Georgios I Papachristou

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. doi request reprint Low serum adiponectin levels are associated with systemic organ failure in acute pancreatitis
    Arun Sharma
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Pancreas 38:907-12. 2009
  2. ncbi request reprint Pharmacological therapy for acute pancreatitis: where are we now? where are we going?
    J J Easler
    University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Minerva Gastroenterol Dietol 58:365-76. 2012
  3. doi request reprint Epidermal growth factor serum levels and the 61 G/A polymorphism in patients with acute pancreatitis
    Georgios I Papachristou
    Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Presbyterian, M2 C Wing, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Dig Dis Sci 55:2676-80. 2010
  4. doi request reprint Comparison of BISAP, Ranson's, APACHE-II, and CTSI scores in predicting organ failure, complications, and mortality in acute pancreatitis
    Georgios I Papachristou
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Gastroenterol 105:435-41; quiz 442. 2010
  5. doi request reprint Comparison of existing clinical scoring systems to predict persistent organ failure in patients with acute pancreatitis
    Rawad Mounzer
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Gastroenterology 142:1476-82; quiz e15-6. 2012
  6. pmc Are genetic variants in the platelet-derived growth factor [beta] gene associated with chronic pancreatitis?
    Venkata Muddana
    Division of Gastroenterology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Pancreas 39:1215-9. 2010
  7. doi request reprint SPINK1 N34S is strongly associated with recurrent acute pancreatitis but is not a risk factor for the first or sentinel acute pancreatitis event
    Elie Aoun
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Gastroenterol 105:446-51. 2010
  8. pmc Pathways to injury in chronic pancreatitis: decoding the role of the high-risk SPINK1 N34S haplotype using meta-analysis
    Elie Aoun
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 3:e2003. 2008
  9. doi request reprint TNF-alpha gene (TNFA) variants increase risk for multi-organ dysfunction syndrome (MODS) in acute pancreatitis
    Faraz Bishehsari
    Department of Medicine, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Pancreatology 12:113-8. 2012
  10. ncbi request reprint The MCP-1 -2518 A/G polymorphism is not a susceptibility factor for chronic pancreatitis
    David A Sass
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Pancreatology 6:297-300. 2006

Detail Information

Publications41

  1. doi request reprint Low serum adiponectin levels are associated with systemic organ failure in acute pancreatitis
    Arun Sharma
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Pancreas 38:907-12. 2009
    ..We tested the hypothesis that serum adiponectin, the primary anti-inflammatory adipokine, is associated with functional polymorphisms in the adiponectin gene (ADIPOQ) and inversely associated with SAP...
  2. ncbi request reprint Pharmacological therapy for acute pancreatitis: where are we now? where are we going?
    J J Easler
    University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Minerva Gastroenterol Dietol 58:365-76. 2012
    ..A few of these therapies have demonstrated promise in significantly altering the progression of this disease. Further studies are needed to clearly elucidate these benefits in patients at risk for poor outcomes...
  3. doi request reprint Epidermal growth factor serum levels and the 61 G/A polymorphism in patients with acute pancreatitis
    Georgios I Papachristou
    Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Presbyterian, M2 C Wing, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Dig Dis Sci 55:2676-80. 2010
    ..In animal models, EGF protects against pancreatic injury and prevents septic complications. The role of EGF in human AP is unknown...
  4. doi request reprint Comparison of BISAP, Ranson's, APACHE-II, and CTSI scores in predicting organ failure, complications, and mortality in acute pancreatitis
    Georgios I Papachristou
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Gastroenterol 105:435-41; quiz 442. 2010
    ....
  5. doi request reprint Comparison of existing clinical scoring systems to predict persistent organ failure in patients with acute pancreatitis
    Rawad Mounzer
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Gastroenterology 142:1476-82; quiz e15-6. 2012
    ..We head-to-head compared the accuracy of these systems in predicting persistent organ failure, developed rules that combined these scores to optimize predictive accuracy, and validated our findings in an independent cohort...
  6. pmc Are genetic variants in the platelet-derived growth factor [beta] gene associated with chronic pancreatitis?
    Venkata Muddana
    Division of Gastroenterology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Pancreas 39:1215-9. 2010
    ..We also tested the hypothesis that PDGF-[beta] polymorphisms in combination with environmental risk factors such as alcohol and smoking are associated with CP...
  7. doi request reprint SPINK1 N34S is strongly associated with recurrent acute pancreatitis but is not a risk factor for the first or sentinel acute pancreatitis event
    Elie Aoun
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Gastroenterol 105:446-51. 2010
    ..Our aim was to study the prevalence of the SPINK1 N34S polymorphism in patients with sentinel and recurrent AP (RAP)...
  8. pmc Pathways to injury in chronic pancreatitis: decoding the role of the high-risk SPINK1 N34S haplotype using meta-analysis
    Elie Aoun
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 3:e2003. 2008
    ..We tested this hypothesis by evaluating the differences in effect size of the high risk SPINK1 N34S haplotype on CP from multiple etiologies after combining clinical reports of SPINK1 N34S frequency using meta-analysis...
  9. doi request reprint TNF-alpha gene (TNFA) variants increase risk for multi-organ dysfunction syndrome (MODS) in acute pancreatitis
    Faraz Bishehsari
    Department of Medicine, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Pancreatology 12:113-8. 2012
    ..Small genetic cohort studies of the TNFA promoter in AP produced ambiguous results. We performed a comprehensive evaluation of TNFA promoter variants to assess both susceptibility to AP and risk of progression to MODS...
  10. ncbi request reprint The MCP-1 -2518 A/G polymorphism is not a susceptibility factor for chronic pancreatitis
    David A Sass
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Pancreatology 6:297-300. 2006
    ..Genetic factors influence susceptibility and modify progression. The monocyte chemotactic protein-1 (MCP-1) -2518 G allele, which modifies the severity of acute pancreatitis, was investigated as a susceptibility factor for CP...
  11. doi request reprint Current management and novel insights in acute pancreatitis
    Venkata Muddana
    Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, PA 15219, USA
    Expert Rev Gastroenterol Hepatol 3:435-44. 2009
    ..The lack of scientific advancements in the management of AP reflects the limited understanding of the early pathogenetic mechanisms and our moderate-to-poor ability to predict severe course at the time of admission...
  12. ncbi request reprint Obesity increases the severity of acute pancreatitis: performance of APACHE-O score and correlation with the inflammatory response
    Georgios I Papachristou
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Pancreatology 6:279-85. 2006
    ..Obese patients appear to be at risk for complications of acute pancreatitis (AP). APACHE-O score has been suggested to improve APACHE-II accuracy in predicting severe outcome in AP...
  13. ncbi request reprint Functional polymorphisms of the GSTT-1 gene do not predict the severity of acute pancreatitis in the United States
    Yasser M Bhat
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Pancreatology 7:180-6. 2007
    ..Our aim was to determine whether the same GSTT-1 polymorphism affects the severity of AP in a population from Pittsburgh, Pa., USA...
  14. ncbi request reprint Risk and markers of severe acute pancreatitis
    Georgios I Papachristou
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Gastroenterol Clin North Am 36:277-96, viii. 2007
    ....
  15. doi request reprint Angiopoietin-2, a regulator of vascular permeability in inflammation, is associated with persistent organ failure in patients with acute pancreatitis from the United States and Germany
    David C Whitcomb
    Department of Medicine, University of Pittsburgh Medical Center, Pennsylvania, USA
    Am J Gastroenterol 105:2287-92. 2010
    ..The aim of this study was to determine whether Ang-1 and/or Ang-2 levels are predictive biomarkers of persistent organ failure (>48 h) and prolonged hospital course...
  16. doi request reprint Elevated serum creatinine as a marker of pancreatic necrosis in acute pancreatitis
    Venkata Muddana
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, UPMC Presbyterian Hospital, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Am J Gastroenterol 104:164-70. 2009
    ..This study focuses on the association between routine laboratory tests and the development of pancreatic necrosis in patients with acute pancreatitis...
  17. ncbi request reprint Rapid evolution from the first episode of acute pancreatitis to chronic pancreatitis in human subjects
    Elie Aoun
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    JOP 8:573-8. 2007
    ..The sentinel acute pancreatitis event hypothesis suggests that an initial episode of acute pancreatitis is the first step in a complicated series of events ultimately leading to chronic pancreatitis...
  18. ncbi request reprint Serum proteomic patterns as a predictor of severity in acute pancreatitis
    Georgios I Papachristou
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Cancer Institute Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Pancreatology 7:317-24. 2007
    ....
  19. doi request reprint Natural history following the first attack of acute pancreatitis
    Dhiraj Yadav
    Division of Gastroenterology and Hepatology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Gastroenterol 107:1096-103. 2012
    ..The objective of this study was to determine the risk of recurrent AP (RAP) and subsequent chronic pancreatitis (CP) diagnosis after the first attack of AP...
  20. doi request reprint Blood urea nitrogen in the early assessment of acute pancreatitis: an international validation study
    Bechien U Wu
    Center for Pancreatic Disease, Division of Gastroenterology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arch Intern Med 171:669-76. 2011
    ..Herein we (1) validate serial blood urea nitrogen (BUN) measurement for early prediction of mortality and (2) develop an objective BUN-based approach to early assessment in AP...
  21. doi request reprint Diagnostic accuracy of interleukin-6 and interleukin-8 in predicting severe acute pancreatitis: a meta-analysis
    Elie Aoun
    Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Pancreatology 9:777-85. 2009
    ..We conducted a meta-analysis to assess the accuracy of IL-6 and IL-8 at predicting SAP...
  22. ncbi request reprint Is the monocyte chemotactic protein-1 -2518 G allele a risk factor for severe acute pancreatitis?
    Georgios I Papachristou
    Department of Medicine, University of Pittsburgh, Pennsylvania 15213, USA
    Clin Gastroenterol Hepatol 3:475-81. 2005
    ..Our aim was to determine whether the MCP-1 -2518 A/G polymorphism affects the severity of AP...
  23. pmc Endoscopic therapy is effective for patients with chronic pancreatitis
    Bridger Clarke
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Clin Gastroenterol Hepatol 10:795-802. 2012
    ..We evaluated use and long-term effectiveness of ET in a well-defined cohort of patients with CP...
  24. ncbi request reprint Inflammatory markers of disease severity in acute pancreatitis
    Georgios I Papachristou
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Clin Lab Med 25:17-37. 2005
    ..Novel conceptions and approaches, such as identification of genetic polymorphisms that predispose to severe course and complications of AP, are needed for a quantum step forward...
  25. pmc Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis
    David C Whitcomb
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Nat Genet 44:1349-54. 2012
    ..These results could partially explain the high frequency of alcohol-related pancreatitis in men (male hemizygote frequency is 0.26, whereas female homozygote frequency is 0.07)...
  26. ncbi request reprint Chronic alcohol consumption is a major risk factor for pancreatic necrosis in acute pancreatitis
    Georgios I Papachristou
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Gastroenterol 101:2605-10. 2006
    ..Early diagnosis of PNEC in high-risk patients is critical to management. Hemoconcentration is one risk factor for PNEC, but additional risk factors are likely implicated...
  27. ncbi request reprint Necrotizing pancreatitis
    Steven J Hughes
    Section of Gastrointestinal Surgery, Department of Surgery, University of Pittsburgh School of Medicine, 497 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Gastroenterol Clin North Am 36:313-23, viii. 2007
    ..This article presents a multidisciplinary literature-based approach to the treatment of patients with necrotizing pancreatitis...
  28. ncbi request reprint Alcohol-associated pancreatitis
    Dhiraj Yadav
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Gastroenterol Clin North Am 36:219-38, vii. 2007
    ..Newer developments in the understanding of complex disorders allow clinicians to understand better the role of cofactors and interactions between known and yet unknown environmental and genetic factors in causing alcoholic pancreatitis...
  29. ncbi request reprint Predictors of severity and necrosis in acute pancreatitis
    Georgios I Papachristou
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Gastroenterol Clin North Am 33:871-90. 2004
    ..Novel conceptions and approaches, such as identification of genetic polymorphisms that predispose to severe course and complications of AP or other approaches are needed for a quantum step forward...
  30. doi request reprint Direct endoscopic necrosectomy for the treatment of walled-off pancreatic necrosis: results from a multicenter U.S. series
    Timothy B Gardner
    Section of Gastroenterology and Hepatology, Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
    Gastrointest Endosc 73:718-26. 2011
    ..Direct endoscopic necrosectomy (DEN) for treatment of walled-off pancreatic necrosis (WOPN) has been performed as an alternative to operative or percutaneous therapy...
  31. ncbi request reprint Acute deterioration of a woman following acute pancreatitis with pseudocysts
    Elie Aoun
    University of Pittsburgh Medical Center, PA 15213, USA
    Nat Clin Pract Gastroenterol Hepatol 2:545-9; quiz 550. 2005
    ..Initial blood work revealed a drop in her hematocrit, and elevated but stable amylase and lipase levels. A CT scan of the abdomen revealed a splenic artery pseudoaneurysm with extravasation of contrast medium into an adjacent pseudocyst...
  32. ncbi request reprint Endoscopic retrograde cholangiopancreatography tissue sampling: when and how?
    Georgios I Papachristou
    Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Clin Gastroenterol Hepatol 5:783-90. 2007
    ..This case-based educational presentation focuses on the importance of interdisciplinary communication between endoscopists and pathologists for optimal tissue sampling, interpretation, and diagnostic accuracy...
  33. doi request reprint Performance characteristics of endoscopic ultrasound in the staging of pancreatic cancer: a meta-analysis
    Haq Nawaz
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center Pittsburgh, PA, USA
    JOP 14:484-97. 2013
    ..The optimal approach to pre-operative imaging assessment of pancreatic cancer is unknown...
  34. ncbi request reprint Systemic silicosis that involves the pancreas
    Georgios I Papachristou
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Gastrointest Endosc 63:170-2. 2006
  35. ncbi request reprint Use of stents in benign and malignant esophageal disease
    Georgios I Papachristou
    Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Rev Gastroenterol Disord 7:74-88. 2007
    ..Future developments in stent design include biodegradable stents, stents with a radioactive coating, and drug-eluting stents...
  36. ncbi request reprint Endoscopist administered sedation during ERCP: impact of chronic narcotic/benzodiazepine use and predictive risk of reversal agent utilization
    Georgios I Papachristou
    Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Am J Gastroenterol 102:738-43. 2007
    ....
  37. ncbi request reprint Endoscopic palliation of pancreatic cancer
    Michael Sanders
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, Mezzanine Level, C Wing, UPMC Presbyterian, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Gastroenterol Clin North Am 36:455-76, xi. 2007
    ....
  38. doi request reprint Pancreaticobiliary complications after composite visceral transplantation: incidence, risk, and management strategies
    Georgios I Papachristou
    Division of Gastroenterology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Gastrointest Endosc 73:1165-73. 2011
    ..Combined liver/small-bowel (L/SB) and multivisceral (MV) transplantation has been increasingly used with significant improvement in outcome...
  39. doi request reprint An update on minimally invasive therapies for pancreatic necrosis
    Jeffrey J Easler
    Division of Gastroenterology, Hepatology and Nutrition, Pittsburgh, PA, USA
    Expert Rev Gastroenterol Hepatol 6:745-53. 2012
    ..However, additional well-designed, randomized trials are needed...
  40. ncbi request reprint EUS features of annular pancreas (with video)
    Georgios I Papachristou
    Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Gastrointest Endosc 65:340-4. 2007
    ..An annular pancreas is a rare congenital anomaly that results in a band of pancreatic tissue, either partially or completely encircling the duodenum...
  41. pmc Expression of integrin-linked kinase and its binding partners in chondrosarcoma: association with prognostic significance
    Dionysios J Papachristou
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Eur J Cancer 44:2518-25. 2008
    ..Moreover, our findings highlight the possibilities that ILK might serve as biological marker that could accurately predict a high-grade tumour and that Mig-2 may function as a promising prognostic indicator of high-risk patients...