Angela Panoskaltsis-Mortari

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Sarcoma derived from cultured mesenchymal stem cells
    Jakub Tolar
    Department of Pediatrics, Division of Hematology Oncology, Blood and Marrow Transplant and Cancer Center, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Stem Cells 25:371-9. 2007
  2. doi request reprint The future of tissue-engineered organs for transplant? It's here!
    Angela Panoskaltsis-Mortari
    Division of Blood and Marrow Transplantation, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Semin Thorac Cardiovasc Surg 24:13-4. 2012
  3. ncbi request reprint Post-BMT lung injury occurs independently of the expression of CCL2 or its receptor, CCR2, on host cells
    Angela Panoskaltsis-Mortari
    University of Minnesota, Department of Pediatrics, Division of Hematology Oncology, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Am J Physiol Lung Cell Mol Physiol 286:L284-92. 2004
  4. ncbi request reprint In vivo imaging of graft-versus-host-disease in mice
    Angela Panoskaltsis-Mortari
    Department of Pediatrics, Division of Hematology Oncology, Blood and Marrow Transplant Program, Mayo Mail Code 366, University of Minnesota, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Blood 103:3590-8. 2004
  5. ncbi request reprint Acceleration of idiopathic pneumonia syndrome (IPS) in the absence of donor MIP-1 alpha (CCL3) after allogeneic BMT in mice
    Angela Panoskaltsis-Mortari
    Department of Pediatrics, Division of Hematology Oncology, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, 55455, USA
    Blood 101:3714-21. 2003
  6. pmc A new murine model for bronchiolitis obliterans post-bone marrow transplant
    Angela Panoskaltsis-Mortari
    University of Minnesota, Department of Pediatrics, Division of Hematology Oncology, Minneapolis, MN 55455, USA
    Am J Respir Crit Care Med 176:713-23. 2007
  7. ncbi request reprint Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients
    Bruce R Blazar
    University of Minnesota Cancer Center and Department of Pediatrics, Division of Bone Marrow Transplantation, Minneapolis, MN, USA
    Blood 101:3741-8. 2003
  8. pmc Constitutively active Stat5b in CD4+ T cells inhibits graft-versus-host disease lethality associated with increased regulatory T-cell potency and decreased T effector cell responses
    Christine Vogtenhuber
    University of Minnesota Cancer Center and Department of Pediatrics, Division of Bone Marrow Transplantation, University of Minnesota, Minneapolis 55455, USA
    Blood 116:466-74. 2010
  9. ncbi request reprint Surfactant protein A decreases lung injury and mortality after murine marrow transplantation
    Shuxia Yang
    Department of Pediatrics, Divisions of Pulmonary and Critical Care, Bone Marrow Transplantation, and University of Minnesota Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Am J Respir Cell Mol Biol 27:297-305. 2002
  10. pmc Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality
    Asim Saha
    Masonic Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN
    Blood 122:3062-73. 2013

Research Grants

  1. POST BMT LUNG INJURY PATHOPHYSIOLOGY
    Angela Panoskaltsis Mortari; Fiscal Year: 2009

Collaborators

Detail Information

Publications96

  1. ncbi request reprint Sarcoma derived from cultured mesenchymal stem cells
    Jakub Tolar
    Department of Pediatrics, Division of Hematology Oncology, Blood and Marrow Transplant and Cancer Center, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Stem Cells 25:371-9. 2007
    ..More importantly, our study indicates that sarcoma can evolve from MSC cultures...
  2. doi request reprint The future of tissue-engineered organs for transplant? It's here!
    Angela Panoskaltsis-Mortari
    Division of Blood and Marrow Transplantation, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Semin Thorac Cardiovasc Surg 24:13-4. 2012
    ..Extensive evaluation of the patient before and after transplant provides some insight into the potential mechanisms of stem cell mobilization and tracheal tissue regeneration...
  3. ncbi request reprint Post-BMT lung injury occurs independently of the expression of CCL2 or its receptor, CCR2, on host cells
    Angela Panoskaltsis-Mortari
    University of Minnesota, Department of Pediatrics, Division of Hematology Oncology, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Am J Physiol Lung Cell Mol Physiol 286:L284-92. 2004
    ..Therefore, IPS can occur independently of host expression of CCL2 or CCR2, and compensatory mechanisms exist for regulating APC recruitment into the lung during the early post-BMT period...
  4. ncbi request reprint In vivo imaging of graft-versus-host-disease in mice
    Angela Panoskaltsis-Mortari
    Department of Pediatrics, Division of Hematology Oncology, Blood and Marrow Transplant Program, Mayo Mail Code 366, University of Minnesota, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Blood 103:3590-8. 2004
    ....
  5. ncbi request reprint Acceleration of idiopathic pneumonia syndrome (IPS) in the absence of donor MIP-1 alpha (CCL3) after allogeneic BMT in mice
    Angela Panoskaltsis-Mortari
    Department of Pediatrics, Division of Hematology Oncology, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, 55455, USA
    Blood 101:3714-21. 2003
    ..Donor-derived MIP-1 alpha may play a role in allogeneic-induced IPS by limiting aggressive expansion of CD4(+) and CD8(+) T cells...
  6. pmc A new murine model for bronchiolitis obliterans post-bone marrow transplant
    Angela Panoskaltsis-Mortari
    University of Minnesota, Department of Pediatrics, Division of Hematology Oncology, Minneapolis, MN 55455, USA
    Am J Respir Crit Care Med 176:713-23. 2007
    ..Better mouse models are needed to study the onset of this disease so that therapeutic interventions can be developed...
  7. ncbi request reprint Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients
    Bruce R Blazar
    University of Minnesota Cancer Center and Department of Pediatrics, Division of Bone Marrow Transplantation, Minneapolis, MN, USA
    Blood 101:3741-8. 2003
    ..These data provide insights as to the mechanisms responsible for OX40/OX40L regulation of GVHD...
  8. pmc Constitutively active Stat5b in CD4+ T cells inhibits graft-versus-host disease lethality associated with increased regulatory T-cell potency and decreased T effector cell responses
    Christine Vogtenhuber
    University of Minnesota Cancer Center and Department of Pediatrics, Division of Bone Marrow Transplantation, University of Minnesota, Minneapolis 55455, USA
    Blood 116:466-74. 2010
    ....
  9. ncbi request reprint Surfactant protein A decreases lung injury and mortality after murine marrow transplantation
    Shuxia Yang
    Department of Pediatrics, Divisions of Pulmonary and Critical Care, Bone Marrow Transplantation, and University of Minnesota Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Am J Respir Cell Mol Biol 27:297-305. 2002
    ..We concluded that basal endogenous SP-A and enhanced alveolar SP-A level modulate donor T-cell-dependent immune responses and prolong survival after allogeneic BMT...
  10. pmc Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality
    Asim Saha
    Masonic Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN
    Blood 122:3062-73. 2013
    ..Taken together, these data provide new insight into the differential roles of host PD-L1 and PD-L2 and their associated cellular and metabolic mechanisms controlling acute GVHD. ..
  11. ncbi request reprint Surfactant protein A is a required mediator of keratinocyte growth factor after experimental marrow transplantation
    Imad Y Haddad
    Univ of Minnesota, Dept of Pediatrics, 420 Delaware St S E, Minneapolis, MN 55455, USA
    Am J Physiol Lung Cell Mol Physiol 285:L602-10. 2003
    ..We conclude that endogenous baseline SP-A levels and optimal upregulation of SP-A are required for the anti-inflammatory protective effects of KGF after allogeneic transplantation...
  12. pmc Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD)
    Patricia A Taylor
    Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota Cancer Center, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Blood 110:3480-8. 2007
    ..Our data further define the mechanisms of action and provide insight as to the potential clinical uses of FTY in allogeneic bone marrow transplant recipients...
  13. ncbi request reprint Intracranial therapy of glioblastoma with the fusion protein DTAT in immunodeficient mice
    Edward Rustamzadeh
    Department of Neurosurgery, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Int J Cancer 120:411-9. 2007
    ..These results suggest that the DTAT recombinant fusion protein is highly effective in an intracranial model and DTAT might be an effective treatment for glioblastoma...
  14. ncbi request reprint Myeloperoxidase deficiency enhances inflammation after allogeneic marrow transplantation
    Carlos Milla
    Division of Pulmonary and Critical Care, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Am J Physiol Lung Cell Mol Physiol 287:L706-14. 2004
    ..We conclude that suppressed MPO-derived oxidative/nitrative stress is associated with enhanced lung inflammation and persistent alveolar epithelial injury...
  15. ncbi request reprint Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism
    Bruce R Blazar
    University of Minnesota Cancer Center and Department of Pediatrics, Minneapolis, MN 55455, USA
    J Immunol 171:1272-7. 2003
    ..These data indicate that PD-1 ligation down-regulates GVHD through modulation of IFN-gamma production and suggest a novel therapeutic target for inhibiting GVHD lethality...
  16. ncbi request reprint Targeting of inducible costimulator (ICOS) expressed on alloreactive T cells down-regulates graft-versus-host disease (GVHD) and facilitates engraftment of allogeneic bone marrow (BM)
    Patricia A Taylor
    University of Minnesota Cancer Center and Department of Pediatrics, Division of BMT, Minneapolis, MN 55455, USA
    Blood 105:3372-80. 2005
    ..These data suggest that the ICOS pathway may be a beneficial therapeutic target for GVHD inhibition, GVHD therapy, and BM graft promotion...
  17. pmc Inducing the tryptophan catabolic pathway, indoleamine 2,3-dioxygenase (IDO), for suppression of graft-versus-host disease (GVHD) lethality
    Lisa K Jasperson
    University of Minnesota Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation, Minneapolis, MN 55455, USA
    Blood 114:5062-70. 2009
    ..We conclude that IDO up-regulation may have therapeutic potential for preventing GVHD in the clinic...
  18. ncbi request reprint Real-time in vivo imaging of stem cells following transgenesis by transposition
    Jakub Tolar
    Department of Pediatrics, Division of Hematology, Oncology, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
    Mol Ther 12:42-8. 2005
    ..This novel dual-reporter imaging approach based on the transgenesis of MAPC with Sleeping Beauty transposons sheds light on the homing patterns of MAPC and paves the way for quantification of MAPC engraftment in real time in vivo...
  19. ncbi request reprint Dendritic cells pulsed or fused with AML cellular antigen provide comparable in vivo antitumor protective responses
    Brenda J Weigel
    University of Minnesota Cancer Center and Department of Pediatrics, Division of Pediatric Hematology Oncology and Blood and Marrow Transplant, Minneapolis, MN 55455, USA
    Exp Hematol 34:1403-12. 2006
    ....
  20. ncbi request reprint Absence of host tumor necrosis factor receptor 1 attenuates manifestations of idiopathic pneumonia syndrome
    Mayank Shukla
    Dept of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Am J Physiol Lung Cell Mol Physiol 288:L942-9. 2005
    ..Our results support a major role of host TNFR1 in regulation of .NO production and lung dysfunction after allogeneic BMT...
  21. ncbi request reprint L-Selectin(hi) but not the L-selectin(lo) CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection
    Patricia A Taylor
    University of Minnesota Cancer Center and Department of Pediatrics, Division of BMT, Minneapolis, MN 55455, USA
    Blood 104:3804-12. 2004
    ..These data indicate that Treg cellular therapy warrants clinical consideration for the inhibition of GVHD and the promotion of alloengraftment...
  22. pmc Hematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cells
    Marta Serafini
    Stem Cell Institute and Cancer Center and Department of Pediatrics, Division of Hematology, Oncology, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
    J Exp Med 204:129-39. 2007
    ..Because GFP+ host-derived CD45.1+ cells were not observed, fusion is not likely to account for the generation of HSCs by MAPCs...
  23. pmc TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection
    Patricia A Taylor
    Cancer Center and the Department of Pediatrics, Division of BMT, University of Minnesota, Minneapolis, USA
    Blood 112:3508-16. 2008
    ..Collectively, these data offer new insight into the mechanism of alloresponses regulating GVHD and BM rejection...
  24. doi request reprint Distribution of aerosols in murine obliterative bronchiolitis lungs by fluorescent imaging
    Dandan Yi
    Department of Pharmaceutics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Exp Lung Res 38:325-32. 2012
    ..The modulation of aerosol deposition in lungs with restrictive airway disease underscores the importance of tailoring aerosolization to optimize drug delivery...
  25. pmc Keratinocyte growth factor and androgen blockade work in concert to protect against conditioning regimen-induced thymic epithelial damage and enhance T-cell reconstitution after murine bone marrow transplantation
    Ryan M Kelly
    Division of Hematology, Oncology, and Blood and Marrow Transplantation, University of Minnesota, Minneapolis 55455, USA
    Blood 111:5734-44. 2008
    ..Thus, KGF combined with androgen blockade represents a novel approach to restore thymic function and facilitates the rapid recovery of peripheral T-cell function after allogeneic BMT...
  26. pmc Preformed antibody, not primed T cells, is the initial and major barrier to bone marrow engraftment in allosensitized recipients
    Patricia A Taylor
    University of Minnesota Cancer Center, Department of Pediatrics, Minneapolis 55455, USA
    Blood 109:1307-15. 2007
    ..These data demonstrate both rapid alloantibody-mediated elimination of BM by host FcR+ cells and priming of host antidonor T cells and suggest a practical strategy to overcome engraftment barriers in primed individuals...
  27. ncbi request reprint Molecular modification of a recombinant, bivalent anti-human CD3 immunotoxin (Bic3) results in reduced in vivo toxicity in mice
    Daniel A Vallera
    Department of Therapeutic Radiology Radiation Oncology, University of Minnesota Cancer Center, Section on Molecular Cancer Therapeutics, MMC 367, Minneapolis, MN 55455, USA
    Leuk Res 29:331-41. 2005
    ..Bic3 warrants investigation as a new drug for treating T-cell malignancy and other T-cell related disorders...
  28. ncbi request reprint Elevation of intracellular cyclic AMP in alloreactive CD4(+) T Cells induces alloantigen-specific tolerance that can prevent GVHD lethality in vivo
    Matthew J O'Shaughnessy
    University of Minnesota Cancer Center, Department of Pediatrics, Division of Bone Marrow Transplantation, Minneapolis, Minnesota 55455, USA
    Biol Blood Marrow Transplant 13:530-42. 2007
    ..Thus, our results provide the first preclinical evidence of using cAMP-elevating pharmaceutical reagents to achieve long-term alloantigen-specific T cell tolerance that is sufficient to prevent GVHD...
  29. ncbi request reprint Radioimmunotherapy of CD22-expressing Daudi tumors in nude mice with a 90Y-labeled anti-CD22 monoclonal antibody
    Daniel A Vallera
    Department of Therapeutic Radiology Radiation Oncology, University of Minnesota Cancer Center, Minneapolis, 55455, USA
    Clin Cancer Res 11:7920-8. 2005
    ..These findings indicate that anti-CD22 radioimmunotherapy with Y22 is highly effective in vivo against CD22-expressing malignancies and may be a useful therapy for drug-refractory B cell leukemia patients...
  30. ncbi request reprint Allogeneic natural killer cells for refractory lymphoma
    Veronika Bachanova
    Blood and Marrow, Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
    Cancer Immunol Immunother 59:1739-44. 2010
    ..Cell therapy trials should incorporate novel strategies to limit Treg expansion...
  31. ncbi request reprint Intracranial therapy of glioblastoma with the fusion protein DTIL13 in immunodeficient mice
    Edward Rustamzadeh
    Department of Neurosurgery, University of Minnesota Cancer Research Center, Minneapolis, MN 55455, USA
    Int J Cancer 118:2594-601. 2006
    ..These results suggest that DTIL13 is as effective in an intracranial rodent model as it was in a flank model in previous studies and that DTIL13 might be an effective treatment for glioblastoma multiforme...
  32. ncbi request reprint Retroviral immunotoxin gene therapy of leukemia in mice using leukemia-specific T cells transduced with an interleukin-3/Bax fusion protein gene
    Daniel A Vallera
    University of Minnesota Cancer Center, Department of Therapeutic Radiology, Section on Experimental Cancer Immunology, Minneapolis, MN 55455, USA
    Hum Gene Ther 14:1787-98. 2003
    ..Furthermore, the Bax construct may be particularly useful as a nonimmunogenic substitute for bacterial toxins in retIT...
  33. pmc Host factors that impact the biodistribution and persistence of multipotent adult progenitor cells
    Jakub Tolar
    Pediatric Hematology Oncology Blood and Marrow Transplantation Program, MMC 366, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Blood 107:4182-8. 2006
    ..Our data indicate that the biodistribution and persistence of reporter gene-labeled MAPCs are maximized after intra-arterial delivery or host irradiation and that T cells, B cells, and NK cells contribute to in vivo MAPC rejection...
  34. pmc Activated notch supports development of cytokine producing NK cells which are hyporesponsive and fail to acquire NK cell effector functions
    Veronika Bachanova
    Division of Adult and Pediatric Hematology, Oncology, and Transplantation, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Biol Blood Marrow Transplant 15:183-94. 2009
    ..However, these NK cells are immature in their cytokine production profile, are hyporesponsive, and poorly acquire NK cell receptors involved in self-tolerance and effector function...
  35. pmc Distribution of aerosols in mouse lobes by fluorescent imaging
    Dandan Yi
    Department of Pharmaceutics, University of Minnesota, Minneapolis, MN 55455, United States
    Int J Pharm 426:108-15. 2012
    ..This approach provides a rapid, economical means to obtain high resolution images of mouse lungs from which detailed analysis of the distribution of deposited aerosol particles can be obtained...
  36. ncbi request reprint Murine and human IL-7 activate STAT5 and induce proliferation of normal human pro-B cells
    Sonja E Johnson
    The Cancer Center, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Immunol 175:7325-31. 2005
    ..Our results support a model wherein IL-7 transduces a replicative signal to normal human B-lineage cells that is complemented by additional stromal cell-derived signals essential for normal human B cell development...
  37. pmc Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13
    Steven L Highfill
    University of Minnesota Masonic Cancer Center, Minneapolis, MN, USA
    Blood 116:5738-47. 2010
    ..MDSC-IL-13 and pegylated form of human arginase-1 represent novel strategies to prevent GVHD that can be clinically translated...
  38. ncbi request reprint Toll-like receptor-7 agonist administered subcutaneously in a prolonged dosing schedule in heavily pretreated recurrent breast, ovarian, and cervix cancers
    Melissa A Geller
    Department of Obstetrics, Gynecology and Women s Health, University of Minnesota, MMC 395 420 Delaware St SE, Minneapolis, MN, 55455, USA
    Cancer Immunol Immunother 59:1877-84. 2010
    ..Secondary objectives included assessment of safety and immune system activation...
  39. pmc IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation
    Christoph Bucher
    University of Minnesota Cancer Center and Department of Pediatrics, Division of BMT, Minneapolis, MN, USA
    Blood 114:5375-84. 2009
    ..Together, these data indicate that IL-21 suppresses inducible Treg conversion and further suggest that IL-21 blockade is an attractive strategy to reduce GVHD-induced injury...
  40. ncbi request reprint Increasing anticarcinoma activity of an anti-erbB2 recombinant immunotoxin by the addition of an anti-EpCAM sFv
    Brad J Stish
    Department of Therapeutic Radiology Radiation Oncology, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Clin Cancer Res 13:3058-67. 2007
    ..The goal of this study was to determine if genetically adding an sFv targeting epithelial cell adhesion molecule (EpCAM) to an anti-Her2 sFv immunotoxin would result in enhanced antitumor activity...
  41. pmc Bispecific and trispecific killer cell engagers directly activate human NK cells through CD16 signaling and induce cytotoxicity and cytokine production
    Michelle K Gleason
    Department of Therapeutic Radiology Radiation Oncology, University of Minnesota Masonic Cancer Center, Minneapolis, Minnesota, USA
    Mol Cancer Ther 11:2674-84. 2012
    ....
  42. pmc Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells
    Rachelle G Veenstra
    University of Minnesota Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation, Minneapolis, MN 55455, USA
    Blood 120:682-90. 2012
    ..Thus, although donor Tregs typically inhibit GVHD, under some conditions, such Tregs actually may contribute to GVHD by reducing activation-induced T-cell death...
  43. pmc Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality
    Lisa K Jasperson
    University of Minnesota Cancer Center and Department of Pediatrics, Division of Bone Marrow Transplantation, Minneapolis, MN 55455, USA
    Blood 111:3257-65. 2008
    ..These studies are the first to identify a function for IDO in GVHD lethality and indicate that modulation of the IDO pathway may be an effective strategy for treatment of this disease...
  44. ncbi request reprint Overexpression of murine TSLP impairs lymphopoiesis and myelopoiesis
    Mark J Osborn
    Department of Laboratory Medicine and Pathology, Division of Medical Technology, University of Minnesota, BSBE 6 118, 312 Church Street SE, Minneapolis, MN 55455, USA
    Blood 103:843-51. 2004
    ..The arrest in lymphopoiesis and the expansion of myeloid progenitor cells in TSLP transgenic mice suggest that TSLP has negative and positive regulatory effects on lymphoid and myeloid development, respectively...
  45. ncbi request reprint Immunotoxin pharmacokinetics: a comparison of the anti-glioblastoma bi-specific fusion protein (DTAT13) to DTAT and DTIL13
    Edward Rustamzadeh
    Department of Neurosurgery, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    J Neurooncol 77:257-66. 2006
    ..These studies show that DTAT13 has properties encompassing those of both DTIL13 and DTAT and warrants further consideration for clinical development...
  46. pmc Inhibiting retinoic acid signaling ameliorates graft-versus-host disease by modifying T-cell differentiation and intestinal migration
    Kazutoshi Aoyama
    University of Minnesota Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation, Minneapolis, MN
    Blood 122:2125-34. 2013
    ..Together, these results suggested that reagents blunting donor T-cell RAR signaling may possess therapeutic anti-GVHD properties. ..
  47. ncbi request reprint A bispecific recombinant cytotoxin (DTEGF13) targeting human interleukin-13 and epidermal growth factor receptors in a mouse xenograft model of prostate cancer
    Brad J Stish
    Department of Therapeutic Radiology Radiation Oncology, Section on Molecular Cancer Therapeutics, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Clin Cancer Res 13:6486-93. 2007
    ....
  48. pmc Multipotent adult progenitor cells can suppress graft-versus-host disease via prostaglandin E2 synthesis and only if localized to sites of allopriming
    Steven L Highfill
    University of Minnesota Masonic Cancer Center and Department of Pediatrics, Division of Bone Marrow Transplantation, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Blood 114:693-701. 2009
    ..Such data have implications for the use of allogeneic MAPCs and possibly other immunomodulatory nonhematopoietic stem cells for preventing GVHD in the clinic...
  49. doi request reprint Targeting CD133 in an in vivo ovarian cancer model reduces ovarian cancer progression
    Amy P N Skubitz
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Gynecol Oncol 130:579-87. 2013
    ..The hypothesis driving this study is that despite their low numbers in ovarian cancer tumors, CSC can be eradicated using CD133 targeted therapy and tumor growth can be inhibited...
  50. ncbi request reprint Cardiac functional and histopathologic findings in humans and mice with mucopolysaccharidosis type I: implications for assessment of therapeutic interventions in hurler syndrome
    Elizabeth Braunlin
    Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
    Pediatr Res 59:27-32. 2006
    ....
  51. pmc Prolonged subcutaneous administration of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced hematologic malignancies
    Brenda J Weigel
    Department of Pediatrics, Division of Hematology Oncology, Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA
    Am J Hematol 87:953-6. 2012
    ..2 mg/m(2) twice weekly with evidence of sustained tolerability and clinical activity in hematologic malignancies. Systemic TLR agonists for the treatment of hematologic malignancies warrant further study...
  52. pmc A deimmunized bispecific ligand-directed toxin that shows an impressive anti-pancreatic cancer effect in a systemic nude mouse orthotopic model
    Seunguk Oh
    Department of Therapeutic Radiology, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Pancreas 41:789-96. 2012
    ..The objective was to test a bispecific ligand-directed toxin (BLT), with reduced immunogenicity for enhanced efficacy in targeting orthotopic pancreatic cancer in vivo...
  53. ncbi request reprint Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer
    Jeffrey S Miller
    Division Medical and Pediatric Hematology Oncology, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Blood 105:3051-7. 2005
    ..These findings suggest that haploidentical NK cells can persist and expand in vivo and may have a role in the treatment of selected malignancies used alone or as an adjunct to HCT...
  54. ncbi request reprint CD30/CD30 ligand (CD153) interaction regulates CD4+ T cell-mediated graft-versus-host disease
    Bruce R Blazar
    Cancer Center and Department of Pediatrics, Division of Bone Marrow Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 173:2933-41. 2004
    ..Blockade of the CD30/CD153 pathway represents a new approach for preventing CD4(+) T cell-mediated GVHD...
  55. pmc Evidence for early fibrosis and increased airway resistance in bone marrow transplant recipient mice deficient in MMP12
    Kristen A England
    Department of Pediatrics, Heme Onc BMT Division, University of Minnesota Cancer Center, USA
    Am J Physiol Lung Cell Mol Physiol 301:L519-26. 2011
    ..These data indicate that host-derived MMP12 may be important in limiting development of IPS by allowing proper remodeling of extracellular matrix and effective repair of BMT-related injury...
  56. ncbi request reprint Targeting glioblastoma multiforme with an IL-13/diphtheria toxin fusion protein in vitro and in vivo in nude mice
    Chunbin Li
    Department of Therapeutic Radiology Radiation Oncology, Section on Experimental Cancer Immunology, University of Minnesota Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Protein Eng 15:419-27. 2002
    ..Together, these data suggest that DT(390)IL13 may provide an important, alternative therapy for brain cancer...
  57. ncbi request reprint Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans
    Ryan Flynn
    Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN
    Blood 123:3988-98. 2014
    ..These data provide novel insights into cGVHD pathogenesis, indicate a role for Tfh cells in these processes, and suggest a new line of therapy using mAbs targeting Tfh cells to reverse cGVHD. ..
  58. pmc Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans
    Mathangi Srinivasan
    Masonic Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Blood 119:1570-80. 2012
    ....
  59. pmc Mactinin, a fragment of cytoskeletal alpha-actinin, is a novel inducer of heat shock protein (Hsp)-90 mediated monocyte activation
    Sharon D Luikart
    Hematology Oncology Section 111E, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    BMC Cell Biol 10:60. 2009
    ..We therefore sought to determine the mechanism by which mactinin stimulates monocytes...
  60. pmc Genetic alteration of a bispecific ligand-directed toxin targeting human CD19 and CD22 receptors resulting in improved efficacy against systemic B cell malignancy
    Daniel A Vallera
    University of Minnesota Cancer Center, Section on Molecular Cancer Therapeutics, Department of Therapeutic Radiology Radiation Oncology, Minneapolis, MN 55455, USA
    Leuk Res 33:1233-42. 2009
    ..DT2219ARL represents a new class of bispecific biological that can be continually improved by genetic mutation...
  61. ncbi request reprint The host immune response is essential for the beneficial effect of adult stem cells after myocardial ischemia
    Jakub Tolar
    Cancer Center and Department of Pediatrics, Division of Hematology Oncology, Blood and Marrow Transplantation, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Exp Hematol 35:682-90. 2007
    ..Multipotent adult progenitor cells (MAPCs) are adult stem cells derived from bone marrow. We investigated the capacity of MAPCs to aid in tissue healing after myocardial ischemia in mice with different levels of immune competence...
  62. doi request reprint Evaluation of a bispecific biological drug designed to simultaneously target glioblastoma and its neovasculature in the brain
    Seunguk Oh
    Department of Therapeutic Radiology Radiation Oncology, Section on Molecular Cancer Therapeutics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosurg 114:1662-71. 2011
    ....
  63. ncbi request reprint Diminished neo-antigen response to keyhole limpet hemocyanin (KLH) vaccines in patients after treatment with chemotherapy or hematopoietic cell transplantation
    Jeffrey S Miller
    Divisions of Medical and Pediatric Hematology Oncology and Transplantation, The Blood and Marrow Transplant Program, Department of Biostatistics, and The University of Minnesota Cancer Center, MN 55455, USA
    Clin Immunol 117:144-51. 2005
    ..KLH vaccines are safe and require only a single injection to test neo-antigen responses providing an optimal platform for definitive testing of strategies to improve diminished immune recovery after chemotherapy or post-HCT...
  64. ncbi request reprint A spontaneous CD8 T cell-dependent autoimmune disease to an antigen expressed under the human keratin 14 promoter
    Maureen A McGargill
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 169:2141-7. 2002
    ..We discuss the potential relationship between autoimmunity and self-Ags that are expressed in stratified epithelium...
  65. ncbi request reprint A picornaviral 2A-like sequence-based tricistronic vector allowing for high-level therapeutic gene expression coupled to a dual-reporter system
    Mark J Osborn
    Pediatrics, Hematology Oncology, Blood and Marrow Transplant Program, Institute of Human Genetics, Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Mol Ther 12:569-74. 2005
    ....
  66. pmc Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells
    Keli L Hippen
    University of Minnesota Cancer Center and Department of Pediatrics, Division of Bone, Blood and Marrow Transplantation, Minneapolis, USA
    Blood 112:2847-57. 2008
    ..These data offer a novel approach for UCB Treg expansion using aAPCs, including those coexpressing OX40L or 4-1BBL...
  67. pmc Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9
    Michelle K Gleason
    Adult Division of Hematology, Oncology and Transplantation, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Blood 119:3064-72. 2012
    ..In conclusion, we show that Tim-3 functions as a human NK-cell coreceptor to enhance IFN-γ production, which has important implications for control of infectious disease and cancer...
  68. ncbi request reprint Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells
    E Ashley Moseman
    University of Minnesota Cancer Center and Department of Pediatrics, and Division of Hematology, Oncology, and Bone Marrow Transplantation, Minneapolis, MN 55455, USA
    J Immunol 173:4433-42. 2004
    ..This study demonstrates that TLR9 stimulation can promote PDC-mediated generation of CD4(+)CD25(+) Treg cells and suggests PDCs may play an important role in the maintenance of immunological tolerance...
  69. ncbi request reprint Radiotherapy of CD45-expressing Daudi tumors in nude mice with yttrium-90-labeled, PEGylated anti-CD45 antibody
    Daniel A Vallera
    Department of Therapeutic Radiology Radiation Oncology, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Cancer Biother Radiopharm 22:488-500. 2007
    ..Also, the final outcome may be impacted by the size of the PEG molecule used for the modification of the blood half-life...
  70. pmc Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging
    Dullei Min
    Division of Stem Cell Transplantation, Department of Pediatrics, Stanford University, CA 94304, USA
    Blood 109:2529-37. 2007
    ..The result suggests that TEC damage is pathophysiologically important in thymic aging, and KGF therapy may be clinically useful in improving thymopoiesis and immune function in the elderly...
  71. pmc Development of a decellularized lung bioreactor system for bioengineering the lung: the matrix reloaded
    Andrew P Price
    Blood and Marrow Transplant Program, Division of Hematology Oncology, Department of Pediatrics, University of Minnesota Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
    Tissue Eng Part A 16:2581-91. 2010
    ..These data illustrate the potential of using decellularized lungs as a natural three-dimensional bioengineering matrix as well as provide a model for the study of lung regeneration from pulmonary stem cells...
  72. pmc Elevated cerebral spinal fluid cytokine levels in boys with cerebral adrenoleukodystrophy correlates with MRI severity
    Troy C Lund
    Division of Pediatric Blood and Marrow Transplant, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS ONE 7:e32218. 2012
    ..The most severe course of ALD progression is the cerebral inflammatory and demyelinating form of the disease, cALD. To date there is very little information on the cytokine mediators in the cerebral spinal fluid (CSF) of these boys...
  73. ncbi request reprint Exuberant inflammation in nicotinamide adenine dinucleotide phosphate-oxidase-deficient mice after allogeneic marrow transplantation
    Shuxia Yang
    Department of Pediatrics, Divisions of Pulmonary and Critical Care and Bone Marrow Transplantation and Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 168:5840-7. 2002
    ....
  74. ncbi request reprint IL-10 and TGF-beta induce alloreactive CD4+CD25- T cells to acquire regulatory cell function
    Zong Ming Chen
    University of Minnesota Cancer Center and Department of Pediatrics, Division of Bone Marrow Transplantation, Minneapolis, MN 55455, USA
    Blood 101:5076-83. 2003
    ..The generation of immunoregulatory cells from a CD4+CD25- population during tolerization with IL-10 and TGF-beta provides an additional mechanism to prevent GVHD lethality by T cells that may escape full tolerance induction...
  75. pmc Mouse fetal and embryonic liver cells differentiate human umbilical cord blood progenitors into CD56-negative natural killer cell precursors in the absence of interleukin-15
    Valarie McCullar
    Division of Medical, University of Minnesota Cancer Center, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Exp Hematol 36:598-608. 2008
    ..Human natural killer (NK) cell maturation involves the orderly acquisition of NK cell receptors. Our aim was to understand how stromal interactions and cytokines are important in this developmental process...
  76. ncbi request reprint Endothelial cell expression of tissue factor in sickle mice is augmented by hypoxia/reoxygenation and inhibited by lovastatin
    Anna Solovey
    Vascular Biology Center and Divisions of Hematology Oncology Transplantation, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA
    Blood 104:840-6. 2004
    ..In addition to identifying tissue expression of endothelial TF in the sickle lung, these studies implicate reperfusion injury physiology in its expression and suggest a rationale for use of statins in sickle disease...
  77. ncbi request reprint Inflammatory cytokines and the development of pulmonary complications after allogeneic hematopoietic cell transplantation in patients with inherited metabolic storage disorders
    Sandhya Kharbanda
    University of Minnesota Cancer Center and Department of Pediatrics, Division of Pediatric Hematology Oncology and Blood and Marrow Transplant, Minneapolis, 55455, USA
    Biol Blood Marrow Transplant 12:430-7. 2006
    ..Larger studies will be required to further elucidate etiologic mechanisms and predictive factors...
  78. pmc A phase II study of allogeneic natural killer cell therapy to treat patients with recurrent ovarian and breast cancer
    Melissa A Geller
    Obstetrics and Gynecology, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Cytotherapy 13:98-107. 2011
    ..We evaluated the tumor response and in vivo expansion of allogeneic NK cells in recurrent ovarian and breast cancer...
  79. ncbi request reprint Sex-dependent attenuation of plaque growth after treatment with bone marrow mononuclear cells
    Wendy D Nelson
    University of Minnesota, Minneapolis R and D Systems, Minneapolis, MN 55455, USA
    Circ Res 101:1319-27. 2007
    ..Our findings may have implications for clinical cell therapy trials for coronary artery disease. Further exploration of sex-based differences in atheroprotection and vascular repair is warranted...
  80. pmc Measurement of the distribution of aerosols among mouse lobes by fluorescent imaging
    Dandan Yi
    Department of Pharmaceutics, University of Minnesota, Minneapolis, MN 55455, USA
    Anal Biochem 403:88-93. 2010
    ..This approach provides a quantitative means to determine the selectivity of drug delivery to mouse lower respiratory tract...
  81. doi request reprint Minimally invasive versus open Roux-en-Y gastric bypass: effect on immune effector cells
    Bryan A Whitson
    Department of Surgery, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Surg Obes Relat Dis 5:181-93. 2009
    ..We hypothesized that the open approach to Roux-en-Y gastric bypass (RYGB) has a more deleterious, negative, quantifiable effect on the peripheral blood mononuclear cells than does the MIS approach...
  82. pmc Cerebrospinal fluid cytokine levels and cognitive impairment in cerebral malaria
    Chandy C John
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Am J Trop Med Hyg 78:198-205. 2008
    ..34, P = 0.04) and working memory (Spearman rho, -0.32, P = 0.06) 6 months later. In children with cerebral malaria, central nervous system TNF-alpha production is associated with subsequent neurologic and cognitive morbidity...
  83. ncbi request reprint Comparative analysis of murine marrow-derived dendritic cells generated by Flt3L or GM-CSF/IL-4 and matured with immune stimulatory agents on the in vivo induction of antileukemia responses
    Brenda J Weigel
    University of Minnesota Cancer Center and Department of Pediatrics, Division of Pediatric Hematology Oncology and Blood and Marrow Transplant, Minneapolis 55455, USA
    Blood 100:4169-76. 2002
    ..These data have important clinical implications and are the first to show that Flt3L-generated DCs can provide antitumor protection and that nontoxic agents such as CpGs and Flt3L may be useful in the clinical development of DC vaccines...
  84. ncbi request reprint A novel system for simultaneous in vivo tracking and biological assessment of leukemia cells and ex vivo generated leukemia-reactive cytotoxic T cells
    Martin G Sauer
    University of Minnesota Cancer Center and Department of Pediatrics, Minneapolis, Minnesota 55455, USA
    Cancer Res 64:3914-21. 2004
    ..This survival advantage was achieved with short-term expanded CTLs only. The site of treatment failure was mainly the central nervous system where no CTLs could be identified at AML sites...
  85. ncbi request reprint Targeting urokinase-type plasminogen activator receptor on human glioblastoma tumors with diphtheria toxin fusion protein DTAT
    Daniel A Vallera
    Section on Molecular Cancer Therapeutics, Department of Therapeutic Radiology Radiation Oncology, University of Minnesota Cancer Center, Minneapolis 55455, USA
    J Natl Cancer Inst 94:597-606. 2002
    ....
  86. pmc Interferon-regulated chemokines as biomarkers of systemic lupus erythematosus disease activity: a validation study
    Jason W Bauer
    University of Minnesota, Minneapolis, MN 55455, USA
    Arthritis Rheum 60:3098-107. 2009
    ..This study was designed to validate IFN-regulated chemokines as biomarkers of SLE disease activity in 267 SLE patients followed up longitudinally...
  87. pmc Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease
    Christian A Wysocki
    Department of Medicine, Lineberger Comprehensive Cancer Center, Campus Box No 7295, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Blood 106:3300-7. 2005
    ....
  88. ncbi request reprint Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation
    Dullei Min
    Division of Research Immunology BMT, Childrens Hospital Los Angeles, CA 90027, USA
    Blood 99:4592-600. 2002
    ..Furthermore, thymic injury and prolonged posttransplantation immune deficiency in BMT recipients can be prevented by KGF administration...
  89. ncbi request reprint Administration of either anti-CD40 or interleukin-12 following lethal total body irradiation induces acute lethal toxicity affecting the gut
    Julie A Hixon
    SAIC Frederick, NCI Frederick, Maryland 21702, USA
    Biol Blood Marrow Transplant 8:316-25. 2002
    ..These results suggest that both anti-CD40 MoAb and rmIL-12 induce an acute fatal toxicity characterized by similar intestinal pathology and mediated in part by IFN-gamma...
  90. ncbi request reprint Abnormal T cell-dependent B-cell responses in SCID mice receiving allogeneic bone marrow in utero. Severe combined immune deficiency
    Thomas J Waldschmidt
    Department of Pathology, University of Iowa College of Medicine, Iowa City 52246, USA
    Blood 100:4557-64. 2002
    ..Thus, although allogeneic BM transplantation results in complete recovery of the B-cell compartment, certain elements of the humoral response remain defective...
  91. pmc Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells
    Britt E Anderson
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA
    Blood 111:5242-51. 2008
    ..Taken together, these data argue against the hypothesis that T(EM) fail to induce GVHD because of inefficient trafficking to LN and PP...
  92. ncbi request reprint The balance between donor T cell anergy and suppression versus lethal graft-versus-host disease is determined by host conditioning
    Mercedes Gonzalez
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 169:5581-9. 2002
    ..These findings underscore the decisive effect of the inflammatory environment created by irradiation in determining the ultimate fate and function of alloreactive T cells in vivo..
  93. pmc Peyer patches are not required for acute graft-versus-host disease after myeloablative conditioning and murine allogeneic bone marrow transplantation
    Lisbeth A Welniak
    Department of Microbiology and Immunology, University of Nevada School of Medicine, Mail Stop 199, Reno, NV 89557, USA
    Blood 107:410-2. 2006
    ..We conclude that neither PPs nor host TNF-alpha is required for the development of acute lethal GVHD in mice that undergo myeloablative conditioning and allogeneic BMT...
  94. pmc Inhibition of acute graft-versus-host disease with retention of graft-versus-tumor effects by the proteasome inhibitor bortezomib
    Kai Sun
    Department of Microbiology and Immunology, University of Nevada, Reno, NV 89557, USA
    Proc Natl Acad Sci U S A 101:8120-5. 2004
    ..Increased cytotoxic T cell killing of the tumor was also observed. Thus, the combination of proteasome inhibition with selective immune attack can markedly increase the efficacy of BMT in cancer...
  95. ncbi request reprint Differential roles for CCR5 expression on donor T cells during graft-versus-host disease based on pretransplant conditioning
    Christian A Wysocki
    Department of Medicine and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 173:845-54. 2004
    ..Our data indicate that the effects of inhibiting CCR5/ligand interaction on donor T cells during GVHD differ depending on conditioning of recipients, a finding with potentially important clinical significance...
  96. ncbi request reprint Deficiency of P-selectin or P-selectin glycoprotein ligand-1 leads to accelerated development of glomerulonephritis and increased expression of CC chemokine ligand 2 in lupus-prone mice
    Xiaodong He
    Department of Genetics, University of Alabama at Birmingham, 720 South 20th Street, Birmingham, AL 35294, USA
    J Immunol 177:8748-56. 2006
    ....

Research Grants1

  1. POST BMT LUNG INJURY PATHOPHYSIOLOGY
    Angela Panoskaltsis Mortari; Fiscal Year: 2009
    ..These translatable approaches offer new avenues for the prevention and treatment of IPS. ..