Charles Parker

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. ncbi request reprint Eculizumab
    Charles J Parker
    Nat Rev Drug Discov 6:515-6. 2007
  2. doi request reprint Paroxysmal nocturnal hemoglobinuria
    Charles J Parker
    Division of Hematology and Hematologic Malignancies, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Curr Opin Hematol 19:141-8. 2012
  3. doi request reprint Management of paroxysmal nocturnal hemoglobinuria in the era of complement inhibitory therapy
    Charles J Parker
    Hematology Division, Department of Internal Medicine, The University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Hematology Am Soc Hematol Educ Program 2011:21-9. 2011
  4. doi request reprint In vitro and in vivo characterization of SGI-1252, a small molecule inhibitor of JAK2
    Kausar Begam Riaz Ahmed
    Department of Medicine, Division of Hematology and Bone Marrow Transplant, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Exp Hematol 39:14-25. 2011
  5. doi request reprint Bone marrow failure syndromes: paroxysmal nocturnal hemoglobinuria
    Charles J Parker
    Division of Hematology and Bone Marrow Transplantation, Department of Medicine, University of Utah School of Medicine, 50 North Medical Drive, Salt Lake City, UT 84132, USA
    Hematol Oncol Clin North Am 23:333-46. 2009
  6. ncbi request reprint Historical aspects of paroxysmal nocturnal haemoglobinuria: 'defining the disease'
    Charles J Parker
    Hematology Oncology Section, VA Medical Center, Salt Lake City, UT 84148, USA
    Br J Haematol 117:3-22. 2002
  7. ncbi request reprint The pathophysiology of paroxysmal nocturnal hemoglobinuria
    Charles J Parker
    Division of Hematology and Bone Marrow Transplant, University of Utah School of Medicine and the George E Whalen Department of Veterans Affairs Medical Center, 500 Foothill Boulevard, Salt Lake City, UT 84114, USA
    Exp Hematol 35:523-33. 2007
  8. pmc Diagnosis and management of paroxysmal nocturnal hemoglobinuria
    Charles Parker
    Division of Hematology, University of Utah School of Medicine and Hematology Oncology Section 111H, George E Whalen VA Medical Center, Salt Lake City, UT 84148, USA
    Blood 106:3699-709. 2005
  9. ncbi request reprint CD4 (+)CD25 (+)Foxp3 (+) regulatory T cells and hematologic malignancies
    Todd W Kelley
    Department of Pathology, University of Utah, Salt Lake City, UT, USA
    Front Biosci (Schol Ed) 2:980-92. 2010
  10. ncbi request reprint Eculizumab for paroxysmal nocturnal haemoglobinuria
    Charles Parker
    Hematology and Bone Marrow Transplant, University of Utah School of Medicine, Salt Lake City, UT, USA
    Lancet 373:759-67. 2009

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Eculizumab
    Charles J Parker
    Nat Rev Drug Discov 6:515-6. 2007
  2. doi request reprint Paroxysmal nocturnal hemoglobinuria
    Charles J Parker
    Division of Hematology and Hematologic Malignancies, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Curr Opin Hematol 19:141-8. 2012
    ..The aim is to report on recent observations related to the natural history of paroxysmal nocturnal hemoglobinuria (PNH) and to review new therapeutic strategies for controlling the hemolysis of PNH...
  3. doi request reprint Management of paroxysmal nocturnal hemoglobinuria in the era of complement inhibitory therapy
    Charles J Parker
    Hematology Division, Department of Internal Medicine, The University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Hematology Am Soc Hematol Educ Program 2011:21-9. 2011
    ..Allogeneic BM transplantation can cure classic PNH, but treatment-related toxicity suggests caution for this approach to management...
  4. doi request reprint In vitro and in vivo characterization of SGI-1252, a small molecule inhibitor of JAK2
    Kausar Begam Riaz Ahmed
    Department of Medicine, Division of Hematology and Bone Marrow Transplant, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Exp Hematol 39:14-25. 2011
    ..To investigate the hypothesis that drugs that inhibit JAK2 have therapeutic potential, we developed a small molecule inhibitor, SGI-1252, that targets the adenosine triphosphate-binding and solvent pocket of the protein...
  5. doi request reprint Bone marrow failure syndromes: paroxysmal nocturnal hemoglobinuria
    Charles J Parker
    Division of Hematology and Bone Marrow Transplantation, Department of Medicine, University of Utah School of Medicine, 50 North Medical Drive, Salt Lake City, UT 84132, USA
    Hematol Oncol Clin North Am 23:333-46. 2009
    ..Management of PNH is discussed also...
  6. ncbi request reprint Historical aspects of paroxysmal nocturnal haemoglobinuria: 'defining the disease'
    Charles J Parker
    Hematology Oncology Section, VA Medical Center, Salt Lake City, UT 84148, USA
    Br J Haematol 117:3-22. 2002
  7. ncbi request reprint The pathophysiology of paroxysmal nocturnal hemoglobinuria
    Charles J Parker
    Division of Hematology and Bone Marrow Transplant, University of Utah School of Medicine and the George E Whalen Department of Veterans Affairs Medical Center, 500 Foothill Boulevard, Salt Lake City, UT 84114, USA
    Exp Hematol 35:523-33. 2007
    ....
  8. pmc Diagnosis and management of paroxysmal nocturnal hemoglobinuria
    Charles Parker
    Division of Hematology, University of Utah School of Medicine and Hematology Oncology Section 111H, George E Whalen VA Medical Center, Salt Lake City, UT 84148, USA
    Blood 106:3699-709. 2005
  9. ncbi request reprint CD4 (+)CD25 (+)Foxp3 (+) regulatory T cells and hematologic malignancies
    Todd W Kelley
    Department of Pathology, University of Utah, Salt Lake City, UT, USA
    Front Biosci (Schol Ed) 2:980-92. 2010
    ..This review focuses on studies of the role of CD4 (+)CD25 (+)FOXP3 (+) Tregs in hematopoietic malignancies and clonal myeloid neoplasms...
  10. ncbi request reprint Eculizumab for paroxysmal nocturnal haemoglobinuria
    Charles Parker
    Hematology and Bone Marrow Transplant, University of Utah School of Medicine, Salt Lake City, UT, USA
    Lancet 373:759-67. 2009
    ..Moreover, due to the heterogeneous nature of the disease, treatment with eculizumab is not appropriate for all patients with PNH...
  11. ncbi request reprint Management issues in paroxysmal nocturnal hemoglobinuria
    Gabrielle Meyers
    Division of Hematology, University of Utah School of Medicine and VA Medical Center, Salt Lake City, Utah 84148, USA
    Int J Hematol 77:125-32. 2003
    ....
  12. pmc Molecular basis of clonal expansion of hematopoiesis in 2 patients with paroxysmal nocturnal hemoglobinuria (PNH)
    Norimitsu Inoue
    Department of Molecular Genetics, Osaka Medical Center for Cancer, Japan
    Blood 108:4232-6. 2006
    ..These observations suggest that aberrant HMGA2 expression, in concert with mutant PIGA, accounts for clonal hematopoiesis in these 2 patients and suggest the concept of PNH as a benign tumor of the bone marrow...
  13. ncbi request reprint Paroxysmal nocturnal hemoglobinuria
    Mitsuhiro Omine
    Division of Hematology, Internal Medicine, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama City 227 8501, Japan
    Int J Hematol 82:417-21. 2005