Roger Papke

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi request reprint Rhesus monkey alpha7 nicotinic acetylcholine receptors: comparisons to human alpha7 receptors expressed in Xenopus oocytes
    Roger L Papke
    Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, Gainesville, 32610, USA
    Eur J Pharmacol 524:11-8. 2005
  2. pmc The effective opening of nicotinic acetylcholine receptors with single agonist binding sites
    Dustin K Williams
    Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL 32610, USA
    J Gen Physiol 137:369-84. 2011
  3. doi request reprint Merging old and new perspectives on nicotinic acetylcholine receptors
    Roger L Papke
    Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, PO Box 100267, 1200 Newell Drive, Gainesville, FL 32610 0267, USA Electronic address
    Biochem Pharmacol 89:1-11. 2014
  4. doi request reprint Similar activity of mecamylamine stereoisomers in vitro and in vivo
    Roger L Papke
    Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, Gainesville, Florida, USA Electronic address
    Eur J Pharmacol 720:264-75. 2013
  5. pmc Intrinsically low open probability of α7 nicotinic acetylcholine receptors can be overcome by positive allosteric modulation and serum factors leading to the generation of excitotoxic currents at physiological temperatures
    Dustin K Williams
    Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, Gainesville, Florida, USA
    Mol Pharmacol 82:746-59. 2012
  6. pmc The nicotinic acetylcholine receptors of zebrafish and an evaluation of pharmacological tools used for their study
    Roger L Papke
    Department of Pharmacology, University of Florida College of Medicine, Gainesville, FL, USA
    Biochem Pharmacol 84:352-65. 2012
  7. pmc Investigation of the molecular mechanism of the α7 nicotinic acetylcholine receptor positive allosteric modulator PNU-120596 provides evidence for two distinct desensitized states
    Dustin K Williams
    Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, FL 32610 0267, USA
    Mol Pharmacol 80:1013-32. 2011
  8. pmc Tricks of perspective: insights and limitations to the study of macroscopic currents for the analysis of nAChR activation and desensitization
    Roger L Papke
    Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, FL 32610 0267, USA
    J Mol Neurosci 40:77-86. 2010
  9. pmc Working with OpusXpress: methods for high volume oocyte experiments
    Roger L Papke
    Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, Gainesville, FL 32610, USA
    Methods 51:121-33. 2010
  10. pmc Activation and desensitization of nicotinic alpha7-type acetylcholine receptors by benzylidene anabaseines and nicotine
    Roger L Papke
    Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, FL 32610 0267, USA
    J Pharmacol Exp Ther 329:791-807. 2009

Research Grants

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Rhesus monkey alpha7 nicotinic acetylcholine receptors: comparisons to human alpha7 receptors expressed in Xenopus oocytes
    Roger L Papke
    Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, Gainesville, 32610, USA
    Eur J Pharmacol 524:11-8. 2005
    ..They also point to the potential importance of a newly identified sequence element for modeling the specific amino acids involved with receptor activation...
  2. pmc The effective opening of nicotinic acetylcholine receptors with single agonist binding sites
    Dustin K Williams
    Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL 32610, USA
    J Gen Physiol 137:369-84. 2011
    ..The longest duration events of the receptors modified at only one binding site were similar to the long bursts of native receptors traditionally associated with the activation of receptors with two sites containing bound agonists...
  3. doi request reprint Merging old and new perspectives on nicotinic acetylcholine receptors
    Roger L Papke
    Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, PO Box 100267, 1200 Newell Drive, Gainesville, FL 32610 0267, USA Electronic address
    Biochem Pharmacol 89:1-11. 2014
    ..This review presents perspectives on the pharmacology and therapeutic targeting of nAChRs for the treatment of nicotine dependence or disease. ..
  4. doi request reprint Similar activity of mecamylamine stereoisomers in vitro and in vivo
    Roger L Papke
    Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, Gainesville, Florida, USA Electronic address
    Eur J Pharmacol 720:264-75. 2013
    ..Our results significantly extend knowledge of the nicotinic acetylcholine receptor activity profile of mecamylamine and support the hypothesis that these effects are not strongly stereoisomer selective. ..
  5. pmc Intrinsically low open probability of α7 nicotinic acetylcholine receptors can be overcome by positive allosteric modulation and serum factors leading to the generation of excitotoxic currents at physiological temperatures
    Dustin K Williams
    Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, Gainesville, Florida, USA
    Mol Pharmacol 82:746-59. 2012
    ....
  6. pmc The nicotinic acetylcholine receptors of zebrafish and an evaluation of pharmacological tools used for their study
    Roger L Papke
    Department of Pharmacology, University of Florida College of Medicine, Gainesville, FL, USA
    Biochem Pharmacol 84:352-65. 2012
    ..Our data therefore indicate that while some pharmacological tools used in zebrafish may function as expected, others will not...
  7. pmc Investigation of the molecular mechanism of the α7 nicotinic acetylcholine receptor positive allosteric modulator PNU-120596 provides evidence for two distinct desensitized states
    Dustin K Williams
    Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, FL 32610 0267, USA
    Mol Pharmacol 80:1013-32. 2011
    ..In the presence of high agonist concentrations, competitive antagonists may have the effect of shifting the balance in favor of D(s) and increasing ion channel currents...
  8. pmc Tricks of perspective: insights and limitations to the study of macroscopic currents for the analysis of nAChR activation and desensitization
    Roger L Papke
    Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, FL 32610 0267, USA
    J Mol Neurosci 40:77-86. 2010
    ..In contrast, with an agonist pulse like that used in Xenopus oocyte experiments, microscopic desensitization rates have a profound impact on peak current amplitude and very little effect on the kinetics of the macroscopic responses...
  9. pmc Working with OpusXpress: methods for high volume oocyte experiments
    Roger L Papke
    Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, Gainesville, FL 32610, USA
    Methods 51:121-33. 2010
    ..Some of our advice is specific to researchers fortunate enough to have access to an OpusXpress system, but most of it is applicable to any group using Xenopus oocytes for the heterologous expression of ion channels...
  10. pmc Activation and desensitization of nicotinic alpha7-type acetylcholine receptors by benzylidene anabaseines and nicotine
    Roger L Papke
    Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, FL 32610 0267, USA
    J Pharmacol Exp Ther 329:791-807. 2009
    ....
  11. pmc Activation and inhibition of mouse muscle and neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes
    Roger L Papke
    Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida 32610 0267, USA
    J Pharmacol Exp Ther 333:501-18. 2010
    ..Hexamethonium was a relatively nonselective antagonist with mixed competitive and noncompetitive activity...
  12. pmc Cysteine accessibility analysis of the human alpha7 nicotinic acetylcholine receptor ligand-binding domain identifies L119 as a gatekeeper
    Roger L Papke
    Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, Gainesville, FL 32610, USA
    Neuropharmacology 60:159-71. 2011
    ..Reaction of L119C with small non-polar reagents increases activation by small agonists but can block the access of large ligands such as benzylidene anabaseines to the ligand-binding domain...
  13. pmc alpha4beta2 Nicotinic acetylcholine receptors, willing if able
    Roger L Papke
    Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL 32610 0267, USA
    Br J Pharmacol 160:1903-5. 2010
    ..These observations provide important and intriguing new pieces of the brain nicotine receptor puzzle...
  14. pmc Electrophysiological perspectives on the therapeutic use of nicotinic acetylcholine receptor partial agonists
    Roger L Papke
    Department of Pharmacology and Therapeutics, University of Florida, P O Box 100267, Gainesville, FL 32610 0267, USA
    J Pharmacol Exp Ther 337:367-79. 2011
    ..These data indicate the dual effects expected for α4β2* partial agonists and provide models and insights for utility of partial agonists in therapeutic development...
  15. pmc High throughput electrophysiology with Xenopus oocytes
    Roger L Papke
    Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida, USA
    Comb Chem High Throughput Screen 12:38-50. 2009
    ..We show some types of data that have been gathered by this system and review realized and potential applications...
  16. ncbi request reprint Effects at a distance in alpha 7 nAChR selective agonists: benzylidene substitutions that regulate potency and efficacy
    Roger L Papke
    Department of Pharmacology and Therapeutics, University of Florida, PO Box 100267 JHMHSC, Gainesville, FL 32610 0267, USA
    Neuropharmacology 46:1023-38. 2004
    ....
  17. pmc The characterization of a novel rigid nicotine analog with alpha7-selective nAChR agonist activity and modulation of agonist properties by boron inclusion
    Roger L Papke
    University of Florida, College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA
    Bioorg Med Chem Lett 15:3874-80. 2005
    ....
  18. ncbi request reprint Estimation of both the potency and efficacy of alpha7 nAChR agonists from single-concentration responses
    Roger L Papke
    Pharmacology and Therapeutics 100267 JHMHSC, 1600 SW Archer Rd University of Florida, College of Medicine Gainesville, FL 32610, USA
    Life Sci 78:2812-9. 2006
    ..This extended analysis, combined with automated recording methods, should greatly increase the efficiency with which promising new drug candidates can be characterized...
  19. pmc Extending the analysis of nicotinic receptor antagonists with the study of alpha6 nicotinic receptor subunit chimeras
    Roger L Papke
    Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, P O Box 100267, JHMHSC, 1600 SW Archer Road, Gainesville, FL 32610 0267, USA
    Neuropharmacology 54:1189-200. 2008
    ..Our data extend the information available on prototypical nAChR antagonists, and establish the alpha4/6 chimera as a useful new tool for screening drugs as selective nAChR antagonists...
  20. ncbi request reprint The pharmacological activity of nicotine and nornicotine on nAChRs subtypes: relevance to nicotine dependence and drug discovery
    Roger L Papke
    Pharmacology and Therapeutics, University of Florida, College of Medicine, Gainesville, Florida 32610, USA
    J Neurochem 101:160-7. 2007
    ..Thus, understanding the actions of nornicotine in the brain may have significance for both emerging therapeutics and the management of nicotine dependence...
  21. ncbi request reprint Molecular dissection of tropisetron, an alpha7 nicotinic acetylcholine receptor-selective partial agonist
    Roger L Papke
    University of Florida College of Medicine, Department of Pharmacology and Therapeutics, Gainesville, FL 32610 0267, USA
    Neurosci Lett 378:140-4. 2005
    ....
  22. ncbi request reprint The effects of subunit composition on the inhibition of nicotinic receptors by the amphipathic blocker 2,2,6,6-tetramethylpiperidin-4-yl heptanoate
    Roger L Papke
    Department of Pharmacology and Therapeutics, 100267 JHMHSC, College of Medicine, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610, USA
    Mol Pharmacol 67:1977-90. 2005
    ..Our data indicate great potential utility for TMPH to help relate the diverse central nervous system effects to specific nAChR subtypes...
  23. ncbi request reprint Partial agonist and neuromodulatory activity of S 24795 for alpha7 nAChR responses of hippocampal interneurons
    Gretchen Lopez-Hernandez
    Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Neuropharmacology 53:134-44. 2007
    ..This dilution factor was consistent with the potency of ACh and S 24795 in the oocyte expression system (EC(50)s approximately 30 microM)...
  24. ncbi request reprint Septal innervation regulates the function of alpha7 nicotinic receptors in CA1 hippocampal interneurons
    Jeffrey S Thinschmidt
    Evelyn F McKnight Brain Institute, Department of Neuroscience, University of Florida, Gainesville, FL 32610, USA
    Exp Neurol 195:342-52. 2005
    ....
  25. ncbi request reprint Modulation of inhibitory synaptic activity by a non-alpha4beta2, non-alpha7 subtype of nicotinic receptors in the substantia gelatinosa of adult rat spinal cord
    Daisuke Takeda
    Department of Oral Surgery, College of Dentistry, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610, USA
    Pain 101:13-23. 2003
    ....
  26. ncbi request reprint Activation and inhibition of native neuronal alpha-bungarotoxin-sensitive nicotinic ACh receptors
    Vladimir V Uteshev
    Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Box 100267 JHMHSC, 1600 SW Archer Rd, University of Florida, Gainesville 32610 0267, FL, USA
    Brain Res 948:33-46. 2002
    ..This could then provide the basis for cytoprotective effects of 4OH-GTS-21 and other nicotinic agonists, mediating trophic and neuromodulatory functions...
  27. ncbi request reprint Nicotinic receptors on local circuit neurons in dentate gyrus: a potential role in regulation of granule cell excitability
    Charles J Frazier
    Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida 32610 0267, USA
    J Neurophysiol 89:3018-28. 2003
    ..Such a relationship between these two afferent pathways could be highly relevant to the study of both age-related memory dysfunction and disorders involving regulation of excitability, such as temporal lobe epilepsy...
  28. pmc Modulation of spontaneous hippocampal synaptic events with 5-hydroxyindole, 4OH-GTS-21, and rAAV-mediated alpha7 nicotinic receptor gene transfer
    Jeffrey S Thinschmidt
    Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida 32610, USA
    Brain Res 1203:51-60. 2008
    ....
  29. pmc Tethered agonist analogs as site-specific probes for domains of the human α7 nicotinic acetylcholine receptor that differentially regulate activation and desensitization
    Jingyi Wang
    Department of Pharmacology and Therapeutics University of Florida, Gainesville, FL 32610 0267, USA
    Mol Pharmacol 78:1012-25. 2010
    ..This insight may provide a new approach for drug development...
  30. pmc Multiple pharmacophores for the selective activation of nicotinic alpha7-type acetylcholine receptors
    Nicole A Horenstein
    Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida 32610 0267, USA
    Mol Pharmacol 74:1496-511. 2008
    ..Our results provide insight for the further development of nicotinic therapeutics and will be useful to direct future experiments with protein structure-based modeling and site-directed mutagenesis...
  31. ncbi request reprint Reversal of agonist selectivity by mutations of conserved amino acids in the binding site of nicotinic acetylcholine receptors
    Nicole A Horenstein
    Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    J Biol Chem 282:5899-909. 2007
    ....
  32. ncbi request reprint A single point mutation confers properties of the muscle-type nicotinic acetylcholine receptor to homomeric alpha7 receptors
    Andon N Placzek
    Department of Pharmacology and Therapeutics, J Hills Miller Health Science Center, University of Florida, Gainesville, FL 32610 0267, USA
    Mol Pharmacol 66:169-77. 2004
    ..Thus, the alpha7 TM2 T6'F mutant displays several features that are similar to the muscle nAChR, some of which are not typically thought to be regulated by the pore-lining domain of the receptor...
  33. ncbi request reprint An alpha7 nicotinic acetylcholine receptor gain-of-function mutant that retains pharmacological fidelity
    Andon N Placzek
    Department of Pharmacology and Therapeutics, P O Box 100267, University of Florida, Gainesville, Florida 32610 0267, USA
    Mol Pharmacol 68:1863-76. 2005
    ....
  34. ncbi request reprint The structural basis for GTS-21 selectivity between human and rat nicotinic alpha7 receptors
    Clare Stokes
    Department of Pharmacology and Therapeutics, P O Box 100267, 1600 SW Archer Rd, University of Florida, College of Medicine, Gainesville, FL 32610, USA
    Mol Pharmacol 66:14-24. 2004
    ..Specific features in the agonist molecule itself are also identified that interact with these structural features of the receptor agonist binding site...
  35. ncbi request reprint Regulation of neuronal function by choline and 4OH-GTS-21 through alpha 7 nicotinic receptors
    Vladimir V Uteshev
    Department of Pharmacology and Therapeutics, University of Florida College of Medicine, University of Florida, Gainesville, Florida 32610 0267, USA
    J Neurophysiol 89:1797-806. 2003
    ....
  36. ncbi request reprint Quinuclidines as selective agonists for alpha-7 nicotinic acetylcholine receptors
    Fedra M Leonik
    Department of Chemistry, University of Florida, Gainesville, FL 32611 7200, USA
    Bioorg Med Chem Lett 17:1520-2. 2007
    ..Arylidene groups at the 3-position and N-methyl quinuclidine were found to be selective agonists with EC(50)s of 1.5 and 40 microM, respectively...
  37. ncbi request reprint Hydroxy metabolites of the Alzheimer's drug candidate 3-[(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride (GTS-21): their molecular properties, interactions with brain nicotinic receptors, and brain penetration
    William R Kem
    Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, FL 32610 0267, USA
    Mol Pharmacol 65:56-67. 2004
    ..Benzylidene anabaseines pharmacologically similar to the hydroxy metabolites, but which enter the brain more readily, may provide greater stimulation of alpha7 receptors in the whole organism...
  38. pmc Selective inhibition of acetylcholine-evoked responses of alpha7 neuronal nicotinic acetylcholine receptors by novel tris- and tetrakis-azaaromatic quaternary ammonium antagonists
    Gretchen Y López-Hernández
    Department of Pharmacology and Therapeutics, University of Florida, P O Box 100267, Gainesville, FL 32610 0267, USA
    Mol Pharmacol 76:652-66. 2009
    ..These agents might be helpful in elucidating complex receptor responses in brain regions with mixed populations of nAChRs...
  39. pmc Differential regulation of receptor activation and agonist selectivity by highly conserved tryptophans in the nicotinic acetylcholine receptor binding site
    Dustin K Williams
    Department of Pharmacology and Therapeutics, University of Florida College of Medicine, P O Box 100267, Gainesville, FL 32610 0267, USA
    J Pharmacol Exp Ther 330:40-53. 2009
    ....
  40. pmc Comparative pharmacology of rat and human alpha7 nAChR conducted with net charge analysis
    Roger L Papke
    Department of Pharmacology and Therapeutics, Box 100267 JHMHSC, University of Florida, Gainesville, Florida, FL 32610 0267, USA
    Br J Pharmacol 137:49-61. 2002
    ..Since these concentrations are relatively non-desensitizing, the contribution of choline-activated alpha7 receptor current may play a significant role in the regulation of calcium homeostasis in alpha7-expressing neurons...
  41. pmc Positive modulation of alpha7 nAChR responses in rat hippocampal interneurons to full agonists and the alpha7-selective partial agonists, 4OH-GTS-21 and S 24795
    Gretchen Y López-Hernández
    Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, Gainesville, FL 32610 0267, USA
    Neuropharmacology 56:821-30. 2009
    ..We demonstrated that the potentiation of alpha7 nAChR response would depend on the nature and the effective concentration of the agonist involved and its particular interaction with the positive modulator...
  42. ncbi request reprint Multiple calcium channels and kinases mediate alpha7 nicotinic receptor neuroprotection in PC12 cells
    Ke Ren
    Department of Pharmaceutics, University of Florida, Gainesville, Florida 32610, USA
    J Neurochem 94:926-33. 2005
    ..ERK1/2 but not JNK and p38 were activated by GTS-21, and the ERK phosphorylation inhibitors PD98059 and U0126 blocked protection...
  43. ncbi request reprint Enhanced inhibition of a mutant neuronal nicotinic acetylcholine receptor by agonists: protection of function by (E)-N-methyl-4-(3-pyridinyl)-3-butene-1-amine (TC-2403)
    Roger L Papke
    Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida 32610 0267, USA
    J Pharmacol Exp Ther 301:765-73. 2002
    ..The ability of TC-2403 to protect receptor function from agonist-induced inhibition may point toward valuable new combination drug therapies...
  44. pmc Synthesis of H-bonding probes of alpha7 nAChR agonist selectivity
    Jingyi Wang
    Department of Chemistry, University of Florida, PO Box 117200, Gainesville, FL 32611 7200, USA
    Bioorg Med Chem Lett 19:474-6. 2009
    ..The pyrrole compounds were confirmed to be alpha7 selective, displaying preference for this receptor over muscle and heteromeric neuronal receptor subtypes...
  45. ncbi request reprint Medial septal/diagonal band cells express multiple functional nicotinic receptor subtypes that are correlated with firing frequency
    Jeffrey S Thinschmidt
    Evelyn F and William L McKnight Brain Institute, Gainesville, FL 32610, USA
    Neurosci Lett 389:163-8. 2005
    ..Responses to ACh were not affected by tetrodotoxin (TTX) and CdC l(2) but were blocked by MLA or MLA and MEC, suggesting that these currents involve direct activation of nicotinic receptors...
  46. ncbi request reprint Taurine-induced long-lasting potentiation in the rat hippocampus shows a partial dissociation from total hippocampal taurine content and independence from activation of known taurine transporters
    John Dominy
    Department of Pharmacodynamics, University of Florida College of Pharmacy, Gainesville, FL 32610, USA
    J Neurochem 89:1195-205. 2004
    ....
  47. ncbi request reprint The neuroprotective effect of 2-(3-pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel alpha7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase
    Mario B Marrero
    Targacept Inc, 200 East First Street, Suite 300, Winston Salem, NC 27101 4165, USA
    J Pharmacol Exp Ther 309:16-27. 2004
    ..This study supports central and opposite roles for JAK2 and SHP-1 in the control of apoptosis and alpha7-mediated neuroprotection in PC12 cells...
  48. pmc Discovery of a novel nicotinic receptor antagonist for the treatment of nicotine addiction: 1-(3-Picolinium)-12-triethylammonium-dodecane dibromide (TMPD)
    Linda P Dwoskin
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Biochem Pharmacol 74:1271-82. 2007
    ....
  49. ncbi request reprint In vivo characterization of a novel inhibitor of CNS nicotinic receptors
    M Imad Damaj
    Department Pharmacology and Toxicology, Medical College Virginia Campus, Virginia Commonwealth University, Box 980613, Richmond VA 23298 0613, USA
    Eur J Pharmacol 521:43-8. 2005
    ..These results indicate that TMPH may possess unique selectivity for specific nicotinic receptor subtypes...
  50. pmc Modeling binding modes of alpha7 nicotinic acetylcholine receptor with ligands: the roles of Gln117 and other residues of the receptor in agonist binding
    Xiaoqin Huang
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 725 Rose Street, Lexington, Kentucky 40536, USA
    J Med Chem 51:6293-302. 2008
    ..The new insights into the binding and structure-activity relationship obtained from this study should be valuable for future rational design of more potent and selective agonists of the alpha7 receptor...
  51. pmc PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that are expressed in reproductive and neuron-rich tissues and possess neuromodulatory activity
    Fiana Levitin
    Department of Cell Research and Immunology, Tel Aviv University, Ramat Aviv, 69978 Israel
    J Biol Chem 283:16928-39. 2008
    ..Taken together, our findings indicate that in addition to participation of the PATE (Pate)-like genes in functions related to fertility and reproduction, some of them likely act as important modulators of neural transmission...
  52. ncbi request reprint Functional central nicotinic acetylcholine receptor antagonism by systemic administration of Tinuvin 770 (BTMPS)
    John H Graham
    Medical College of Georgia, Alzheimer s Research Center, Augusta, GA 30912 2300, USA
    Curr Alzheimer Res 2:141-7. 2005
    ..Therefore, BTMPS can be considered as an alternative to or as a confirmatory drug for mecamylamine when inhibition of central nicotinic receptors is required...

Research Grants8

  1. TARGETING ALPHA7 NACHR FOR THERAPEUTICS EFFECTS
    Roger Papke; Fiscal Year: 2003
    ..abstract_text> ..
  2. Targeting alpha7 nAChR for Therapeutic Effects
    Roger Papke; Fiscal Year: 2007
    ....
  3. Targeting alpha7 nAChR for Therapeutic Effects
    Roger L Papke; Fiscal Year: 2010
    ....