Research Topics
| Michael M PaparellaSummaryAffiliation: University of Minnesota Country: USA Publications
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Publications
Etiology, pathophysiology of symptoms, and pathogenesis of Meniere's diseaseMichael M Paparella
Minnesota Ear, Head, and Neck Clinic, Suite 200, 701 25th Avenue South, Minneapolis, MN 55454, USA
Otolaryngol Clin North Am 35:529-45, vi. 2002..Various factors associated with the phenomenon of hydrops include functional or anatomic obstruction of endolymphatic flow, malabsorption of endolymph, genetic anomalies, vasodilation, allergy, viral infection, and autoimmunity...
Endolymphatic sac enhancement: reversal of pathogenesisMichael M Paparella
Minnesota Ear, Head, and Neck Clinic, Suite 200, 701 25th Avenue South, Minneapolis, MN 55454, USA
Otolaryngol Clin North Am 35:621-37. 2002..With additional clinical and molecular biologic research, endolymphatic sac enhancement will continue to improve and become more efficacious in the new millennium...
Revision of endolymphatic sac surgery for recurrent Meniere's diseaseMichael M Paparella
Minnesota Ear, Head, and Neck Clinic, Suite 200, 701 25th Avenue South, Minneapolis, MN 55454, USA
Otolaryngol Clin North Am 35:607-19, viii. 2002..The procedures and findings from such revisions, which are briefly described in this article, have provided the best opportunity for the author to understand and observe the pathogenesis of Meniere's disease...
Otosclerosis and associated otopathologic conditionsMichael M Paparella
Minnesota Ear, Head and Neck Clinic, University of Minnesota, Minneapolis, MN 55454, USA
Adv Otorhinolaryngol 65:31-44. 2007....
Cochlear changes in presbycusis with tinnitusKyoichi Terao
Department of Otolaryngology, University of Minnesota, Minneapolis, MN55455, USA
Am J Otolaryngol 32:215-20. 2011..We revealed the histopathologic findings of the cochlea in subjects with presbycusis and tinnitus...
Cochlear pathology in human temporal bones with otitis mediaShruti Joglekar
Department of Otolaryngology, University of Minnesota, 420 Delaware Street, Minneapolis, MN 55455, USA
Acta Otolaryngol 130:472-6. 2010..More severe pathological changes observed in the basal turn of the cochlea are consistent with prevalence of sensorineural hearing loss at higher frequencies in patients with otitis media...
Role of pneumococcal proteins in sensorineural hearing loss due to otitis mediaVladimir Tsuprun
Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, 55455, USA
Otol Neurotol 29:1056-60. 2008..Two Streptococcus pneumoniae proteins, pneumococcal surface protein A (PspA) and pneumolysin (Ply), have functional and histopathologic effects on the inner ear...
Association between type 1 diabetes mellitus and deposits in the semicircular canalsShigetoshi Yoda
Department of Otolaryngology, University of Minnesota, Minneapolis, MN, USA
Otolaryngol Head Neck Surg 145:458-62. 2011..To compare the prevalence of cupular and free-floating deposits in the semicircular canals between temporal bones of type 1 diabetes mellitus patients and normal controls...
Vascular findings in the stria vascularis of patients with unilateral or bilateral Ménière's disease: a histopathologic temporal bone studyShin Kariya
International Hearing Foundation, Minneapolis, Minnesota, USA
Otol Neurotol 30:1006-12. 2009..There are pathologic changes of vessels in the stria vascularis in patients with Ménière's disease...
Quantitative study of the vestibular sensory epithelium in cochleosaccular dysplasiaShin Kariya
Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, USA
Otol Neurotol 26:495-9. 2005..Further studies should be performed to establish the pathogenesis of cochleosaccular dysplasia in humans...
Effects of aminoglycoside administration on cochlear elements in human temporal bonesTakeshi Kusunoki
International Hearing Foundation, Minneapolis, MN, USA
Auris Nasus Larynx 31:383-8. 2004..CONCLUSION: This study demonstrates that in a short period (within 2 weeks) after aminoglycoside administration, a decrease in hair cells and in the area of the stria vascularis occurred...
Generalized arteriosclerosis and changes of the cochlea in young adultsRie Nomiya
Otitis Media Research Center, Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota 55455, USA
Otol Neurotol 29:1193-7. 2008..To disclose the histopathologic findings of the cochlea in young adults with generalized arteriosclerosis...
Age-related histopathologic changes in the human cochlea: a temporal bone studyTakeshi Kusunoki
International Hearing Foundation, Minneapolis, Minnesota, USA
Otolaryngol Head Neck Surg 131:897-903. 2004..Degeneration of stria vascularis due to aging appears to be slower than spiral ligament. EBM RATING: C...
Cochlear otosclerosis adjacent to round window and oval window: a histopathological temporal bone studyTeruyuki Sato
International Hearing Foundation, Minneapolis, MN 55455, USA
Otol Neurotol 31:574-9. 2010..The purpose of this histopathological study is to examine temporal bones of patients with cochlear otosclerosis adjacent to the round window or adjacent to the oval window as compared with healthy controls...
Posterior semicircular canal dehiscence: a histopathologic human temporal bone studyShigenobu Nomiya
Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota 55455, U S A
Otol Neurotol 31:1122-7. 2010..Posterior semicircular canal dehiscence has been shown to cause ear symptoms...
Effects of type 2 diabetes mellitus on cochlear structure in humansHisaki Fukushima
International Hearing Foundation, Department of Otolaryngology, Otitis Media Research Center, University of Minnesota, and Minnesota Ear, Head and Neck Clinic, Minneapolis, USA
Arch Otolaryngol Head Neck Surg 132:934-8. 2006..CONCLUSION: This study demonstrates that cochlear microangiopathy and degeneration of the stria vascularis and cochlear outer hair cells are found in patients with type 2 diabetes mellitus...
Inner ear changes in mucopolysaccharidosis type I/Hurler syndromeShin Kariya
Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota 55455, USA
Otol Neurotol 33:1323-7. 2012..The purpose of this study is to evaluate the quantitative inner ear histopathology of the temporal bones of patients with Hurler syndrome...
Tympanic membrane changes in central tympanic membrane perforationsMehmet F Oktay
Department of Otolaryngology, Otitis Media Research Center, University of Minnesota, Minneapolis, MN 55455, USA
Am J Otolaryngol 26:393-7. 2005....
Cupular deposits and aminoglycoside administration in human temporal bonesTakeshi Kusunoki
International Hearing Foundation, Minneapolis, Minnesota, USA
J Laryngol Otol 119:87-91. 2005..Such changes may be related to the benign paroxysmal positional vertigo (BPPV) seen in some patients who have had aminoglycoside administration...
Association between cupular deposits and otosclerosisHideo Hayashi
Department of Otolaryngology, Otitis Media Research Center, University of Minnesota, Minneapolis, USA
Arch Otolaryngol Head Neck Surg 132:1331-4. 2006..CONCLUSIONS: Our results suggest otosclerosis as an underlying mechanism for the production of cupular deposits; however, we did not find an association between these deposits and vestibular symptoms...
Comparing the cochlear spiral modiolar artery in type-1 and type-2 diabetes mellitus:a human temporal bone studyShin Kariya
International Hearing Foundation, Minneapolis, Minnesota 55454, USA
Acta Med Okayama 64:375-83. 2010..In conclusion, the cochlea in patients with diabetes mellitus shows circulatory disturbance compared to age-matched normal controls...
Otosclerosis: etiopathogenesis and histopathologySebahattin Cureoglu
Department of Otolaryngology, University of Minnesota, Minneapolis, MN, USA
Am J Otolaryngol 27:334-40. 2006..Both genetic and environmental factors have been implicated, however...
Histopathological incidence of facial canal dehiscence in otosclerosisShigenobu Nomiya
Department of Otolaryngology, University of Minnesota, Minneapolis, MN, 55455, USA
Eur Arch Otorhinolaryngol 268:1267-71. 2011..Our findings in this study suggest that otosclerotic lesions have the potential to close dehiscence of the facial canal in the oval window area...
Pathologic correlations of otologic symptoms in acute lymphocytic leukemiaKyoichi Terao
Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, USA
Am J Otolaryngol 32:13-8. 2011..To assess the clinicopathologic correlations of otologic complaints in patients with acute lymphocytic leukemia...
Temperature-sensitive SV40-immortalized rat middle ear epithelial cellsKatsuhiro Toyama
Otitis Media Research Center, Department of Otolaryngology, University of Minnesota School of Medicine, Minneapolis, Minnesota, USA
Ann Otol Rhinol Laryngol 113:967-74. 2004..Therefore, we conclude that a temperature-sensitive middle ear epithelial cell line has successfully been established...
Effects of gentamicin on sensorineural elements of the cochlea in human temporal bonesTakeshi Kusunoki
International Hearing Foundation, Minneapolis, MN, USA
Am J Otolaryngol 25:313-7. 2004..During the administration of this drug, hearing of the patient should be carefully monitored...
Large vestibular aqueduct syndrome: a human temporal bone studyShigeo Hirai
International Hearing Foundation, Minneapolis, Minnesota, USA
Laryngoscope 116:2007-11. 2006..This study was undertaken to determine prevalence of LVAS in our temporal bone (TB) collection and its relationship to other systemic or otologic anomalies...
Vestibular system changes in sudden deafness with and without vertigo: a human temporal bone studyTaro Inagaki
Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota 55455, USA
Otol Neurotol 33:1151-5. 2012..To investigate the vestibular system changes in sudden deafness with vertigo (SDwV) and sudden deafness without vertigo (SDwoV) and the cause of persistent canal paresis (CP) in SDwV patients...
Peripheral vestibular system in Down syndrome: quantitative assessment of vestibular histopathologyTaro Inagaki
Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota 55455, USA
Otolaryngol Head Neck Surg 144:280-3. 2011..To evaluate the maturity of the peripheral vestibular system in Down syndrome by examining the number of Scarpa's ganglion cells and the density of vestibular hair cells...
Induction of mucous cell metaplasia by tumor necrosis factor alpha in rat middle ear: the pathological basis for mucin hyperproduction in mucoid otitis mediaHirokazu Kawano
University of Minnesota Otitis Media Research Center, Department of Otolaryngology, University of Minnesota School of Medicine, Minneapolis, USA
Ann Otol Rhinol Laryngol 111:415-22. 2002..This finding suggests that TNF-alpha plays a key role in the pathogenesis of MOM through induction of mucous cell metaplasia-hyperplasia and mucin production...
Histopathological temporal bone study of the metastatic rhabdomyosarcomaShin Kariya
Otitis Media Research Center, Department of Otolaryngology, University of Minnesota, 55455, USA
Auris Nasus Larynx 36:221-3. 2009..No remarkable bony destruction was observed in the internal auditory canal. Histopathological examination revealed that hearing loss and facial nerve paralysis of the patient was due to temporal bone metastasis of rhabdomyosarcoma...
Effect of apolactoferrin on experimental pneumococcal otitis mediaPatricia A Schachern
Department of Otolaryngology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Arch Otolaryngol Head Neck Surg 136:1127-31. 2010..To find the effect of apolactoferrin administration on the middle and inner ears after experimentally induced pneumococcal otitis media...
Effect of lipooligosaccharide mutations of Haemophilus influenzae on the middle and inner earsPatricia A Schachern
Department of Otolaryngology, University of Minnesota, Minneapolis, MN, United States
Int J Pediatr Otorhinolaryngol 73:1757-60. 2009....
Cochlear changes in chronic otitis mediaSebahattin Cureoglu
Department of Otolaryngology, Otitis Media Research Center, University of Minnesota, Minneapolis, Minnesota, USA
Laryngoscope 114:622-6. 2004..The objective was to describe the morphological changes in the cochlea in chronic otitis media...
Age-related functional and histopathological changes of the ear in the MPS I mousePatricia A Schachern
Department of Otolaryngology, Otitis Media Research Center, University of Minnesota, Minneapolis, MN, USA
Int J Pediatr Otorhinolaryngol 71:197-203. 2007..Cellular and molecular mechanisms of ear pathology and hearing loss are not understood. The purpose of this study is to describe the age-related audiologic and histopathologic changes of the ear in the mouse model of MPS I...
Round window membrane in Ménière's disease: a human temporal bone studyShigetoshi Yoda
Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, USA
Otol Neurotol 32:147-51. 2011..To disclose the histopathologic findings of the thickness of the round window membrane and the presence of false round window membrane in Ménière's disease...
Vascular findings in the facial nerve canal in human temporal bones with diabetes mellitusShin Kariya
Otitis Media Research Center, Department of Otolaryngology, University of Minnesota, Minneapolis, 55455, USA
Otol Neurotol 30:402-7. 2009..To identify pathological changes to vessels in the facial nerve canal among patients with diabetes mellitus...
Expression of mucins in mucoid otitis mediaJizhen Lin
Department of Otolaryngology, Otitis Media Research Center, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
J Assoc Res Otolaryngol 4:384-93. 2003..Further study indicated that the mucin hyperproduction was significantly linked to CD4+ and CD8+ T cells and/or CD68+ monocyte macrophages. It suggests that MUC5B and MUC4 expression may be regulated by the products of these cells...
Cochlear changes in patients with type 1 diabetes mellitusHisaki Fukushima
International Hearing Foundation, Minneapolis, USA
Otolaryngol Head Neck Surg 133:100-6. 2005..CONCLUSION: This study suggests that type 1 diabetes mellitus can cause cochlear microangiopathy and subsequently degeneration of cochlear lateral walls and OHCs...
Round window membrane and labyrinthine pathological changes: an overviewSebahattin Cureoglu
Department of Otolaryngology, University of Minnesota, Minneapolis, MN, USA
Acta Otolaryngol 125:9-15. 2005....
Cochlear otosclerosisHideo Hayashi
Department of Otolaryngology, Otitis Media Research Center, University of Minnesota, Minneapolis, Minnesota, USA
Otol Neurotol 27:905-6. 2006
Hearing loss associated with systemic lupus erythematosus: temporal bone histopathologyNaomi Fukushima
International Hearing Foundation, Minneapolis, Minnesota 55455, USA
Otol Neurotol 27:127-8. 2006
Chronic silent otitis mediaMichael M Paparella
Department of Otolaryngology, University of Minnesota, Minneapolis 55454-1449, USA
ORL J Otorhinolaryngol Relat Spec 64:65-72. 2002..The clinical pathological correlates of this important disease are discussed herein...
The shortened cochlea: its classification and histopathologic featuresYiqing Zheng
Department of Otolaryngology, School of Medicine, University of Minnesota, Minneapolis, USA
Int J Pediatr Otorhinolaryngol 63:29-39. 2002..We suggest the use of common cavity cochlear dysplasia, Mondini dysplasia and Mondini-like dysplasia to describe these variable anomalies...
Cochlear otosclerosisSebahattin Cureoglu
Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, USA
Curr Opin Otolaryngol Head Neck Surg 18:357-62. 2010..The aim of this study is to summarize current advances in research and clinical aspects of cochlear otosclerosis...
Submucosal cholesteatoma in the middle ear: a histopathologic observationSebahattin Cureoglu
Department of Otolaryngology, University of Minnesota, Minneapolis, MN, USA
Otol Neurotol 24:968-9. 2003
Massive endolymphatic sac and vestibular aqueduct in Mondini dysplasiaAndre L L Sampaio
International Hearing Foundation, Minneapolis, MN, USA
Arch Otolaryngol Head Neck Surg 130:678-80. 2004..The physician should be prepared to diagnose congenital hearing impairment promptly to avoid complications during the clinical and surgical treatment of patients with Mondini dysplasia...
Virulence of pneumococcal proteins on the inner earPatricia A Schachern
Department of Otolaryngology, University of Minnesota, Minneapolis, MN 55455, USA
Arch Otolaryngol Head Neck Surg 135:657-61. 2009..To investigate the effects of the virulence characteristics of specific pneumococcal proteins on the inner ear...
Marrow-middle ear connections: a potential cause of otogenic meningitisKyoichi Terao
Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, USA
Otol Neurotol 32:77-80. 2011..We hypothesize that the connections between the hematopoietic bone marrow and middle ear is a potential cause of childhood otogenic meningitis...
Histologic changes in the anterior mallear ligament and the head of the malleus in otosclerosisMehmet F Oktay
Department of Otolaryngology, Otitis Media Research Center, University of Minnesota, Minneapolis, Minnesota, USA
Otolaryngol Head Neck Surg 134:232-5. 2006..CONCLUSION: Based on our findings, we do not believe that there is a relationship between hyalinization of the AML and otosclerosis; however, otosclerosis with SF seems to be a predisposing factor for fixation of the head of the malleus...
Effect of parenteral aminoglycoside administration on dark cells in the crista ampullarisSebahattin Cureoglu
Department of Otolaryngology, University of Minnesota, Minneapolis 55455, USA
Arch Otolaryngol Head Neck Surg 129:626-8. 2003..CONCLUSIONS: The result of this study suggests that the treatment period was probably too short to destroy the dark cells. Therefore, long-term aminoglycoside therapy may be necessary to get a more permanent result...
Otologic manifestations of metastatic tumors to the temporal boneSebahattin Cureoglu
Department of Otolaryngology, University of Minnesota, Minneapolis, MN, USA
Acta Otolaryngol 124:1117-23. 2004..In this paper, we review the distinctive patterns of involvement and presentation of metastatic tumors of the temporal bone, with emphasis on measures that should be taken to ensure early diagnosis...
Purulent otitis media in children and adultsMuhammet Tekin
The Otitis Media Research Center, Department of Otolaryngology, University of Minnesota Medical School, Minneapolis, USA
Eur Arch Otorhinolaryngol 259:67-72. 2002..Our findings suggest the need to monitor children carefully under the age of 2 years who have POM...
Scheibe dysplasiaSebahattin Cureoglu
Department of Otolaryngology, University of Minnesota, Minneapolis, USA
Otol Neurotol 24:125-6. 2003
Temporal bone study of trisomy 13 syndromeHisaki Fukushima
Department of Otolaryngology, University of Minnesota, Minneapolis, MN, USA
Laryngoscope 118:506-7. 2008..This is a rare report describing a patient with abnormalities in three nerves, including the facial, vestibular, and cochlear nerves...
Endolymphatic sac revision for recurrent intractable Meniere's diseaseMichael M Paparella
Minnesota Ear, Head and Neck Clinic, 701 25 th Avenue South, Suite 200, Minneapolis, MN 55454, USA
Otolaryngol Clin North Am 39:713-21, vi. 2006..This conservative treatment allows patients (many of whom may develop bilateral Meniere's) to retain capacity to accept cochlear implants should they become advisable later...
Persistent stapedial arterySebahattin Cureoglu
Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota 55455, USA
Otol Neurotol 24:833-4. 2003
Cellular changes of Reissner's membrane in Meniere's disease: human temporal bone studySebahattin Cureoglu
Department of Otolaryngology, Otitis Media Research Center, University of Minnesota, Minneapolis, USA
Otolaryngol Head Neck Surg 130:113-9. 2004..DISCUSSION: Similar findings in cellularity of RM in temporal bones with EH/+MD and EH/-MD suggest that pathophysiologic mechanisms other than hydrops may be responsible for symptoms in Meniere's disease...
Temporal bone histopathology related to cochlear implantation in congenital malformation of the bony cochleaYiqing Zheng
Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, USA
Otol Neurotol 23:181-6. 2002..An anomalous course of the facial nerve is a common finding. Tympanic malformations such as round and oval window deformities and small middle ear cleft should be noted preoperatively to better guide surgery...
Endaural labyrinthectomyMichael M Paparella
Department of Otolaryngology, University of Minnesota, USA
Ear Nose Throat J 87:204-5. 2008
Induction of mucous cell metaplasia in the middle ear of rats using a three-step method: an improved model for otitis media with mucoid effusionYasuhiro Tsuboi
Department of Otolaryngology, University of Minnesota Otitis Media Research Center, University of Minnesota School of Medicine, Minneapolis, USA
Acta Otolaryngol 122:153-60. 2002....
Histopathologic changes of contralateral human temporal bone in unilateral Ménière's diseaseShin Kariya
Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
Otol Neurotol 28:1063-8. 2007..To disclose the histopathologic findings in the contralateral temporal bone in unilateral Ménière's disease...
Cochleosaccular dysplasia: a morphometric and histopathologic study in a series of temporal bonesAndre L L Sampaio
Brasilia University Medical School-Capes, Fulbright Scholarship, Brasilia, Brazil
Otol Neurotol 25:530-5. 2004..CONCLUSION: Pathologic findings were variable and limited to the saccule and scala media. The variation, perhaps, reflects the different etiologies involved in the origin of cochleosaccular dysplasia...
Recent advances in otitis media. 4. Anatomy, cell biology, pathology, and animal modelsCuneyt M Alper
Ann Otol Rhinol Laryngol Suppl 188:36-51. 2002
Cholesterol granuloma of the temporal bone: a pathologic designation or a clinical diagnosis?Alessandra Rinaldo
Acta Otolaryngol 125:86-90. 2005
Pathogenesis of Meniere's disease: treatment considerations. PrefaceMichael M Paparella
Otolaryngol Clin North Am 35:xi-xiii. 2002
Comparison of the quantity of cochlear melanin in young and old C57BL/6 miceHideo Hayashi
Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
Arch Otolaryngol Head Neck Surg 133:151-4. 2007..To elucidate the functional relationship between cochlear melanin and aging...
Contralateral ear in chronic otitis media: a histologic studyLetícia Petersen Schmidt Rosito
Division of Otolaryngology Head and Neck Surgery, Hospital de Clinicas de Porto Alegre, Brasil
Laryngoscope 117:1809-14. 2007..The objective of this study is to determine the prevalence of the contralateral ear changes in human temporal bones of donors with chronic otitis media...
The entity known as chronic silent (subclinical) otitis media: a common lesion and a forgotten diagnosisAlfio Ferlito
Acta Otolaryngol 123:749-51. 2003
Recent advances in otitis media. 3. Animal models; anatomy and pathology; pathogenesis; cell biology and geneticsDavid J Lim
Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, California, USA
Ann Otol Rhinol Laryngol Suppl 194:31-41. 2005
Meniere's diseaseHamed Sajjadi
Department of Otolaryngology Head and Neck Surgery, Stanford University Medical Center, San Jose, CA 95124, USA
Lancet 372:406-14. 2008..Labyrinthectomy is undertaken as a last resort and is best reserved for patients with unilateral disease and deafness...
