California, USA
    J Neurosurg 114:566-73. 2011
    ..Given the lack of long-term survival data, the prognostic significance of eloquent brain tumor location and the role of functional mapping during resective surgery in presumed eloquent brain regions are unknown...
  55. doi request reprint Predictors of mortality following treatment of intracranial hemangiopericytoma
    Martin J Rutkowski
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California, USA
    J Neurosurg 113:333-9. 2010
    ..A systematic review of the published literature was performed to ascertain predictors of death following treatment for intracranial HPC...
  56. doi request reprint A critical evaluation of vestibular schwannoma surgery for patients younger than 40 years of age
    Michael E Sughrue
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94143, USA
    Neurosurgery 67:1646-53; discussion 1653-4. 2010
    ..There are few published prospective data sets specifically focusing on patients younger than 40 years old undergoing microsurgery for vestibular schwannoma...
  57. doi request reprint Clinical and surgical considerations for cerebellopontine angle meningiomas
    Ari J Kane
    Department of Neurological Surgery, Brain Tumor Research Center, University of California at San Francisco, San Francisco, CA 94143, USA
    J Clin Neurosci 18:755-9. 2011
    ..Caution must be used when attempting to resect tumor extensions into the jugular foramen given the high rates of lower CN complications...
  58. pmc Anatomic location is a risk factor for atypical and malignant meningiomas
    Ari J Kane
    Brain Tumor Research Center, Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94143, USA
    Cancer 117:1272-8. 2011
    ..Hence, the authors have reviewed a large series of their patients to determine risk factors for higher-grade pathology, with particular interest paid to tumor location...
  59. doi request reprint Incidence, risk factors, and outcome of venous infarction after meningioma surgery in 705 patients
    Michael E Sughrue
    Brain Tumor Research Center, Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, P O Box 0112, San Francisco, California 94143, USA
    J Clin Neurosci 18:628-32. 2011
    ..9%, χ(2)p<0.05). We demonstrated that the most important factor determining the risk of venous infarction is the approach used to access the tumor...
  60. doi request reprint Postoperative seizures following the resection of convexity meningiomas: are prophylactic anticonvulsants indicated? Clinical article
    Michael E Sughrue
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California, USA
    J Neurosurg 114:705-9. 2011
    ..Given the paucity of tumor-type and site-specific data, the authors evaluated the incidence of postoperative seizures in patients with convexity meningiomas and no prior seizures...
  61. doi request reprint Increased expression of the glioma-associated antigen ARF4L after loss of the tumor suppressor PTEN. Laboratory investigation
    John H Chi
    Department of Neurological Surgery, Brain Tumor Research Center, University of California, San Francisco, California 94143, USA
    J Neurosurg 108:299-303. 2008
    ..The authors investigated the relationship between PTEN status and the expression of a glioma-associated antigen, adenosine diphosphate-ribosylation factor 4-like (ARF4L) protein...
  62. ncbi request reprint Adjuvant radiation therapy and chondroid chordoma subtype are associated with a lower tumor recurrence rate of cranial chordoma
    Brian J Jian
    Department of Neurological Surgery, University of California at San Francisco, 505, Parnassus Ave, San Francisco, CA 94143, USA
    J Neurooncol 98:101-8. 2010
    ..Our data suggests that younger patients with chondroid type cranial chordoma treated with both surgery and radiation may have improved rates of tumor recurrence in the treatment of these tumors...
  63. pmc The prognostic implications of Hyam's subtype for patients with Kadish stage C esthesioneuroblastoma
    Gurvinder Kaur
    Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    J Clin Neurosci 20:281-6. 2013
    ..The patient's tumor histology (Hyam's criteria) appeared to be the best way of predicting the prognosis and for selecting patients for adjuvant radiotherapy...
  64. pmc Ubiquitin-specific protease 8 links the PTEN-Akt-AIP4 pathway to the control of FLIPS stability and TRAIL sensitivity in glioblastoma multiforme
    Amith Panner
    Brain Tumor Research Center, Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA
    Cancer Res 70:5046-53. 2010
    ..These results show that USP8, a downstream target of Akt, regulates the ability of AIP4 to control FLIP(S) stability and TRAIL sensitivity...
  65. pmc Gliomas promote immunosuppression through induction of B7-H1 expression in tumor-associated macrophages
    Orin Bloch
    Department of Neurological Surgery, University of California San Francisco, CA 94143, USA
    Clin Cancer Res 19:3165-75. 2013
    ..Tumor-associated macrophages are a significant component of the immune infiltrate in gliomas and may express immunosuppressive surface ligands, such as B7-H1...
  66. doi request reprint The relative patient benefit of gross total resection in adult choroid plexus papillomas
    Michael Safaee
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143 0112, USA
    J Clin Neurosci 20:808-12. 2013
    ..Our analysis suggests that these lesions are not as indolent as previously thought and while GTR is preferred, it is not always curative...
  67. doi request reprint G-protein coupled receptor kinase (GRK)-5 regulates proliferation of glioblastoma-derived stem cells
    Gurvinder Kaur
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA 94143, USA
    J Clin Neurosci 20:1014-8. 2013
    ..Using an ATP chemiluminescence assay, we show, for the first time, that knocking down the expression of GRK5 decreased the proliferation rate of GSC in contrast to control...
  68. doi request reprint Surgical outcomes in choroid plexus papillomas: an institutional experience
    Michael Safaee
    Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Ave, San Francisco, CA 94117, USA
    J Neurooncol 113:117-25. 2013
    ..This modern experience at a tertiary care center performed exclusively during the MRI-era demonstrates that CPPs can be safely removed with minimal morbidity and good tumor control...
  69. doi request reprint Individual patient-specific immunity against high-grade glioma after vaccination with autologous tumor derived peptides bound to the 96 KD chaperone protein
    Courtney A Crane
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA 94141, USA
    Clin Cancer Res 19:205-14. 2013
    ..Here we show that peptides bound to a 96 kD chaperone protein (HSP-96) from brain tissue containing glioblastoma multiforme (GBM) can be used to safely immunize patients with recurrent GBM...
  70. doi request reprint The effect of the 2003 Consensus Reporting Standards on publications describing patients with vestibular schwannoma treated with stereotactic radiosurgery
    Seunggu J Han
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA 94117, USA
    J Clin Neurosci 19:1144-7. 2012
    ..001). Our findings suggest a potentially significant impact of the Guidelines on the quality of the information included in studies...
  71. doi request reprint Implications of cystic features in vestibular schwannomas of patients undergoing microsurgical resection
    Brian J Jian
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, California, USA
    Neurosurgery 68:874-80; discussion 879-80. 2011
    ..Cystic vestibular schwannomas (VSs) are described as being more aggressive than solid tumors...
  72. doi request reprint An extent of resection threshold for newly diagnosed glioblastomas
    Nader Sanai
    Brain Tumor Research Center, University of California, San Francisco, California, USA
    J Neurosurg 115:3-8. 2011
    ..The authors attempt to define these values for the patient with newly diagnosed GBM in the modern neurosurgical era...
  73. doi request reprint Preoperative prognostic classification system for hemispheric low-grade gliomas in adults
    Edward F Chang
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurosurg 109:817-24. 2008
    ..As a result, the objective in the present study was to design a preoperative scoring system to prognosticate long-term outcomes in patients with LGGs...
  74. ncbi request reprint A prospective study of hearing preservation in untreated vestibular schwannomas
    Michael E Sughrue
    Department of Neurological Surgery, University of California, San Francisco, 94143, USA
    J Neurosurg 114:381-5. 2011
    ..In this paper the authors present an analysis of prospectively collected outcomes in patients with untreated VS from their institution that confirms their previous findings...
  75. doi request reprint Prevalence of previous extracranial malignancies in a series of 1228 patients presenting with meningioma
    Michael E Sughrue
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurosurg 113:1115-21. 2010
    ..The authors present an analysis of the prevalence of previously diagnosed extracranial malignancies at the time of meningioma diagnosis in 1228 patients evaluated at a single institution...
  76. doi request reprint Factors affecting outcome following treatment of patients with cavernous sinus meningiomas
    Michael E Sughrue
    Department of Neurological Surgery, University of California at San Francisco, California 94143, USA
    J Neurosurg 113:1087-92. 2010
    ..The authors performed a meta-analysis of reported tumor control and survival rates of patients described in the published literature, with an emphasis on specific prognostic factors...
  77. doi request reprint Treatment-related morbidity and the management of pediatric craniopharyngioma: a systematic review
    Aaron J Clark
    Department of Neurological Surgery, University of California, San Francisco, California 94143 0112, USA
    J Neurosurg Pediatr 10:293-301. 2012
    ..Currently, there is controversy regarding the extent, timing, and modality of treatment for pediatric craniopharyngioma...
  78. ncbi request reprint Changes in transcranial motor evoked potentials during intramedullary spinal cord tumor resection correlate with postoperative motor function
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 56:982-93; discussion 982-93. 2005
    ..In this study, we hypothesized that changes in the intraoperative MEPs during tumor resection correlate with postoperative motor function deficits...
  79. doi request reprint Reporting standard compliance in publications of vestibular schwannoma patients treated with microsurgery
    Seunggu J Han
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94117, USA
    Otol Neurotol 33:648-50. 2012
    ..In 2003, Kanzaki and colleagues published a set of reporting standards for vestibular schwannoma (VS) to serve as a guide for future publication, with the specific purpose of promoting standardization of reporting results in VS...
  80. doi request reprint The long-term postsurgical prognosis of patients with pineoblastoma
    Matthew Tate
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0350, USA
    Cancer 118:173-9. 2012
    ..For this report, the authors comprehensively summarized the existing literature on patients with pineoblastoma and identified the variables and treatments that had an impact patient on outcomes...
  81. doi request reprint Post-radiation reactive changes in a single vertebral body mimicking metastatic pineoblastoma
    Matthew C Tate
    Departments of Neurological Surgery, University of California San Francisco, California, USA
    J Neurosurg Pediatr 4:479-83. 2009
    ..To the authors' knowledge this is the first reported case of reactive changes mimicking metastasis in a single vertebral body following standard therapy for resected primary pineoblastoma...
  82. doi request reprint Hearing preservation after stereotactic radiosurgery for vestibular schwannoma: a systematic review
    Isaac Yang
    Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, San Francisco, California 94143, USA
    J Clin Neurosci 16:742-7. 2009
    ..2 months. Our data suggest that an overall hearing preservation rate of about 57% can be expected after radiosurgical treatment, and patients treated with 12.5 Gy were more likely to have preserved hearing...
  83. pmc EMR-3: a potential mediator of invasive phenotypic variation in glioblastoma and novel therapeutic target
    Ari J Kane
    Department of Neurological Surgery, Division of Neuropathology, University of California at San Francisco, San Francisco, California 94143, USA
    Neuroreport 21:1018-22. 2010
    ..EMR-3 is a potential mediator of cellular invasion in GBM. Given the poor survival associated with high levels of EMR-3 expression in glioma patients, our results provide impetus to explore EMR-3 as a potential therapeutic target...
  84. ncbi request reprint A comprehensive analysis of intracranial chordoma and survival: a systematic review
    Brian J Jian
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, California, USA
    Br J Neurosurg 25:446-53. 2011
    ..Here, we perform a systematic review of the literature to evaluate across multiple institutions the overall survival after treatment for intracranial chordoma...
  85. ncbi request reprint Surgical resection and adjuvant radiotherapy for a large pineal hemangiopericytoma
    Brian J Jian
    Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    J Clin Neurosci 17:1209-11. 2010
    ..The patient remains recurrence free 4 years after treatment...
  86. ncbi request reprint Intramedullary spinal cord tumors: molecular insights and surgical innovation
    Andrew T Parsa
    Department of Neurological Surgery, University of California, San Francisco, USA
    Clin Neurosurg 52:76-84. 2005
  87. pmc TGF-beta downregulates the activating receptor NKG2D on NK cells and CD8+ T cells in glioma patients
    Courtney A Crane
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94143, USA
    Neuro Oncol 12:7-13. 2010
    ....
  88. doi request reprint Intratumoral hemorrhage and fibrosis in vestibular schwannoma: a possible mechanism for hearing loss
    Michael E Sughrue
    Department of Neurological Surgery, University of California, San Francisco, 94143, USA
    J Neurosurg 114:386-93. 2011
    ..In this case-control study, the authors investigated the relationship between preoperative hearing loss and histological changes such as intratumoral microhemorrhage and extensive fibrosis...
  89. doi request reprint Mapping clinical outcomes expectations to treatment decisions: an application to vestibular schwannoma management
    Steven W Cheung
    Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, California 94115, USA
    Otol Neurotol 31:284-93. 2010
    ..We aimed to demonstrate methodology and feasibility of adapting conjoint analysis for mapping clinical outcomes expectations to treatment decisions in vestibular schwannoma (VS) management...
  90. ncbi request reprint Pathologic and epidemiologic findings of intramedullary spinal cord tumors
    Tarik Tihan
    Department of Pathology, University of California, San Francisco, CA 94143, USA
    Neurosurg Clin N Am 17:7-11. 2006
  91. doi request reprint Posttreatment prognosis of patients with esthesioneuroblastoma
    Ari J Kane
    Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurosurg 113:340-51. 2010
    ..The objective was to ascertain what variables predict prognosis in these patients and to determine the relative effect of different therapies...
  92. ncbi request reprint Serial diffusion-weighted magnetic resonance imaging in cases of glioma: distinguishing tumor recurrence from postresection injury
    Justin S Smith
    Department of Neurological Surgery, Brain Tumor Research Center, University of California, San Francisco School of Medicine, San Francisco, California 94143 0112, USA
    J Neurosurg 103:428-38. 2005
    ..The purpose of this study was to investigate prospectively the incidence, time course, and ultimate outcome of these abnormalities...
  93. doi request reprint Early surgical intervention in adult patients with ganglioglioma is associated with improved clinical seizure outcomes
    Isaac Yang
    Department of Neurological Surgery, University of California at Los Angeles, Los Angeles, California, USA
    J Clin Neurosci 18:29-33. 2011
    ..Our findings also support that an early surgical intervention is significantly associated with improved clinical seizure control...
  94. doi request reprint Preservation of facial nerve function after resection of vestibular schwannoma
    Michael E Sughrue
    Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Ave, San Francisco, CA 94143, USA
    Br J Neurosurg 24:666-71. 2010
    ..The objective of this study was to provide a comprehensive assessment of reported outcomes for facial nerve preservation after VS surgery...
  95. doi request reprint Treatment decision making based on the published natural history and growth rate of small meningiomas
    Michael E Sughrue
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurosurg 113:1036-42. 2010
    ..To address this need, the authors systematically reviewed the published literature regarding the natural history of small, untreated meningiomas...
  96. doi request reprint Distinguishing glioma recurrence from treatment effect after radiochemotherapy and immunotherapy
    Isaac Yang
    Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Neurosurg Clin N Am 21:181-6. 2010
    ..Further investigations are necessary to assess the imaging algorithms and accuracy of these modalities to differentiate true glioma recurrence from radiotherapy or immunotherapy treatment effect...
  97. pmc Glioblastoma multiforme regional genetic and cellular expression patterns: influence on anatomic and physiologic MR imaging
    Ramon F Barajas
    Department of Radiology, University of California, San Francisco, 505 Parnassus Ave, Long L200B, Box 0628, San Francisco, CA 94143, USA
    Radiology 254:564-76. 2010
    ..To determine whether magnetic resonance (MR) imaging is influenced by genetic and cellular features of glioblastoma multiforme (GBM) aggressiveness...
  98. doi request reprint Radiobiology of vestibular schwannomas: mechanisms of radioresistance and potential targets for therapeutic sensitization
    Andrea H Yeung
    Departments of Otolaryngology Head and Neck Surgery, University of California at San Francisco, San Francisco, California, USA
    Neurosurg Focus 27:E2. 2009
    ..An improved understanding of the radiobiological behavior of VS may help guide appropriate patient selection for SRS and potentially aid in the design of novel therapies to treat radioresistant tumors...
  99. pmc Honokiol-mediated inhibition of PI3K/mTOR pathway: a potential strategy to overcome immunoresistance in glioma, breast, and prostate carcinoma without impacting T cell function
    Courtney Crane
    Department of Neurological Surgery, University of California, San Francisco, CA, USA
    J Immunother 32:585-92. 2009
    ..Honokiol is clinically available for human testing and may serve to augment T cell-mediated cancer immunotherapy...
  100. ncbi request reprint Defective receptor expression and dendritic cell differentiation of monocytes in glioblastomas
    Alfred T Ogden
    Department of Neurological Surgery, The Neurological Institute, Columbia University, New York, New York 10032, USA
    Neurosurgery 59:902-9; discussion 909-10. 2006
    ..This study seeks to develop understanding of the phenotypic changes that occur in circulating monocytes of patients with intracranial cancer and to assess the ability of these cells to differentiate into mature dendritic cells...
  101. ncbi request reprint Restoration of p53 function for selective Fas-mediated apoptosis in human and rat glioma cells in vitro and in vivo by a p53 COOH-terminal peptide
    Patrick B Senatus
    Department of Neurological Surgery, Columbia University Medical Center, 650 West 168th Street, BB 20 05, New York, NY 10032, USA
    Mol Cancer Ther 5:20-8. 2006
    ....

Research Grants1

  1. Antigen specific modeling of glioma immunotherapy
    Andrew Parsa; Fiscal Year: 2007
    ..The long-term goal of this proposal is to facilitate the development of Dr. Parsa into an independent investigator capable of making meaningful scientific contributions. ..