Affiliation: University of California
- Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in AfricaS Parikh
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, USA
Clin Pharmacol Ther 82:197-203. 2007..Variable CYP2C8 activity owing to genetic variation and drug interactions may have important clinical implications for the efficacy and toxicity of AQ...
- Impact of the method of G6PD deficiency assessment on genetic association studies of malaria susceptibilityMarla K Johnson
Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 4:e7246. 2009..Analyses have been complicated by varied methods used to diagnose G6PD deficiency...
- Antimalarial effects of human immunodeficiency virus type 1 protease inhibitors differ from those of the aspartic protease inhibitor pepstatinSunil Parikh
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, 94110, USA
Antimicrob Agents Chemother 50:2207-9. 2006..As with pepstatin, HIVPIs were equally active against wild-type parasites and against parasites with the food vacuole plasmepsin aspartic proteases knocked out. The antimalarial mechanism of HIVPIs differs from that of pepstatin...
- Intermittent preventive therapy for malaria in pregnancy: is sulfadoxine-pyrimethamine the right drug?S Parikh
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA
Clin Pharmacol Ther 87:160-2. 2010..We discuss IPT with SP in light of several concerns and highlight recent findings from a pharmacokinetic study of SP in this population...
- Pharmacokinetics of artemether-lumefantrine and artesunate-amodiaquine in children in Kampala, UgandaJulia Mwesigwa
Department of Medicine, 1001 Potrero Avenue, Building 30, Room 3402, University of California, San Francisco, San Francisco, CA 94143 0811, USA
Antimicrob Agents Chemother 54:52-9. 2010..For the artemisinin derivatives, differences between children and adults were variable and drug specific. The PK results generated for children must be considered to optimize the dosing strategies for these widely utilized ACT regimens...
- Concomitant efavirenz reduces pharmacokinetic exposure to the antimalarial drug artemether-lumefantrine in healthy volunteersLiusheng Huang
Drug Research Unit, Department of Clinical Pharmacy, University of California, San Francisco, CA Department of Medicine, University of California, San Francisco, CA, USA
J Acquir Immune Defic Syndr 61:310-6. 2012..A study in healthy volunteers was completed to address the concern that EFV impacts AL pharmacokinetics (PKs)...
- Antimalarial activity of human immunodeficiency virus type 1 protease inhibitorsSunil Parikh
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, Box 0811, San Francisco, California 94110, USA
Antimicrob Agents Chemother 49:2983-5. 2005..Lopinavir also inhibited the P. falciparum aspartic protease plasmepsin II at a similar concentration (IC50, 2.7 microM). These findings suggest that use of HIV-1 protease inhibitors may offer clinically relevant antimalarial activity...
- Lopinavir/ritonavir affects pharmacokinetic exposure of artemether/lumefantrine in HIV-uninfected healthy volunteersPolina German
Department of Clinical Pharmacy, Drug Research, University of California, School of Medicine, San Francisco, CA 94143 0622, USA
J Acquir Immune Defic Syndr 51:424-9. 2009....
- Host polymorphisms and the incidence of malaria in Ugandan childrenSunil Parikh
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
Am J Trop Med Hyg 71:750-3. 2004..69, P = 0.05). Host polymorphisms appear to impact upon the incidence of uncomplicated malaria in Ugandan children...
- In vitro metabolism of piperaquine is primarily mediated by CYP3A4Tina Ming Na Lee
School of Clinical Pharmacy, University of California, San Francisco, San Francisco, CA 94110, USA
Xenobiotica 42:1088-95. 2012..Further studies to support these findings through the identification and characterization of PQ metabolites are planned...
- Experimental malaria infection triggers early expansion of natural killer cellsCharles C Kim
Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA
Infect Immun 76:5873-82. 2008..These data indicate that the early response to P. chabaudi infection of the blood is marked by a primary wave of interferon with a subsequent response by NK cells...
- Biochemical and immunological mechanisms by which sickle cell trait protects against malariaLauren Gong
University of California, Box 1234, San Francisco 94143, CA, USA
Malar J 12:317. 2013..A better understanding of relevant mechanisms will provide valuable insight into the host-parasite relationship, including the role of the host immune system in protection against malaria. ..
- Molecular evaluation of the natural history of asymptomatic parasitemia in Ugandan childrenSammuel L Nsobya
Makerere University Medical School, Kampala, Uganda
J Infect Dis 189:2220-6. 2004..Asymptomatic parasitemia detected by microscopy, but not by PCR, strongly predicted subsequent clinical malaria, often due to persistent infection...
- Host Polymorphisms and Uncomplicated MalariaSunil Parikh; Fiscal Year: 2007..The applicant, Dr. Sunil Parikh, is an infectious disease specialist with a strong commitment to malaria research and international health...