FEROZ PAPA

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Bypassing a kinase activity with an ATP-competitive drug
    Feroz R Papa
    Department of Medicine, University of California, San Francisco, CA 94143 2200, USA
    Science 302:1533-7. 2003
  2. ncbi Endoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes
    Feroz R Papa
    Department of Medicine, The Diabetes Center, The Lung Biology Center, and the California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA 94143 2520, USA
    Cold Spring Harb Perspect Med 2:a007666. 2012
  3. ncbi On the mechanism of sensing unfolded protein in the endoplasmic reticulum
    Joel J Credle
    Howard Hughes Medical Institute, Departments of Biochemistry and Biophysics and Medicine, University of California, San Francisco, CA 94143-2200, USA
    Proc Natl Acad Sci U S A 102:18773-84. 2005
  4. ncbi Intracellular signaling by the unfolded protein response
    Sebastián Bernales
    Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143, USA
    Annu Rev Cell Dev Biol 22:487-508. 2006
  5. ncbi A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress
    Dan Han
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 2520, USA
    Biochem Biophys Res Commun 365:777-83. 2008
  6. ncbi IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates
    Dan Han
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 2520, USA
    Cell 138:562-75. 2009
  7. ncbi Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1
    Xiaoyong Lei
    Department of Medicine, Mass Spectrometry Resource, and Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 285:6693-705. 2010
  8. ncbi Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress
    John Paul Upton
    Department of Pathology, Medicine, University of California, San Francisco, California 94143, USA
    Mol Cell Biol 28:3943-51. 2008
  9. ncbi Rationalizing translation attenuation in the network architecture of the unfolded protein response
    Ala Trusina
    California Institute for Quantitative Biosciences, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 105:20280-5. 2008
  10. ncbi Real-time redox measurements during endoplasmic reticulum stress reveal interlinked protein folding functions
    Philip I Merksamer
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell 135:933-47. 2008

Research Grants

  1. Role of the Unfolded Protein Response in Type 2 Diabetes
    FEROZ PAPA; Fiscal Year: 2007
  2. Cytoprotection of Beta Cells Through Modulation of Ire1Alpha Function
    FEROZ PAPA; Fiscal Year: 2009
  3. Cytoprotection of Beta Cells Through Modulation of Ire1Alpha Function
    Feroz R Papa; Fiscal Year: 2010

Collaborators

Detail Information

Publications10

  1. ncbi Bypassing a kinase activity with an ATP-competitive drug
    Feroz R Papa
    Department of Medicine, University of California, San Francisco, CA 94143 2200, USA
    Science 302:1533-7. 2003
    ..Thus, rather than through phosphorylation per se, a conformational change in the kinase domain triggered by occupancy of the active site with a ligand leads to activation of all known downstream functions...
  2. ncbi Endoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes
    Feroz R Papa
    Department of Medicine, The Diabetes Center, The Lung Biology Center, and the California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA 94143 2520, USA
    Cold Spring Harb Perspect Med 2:a007666. 2012
    ..These findings promise to enhance our molecular understanding of human diabetes significantly and may lead to new and effective therapies...
  3. ncbi On the mechanism of sensing unfolded protein in the endoplasmic reticulum
    Joel J Credle
    Howard Hughes Medical Institute, Departments of Biochemistry and Biophysics and Medicine, University of California, San Francisco, CA 94143-2200, USA
    Proc Natl Acad Sci U S A 102:18773-84. 2005
    ..The changes in the ER lumen in turn position Ire1 kinase domains in the cytoplasm optimally for autophosphorylation to initiate the UPR...
  4. ncbi Intracellular signaling by the unfolded protein response
    Sebastián Bernales
    Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143, USA
    Annu Rev Cell Dev Biol 22:487-508. 2006
    ....
  5. ncbi A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress
    Dan Han
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 2520, USA
    Biochem Biophys Res Commun 365:777-83. 2008
    ..Thus kinase inhibitors of IRE1alpha are useful for altering the apoptotic outcome to ER stress, and could possibly be developed into drugs to treat ER stress-related diseases...
  6. ncbi IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates
    Dan Han
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 2520, USA
    Cell 138:562-75. 2009
    ..We propose that divergent cell fates during ER stress hinge on a balance between IRE1alpha RNase outputs that can be tilted with kinase inhibitors to favor survival...
  7. ncbi Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1
    Xiaoyong Lei
    Department of Medicine, Mass Spectrometry Resource, and Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 285:6693-705. 2010
    ..Consistent with this, SREBP-1, iPLA(2)beta, and NSMase messages in Akita mouse islets are higher than in WT islets...
  8. ncbi Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress
    John Paul Upton
    Department of Pathology, Medicine, University of California, San Francisco, California 94143, USA
    Mol Cell Biol 28:3943-51. 2008
    ..Our work defines a novel signaling pathway that couples the ER and mitochondria and establishes a principal apoptotic effector downstream of ER stress...
  9. ncbi Rationalizing translation attenuation in the network architecture of the unfolded protein response
    Ala Trusina
    California Institute for Quantitative Biosciences, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 105:20280-5. 2008
    ..Low expression of PERK in nonsecretory cells, and its absence in yeast, can be rationalized by lower trafficking of secretory proteins through their ERs...
  10. ncbi Real-time redox measurements during endoplasmic reticulum stress reveal interlinked protein folding functions
    Philip I Merksamer
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell 135:933-47. 2008
    ..Using genetic analysis we uncovered redox heterogeneities in isogenic cell populations, and revealed functional interlinks between ER protein folding, modification, and quality control systems...

Research Grants5

  1. Role of the Unfolded Protein Response in Type 2 Diabetes
    FEROZ PAPA; Fiscal Year: 2007
    ..The UCSF Department of Medicine is fully committed to Dr. Papa's career development, and will make all necessary resources available to facilitate the success of the project. ..
  2. Cytoprotection of Beta Cells Through Modulation of Ire1Alpha Function
    FEROZ PAPA; Fiscal Year: 2009
    ..We hypothesize that the stress from having to overwork may be responsible for ?-cell death in T2D. In this proposal we are testing this concept using molecular and cellular approaches. ..
  3. Cytoprotection of Beta Cells Through Modulation of Ire1Alpha Function
    Feroz R Papa; Fiscal Year: 2010
    ..We hypothesize that the stress from having to overwork may be responsible for ?-cell death in T2D. In this proposal we are testing this concept using molecular and cellular approaches. ..