Research Topics
Genomes and Genes | Dipen J ParekhSummaryAffiliation: University of Texas Health Science Center Country: USA Publications
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Publications
Biomarkers for prostate cancer detectionDipen J Parekh
Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284 7802, USA
J Urol 178:2252-9. 2007..New markers that differentiate indolent from aggressive cancers to decrease potential the over treatment of prostate cancer are needed. We reviewed current and potential biomarkers for prostate cancer detection...
External validation of the Prostate Cancer Prevention Trial risk calculator in a screened populationDipen J Parekh
Department of Urology, University of Texas Health Science Center, San Antonio, Texas 78229, USA
Urology 68:1152-5. 2006....
Assessment of 54 biomarkers for biopsy-detectable prostate cancerDipen J Parekh
Department of Urology, University of Texas Health Sciences Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284 7802, USA
Cancer Epidemiol Biomarkers Prev 16:1966-72. 2007....
Yearly prostate specific antigen and digital rectal examination fluctuations in a screened populationDonna Pauler Ankerst
Depatment of Urology, University of Texas Health Sciences Center, San Antonio, Texas, USA
J Urol 181:2071-5; discussion 2076. 2009..Prostate biopsy is often recommended based on increases in prostate specific antigen and/or abnormal digital rectal examination. We investigated the stability of a single positive test during the next 3 consecutive years...
Prostate cancer risk with positive family history, normal prostate examination findings, and PSA less than 4.0 ng/mLEdith Canby Hagino
Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
Urology 70:748-52. 2007..We assessed the risk of prostate cancer in men with a positive family history (at least one first-degree or second-degree relative), normal digital rectal examination (DRE) and a serum prostate-specific antigen (PSA) level of 4.0 ng/mL...
microRNA-21 governs TORC1 activation in renal cancer cell proliferation and invasionNirmalya Dey
Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
PLoS ONE 7:e37366. 2012..Our results uncover a layer of post-transcriptional regulation of PTEN by transcriptional activation of miR-21 to force the canonical oncogenic Akt/TORC1 signaling conduit to drive renal cancer cell proliferation and invasion...
Nox4 mediates renal cell carcinoma cell invasion through hypoxia-induced interleukin 6- and 8- productionJohn P Fitzgerald
Department of Urology, University of Texas Health Science Center, San Antonio, Texas, United States of America
PLoS ONE 7:e30712. 2012..AMP-activated protein kinase (AMPK) is a highly conserved sensor of cellular energy status and a role for AMPK in the regulation of cell inflammatory processes has recently been demonstrated...
Total prostate specific antigen stability confirmed after long-term storage of serum at -80CAmanda Beth Reed
Department of Urology, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas
J Urol 180:534-7; discussion 537-8. 2008..We characterized the long-term stability of total prostate specific antigen in serum samples after storage at -80C from 2001 until 2007...
Evaluating the PCPT risk calculator in ten international biopsy cohorts: results from the Prostate Biopsy Collaborative GroupDonna P Ankerst
Department of Urology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
World J Urol 30:181-7. 2012....
Current age and race adjusted prostate specific antigen threshold values delay diagnosis of high grade prostate cancerAmanda Reed
Department of Urology, University of Texas Health Sciences Center San Antonio, San Antonio, Texas 78229, USA
J Urol 178:1929-32; discussion 1932. 2007..We suggest that prostate specific antigen is not a dichotomous biomarker and age specific reference ranges delays the diagnosis of high grade prostate cancer in older and black American men...
Biomarkers for prostate cancer detectionAmanda Beth Reed
Department of Urology, University of Texas Health Sciences Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284 7840, USA
Expert Rev Anticancer Ther 10:103-14. 2010....
Active surveillance: pitfalls to considerBarbara Ercole
Department of Urology, University of Texas Health Sciences Center at San Antonio, USA
Arch Esp Urol 64:695-702. 2011..As with any active treatment option offered to patients with PCa, those who are offered AS must be appropriately selected and counseled as to its risks and benefits...
The utility of 5-alpha reductase inhibitors in the prevention and diagnosis of prostate cancerAmanda Beth Reed
Department of Urology, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas 78284 7840, USA
Curr Opin Urol 19:238-42. 2009....
Reduced expression of fumarate hydratase in clear cell renal cancer mediates HIF-2α accumulation and promotes migration and invasionSunil Sudarshan
Department of Urology, University of Texas Health Sciences Center at San Antonio, Texas, United States of America
PLoS ONE 6:e21037. 2011..Finally, we demonstrate that overexpression of FH in renal cancer cells inhibits cellular migration and invasion. These data provide novel insights into the tumor suppressor functions of FH in sporadic kidney cancer...
Surgical management of von Hippel-Lindau disease: urologic considerationsAmanda Beth Reed
Department of Urology, University of Texas Health Sciences Center at San Antonio, San Antonio, TX 78284 7840, USA
Surg Oncol Clin N Am 18:157-74, x. 2009....
Efficacy of combined intravesical immunotherapy and chemotherapy for non-muscle invasive bladder cancerWilliam M Hilton
Department of Urology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 7845, San Antonio, TX 78229 3900, USA
Expert Rev Anticancer Ther 11:949-57. 2011..The authors discuss the most recent data regarding combining these agents in an alternating or sequential regimen...
The NADPH oxidase subunit p22phox inhibits the function of the tumor suppressor protein tuberinKaren Block
Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
Am J Pathol 176:2447-55. 2010..Our data provide the first evidence that p22(phox)-based Nox oxidases maintain HIF-2alpha protein expression through inactivation of tuberin and downstream activation of ribosomal protein S6 kinase 1/4E-BP1 pathway...
Perioperative outcomes and oncologic efficacy from a pilot prospective randomized clinical trial of open versus robotic assisted radical cystectomyDipen J Parekh
Department of Urology, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas, USA
J Urol 189:474-9. 2013..However, most studies are retrospective with significant selection bias...
12th Annual meeting of the Society of Urologic Oncology (SUO) bladder cancer sessions I and II summary reportSam S Chang
Department of Urology, Vanderbilt University Medical Center, Nashville, TN, USA
Urol Oncol 30:944-7. 2012....
Methods to predict and lower the risk of prostate cancerBarbara Ercole
Department of Urology, University of Texas Health Science Center, San Antonio, USA
ScientificWorldJournal 11:742-8. 2011....
Urinary diversion: options, patient selection, and outcomesDipen J Parekh
Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Semin Oncol 34:98-109. 2007....
Prospective evaluation of p53 as a prognostic marker in T1 transitional cell carcinoma of the bladderGuido Dalbagni
Department of Urology, Division of Epidemiology and Biostatistics, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
BJU Int 99:281-5. 2007....
Prostate-specific antigen levels, prostate-specific antigen kinetics, and prostate cancer prognosis: a tocsin calling for prospective studiesDipen J Parekh
J Natl Cancer Inst 99:496-7. 2007
Commentary on early hormonal therapy for PSA only recurrence after radical prostatectomy--success towards survival or antidote to anxiety?Dipen J Parekh
J Urol 179:S60. 2008
Optical spectroscopy characteristics can differentiate benign and malignant renal tissues: a potentially useful modalityDipen J Parekh
Department of Urologic Surgery and Biomedical Engineering, Vanderbilt University Medical Center, Nashville, Tennessee, USA
J Urol 174:1754-8. 2005..This initial study examined the feasibility of using fluorescence and diffuse reflectance spectroscopy to differentiate between malignant and benign renal tissues...
Randomized prospective evaluation of extended versus limited lymph node dissection in patients with clinically localized prostate cancerTravis Clark
Department of Urologic Surgery, Vanderbilt University, Nashville, TN, USA
J Urol 169:145-7; discussion 147-8. 2003..A trend toward an increased risk of complications attributable to the lymphadenectomy occurs with an extended dissection...
