D R Park
Affiliation: University of Washington
- cDNA microarray analysis reveals fundamental differences in the expression profiles of primary human monocytes, monocyte-derived macrophages, and alveolar macrophagesJiangning Li
Department of Pathology, University of Washington, 815 Mercer Street, Seattle, WA 98109 4714, USA
J Leukoc Biol 81:328-35. 2007..This study underscores the need to scrutinize models of MAC biology for relevance to specific disease processes...
- Factors associated with mortality in patients with tuberculosisDavid J Horne
Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA
BMC Infect Dis 10:258. 2010..Known risk factors for death following a diagnosis of tuberculosis may not be applicable to current U.S. cases. We evaluated the factors associated with all-cause mortality in patients with tuberculosis in Washington State...
- The etiology of community-acquired pneumonia at an urban public hospital: influence of human immunodeficiency virus infection and initial severity of illnessD R Park
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Harborview Medical Center, Seattle, WA 98104, USA
J Infect Dis 184:268-77. 2001....
- Antimicrobial treatment of ventilator-associated pneumoniaDavid R Park
Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, University of Washington, Box 359762, 325 9th Avenue, Seattle Washington 98104, USA
Respir Care 50:932-52; discussion 952-5. 2005..The best diagnostic approach used to guide therapy, the optimum duration of therapy, and the roles of combination therapy, rotating therapy, and unconventional approaches to antimicrobial therapy all remain uncertain...
- Fas (CD95) induces proinflammatory cytokine responses by human monocytes and monocyte-derived macrophagesDavid R Park
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98104, USA
J Immunol 170:6209-16. 2003..Rather than contributing to the resolution of inflammation, Fas ligation on circulating monocytes and tissue macrophages may induce proinflammatory cytokine responses that can initiate acute inflammatory responses and tissue injury...
- The microbiology of ventilator-associated pneumoniaDavid R Park
Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, University of Washington, Seattle, WA 98104, USA
Respir Care 50:742-63; discussion 763-5. 2005..The roles of atypical bacterial and nonbacterial pathogens in VAP are incompletely understood and should be investigated further...
- Septic shock and acute lung injury in rabbits with peritonitis: failure of the neutrophil response to localized infectionG Matute-Bello
Medical Research Service of the Veterans Affairs/Puget Sound Health Care System, and Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98108-1597, USA
Am J Respir Crit Care Med 163:234-43. 2001..Bacteremia alone is not sufficient to cause lung injury. Lung injury occurs only in the setting of a severe systemic inflammatory response and an inadequate leukocyte response at the primary site of infection...
- Cost and incidence of social comorbidities in low-risk patients with community-acquired pneumonia admitted to a public hospitalChristopher H Goss
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington School of Medicine, Medical Center Campus, Box 356522, 1959 N E Pacific, Seattle, WA 98195, USA
Chest 124:2148-55. 2003..A newly validated CAP outcomes prediction rule developed by Fine and colleagues has been advocated as a guide to hospitalization decisions...
- Long-term survival after hospitalization for community-acquired and healthcare-associated pneumoniaLaura M Cecere
Division of Pulmonary and Critical Care Medicine, University of Washington School of Medicine, Seattle, WA 98101, USA
Respiration 79:128-36. 2010..Elderly patients surviving community-acquired pneumonia (CAP) have subsequent increased mortality. However, little is known regarding long-term survival in younger adults or those with healthcare-associated pneumonia (HCAP)...
- Mapping the lung proteome in cystic fibrosisSina A Gharib
Center for Lung Biology and, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
J Proteome Res 8:3020-8. 2009..Our approach should be applicable to a wide range of proteomics-based clinical research...
- Implementation and impact of a translational research training program in pulmonary and critical care medicineLynn M Schnapp
Pulmonary and Critical Care Medicine, Harborview Medical Center, University of Washington, 325 Ninth Ave, Seattle, WA 98104, USA
Chest 135:688-94. 2009....
- Essential role of MMP-12 in Fas-induced lung fibrosisGustavo Matute-Bello
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, South Lake Union Campus, 815 Mercer Street, Seattle, WA 98109, USA
Am J Respir Cell Mol Biol 37:210-21. 2007..We speculate that MMP-12 activity is required for activation of the profibrotic genes egr1 and cyr61...
- Proteomic and computational analysis of bronchoalveolar proteins during the course of the acute respiratory distress syndromeDong W Chang
Medical Research Service, VA Puget Sound Healthcare System, Seattle, Washington 98108, USA
Am J Respir Crit Care Med 178:701-9. 2008..Whereas most prior studies focused on single proteins, newer methods allowing the simultaneous study of many proteins could lead to a better understanding of pathogenesis and new targets for treatment...
- Anti-inflammatory treatment of acute and chronic pneumoniaS J Skerrett
Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, USA
Semin Respir Infect 16:76-84. 2001..Nonsteroidal anti-inflammatory drugs may have limited applications in the modulation of chronic airway inflammation. Strategies targeting specific cytokines have not been effective to date, but remain active areas of investigation...
- Cytokine balance in the lungs of patients with acute respiratory distress syndromeW Y Park
Section of Pulmonary/Critical Care Medicine, Harborview Medical Center, Medical Research Service of the VA Puget Sound Health Care System, Seattle, Washington, USA
Am J Respir Crit Care Med 164:1896-903. 2001..This significant antiinflammatory response early in ARDS may provide a key mechanism for limiting the net inflammatory response in the lungs...
- Spectral index for assessment of differential protein expression in shotgun proteomicsXiaoyun Fu
Department of Medicine, School of Medicine, University of Washington, Seattle, Washington 98195, USA
J Proteome Res 7:845-54. 2008..Therefore, it should be useful for biomarker discovery and comparisons of protein expression between normal and disease states...
- Evidence for limited genetic compartmentalization of HIV-1 between lung and bloodLaura Heath
Department of Microbiology, University of Washington, Seattle, WA, USA
PLoS ONE 4:e6949. 2009..The unique environment of the lung, rich in alveolar macrophages and with specialized local immune responses, may contribute to differential evolution or selection of HIV-1...