Jack Parent

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Prolonged seizures increase proliferating neuroblasts in the adult rat subventricular zone-olfactory bulb pathway
    Jack M Parent
    Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan 48104, USA
    J Neurosci 22:3174-88. 2002
  2. ncbi request reprint Prolonged seizures recruit caudal subventricular zone glial progenitors into the injured hippocampus
    Jack M Parent
    Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0585, USA
    Hippocampus 16:321-8. 2006
  3. ncbi request reprint Adult neurogenesis in the intact and epileptic dentate gyrus
    Jack M Parent
    Department of Neurology, University of Michigan Medical Center, Ann Arbor, MI 48109 2200, USA
    Prog Brain Res 163:529-40. 2007
  4. ncbi request reprint Injury-induced neurogenesis in the adult mammalian brain
    Jack M Parent
    Department of Neurology, University of Michigan Medical Center, Ann Arbor 48109 0585, USA
    Neuroscientist 9:261-72. 2003
  5. ncbi request reprint Is neurogenesis reparative after status epilepticus?
    Jack M Parent
    Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 2200, USA
    Epilepsia 48:69-71. 2007
  6. ncbi request reprint Rat forebrain neurogenesis and striatal neuron replacement after focal stroke
    Jack M Parent
    Department of Neurology, University of Michigan Medical Center, 4412 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109 0585, USA
    Ann Neurol 52:802-13. 2002
  7. pmc Intact and injured endothelial cells differentially modulate postnatal murine forebrain neural stem cells
    Jennifer M Plane
    Department of Neurology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Neurobiol Dis 37:218-27. 2010
  8. ncbi request reprint The role of seizure-induced neurogenesis in epileptogenesis and brain repair
    Jack M Parent
    Department of Neurology, Neuroscience Laboratory Building, University of Michigan Medical Center, 1103 E Huron Street, Ann Arbor, MI 48104 1687, USA
    Epilepsy Res 50:179-89. 2002
  9. ncbi request reprint Seizure-induced neurogenesis: are more new neurons good for an adult brain?
    Jack M Parent
    Department of Neurology, University of Michigan Medical Center, Ann Arbor, MI 48104 1687, USA
    Prog Brain Res 135:121-31. 2002
  10. ncbi request reprint Aberrant seizure-induced neurogenesis in experimental temporal lobe epilepsy
    Jack M Parent
    Department of Neurology, University of Michigan Medical Center, 4412 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109 0585, USA
    Ann Neurol 59:81-91. 2006

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Prolonged seizures increase proliferating neuroblasts in the adult rat subventricular zone-olfactory bulb pathway
    Jack M Parent
    Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan 48104, USA
    J Neurosci 22:3174-88. 2002
    ..Identification of the mechanisms underlying the response of neural progenitors to seizure-induced injury may help to advance brain regenerative therapies by using either transplanted or endogenous neural precursor cells...
  2. ncbi request reprint Prolonged seizures recruit caudal subventricular zone glial progenitors into the injured hippocampus
    Jack M Parent
    Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0585, USA
    Hippocampus 16:321-8. 2006
    ..Further study of seizure-induced gliogenesis may provide insight into mechanisms of adult neural progenitor regulation and epileptogenesis...
  3. ncbi request reprint Adult neurogenesis in the intact and epileptic dentate gyrus
    Jack M Parent
    Department of Neurology, University of Michigan Medical Center, Ann Arbor, MI 48109 2200, USA
    Prog Brain Res 163:529-40. 2007
    ..Similar findings of granule cell layer dispersion and ectopic granule neurons in human TLE suggest that aberrant neurogenesis contributes to epileptogenesis or learning and memory disturbances in this epilepsy syndrome...
  4. ncbi request reprint Injury-induced neurogenesis in the adult mammalian brain
    Jack M Parent
    Department of Neurology, University of Michigan Medical Center, Ann Arbor 48109 0585, USA
    Neuroscientist 9:261-72. 2003
    ..These findings underscore the need for a better understanding of injury-induced neurogenesis in the adult and suggest that the manipulation of endogenous neural precursors is a potential strategy for brain reparative therapies...
  5. ncbi request reprint Is neurogenesis reparative after status epilepticus?
    Jack M Parent
    Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 2200, USA
    Epilepsia 48:69-71. 2007
  6. ncbi request reprint Rat forebrain neurogenesis and striatal neuron replacement after focal stroke
    Jack M Parent
    Department of Neurology, University of Michigan Medical Center, 4412 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109 0585, USA
    Ann Neurol 52:802-13. 2002
    ..Moreover, neuroblasts in the injured neostriatum appear to differentiate into a region-appropriate phenotype, which suggests that the mature brain is capable of replacing some neurons lost after ischemic injury...
  7. pmc Intact and injured endothelial cells differentially modulate postnatal murine forebrain neural stem cells
    Jennifer M Plane
    Department of Neurology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Neurobiol Dis 37:218-27. 2010
    ..These data indicate that intact and injured endothelial cells exert differing effects on NSCs, and suggest targets for stimulating regeneration after brain insults...
  8. ncbi request reprint The role of seizure-induced neurogenesis in epileptogenesis and brain repair
    Jack M Parent
    Department of Neurology, Neuroscience Laboratory Building, University of Michigan Medical Center, 1103 E Huron Street, Ann Arbor, MI 48104 1687, USA
    Epilepsy Res 50:179-89. 2002
    ..However, the presence of endogenous neural progenitors in other proliferative regions may offer potential strategies for the development of anti-epileptogenic or neuronal replacement therapies...
  9. ncbi request reprint Seizure-induced neurogenesis: are more new neurons good for an adult brain?
    Jack M Parent
    Department of Neurology, University of Michigan Medical Center, Ann Arbor, MI 48104 1687, USA
    Prog Brain Res 135:121-31. 2002
    ....
  10. ncbi request reprint Aberrant seizure-induced neurogenesis in experimental temporal lobe epilepsy
    Jack M Parent
    Department of Neurology, University of Michigan Medical Center, 4412 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109 0585, USA
    Ann Neurol 59:81-91. 2006
    ....
  11. ncbi request reprint Sox3 expression identifies neural progenitors in persistent neonatal and adult mouse forebrain germinative zones
    Tsu Wei Wang
    Department of Neurology and Neuroscience Graduate Program, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    J Comp Neurol 497:88-100. 2006
    ..Persistent Sox3 expression in some mature neuronal populations suggests additional undefined roles for Sox3 in neuronal function...
  12. ncbi request reprint Reelin regulates neuronal progenitor migration in intact and epileptic hippocampus
    Chao Gong
    Department of Neurology and Program for Neuroscience, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Neurosci 27:1803-11. 2007
    ..Loss of Reelin expression in the epileptic adult hippocampus, moreover, likely contributes to ectopic chain migration and aberrant integration of newborn DGCs...
  13. doi request reprint The developmental stage of dentate granule cells dictates their contribution to seizure-induced plasticity
    Michelle M Kron
    Department of Neurology and Neuroscience Program, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Neurosci 30:2051-9. 2010
    ..Treatments that restore normal DGC development after epileptogenic insults may therefore ameliorate epileptogenic network dysfunction and associated morbidities...
  14. pmc Conditional ablation and recovery of forebrain neurogenesis in the mouse
    Benjamin H Singer
    Department of Neurology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Comp Neurol 514:567-82. 2009
    ..The nestin-tk mouse should be useful for studying how reversible depletion of adult neurogenesis influences neurophysiology, other behaviors, and neural progenitor dynamics...
  15. pmc Interaction of cellular and network mechanisms in spatiotemporal pattern formation in neuronal networks
    Andrew Bogaard
    Department of Physics, Biophysics Research Division, Neuroscience Graduate Program, and Michigan Center for Theoretical Physics, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 29:1677-87. 2009
    ....
  16. ncbi request reprint Neonatal hypoxic-ischemic injury increases forebrain subventricular zone neurogenesis in the mouse
    Jennifer M Plane
    Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Neurobiol Dis 16:585-95. 2004
    ..These results suggest that augmenting SVZ neuroblast recruitment and survival may improve neural repair after neonatal brain injury...
  17. ncbi request reprint Adult neurogenesis and the ischemic forebrain
    Robin J Lichtenwalner
    Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0585, USA
    J Cereb Blood Flow Metab 26:1-20. 2006
    ..Current strategies used to modify endogenous neurogenesis after ischemic brain injury also will be discussed, as well as future research directions with potential for achieving regeneration after stroke and other brain insults...
  18. doi request reprint Mechanisms and functional significance of aberrant seizure-induced hippocampal neurogenesis
    Jack M Parent
    Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Epilepsia 49:19-25. 2008
    ..We also describe the effects of seizure-induced neurogenesis on hippocampal network function and the potential relevance of aberrant neurogenesis to human mTLE...
  19. ncbi request reprint Transition from local to global phase synchrony in small world neural network and its possible implications for epilepsy
    Bethany Percha
    Department of Physics and Biophysics Research Division, University of Michigan, Ann Arbor, Michigan 48109, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 72:031909. 2005
    ....
  20. ncbi request reprint Retinoic acid regulates postnatal neurogenesis in the murine subventricular zone-olfactory bulb pathway
    Tsu Wei Wang
    Department of Neurology and Program for Neuroscience, University of Michigan Medical Center, Ann Arbor, MI 48109 0585, USA
    Development 132:2721-32. 2005
    ..The regulation of multiple steps in the SVZ-olfactory bulb neurogenic pathway by RA suggests that manipulation of retinoid signaling is a potential therapeutic strategy to augment neurogenesis after brain injury...
  21. ncbi request reprint Hypoxic-ischemic injury stimulates subventricular zone proliferation and neurogenesis in the neonatal rat
    Jennifer Ong
    Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA
    Pediatr Res 58:600-6. 2005
    ..Identification of the trophic factors that enhance maturation and survival of immature neurons could provide important clues for improving recovery after neonatal brain injury...
  22. pmc Retinoic acid and environmental enrichment alter subventricular zone and striatal neurogenesis after stroke
    Jennifer M Plane
    University of Michigan Department of Neurology, Ann Arbor, MI 48109 2200, USA
    Exp Neurol 214:125-34. 2008
    ..Further study of the integration of adult-born neurons in the ischemic striatum is necessary to determine their restorative potential...
  23. ncbi request reprint Markers of cellular proliferation are expressed in cortical tubers
    Allana Lee
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Ann Neurol 53:668-73. 2003
    ..Tubers and SEGAs exhibit a heterogeneous profile of differentiation and may share a common cellular lineage. Tubers may contain a subpopulation of newly generated cells...
  24. ncbi request reprint Microglial expression of chemokine receptor CCR5 during rat forebrain development and after perinatal hypoxia-ischemia
    Rita M Cowell
    Department of Neurology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Neuroimmunol 173:155-65. 2006
    ..These data implicate CCR5 in microglial recruitment and activation during brain development and after neonatal brain injury...
  25. ncbi request reprint Speech preservation during language-dominant, left temporal lobe seizures: report of a rare, potentially misleading finding
    Kitti Kaiboriboon
    Department of Neurology, University of California, San Francisco, California 94143 0138, USA
    Epilepsia 47:1343-6. 2006
    ..To evaluate the prevalence and mechanism of ictal speech in patients with language-dominant, left temporal lobe seizures...
  26. ncbi request reprint Olfactory discrimination deficits in mice lacking the dopamine transporter or the D2 dopamine receptor
    Jennifer L Tillerson
    Center for Neurodegenerative Disease, Emory University, Atlanta, GA 30322, USA
    Behav Brain Res 172:97-105. 2006
    ..The findings presented in this paper reinforce the functional significance of dopamine and more specifically the D2 receptor in olfactory discrimination and may help explain the behavioral phenotype in the DAT and D2 knockout mice...
  27. doi request reprint Persistent hippocampal neurogenesis and epilepsy
    Jack M Parent
    Epilepsia 49:1-2. 2008
  28. ncbi request reprint Replacing neocortical neurons after stroke
    Jack M Parent
    Ann Neurol 61:185-6. 2007
  29. ncbi request reprint Involvement of matrix metalloproteinase in neuroblast cell migration from the subventricular zone after stroke
    Seong Ryong Lee
    Department of Neurology and Radiology, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    J Neurosci 26:3491-5. 2006
    ..These data suggest that MMPs are involved in endogenous mechanisms of neurogenic migration as the brain seeks to heal itself after injury...
  30. ncbi request reprint Damage control: the influence of environment on recovery from brain injury
    Robert S Greenwood
    Neurology 59:1302-3. 2002

Research Grants10

  1. Aberrant Neurogenesis in Experimental Temporal Lobe Epilepsy
    Jack M Parent; Fiscal Year: 2010
    ..Progress in this area therefore may offer novel treatments to prevent TLE after brain insults. ..
  2. Augmentation of Neurogenesis and Recovery After Stroke
    Jack Parent; Fiscal Year: 2003
    ..Progress in these aims will advance our understanding of mechanisms underlying neural stem cell regulation and rehabilitative plasticity after brain injury, and may lead to novel regenerative therapies for stroke. ..
  3. Neural Progenitor Grafting for Restorative Stroke Therapy
    Jack M Parent; Fiscal Year: 2010
    ..Progress in this area offers advances toward novel cell-based restorative therapies for stroke and other brain insults. ..
  4. Aberrant Neurogenesis in Experimental Temporal Lobe Epilepsy
    Jack Parent; Fiscal Year: 2009
    ..Progress in this area therefore may offer novel treatments to prevent TLE after brain insults. ..
  5. Augmentation of Neurogenesis and Recovery After Stroke
    Jack Parent; Fiscal Year: 2007
    ..Progress in these aims will advance our understanding of mechanisms underlying neural stem cell regulation and rehabilitative plasticity after brain injury, and may lead to novel regenerative therapies for stroke. ..
  6. Augmentation of Neurogenesis and Recovery After Stroke
    Jack Parent; Fiscal Year: 2006
    ..Progress in these aims will advance our understanding of mechanisms underlying neural stem cell regulation and rehabilitative plasticity after brain injury, and may lead to novel regenerative therapies for stroke. ..
  7. Adult Forebrain Neural Stem Cell Response to Ischemia
    Jack Parent; Fiscal Year: 2005
    ..Progress in these Aims will advance our understanding of adult SVZ neurogenesis in the normal and ischemic brain, and may provide insight into the potential use of neural stem cells for stroke therapy. ..