Chang Won Park

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. doi request reprint Human DNA methyltransferase 3a does not associate with microRNAs in the regulation of DNA methylation
    Chang Won Park
    Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Cardiovasc Transl Res 3:290-5. 2010
  2. pmc High-level genomic integration, epigenetic changes, and expression of sleeping beauty transgene
    Jianhui Zhu
    Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Biochemistry 49:1507-21. 2010
  3. pmc Erythroid-specific expression of β-globin from Sleeping Beauty-transduced human hematopoietic progenitor cells
    Lucas M Sjeklocha
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    PLoS ONE 6:e29110. 2011
  4. ncbi request reprint Sleeping Beauty transposition in the mouse genome is associated with changes in DNA methylation at the site of insertion
    Chang Won Park
    Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Genomics 88:204-13. 2006
  5. pmc Efficient mammalian germline transgenesis by cis-enhanced Sleeping Beauty transposition
    Daniel F Carlson
    The Center for Genome Engineering, Minneapolis, MN, USA
    Transgenic Res 20:29-45. 2011
  6. ncbi request reprint DNA methylation of Sleeping Beauty with transposition into the mouse genome
    Chang Won Park
    Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Genes Cells 10:763-76. 2005
  7. ncbi request reprint Erythroid-specific expression of beta-globin by the sleeping beauty transposon for Sickle cell disease
    Jianhui Zhu
    Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Biochemistry 46:6844-58. 2007
  8. pmc Mature microRNAs identified in highly purified nuclei from HCT116 colon cancer cells
    Chang Won Park
    Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA
    RNA Biol 7:606-14. 2010
  9. ncbi request reprint Double-stranded siRNA targeted to the huntingtin gene does not induce DNA methylation
    Chang Won Park
    Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Biochem Biophys Res Commun 323:275-80. 2004

Collaborators

Detail Information

Publications9

  1. doi request reprint Human DNA methyltransferase 3a does not associate with microRNAs in the regulation of DNA methylation
    Chang Won Park
    Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Cardiovasc Transl Res 3:290-5. 2010
    ..DNMT3a was not directly associated with microRNAs. But, other classes of small non-coding RNA could still be implicated with DNMTs in a specific tissue such as testis where such RNA species are highly abundant...
  2. pmc High-level genomic integration, epigenetic changes, and expression of sleeping beauty transgene
    Jianhui Zhu
    Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Biochemistry 49:1507-21. 2010
    ..In addition, long-range activation of host genes must now be recognized as a potential consequence of an inserted transgene cassette containing enhancer elements...
  3. pmc Erythroid-specific expression of β-globin from Sleeping Beauty-transduced human hematopoietic progenitor cells
    Lucas M Sjeklocha
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    PLoS ONE 6:e29110. 2011
    ..These results support the use of Sleeping Beauty vectors in carrying an insulated IHK-β-globin transgene for gene therapy of sickle cell disease...
  4. ncbi request reprint Sleeping Beauty transposition in the mouse genome is associated with changes in DNA methylation at the site of insertion
    Chang Won Park
    Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Genomics 88:204-13. 2006
    ....
  5. pmc Efficient mammalian germline transgenesis by cis-enhanced Sleeping Beauty transposition
    Daniel F Carlson
    The Center for Genome Engineering, Minneapolis, MN, USA
    Transgenic Res 20:29-45. 2011
    ..Given its simplicity, versatility and high efficiency, TnT with enhanced Sleeping Beauty components represents a compelling non-viral approach to modifying the mammalian germline...
  6. ncbi request reprint DNA methylation of Sleeping Beauty with transposition into the mouse genome
    Chang Won Park
    Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Genes Cells 10:763-76. 2005
    ..This may depend on a number of different factors including the cargo DNA sequence, chromosomal context of the insertion site, and/or host genetic background...
  7. ncbi request reprint Erythroid-specific expression of beta-globin by the sleeping beauty transposon for Sickle cell disease
    Jianhui Zhu
    Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Biochemistry 46:6844-58. 2007
    ..The SB-Tn system is a promising nonviral vector for efficient genomic insertion conferring stable, persistent erythroid-specific expression of beta-globin...
  8. pmc Mature microRNAs identified in highly purified nuclei from HCT116 colon cancer cells
    Chang Won Park
    Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA
    RNA Biol 7:606-14. 2010
    ..These results will likely provide a basis for further studies concerning the intracellular trafficking and nuclear location of miRNAs...
  9. ncbi request reprint Double-stranded siRNA targeted to the huntingtin gene does not induce DNA methylation
    Chang Won Park
    Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Biochem Biophys Res Commun 323:275-80. 2004
    ..These results indicate that siRNA is not directly linked to DNA methylation at the target huntingtin genomic locus in human cells...