ROBERT PARMER

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc The plasminogen activation system and the regulation of catecholaminergic function
    Hongdong Bai
    Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    J Biomed Biotechnol 2012:721657. 2012
  2. ncbi request reprint Catecholaminergic pathways, chromaffin cells, and human disease
    Robert J Parmer
    Department of Medicine, University of California, and San Diego VA Healthcare System, San Diego, California 92161, USA
    Ann N Y Acad Sci 971:497-505. 2002
  3. ncbi request reprint Tissue plasminogen activator (t-PA) is targeted to the regulated secretory pathway. Catecholamine storage vesicles as a reservoir for the rapid release of t-PA
    R J Parmer
    Department of Medicine and Center for Molecular Genetics, University of California, and Veterans Affairs Medical Center, San Diego, California 92161, USA
    J Biol Chem 272:1976-82. 1997
  4. pmc Processing of chromogranin A by plasmin provides a novel mechanism for regulating catecholamine secretion
    R J Parmer
    Department of Medicine, University of California, and Veterans Administration Medical Center, San Diego, California 92161, USA
    J Clin Invest 106:907-15. 2000
  5. pmc Novel autocrine feedback control of catecholamine release. A discrete chromogranin a fragment is a noncompetitive nicotinic cholinergic antagonist
    S K Mahata
    Department of Medicine and Center for Molecular Genetics, University of California, San Diego, California 92093, USA
    J Clin Invest 100:1623-33. 1997
  6. ncbi request reprint Heredity and the autonomic nervous system in human hypertension
    D T O'Connor
    Departments of Medicine and Pharmacology and Center for Molecular Genetics, University of California, San Diego, and VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Curr Hypertens Rep 2:16-22. 2000
  7. ncbi request reprint Interaction of the catecholamine release-inhibitory peptide catestatin (human chromogranin A(352-372)) with the chromaffin cell surface and Torpedo electroplax: implications for nicotinic cholinergic antagonism
    L Taupenot
    Department of Medicine and Center for Molecular Genetics, University of California, and Veteran Affairs San Diego Healthcare System, 92161 9111H, San Diego, CA, USA
    Regul Pept 95:9-17. 2000
  8. ncbi request reprint Early alteration in glomerular reserve in humans at genetic risk of essential hypertension: mechanisms and consequences
    D T O'Connor
    Department of Medicine and Center for Molecular Genetics, University of California at San Diego, San Diego, CA92161, USA
    Hypertension 37:898-906. 2001
  9. ncbi request reprint Proteolytic cleavage of chromogranin A (CgA) by plasmin. Selective liberation of a specific bioactive CgA fragment that regulates catecholamine release
    Q Jiang
    Department of Medicine, University of California San Diego, 3350 La Jolla Village Dr, San Diego, CA 92161, USA
    J Biol Chem 276:25022-9. 2001
  10. ncbi request reprint Interleukin-6-induced plasminogen gene expression in murine hepatocytes is mediated by transcription factor CCAAT/enhancer binding protein beta (C/EBPbeta)
    F G Bannach
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92103 8411, USA
    J Thromb Haemost 2:2205-12. 2004

Research Grants

Collaborators

Detail Information

Publications37

  1. pmc The plasminogen activation system and the regulation of catecholaminergic function
    Hongdong Bai
    Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    J Biomed Biotechnol 2012:721657. 2012
    ..Plg-R(KT)-dependent plasminogen activation plays a key role in regulating catecholaminergic neurosecretory cell function...
  2. ncbi request reprint Catecholaminergic pathways, chromaffin cells, and human disease
    Robert J Parmer
    Department of Medicine, University of California, and San Diego VA Healthcare System, San Diego, California 92161, USA
    Ann N Y Acad Sci 971:497-505. 2002
    ....
  3. ncbi request reprint Tissue plasminogen activator (t-PA) is targeted to the regulated secretory pathway. Catecholamine storage vesicles as a reservoir for the rapid release of t-PA
    R J Parmer
    Department of Medicine and Center for Molecular Genetics, University of California, and Veterans Affairs Medical Center, San Diego, California 92161, USA
    J Biol Chem 272:1976-82. 1997
    ..In addition, expression of t-PA by chromaffin cells suggests a role for this protease in the proteolytic processing of chromaffin cell proteins...
  4. pmc Processing of chromogranin A by plasmin provides a novel mechanism for regulating catecholamine secretion
    R J Parmer
    Department of Medicine, University of California, and Veterans Administration Medical Center, San Diego, California 92161, USA
    J Clin Invest 106:907-15. 2000
    ..Interactions between CgA and plasmin(ogen) define a previously unrecognized autocrine/paracrine system that may have a dramatic impact upon catecholamine secretion...
  5. pmc Novel autocrine feedback control of catecholamine release. A discrete chromogranin a fragment is a noncompetitive nicotinic cholinergic antagonist
    S K Mahata
    Department of Medicine and Center for Molecular Genetics, University of California, San Diego, California 92093, USA
    J Clin Invest 100:1623-33. 1997
    ..This small domain within chromogranin A may contribute to a novel, autocrine, homeostatic (negative-feedback) mechanism controlling catecholamine release from chromaffin cells and neurons...
  6. ncbi request reprint Heredity and the autonomic nervous system in human hypertension
    D T O'Connor
    Departments of Medicine and Pharmacology and Center for Molecular Genetics, University of California, San Diego, and VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Curr Hypertens Rep 2:16-22. 2000
    ..Such biochemical, physiologic, or pharmacologic autonomic traits may be especially valuable as phenotypic anchor points in linkage or association studies probing the genetic basis of human hypertension...
  7. ncbi request reprint Interaction of the catecholamine release-inhibitory peptide catestatin (human chromogranin A(352-372)) with the chromaffin cell surface and Torpedo electroplax: implications for nicotinic cholinergic antagonism
    L Taupenot
    Department of Medicine and Center for Molecular Genetics, University of California, and Veteran Affairs San Diego Healthcare System, 92161 9111H, San Diego, CA, USA
    Regul Pept 95:9-17. 2000
    ..Such binding provides a physical explanation for non-competitive antagonism of the peptide at the nicotinic receptor...
  8. ncbi request reprint Early alteration in glomerular reserve in humans at genetic risk of essential hypertension: mechanisms and consequences
    D T O'Connor
    Department of Medicine and Center for Molecular Genetics, University of California at San Diego, San Diego, CA92161, USA
    Hypertension 37:898-906. 2001
    ..This glomerular reserve phenotype may be useful in genetic studies of renal traits preceding or predisposing to hypertension...
  9. ncbi request reprint Proteolytic cleavage of chromogranin A (CgA) by plasmin. Selective liberation of a specific bioactive CgA fragment that regulates catecholamine release
    Q Jiang
    Department of Medicine, University of California San Diego, 3350 La Jolla Village Dr, San Diego, CA 92161, USA
    J Biol Chem 276:25022-9. 2001
    ....
  10. ncbi request reprint Interleukin-6-induced plasminogen gene expression in murine hepatocytes is mediated by transcription factor CCAAT/enhancer binding protein beta (C/EBPbeta)
    F G Bannach
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92103 8411, USA
    J Thromb Haemost 2:2205-12. 2004
    ....
  11. ncbi request reprint Catecholamine storage vesicle protein expression in genetic hypertension
    D T O'Connor
    Department of Medicine, Center for Molecular Genetics, University of California, V A San Diego Healthcare System, USA
    Blood Press 8:285-95. 1999
    ..In one rodent model (the SHR), over-expression of chromogranin A is largely controlled by a single genetic locus, but the chromogranin A locus itself is not directly linked to determination of the blood pressure elevation of the SHR...
  12. ncbi request reprint Desensitization of catecholamine release. The novel catecholamine release-inhibitory peptide catestatin (chromogranin a344-364) acts at the receptor to prevent nicotinic cholinergic tolerance
    S K Mahata
    Department of Medicine and Center for Molecular Genetics, University of California, and San Diego Veterans Administration Healthcare System, San Diego, California 92161, USA
    J Biol Chem 274:2920-8. 1999
    ..003). We conclude that catestatin is a highly potent, dose-dependent, noncompetitive, noncooperative, specific inhibitor of nicotinic desensitization, an effect which may have implications for control of catecholamine release...
  13. pmc Mechanism of action of chromogranin A on catecholamine release: molecular modeling of the catestatin region reveals a beta-strand/loop/beta-strand structure secured by hydrophobic interactions and predictive of activity
    I Tsigelny
    Department of Medicine, Center for Molecular Genetics, University of California, San Diego, USA
    Regul Pept 77:43-53. 1998
    ..The model suggests particular spatial and charge features of the peptide which may serve as starting points in the development of non-peptide mimetics of this endogenous nicotinic cholinergic antagonist...
  14. ncbi request reprint Stimulus-transcription coupling in pheochromocytoma cells. Promoter region-specific activation of chromogranin a biosynthesis
    K Tang
    Department of Medicine and Center for Molecular Genetics, University of California, and Department of Veterans Affairs Medical Center, San Diego, California 92161, USA
    J Biol Chem 271:28382-90. 1996
    ....
  15. ncbi request reprint Vesicular monoamine transport inhibitors. Novel action at calcium channels to prevent catecholamine secretion
    M Mahata
    Department of Medicine, University of California, San Diego 92161, USA
    Hypertension 28:414-20. 1996
    ..Furthermore, these novel actions are seen at concentrations of these compounds frequently taken to be specific in vitro and likely to occur during antihypertensive treatment in vivo...
  16. ncbi request reprint Is physiologic sympathoadrenal catecholamine release exocytotic in humans?
    M A Takiyyuddin
    Department of Medicine, University of California, San Diego
    Circulation 81:185-95. 1990
    ..CgA appears to be transported by a route different from that of catecholamines from adrenal medullary chromaffin cells to the circulation in vivo...
  17. ncbi request reprint Molecular cloning of chromogranin A from rat pheochromocytoma cells
    R J Parmer
    Department of Medicine, University of California, San Diego
    Hypertension 14:435-44. 1989
    ..Finally, comparison of the present rat pheochromocytoma cDNA clones with those recently obtained from normal rat adrenal gland reveals minor but apparently real differences that suggest CgA microheterogeneity...
  18. ncbi request reprint Structure and function of the chromogranin A gene. Clues to evolution and tissue-specific expression
    H J Wu
    Department of Medicine, University of California, San Diego
    J Biol Chem 266:13130-4. 1991
    ....
  19. ncbi request reprint Physical mapping of autonomic/sympathetic candidate genetic loci for hypertension in the human genome: a somatic cell radiation hybrid library approach
    S W Chitbangonsyn
    Department of Medicine and Center for Molecular Genetics, University of California at San Diego, and the V A San Diego Healthcare System, San Diego, CA 92161, USA
    J Hum Hypertens 17:319-24. 2003
    ....
  20. ncbi request reprint Molecular cloning, structure, and expression of dopamine-beta-hydroxylase from bovine adrenal medulla
    H J Wu
    Department of Medicine, University of California, San Diego
    J Neurochem 55:97-105. 1990
    ..The results suggest that a single DBH gene encodes a message specifying a single DBH polypeptide chain...
  21. ncbi request reprint Molecular genetics of essential hypertension: recent results and emerging strategies
    D S Timberlake
    Department of Medicine, University of California at San Diego, and Veterans Administration Medical Center, 92161, USA
    Curr Opin Nephrol Hypertens 10:71-9. 2001
    ....
  22. ncbi request reprint Factitious pheochromocytoma: novel mimickry by Valsalva maneuver and clues to diagnosis
    M T Kailasam
    Department of Medicine, University of California, San Diego 92161, USA
    Am J Hypertens 8:651-5. 1995
    ..We reproduced, in part, the hemodynamic and biochemical manifestations of this presentation with Valsalva maneuver in healthy subjects...
  23. ncbi request reprint Assignment of the chromogranin A (Chga) locus to homologous regions on mouse chromosome 12 and rat chromosome 6
    D Simon-Chazottes
    Department of Medicine, University of California, San Diego 92161
    Genomics 17:252-5. 1993
    ..In each case (mouse, rat, and human), chromogranin A is in a conserved region with nearby markers including the immunoglobulin heavy chain locus...
  24. ncbi request reprint Early decline in the catecholamine release-inhibitory peptide catestatin in humans at genetic risk of hypertension
    DANIEL T O'CONNOR
    Department of Medicine and Center for Molecular Genetics, University of California and V A San Diego Healthcare System, San Diego, California, USA
    J Hypertens 20:1335-45. 2002
    ....
  25. ncbi request reprint Cell-surface actin binds plasminogen and modulates neurotransmitter release from catecholaminergic cells
    Lindsey A Miles
    Department of Cell Biology, Division of Vascular Biology, The Scripps Research Institute, La Jolla, California, 92037, USA
    J Neurosci 26:13017-24. 2006
    ..Our results suggest that cell-surface-expressed forms of actin bind plasminogen, thereby promoting plasminogen activation and increased prohormone processing leading to inhibition of neurotransmitter release...
  26. ncbi request reprint Primary sequence characterization of catestatin intermediates and peptides defines proteolytic cleavage sites utilized for converting chromogranin a into active catestatin secreted from neuroendocrine chromaffin cells
    Jean C Lee
    The Buck Institute for Age Research, Novato, California 94945, USA
    Biochemistry 42:6938-46. 2003
    ..These findings demonstrate that production of catestatin involves cleavage of CgA at paired basic and monobasic residues, necessary steps for catestatin peptide regulation of nicotinic cholinergic-induced catecholamine release...
  27. ncbi request reprint The local chromaffin cell plasminogen/plasmin system and the regulation of catecholamine secretion
    Qijiao Jiang
    Department of Medicine, University of California, and San Diego VA Healthcare System, San Diego, California 92161, USA
    Ann N Y Acad Sci 971:445-9. 2002
    ..These results suggest the presence of a local, functionally active, chromaffin cell plasminogen/plasmin system that plays a major role in the regulation of catecholamine release from catecholaminergic cells...
  28. ncbi request reprint The catecholamine release-inhibitory "catestatin" region of chromogranin a: early decline in humans at genetic risk of hypertension
    DANIEL T O'CONNOR
    Department of Medicine and Center for Molecular Genetics, University of California, and VA San Diego Healthcare System, San Diego, California 92037, USA
    Ann N Y Acad Sci 971:533-5. 2002
  29. ncbi request reprint Chromaffin cell plasminogen receptors
    Lindsey A Miles
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Ann N Y Acad Sci 971:454-9. 2002
  30. ncbi request reprint Intracellular protein trafficking into catecholamine storage vesicles: novel chimeric photoproteins visualized by deconvolution fluorescence microscopy
    Laurent Taupenot
    Department of Medicine and Center for Molecular Genetics, University of California and VA San Diego Healthcare System, San Diego, California 92161, USA
    Ann N Y Acad Sci 971:262-5. 2002
  31. ncbi request reprint Identification of a novel sorting determinant for the regulated pathway in the secretory protein chromogranin A
    Laurent Taupenot
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    J Cell Sci 115:4827-41. 2002
    ..Moreover, our data reveal for the first time that the CgA(77-115) domain of the mature protein may be necessary (though perhaps not sufficient) for trafficking CgA into the regulated pathway of secretion...
  32. ncbi request reprint Localization of regulatory elements mediating constitutive and cytokine-stimulated plasminogen gene expression
    Felizabel Garcia Bannach
    Department of Cell Biology, Division of Vascular Biology, Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 277:38579-88. 2002
    ..These results indicate the presence of regulatory elements in the 5'-flanking region of the murine plasminogen promoter that may regulate murine plasminogen gene expression and, hence, plasmin activity...
  33. ncbi request reprint Plasminogen has a broad extrahepatic distribution
    Lu Zhang
    The Scripps Research Institute, Department of Vascular Biology, La Jolla, CA 92037, USA
    Thromb Haemost 87:493-501. 2002
    ..Thus, tissues separated by local anatomic barriers as well as tissues accessible to circulating plasminogen have the capacity to provide local sources of plasminogen...
  34. ncbi request reprint Human sympathetic activation by alpha2-adrenergic blockade with yohimbine: Bimodal, epistatic influence of cytochrome P450-mediated drug metabolism
    Pascal Le Corre
    Laboratoire de Pharmacie Galenique et Biopharmacie, Universite de Rennes I, Rennes, France
    Clin Pharmacol Ther 76:139-53. 2004
    ..alpha2-Adrenergic blockade responses suggest adrenergic dysfunction in hypertension. alpha2-Blockade is also used to treat autonomic dysfunction. However, pharmacokinetic determinants of yohimbine disposition are not understood...
  35. ncbi request reprint Plasminogen receptors: the sine qua non of cell surface plasminogen activation
    Lindsey A Miles
    Department of Cell Biology, Division of Vascular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Front Biosci 10:1754-62. 2005
    ..This issue includes chapters on the well studied plasminogen receptor functions...
  36. ncbi request reprint Genetic variation at the human alpha2B-adrenergic receptor locus: role in blood pressure variation and yohimbine response
    Jason P Etzel
    Department of Medicine, University of California at San Diego, CA, USA
    Hypertension 45:1207-13. 2005
    ..Thus, despite considerable polymorphism in alpha2-AR genes, such variation is not a major determinant of variability in yohimbine response and by inference, in susceptibility to essential hypertension...
  37. ncbi request reprint Diminished renal kallikrein responses to mineralocorticoid stimulation in African Americans: determinants of an intermediate phenotype for hypertension
    Caroline M Wong
    Department of Medicine and Center for Molecular Genetics, University of California, San Diego 92161, USA
    Am J Hypertens 16:281-9. 2003
    ..We, therefore, tested whether short-term indirect (K(+)) or direct (fludrocortisone) stimulation of mineralocorticoid activity might be capable of restoring kallikrein excretion in African Americans...

Research Grants4