D R Park

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi cDNA microarray analysis reveals fundamental differences in the expression profiles of primary human monocytes, monocyte-derived macrophages, and alveolar macrophages
    Jiangning Li
    Department of Pathology, University of Washington, 815 Mercer Street, Seattle, WA 98109 4714, USA
    J Leukoc Biol 81:328-35. 2007
  2. pmc Factors associated with mortality in patients with tuberculosis
    David J Horne
    Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA
    BMC Infect Dis 10:258. 2010
  3. ncbi The etiology of community-acquired pneumonia at an urban public hospital: influence of human immunodeficiency virus infection and initial severity of illness
    D R Park
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Harborview Medical Center, Seattle, WA 98104, USA
    J Infect Dis 184:268-77. 2001
  4. ncbi Antimicrobial treatment of ventilator-associated pneumonia
    David R Park
    Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, University of Washington, Box 359762, 325 9th Avenue, Seattle Washington 98104, USA
    Respir Care 50:932-52; discussion 952-5. 2005
  5. ncbi Fas (CD95) induces proinflammatory cytokine responses by human monocytes and monocyte-derived macrophages
    David R Park
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98104, USA
    J Immunol 170:6209-16. 2003
  6. ncbi The microbiology of ventilator-associated pneumonia
    David R Park
    Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, University of Washington, Seattle, WA 98104, USA
    Respir Care 50:742-63; discussion 763-5. 2005
  7. ncbi Septic shock and acute lung injury in rabbits with peritonitis: failure of the neutrophil response to localized infection
    G Matute-Bello
    Medical Research Service of the Veterans Affairs/Puget Sound Health Care System, and Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98108-1597, USA
    Am J Respir Crit Care Med 163:234-43. 2001
  8. ncbi Cost and incidence of social comorbidities in low-risk patients with community-acquired pneumonia admitted to a public hospital
    Christopher H Goss
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington School of Medicine, Medical Center Campus, Box 356522, 1959 N E Pacific, Seattle, WA 98195, USA
    Chest 124:2148-55. 2003
  9. pmc Long-term survival after hospitalization for community-acquired and healthcare-associated pneumonia
    Laura M Cecere
    Division of Pulmonary and Critical Care Medicine, University of Washington School of Medicine, Seattle, WA 98101, USA
    Respiration 79:128-36. 2010
  10. doi Mapping the lung proteome in cystic fibrosis
    Sina A Gharib
    Center for Lung Biology and, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Proteome Res 8:3020-8. 2009

Collaborators

Detail Information

Publications17

  1. ncbi cDNA microarray analysis reveals fundamental differences in the expression profiles of primary human monocytes, monocyte-derived macrophages, and alveolar macrophages
    Jiangning Li
    Department of Pathology, University of Washington, 815 Mercer Street, Seattle, WA 98109 4714, USA
    J Leukoc Biol 81:328-35. 2007
    ..This study underscores the need to scrutinize models of MAC biology for relevance to specific disease processes...
  2. pmc Factors associated with mortality in patients with tuberculosis
    David J Horne
    Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA
    BMC Infect Dis 10:258. 2010
    ..Known risk factors for death following a diagnosis of tuberculosis may not be applicable to current U.S. cases. We evaluated the factors associated with all-cause mortality in patients with tuberculosis in Washington State...
  3. ncbi The etiology of community-acquired pneumonia at an urban public hospital: influence of human immunodeficiency virus infection and initial severity of illness
    D R Park
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Harborview Medical Center, Seattle, WA 98104, USA
    J Infect Dis 184:268-77. 2001
    ....
  4. ncbi Antimicrobial treatment of ventilator-associated pneumonia
    David R Park
    Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, University of Washington, Box 359762, 325 9th Avenue, Seattle Washington 98104, USA
    Respir Care 50:932-52; discussion 952-5. 2005
    ..The best diagnostic approach used to guide therapy, the optimum duration of therapy, and the roles of combination therapy, rotating therapy, and unconventional approaches to antimicrobial therapy all remain uncertain...
  5. ncbi Fas (CD95) induces proinflammatory cytokine responses by human monocytes and monocyte-derived macrophages
    David R Park
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98104, USA
    J Immunol 170:6209-16. 2003
    ..Rather than contributing to the resolution of inflammation, Fas ligation on circulating monocytes and tissue macrophages may induce proinflammatory cytokine responses that can initiate acute inflammatory responses and tissue injury...
  6. ncbi The microbiology of ventilator-associated pneumonia
    David R Park
    Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, University of Washington, Seattle, WA 98104, USA
    Respir Care 50:742-63; discussion 763-5. 2005
    ..The roles of atypical bacterial and nonbacterial pathogens in VAP are incompletely understood and should be investigated further...
  7. ncbi Septic shock and acute lung injury in rabbits with peritonitis: failure of the neutrophil response to localized infection
    G Matute-Bello
    Medical Research Service of the Veterans Affairs/Puget Sound Health Care System, and Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98108-1597, USA
    Am J Respir Crit Care Med 163:234-43. 2001
    ..Bacteremia alone is not sufficient to cause lung injury. Lung injury occurs only in the setting of a severe systemic inflammatory response and an inadequate leukocyte response at the primary site of infection...
  8. ncbi Cost and incidence of social comorbidities in low-risk patients with community-acquired pneumonia admitted to a public hospital
    Christopher H Goss
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington School of Medicine, Medical Center Campus, Box 356522, 1959 N E Pacific, Seattle, WA 98195, USA
    Chest 124:2148-55. 2003
    ..A newly validated CAP outcomes prediction rule developed by Fine and colleagues has been advocated as a guide to hospitalization decisions...
  9. pmc Long-term survival after hospitalization for community-acquired and healthcare-associated pneumonia
    Laura M Cecere
    Division of Pulmonary and Critical Care Medicine, University of Washington School of Medicine, Seattle, WA 98101, USA
    Respiration 79:128-36. 2010
    ..Elderly patients surviving community-acquired pneumonia (CAP) have subsequent increased mortality. However, little is known regarding long-term survival in younger adults or those with healthcare-associated pneumonia (HCAP)...
  10. doi Mapping the lung proteome in cystic fibrosis
    Sina A Gharib
    Center for Lung Biology and, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Proteome Res 8:3020-8. 2009
    ..Our approach should be applicable to a wide range of proteomics-based clinical research...
  11. pmc Implementation and impact of a translational research training program in pulmonary and critical care medicine
    Lynn M Schnapp
    Pulmonary and Critical Care Medicine, Harborview Medical Center, University of Washington, 325 Ninth Ave, Seattle, WA 98104, USA
    Chest 135:688-94. 2009
    ....
  12. pmc Essential role of MMP-12 in Fas-induced lung fibrosis
    Gustavo Matute-Bello
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, South Lake Union Campus, 815 Mercer Street, Seattle, WA 98109, USA
    Am J Respir Cell Mol Biol 37:210-21. 2007
    ..We speculate that MMP-12 activity is required for activation of the profibrotic genes egr1 and cyr61...
  13. pmc Proteomic and computational analysis of bronchoalveolar proteins during the course of the acute respiratory distress syndrome
    Dong W Chang
    Medical Research Service, VA Puget Sound Healthcare System, Seattle, Washington 98108, USA
    Am J Respir Crit Care Med 178:701-9. 2008
    ..Whereas most prior studies focused on single proteins, newer methods allowing the simultaneous study of many proteins could lead to a better understanding of pathogenesis and new targets for treatment...
  14. ncbi Anti-inflammatory treatment of acute and chronic pneumonia
    S J Skerrett
    Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, USA
    Semin Respir Infect 16:76-84. 2001
    ..Nonsteroidal anti-inflammatory drugs may have limited applications in the modulation of chronic airway inflammation. Strategies targeting specific cytokines have not been effective to date, but remain active areas of investigation...
  15. ncbi Cytokine balance in the lungs of patients with acute respiratory distress syndrome
    W Y Park
    Section of Pulmonary/Critical Care Medicine, Harborview Medical Center, Medical Research Service of the VA Puget Sound Health Care System, Seattle, Washington, USA
    Am J Respir Crit Care Med 164:1896-903. 2001
    ..This significant antiinflammatory response early in ARDS may provide a key mechanism for limiting the net inflammatory response in the lungs...
  16. doi Spectral index for assessment of differential protein expression in shotgun proteomics
    Xiaoyun Fu
    Department of Medicine, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Proteome Res 7:845-54. 2008
    ..Therefore, it should be useful for biomarker discovery and comparisons of protein expression between normal and disease states...
  17. pmc Evidence for limited genetic compartmentalization of HIV-1 between lung and blood
    Laura Heath
    Department of Microbiology, University of Washington, Seattle, WA, USA
    PLoS ONE 4:e6949. 2009
    ..The unique environment of the lung, rich in alveolar macrophages and with specialized local immune responses, may contribute to differential evolution or selection of HIV-1...