Research Topics
Genomes and Genes | Georgios I PapachristouSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Low serum adiponectin levels are associated with systemic organ failure in acute pancreatitisArun Sharma
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Pancreas 38:907-12. 2009..We tested the hypothesis that serum adiponectin, the primary anti-inflammatory adipokine, is associated with functional polymorphisms in the adiponectin gene (ADIPOQ) and inversely associated with SAP...
Pharmacological therapy for acute pancreatitis: where are we now? where are we going?J J Easler
University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Minerva Gastroenterol Dietol 58:365-76. 2012..A few of these therapies have demonstrated promise in significantly altering the progression of this disease. Further studies are needed to clearly elucidate these benefits in patients at risk for poor outcomes...- Epidermal growth factor serum levels and the 61 G/A polymorphism in patients with acute pancreatitisGeorgios I Papachristou
Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Presbyterian, M2 C Wing, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Dig Dis Sci 55:2676-80. 2010..In animal models, EGF protects against pancreatic injury and prevents septic complications. The role of EGF in human AP is unknown... - Comparison of BISAP, Ranson's, APACHE-II, and CTSI scores in predicting organ failure, complications, and mortality in acute pancreatitisGeorgios I Papachristou
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Am J Gastroenterol 105:435-41; quiz 442. 2010.... - Comparison of existing clinical scoring systems to predict persistent organ failure in patients with acute pancreatitisRawad Mounzer
Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Gastroenterology 142:1476-82; quiz e15-6. 2012..We head-to-head compared the accuracy of these systems in predicting persistent organ failure, developed rules that combined these scores to optimize predictive accuracy, and validated our findings in an independent cohort... 
Are genetic variants in the platelet-derived growth factor [beta] gene associated with chronic pancreatitis?Venkata Muddana
Division of Gastroenterology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Pancreas 39:1215-9. 2010..We also tested the hypothesis that PDGF-[beta] polymorphisms in combination with environmental risk factors such as alcohol and smoking are associated with CP...- SPINK1 N34S is strongly associated with recurrent acute pancreatitis but is not a risk factor for the first or sentinel acute pancreatitis eventElie Aoun
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Am J Gastroenterol 105:446-51. 2010..Our aim was to study the prevalence of the SPINK1 N34S polymorphism in patients with sentinel and recurrent AP (RAP)... - Pathways to injury in chronic pancreatitis: decoding the role of the high-risk SPINK1 N34S haplotype using meta-analysisElie Aoun
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 3:e2003. 2008..We tested this hypothesis by evaluating the differences in effect size of the high risk SPINK1 N34S haplotype on CP from multiple etiologies after combining clinical reports of SPINK1 N34S frequency using meta-analysis... - TNF-alpha gene (TNFA) variants increase risk for multi-organ dysfunction syndrome (MODS) in acute pancreatitisFaraz Bishehsari
Department of Medicine, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Pancreatology 12:113-8. 2012..Small genetic cohort studies of the TNFA promoter in AP produced ambiguous results. We performed a comprehensive evaluation of TNFA promoter variants to assess both susceptibility to AP and risk of progression to MODS... - The MCP-1 -2518 A/G polymorphism is not a susceptibility factor for chronic pancreatitisDavid A Sass
Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Pancreatology 6:297-300. 2006..Genetic factors influence susceptibility and modify progression. The monocyte chemotactic protein-1 (MCP-1) -2518 G allele, which modifies the severity of acute pancreatitis, was investigated as a susceptibility factor for CP... - Current management and novel insights in acute pancreatitisVenkata Muddana
Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, PA 15219, USA
Expert Rev Gastroenterol Hepatol 3:435-44. 2009..The lack of scientific advancements in the management of AP reflects the limited understanding of the early pathogenetic mechanisms and our moderate-to-poor ability to predict severe course at the time of admission... - Obesity increases the severity of acute pancreatitis: performance of APACHE-O score and correlation with the inflammatory responseGeorgios I Papachristou
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Pancreatology 6:279-85. 2006..CONCLUSIONS: Obesity is an independent risk for SAP. Admission APACHE-O score is not more accurate than APACHE-II. Our study results suggest that obesity increases the severity of AP by amplifying the immune response to injury... - Functional polymorphisms of the GSTT-1 gene do not predict the severity of acute pancreatitis in the United StatesYasser M Bhat
Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Pancreatology 7:180-6. 2007..Our aim was to determine whether the same GSTT-1 polymorphism affects the severity of AP in a population from Pittsburgh, Pa., USA... - Risk and markers of severe acute pancreatitisGeorgios I Papachristou
Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Gastroenterol Clin North Am 36:277-96, viii. 2007.... - Serum proteomic patterns as a predictor of severity in acute pancreatitisGeorgios I Papachristou
Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Cancer Institute Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Pancreatology 7:317-24. 2007.... - Elevated serum creatinine as a marker of pancreatic necrosis in acute pancreatitisVenkata Muddana
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, UPMC Presbyterian Hospital, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Am J Gastroenterol 104:164-70. 2009..This study focuses on the association between routine laboratory tests and the development of pancreatic necrosis in patients with acute pancreatitis... - Rapid evolution from the first episode of acute pancreatitis to chronic pancreatitis in human subjectsElie Aoun
Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
JOP 8:573-8. 2007..The sentinel acute pancreatitis event hypothesis suggests that an initial episode of acute pancreatitis is the first step in a complicated series of events ultimately leading to chronic pancreatitis... - Angiopoietin-2, a regulator of vascular permeability in inflammation, is associated with persistent organ failure in patients with acute pancreatitis from the United States and GermanyDavid C Whitcomb
Department of Medicine, University of Pittsburgh Medical Center, Pennsylvania, USA
Am J Gastroenterol 105:2287-92. 2010..The aim of this study was to determine whether Ang-1 and/or Ang-2 levels are predictive biomarkers of persistent organ failure (>48 h) and prolonged hospital course... - Natural history following the first attack of acute pancreatitisDhiraj Yadav
Division of Gastroenterology and Hepatology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Am J Gastroenterol 107:1096-103. 2012..The objective of this study was to determine the risk of recurrent AP (RAP) and subsequent chronic pancreatitis (CP) diagnosis after the first attack of AP... - Diagnostic accuracy of interleukin-6 and interleukin-8 in predicting severe acute pancreatitis: a meta-analysisElie Aoun
Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Pancreatology 9:777-85. 2009..We conducted a meta-analysis to assess the accuracy of IL-6 and IL-8 at predicting SAP... - Is the monocyte chemotactic protein-1 -2518 G allele a risk factor for severe acute pancreatitis?Georgios I Papachristou
Department of Medicine, University of Pittsburgh, Pennsylvania 15213, USA
Clin Gastroenterol Hepatol 3:475-81. 2005..Our aim was to determine whether the MCP-1 -2518 A/G polymorphism affects the severity of AP... - Blood urea nitrogen in the early assessment of acute pancreatitis: an international validation studyBechien U Wu
Center for Pancreatic Disease, Division of Gastroenterology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Arch Intern Med 171:669-76. 2011..Herein we (1) validate serial blood urea nitrogen (BUN) measurement for early prediction of mortality and (2) develop an objective BUN-based approach to early assessment in AP... - Endoscopic therapy is effective for patients with chronic pancreatitisBridger Clarke
Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Clin Gastroenterol Hepatol 10:795-802. 2012..We evaluated use and long-term effectiveness of ET in a well-defined cohort of patients with CP... - Inflammatory markers of disease severity in acute pancreatitisGeorgios I Papachristou
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Clin Lab Med 25:17-37. 2005..Novel conceptions and approaches, such as identification of genetic polymorphisms that predispose to severe course and complications of AP, are needed for a quantum step forward... - Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitisDavid C Whitcomb
Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Nat Genet 44:1349-54. 2012..These results could partially explain the high frequency of alcohol-related pancreatitis in men (male hemizygote frequency is 0.26, whereas female homozygote frequency is 0.07)... - Predictors of severity and necrosis in acute pancreatitisGeorgios I Papachristou
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Gastroenterol Clin North Am 33:871-90. 2004..Novel conceptions and approaches, such as identification of genetic polymorphisms that predispose to severe course and complications of AP or other approaches are needed for a quantum step forward... - Chronic alcohol consumption is a major risk factor for pancreatic necrosis in acute pancreatitisGeorgios I Papachristou
Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Am J Gastroenterol 101:2605-10. 2006..012, OR 2.27, CI 1.19-4.30). CONCLUSION: Chronic alcohol consumption seems to constitute a strong risk factor for PNEC... - Alcohol-associated pancreatitisDhiraj Yadav
Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Gastroenterol Clin North Am 36:219-38, vii. 2007..Newer developments in the understanding of complex disorders allow clinicians to understand better the role of cofactors and interactions between known and yet unknown environmental and genetic factors in causing alcoholic pancreatitis... - Necrotizing pancreatitisSteven J Hughes
Section of Gastrointestinal Surgery, Department of Surgery, University of Pittsburgh School of Medicine, 497 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Gastroenterol Clin North Am 36:313-23, viii. 2007..This article presents a multidisciplinary literature-based approach to the treatment of patients with necrotizing pancreatitis... - Endoscopic retrograde cholangiopancreatography tissue sampling: when and how?Georgios I Papachristou
Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Clin Gastroenterol Hepatol 5:783-90. 2007..This case-based educational presentation focuses on the importance of interdisciplinary communication between endoscopists and pathologists for optimal tissue sampling, interpretation, and diagnostic accuracy... - Acute deterioration of a woman following acute pancreatitis with pseudocystsElie Aoun
University of Pittsburgh Medical Center, PA 15213, USA
Nat Clin Pract Gastroenterol Hepatol 2:545-9; quiz 550. 2005..DIAGNOSIS: Splenic artery pseudoaneurysm bleeding into an adjacent pseudocyst. MANAGEMENT: Embolization of the splenic artery across the neck of the pseudoaneurysm... - Direct endoscopic necrosectomy for the treatment of walled-off pancreatic necrosis: results from a multicenter U.S. seriesTimothy B Gardner
Section of Gastroenterology and Hepatology, Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
Gastrointest Endosc 73:718-26. 2011..Direct endoscopic necrosectomy (DEN) for treatment of walled-off pancreatic necrosis (WOPN) has been performed as an alternative to operative or percutaneous therapy... - Endoscopist administered sedation during ERCP: impact of chronic narcotic/benzodiazepine use and predictive risk of reversal agent utilizationGeorgios I Papachristou
Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Am J Gastroenterol 102:738-43. 2007.... - Endoscopic palliation of pancreatic cancerMichael Sanders
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, Mezzanine Level, C Wing, UPMC Presbyterian, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Gastroenterol Clin North Am 36:455-76, xi. 2007.... - Use of stents in benign and malignant esophageal diseaseGeorgios I Papachristou
Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Rev Gastroenterol Disord 7:74-88. 2007..Future developments in stent design include biodegradable stents, stents with a radioactive coating, and drug-eluting stents... - Systemic silicosis that involves the pancreasGeorgios I Papachristou
Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Gastrointest Endosc 63:170-2. 2006 - Pancreaticobiliary complications after composite visceral transplantation: incidence, risk, and management strategiesGeorgios I Papachristou
Division of Gastroenterology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Gastrointest Endosc 73:1165-73. 2011..Combined liver/small-bowel (L/SB) and multivisceral (MV) transplantation has been increasingly used with significant improvement in outcome... - Expression of integrin-linked kinase and its binding partners in chondrosarcoma: association with prognostic significanceDionysios J Papachristou
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Eur J Cancer 44:2518-25. 2008..Moreover, our findings highlight the possibilities that ILK might serve as biological marker that could accurately predict a high-grade tumour and that Mig-2 may function as a promising prognostic indicator of high-risk patients... - EUS features of annular pancreas (with video)Georgios I Papachristou
Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Gastrointest Endosc 65:340-4. 2007..An annular pancreas is a rare congenital anomaly that results in a band of pancreatic tissue, either partially or completely encircling the duodenum...