Research Topics
| Jack ParentSummaryAffiliation: University of Michigan Country: USA Publications
Research Grants
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Detail Information
Publications
Prolonged seizures increase proliferating neuroblasts in the adult rat subventricular zone-olfactory bulb pathwayJack M Parent
Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan 48104, USA
J Neurosci 22:3174-88. 2002..Identification of the mechanisms underlying the response of neural progenitors to seizure-induced injury may help to advance brain regenerative therapies by using either transplanted or endogenous neural precursor cells...- Prolonged seizures recruit caudal subventricular zone glial progenitors into the injured hippocampusJack M Parent
Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0585, USA
Hippocampus 16:321-8. 2006..Further study of seizure-induced gliogenesis may provide insight into mechanisms of adult neural progenitor regulation and epileptogenesis... - Adult neurogenesis in the intact and epileptic dentate gyrusJack M Parent
Department of Neurology, University of Michigan Medical Center, Ann Arbor, MI 48109 2200, USA
Prog Brain Res 163:529-40. 2007..Similar findings of granule cell layer dispersion and ectopic granule neurons in human TLE suggest that aberrant neurogenesis contributes to epileptogenesis or learning and memory disturbances in this epilepsy syndrome... - Injury-induced neurogenesis in the adult mammalian brainJack M Parent
Department of Neurology, University of Michigan Medical Center, Ann Arbor 48109 0585, USA
Neuroscientist 9:261-72. 2003..These findings underscore the need for a better understanding of injury-induced neurogenesis in the adult and suggest that the manipulation of endogenous neural precursors is a potential strategy for brain reparative therapies... - Is neurogenesis reparative after status epilepticus?Jack M Parent
Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 2200, USA
Epilepsia 48:69-71. 2007 - Rat forebrain neurogenesis and striatal neuron replacement after focal strokeJack M Parent
Department of Neurology, University of Michigan Medical Center, 4412 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109 0585, USA
Ann Neurol 52:802-13. 2002..Moreover, neuroblasts in the injured neostriatum appear to differentiate into a region-appropriate phenotype, which suggests that the mature brain is capable of replacing some neurons lost after ischemic injury... 
Intact and injured endothelial cells differentially modulate postnatal murine forebrain neural stem cellsJennifer M Plane
Department of Neurology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
Neurobiol Dis 37:218-27. 2010..These data indicate that intact and injured endothelial cells exert differing effects on NSCs, and suggest targets for stimulating regeneration after brain insults...- The role of seizure-induced neurogenesis in epileptogenesis and brain repairJack M Parent
Department of Neurology, Neuroscience Laboratory Building, University of Michigan Medical Center, 1103 E Huron Street, Ann Arbor, MI 48104 1687, USA
Epilepsy Res 50:179-89. 2002..However, the presence of endogenous neural progenitors in other proliferative regions may offer potential strategies for the development of anti-epileptogenic or neuronal replacement therapies... - Seizure-induced neurogenesis: are more new neurons good for an adult brain?Jack M Parent
Department of Neurology, University of Michigan Medical Center, Ann Arbor, MI 48104 1687, USA
Prog Brain Res 135:121-31. 2002.... - Aberrant seizure-induced neurogenesis in experimental temporal lobe epilepsyJack M Parent
Department of Neurology, University of Michigan Medical Center, 4412 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109 0585, USA
Ann Neurol 59:81-91. 2006.... - Sox3 expression identifies neural progenitors in persistent neonatal and adult mouse forebrain germinative zonesTsu-Wei Wang
Department of Neurology and Neuroscience Graduate Program, University of Michigan Medical Center, Ann Arbor, Michigan, USA
J Comp Neurol 497:88-100. 2006..Persistent Sox3 expression in some mature neuronal populations suggests additional undefined roles for Sox3 in neuronal function... - Reelin regulates neuronal progenitor migration in intact and epileptic hippocampusChao Gong
Department of Neurology and Program for Neuroscience, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
J Neurosci 27:1803-11. 2007..Loss of Reelin expression in the epileptic adult hippocampus, moreover, likely contributes to ectopic chain migration and aberrant integration of newborn DGCs... 
The developmental stage of dentate granule cells dictates their contribution to seizure-induced plasticityMichelle M Kron
Department of Neurology and Neuroscience Program, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
J Neurosci 30:2051-9. 2010..Treatments that restore normal DGC development after epileptogenic insults may therefore ameliorate epileptogenic network dysfunction and associated morbidities...- Conditional ablation and recovery of forebrain neurogenesis in the mouseBenjamin H Singer
Department of Neurology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
J Comp Neurol 514:567-82. 2009..The nestin-tk mouse should be useful for studying how reversible depletion of adult neurogenesis influences neurophysiology, other behaviors, and neural progenitor dynamics... - Interaction of cellular and network mechanisms in spatiotemporal pattern formation in neuronal networksAndrew Bogaard
Department of Physics, Biophysics Research Division, Neuroscience Graduate Program, and Michigan Center for Theoretical Physics, University of Michigan, Ann Arbor, Michigan 48109, USA
J Neurosci 29:1677-87. 2009.... - Neonatal hypoxic-ischemic injury increases forebrain subventricular zone neurogenesis in the mouseJennifer M Plane
Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
Neurobiol Dis 16:585-95. 2004..These results suggest that augmenting SVZ neuroblast recruitment and survival may improve neural repair after neonatal brain injury... - Adult neurogenesis and the ischemic forebrainRobin J Lichtenwalner
Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0585, USA
J Cereb Blood Flow Metab 26:1-20. 2006..Current strategies used to modify endogenous neurogenesis after ischemic brain injury also will be discussed, as well as future research directions with potential for achieving regeneration after stroke and other brain insults... - Mechanisms and functional significance of aberrant seizure-induced hippocampal neurogenesisJack M Parent
Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
Epilepsia 49:19-25. 2008..We also describe the effects of seizure-induced neurogenesis on hippocampal network function and the potential relevance of aberrant neurogenesis to human mTLE... - Transition from local to global phase synchrony in small world neural network and its possible implications for epilepsyBethany Percha
Department of Physics and Biophysics Research Division, University of Michigan, Ann Arbor, Michigan 48109, USA
Phys Rev E Stat Nonlin Soft Matter Phys 72:031909. 2005.... - Retinoic acid regulates postnatal neurogenesis in the murine subventricular zone-olfactory bulb pathwayTsu-Wei Wang
Department of Neurology and Program for Neuroscience, University of Michigan Medical Center, Ann Arbor, MI 48109-0585, USA
Development 132:2721-32. 2005..The regulation of multiple steps in the SVZ-olfactory bulb neurogenic pathway by RA suggests that manipulation of retinoid signaling is a potential therapeutic strategy to augment neurogenesis after brain injury... - Hypoxic-ischemic injury stimulates subventricular zone proliferation and neurogenesis in the neonatal ratJennifer Ong
Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA
Pediatr Res 58:600-6. 2005..Identification of the trophic factors that enhance maturation and survival of immature neurons could provide important clues for improving recovery after neonatal brain injury... - Retinoic acid and environmental enrichment alter subventricular zone and striatal neurogenesis after strokeJennifer M Plane
University of Michigan Department of Neurology, Ann Arbor, MI 48109 2200, USA
Exp Neurol 214:125-34. 2008..Further study of the integration of adult-born neurons in the ischemic striatum is necessary to determine their restorative potential... - Markers of cellular proliferation are expressed in cortical tubersAllana Lee
Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Ann Neurol 53:668-73. 2003..Tubers and SEGAs exhibit a heterogeneous profile of differentiation and may share a common cellular lineage. Tubers may contain a subpopulation of newly generated cells... - Microglial expression of chemokine receptor CCR5 during rat forebrain development and after perinatal hypoxia-ischemiaRita M Cowell
Department of Neurology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Neuroimmunol 173:155-65. 2006..These data implicate CCR5 in microglial recruitment and activation during brain development and after neonatal brain injury... - Speech preservation during language-dominant, left temporal lobe seizures: report of a rare, potentially misleading findingKitti Kaiboriboon
Department of Neurology, University of California, San Francisco, California 94143-0138, USA
Epilepsia 47:1343-6. 2006..Based on intracranial EEG recordings, the likely mechanism underlying this potentially misleading clinical finding is the preservation of language areas due to limited seizure-propagation patterns... - Olfactory discrimination deficits in mice lacking the dopamine transporter or the D2 dopamine receptorJennifer L Tillerson
Center for Neurodegenerative Disease, Emory University, Atlanta, GA 30322, USA
Behav Brain Res 172:97-105. 2006..The findings presented in this paper reinforce the functional significance of dopamine and more specifically the D2 receptor in olfactory discrimination and may help explain the behavioral phenotype in the DAT and D2 knockout mice... - Persistent hippocampal neurogenesis and epilepsyJack M Parent
Epilepsia 49:1-2. 2008 - Replacing neocortical neurons after strokeJack M Parent
Ann Neurol 61:185-6. 2007 - Involvement of matrix metalloproteinase in neuroblast cell migration from the subventricular zone after strokeSeong-Ryong Lee
Department of Neurology and Radiology, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
J Neurosci 26:3491-5. 2006..These data suggest that MMPs are involved in endogenous mechanisms of neurogenic migration as the brain seeks to heal itself after injury... - Damage control: the influence of environment on recovery from brain injuryRobert S Greenwood
Neurology 59:1302-3. 2002
Research Grants
- Aberrant Neurogenesis in Experimental Temporal Lobe EpilepsyJack M Parent; Fiscal Year: 2010..Progress in this area therefore may offer novel treatments to prevent TLE after brain insults. ..
- Augmentation of Neurogenesis and Recovery After StrokeJack Parent; Fiscal Year: 2003..Progress in these aims will advance our understanding of mechanisms underlying neural stem cell regulation and rehabilitative plasticity after brain injury, and may lead to novel regenerative therapies for stroke. ..
- Neural Progenitor Grafting for Restorative Stroke TherapyJack M Parent; Fiscal Year: 2010..Progress in this area offers advances toward novel cell-based restorative therapies for stroke and other brain insults. ..
- Aberrant Neurogenesis in Experimental Temporal Lobe EpilepsyJack Parent; Fiscal Year: 2009..Progress in this area therefore may offer novel treatments to prevent TLE after brain insults. ..
- Augmentation of Neurogenesis and Recovery After StrokeJack Parent; Fiscal Year: 2007..Progress in these aims will advance our understanding of mechanisms underlying neural stem cell regulation and rehabilitative plasticity after brain injury, and may lead to novel regenerative therapies for stroke. ..
- Augmentation of Neurogenesis and Recovery After StrokeJack Parent; Fiscal Year: 2006..Progress in these aims will advance our understanding of mechanisms underlying neural stem cell regulation and rehabilitative plasticity after brain injury, and may lead to novel regenerative therapies for stroke. ..
- Adult Forebrain Neural Stem Cell Response to IschemiaJack Parent; Fiscal Year: 2005..Progress in these Aims will advance our understanding of adult SVZ neurogenesis in the normal and ischemic brain, and may provide insight into the potential use of neural stem cells for stroke therapy. ..