Research Topics
Genomes and Genes
| Angela Panoskaltsis-MortariSummaryAffiliation: University of Minnesota Country: USA Publications
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Publications
Sarcoma derived from cultured mesenchymal stem cellsJakub Tolar
Department of Pediatrics, Division of Hematology Oncology, Blood and Marrow Transplant and Cancer Center, University of Minnesota Medical School, Minneapolis, Minnesota, USA
Stem Cells 25:371-9. 2007..More importantly, our study indicates that sarcoma can evolve from MSC cultures...
The future of tissue-engineered organs for transplant? It's here!Angela Panoskaltsis-Mortari
Division of Blood and Marrow Transplantation, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
Semin Thorac Cardiovasc Surg 24:13-4. 2012..Extensive evaluation of the patient before and after transplant provides some insight into the potential mechanisms of stem cell mobilization and tracheal tissue regeneration...- Post-BMT lung injury occurs independently of the expression of CCL2 or its receptor, CCR2, on host cellsAngela Panoskaltsis-Mortari
University of Minnesota, Department of Pediatrics, Division of Hematology Oncology, 420 Delaware St SE, Minneapolis, MN 55455, USA
Am J Physiol Lung Cell Mol Physiol 286:L284-92. 2004..Therefore, IPS can occur independently of host expression of CCL2 or CCR2, and compensatory mechanisms exist for regulating APC recruitment into the lung during the early post-BMT period... - In vivo imaging of graft-versus-host-disease in miceAngela Panoskaltsis-Mortari
Department of Pediatrics, Division of Hematology Oncology, Blood and Marrow Transplant Program, Mayo Mail Code 366, University of Minnesota, 420 Delaware St SE, Minneapolis, MN 55455, USA
Blood 103:3590-8. 2004.... 
A new murine model for bronchiolitis obliterans post-bone marrow transplantAngela Panoskaltsis-Mortari
University of Minnesota, Department of Pediatrics, Division of Hematology Oncology, Minneapolis, MN 55455, USA
Am J Respir Crit Care Med 176:713-23. 2007..Better mouse models are needed to study the onset of this disease so that therapeutic interventions can be developed...- Acceleration of idiopathic pneumonia syndrome (IPS) in the absence of donor MIP-1 alpha (CCL3) after allogeneic BMT in miceAngela Panoskaltsis-Mortari
Department of Pediatrics, Division of Hematology Oncology, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, 55455, USA
Blood 101:3714-21. 2003..Donor-derived MIP-1 alpha may play a role in allogeneic-induced IPS by limiting aggressive expansion of CD4(+) and CD8(+) T cells... - Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipientsBruce R Blazar
University of Minnesota Cancer Center and Department of Pediatrics, Division of Bone Marrow Transplantation, Minneapolis, MN, USA
Blood 101:3741-8. 2003..These data provide insights as to the mechanisms responsible for OX40/OX40L regulation of GVHD... - Constitutively active Stat5b in CD4+ T cells inhibits graft-versus-host disease lethality associated with increased regulatory T-cell potency and decreased T effector cell responsesChristine Vogtenhuber
University of Minnesota Cancer Center and Department of Pediatrics, Division of Bone Marrow Transplantation, University of Minnesota, Minneapolis 55455, USA
Blood 116:466-74. 2010.... - Surfactant protein A decreases lung injury and mortality after murine marrow transplantationShuxia Yang
Department of Pediatrics, Divisions of Pulmonary and Critical Care, Bone Marrow Transplantation, and University of Minnesota Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
Am J Respir Cell Mol Biol 27:297-305. 2002..We concluded that basal endogenous SP-A and enhanced alveolar SP-A level modulate donor T-cell-dependent immune responses and prolong survival after allogeneic BMT... - Surfactant protein A is a required mediator of keratinocyte growth factor after experimental marrow transplantationImad Y Haddad
Univ of Minnesota, Dept of Pediatrics, 420 Delaware St S E, Minneapolis, MN 55455, USA
Am J Physiol Lung Cell Mol Physiol 285:L602-10. 2003..We conclude that endogenous baseline SP-A levels and optimal upregulation of SP-A are required for the anti-inflammatory protective effects of KGF after allogeneic transplantation... - Myeloperoxidase deficiency enhances inflammation after allogeneic marrow transplantationCarlos Milla
Division of Pulmonary and Critical Care, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
Am J Physiol Lung Cell Mol Physiol 287:L706-14. 2004..We conclude that suppressed MPO-derived oxidative/nitrative stress is associated with enhanced lung inflammation and persistent alveolar epithelial injury... - Targeting of inducible costimulator (ICOS) expressed on alloreactive T cells down-regulates graft-versus-host disease (GVHD) and facilitates engraftment of allogeneic bone marrow (BM)Patricia A Taylor
University of Minnesota Cancer Center and Department of Pediatrics, Division of BMT, Minneapolis, MN 55455, USA
Blood 105:3372-80. 2005..These data suggest that the ICOS pathway may be a beneficial therapeutic target for GVHD inhibition, GVHD therapy, and BM graft promotion... - Inducing the tryptophan catabolic pathway, indoleamine 2,3-dioxygenase (IDO), for suppression of graft-versus-host disease (GVHD) lethalityLisa K Jasperson
University of Minnesota Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation, Minneapolis, MN 55455, USA
Blood 114:5062-70. 2009..We conclude that IDO up-regulation may have therapeutic potential for preventing GVHD in the clinic... - Real-time in vivo imaging of stem cells following transgenesis by transpositionJakub Tolar
Department of Pediatrics, Division of Hematology, Oncology, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
Mol Ther 12:42-8. 2005..This novel dual-reporter imaging approach based on the transgenesis of MAPC with Sleeping Beauty transposons sheds light on the homing patterns of MAPC and paves the way for quantification of MAPC engraftment in real time in vivo... - Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD)Patricia A Taylor
Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota Cancer Center, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Blood 110:3480-8. 2007..Our data further define the mechanisms of action and provide insight as to the potential clinical uses of FTY in allogeneic bone marrow transplant recipients... - TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejectionPatricia A Taylor
Cancer Center and the Department of Pediatrics, Division of BMT, University of Minnesota, Minneapolis, USA
Blood 112:3508-16. 2008..Collectively, these data offer new insight into the mechanism of alloresponses regulating GVHD and BM rejection... - Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanismBruce R Blazar
University of Minnesota Cancer Center and Department of Pediatrics, Minneapolis, MN 55455, USA
J Immunol 171:1272-7. 2003..These data indicate that PD-1 ligation down-regulates GVHD through modulation of IFN-gamma production and suggest a novel therapeutic target for inhibiting GVHD lethality... - Absence of host tumor necrosis factor receptor 1 attenuates manifestations of idiopathic pneumonia syndromeMayank Shukla
Dept of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
Am J Physiol Lung Cell Mol Physiol 288:L942-9. 2005..Our results support a major role of host TNFR1 in regulation of .NO production and lung dysfunction after allogeneic BMT... - L-Selectin(hi) but not the L-selectin(lo) CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejectionPatricia A Taylor
University of Minnesota Cancer Center and Department of Pediatrics, Division of BMT, Minneapolis, MN 55455, USA
Blood 104:3804-12. 2004..These data indicate that Treg cellular therapy warrants clinical consideration for the inhibition of GVHD and the promotion of alloengraftment... - Dendritic cells pulsed or fused with AML cellular antigen provide comparable in vivo antitumor protective responsesBrenda J Weigel
University of Minnesota Cancer Center and Department of Pediatrics, Division of Pediatric Hematology Oncology and Blood and Marrow Transplant, Minneapolis, MN 55455, USA
Exp Hematol 34:1403-12. 2006.... - Distribution of aerosols in murine obliterative bronchiolitis lungs by fluorescent imagingDandan Yi
Department of Pharmaceutics, University of Minnesota, Minneapolis, Minnesota 55455, USA
Exp Lung Res 38:325-32. 2012..The modulation of aerosol deposition in lungs with restrictive airway disease underscores the importance of tailoring aerosolization to optimize drug delivery... - Molecular modification of a recombinant, bivalent anti-human CD3 immunotoxin (Bic3) results in reduced in vivo toxicity in miceDaniel A Vallera
Department of Therapeutic Radiology Radiation Oncology, University of Minnesota Cancer Center, Section on Molecular Cancer Therapeutics, MMC 367, Minneapolis, MN 55455, USA
Leuk Res 29:331-41. 2005..Bic3 warrants investigation as a new drug for treating T-cell malignancy and other T-cell related disorders... - Preformed antibody, not primed T cells, is the initial and major barrier to bone marrow engraftment in allosensitized recipientsPatricia A Taylor
University of Minnesota Cancer Center, Department of Pediatrics, Minneapolis 55455, USA
Blood 109:1307-15. 2007..These data demonstrate both rapid alloantibody-mediated elimination of BM by host FcR+ cells and priming of host antidonor T cells and suggest a practical strategy to overcome engraftment barriers in primed individuals... - Keratinocyte growth factor and androgen blockade work in concert to protect against conditioning regimen-induced thymic epithelial damage and enhance T-cell reconstitution after murine bone marrow transplantationRyan M Kelly
Division of Hematology, Oncology, and Blood and Marrow Transplantation, University of Minnesota, Minneapolis 55455, USA
Blood 111:5734-44. 2008..Thus, KGF combined with androgen blockade represents a novel approach to restore thymic function and facilitates the rapid recovery of peripheral T-cell function after allogeneic BMT... - Activated notch supports development of cytokine producing NK cells which are hyporesponsive and fail to acquire NK cell effector functionsVeronika Bachanova
Division of Adult and Pediatric Hematology, Oncology, and Transplantation, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
Biol Blood Marrow Transplant 15:183-94. 2009..However, these NK cells are immature in their cytokine production profile, are hyporesponsive, and poorly acquire NK cell receptors involved in self-tolerance and effector function... - Radioimmunotherapy of CD22-expressing Daudi tumors in nude mice with a 90Y-labeled anti-CD22 monoclonal antibodyDaniel A Vallera
Department of Therapeutic Radiology Radiation Oncology, University of Minnesota Cancer Center, Minneapolis, 55455, USA
Clin Cancer Res 11:7920-8. 2005..These findings indicate that anti-CD22 radioimmunotherapy with Y22 is highly effective in vivo against CD22-expressing malignancies and may be a useful therapy for drug-refractory B cell leukemia patients... - Intracranial therapy of glioblastoma with the fusion protein DTIL13 in immunodeficient miceEdward Rustamzadeh
Department of Neurosurgery, University of Minnesota Cancer Research Center, Minneapolis, MN 55455, USA
Int J Cancer 118:2594-601. 2006..These results suggest that DTIL13 is as effective in an intracranial rodent model as it was in a flank model in previous studies and that DTIL13 might be an effective treatment for glioblastoma multiforme... - A bispecific recombinant cytotoxin (DTEGF13) targeting human interleukin-13 and epidermal growth factor receptors in a mouse xenograft model of prostate cancerBrad J Stish
Department of Therapeutic Radiology Radiation Oncology, Section on Molecular Cancer Therapeutics, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
Clin Cancer Res 13:6486-93. 2007.... - Allogeneic natural killer cells for refractory lymphomaVeronika Bachanova
Blood and Marrow, Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
Cancer Immunol Immunother 59:1739-44. 2010..Cell therapy trials should incorporate novel strategies to limit Treg expansion... - Hematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cellsMarta Serafini
Stem Cell Institute and Cancer Center and Department of Pediatrics, Division of Hematology, Oncology, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
J Exp Med 204:129-39. 2007..Because GFP+ host-derived CD45.1+ cells were not observed, fusion is not likely to account for the generation of HSCs by MAPCs... - Intracranial therapy of glioblastoma with the fusion protein DTAT in immunodeficient miceEdward Rustamzadeh
Department of Neurosurgery, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
Int J Cancer 120:411-9. 2007..These results suggest that the DTAT recombinant fusion protein is highly effective in an intracranial model and DTAT might be an effective treatment for glioblastoma... - Retroviral immunotoxin gene therapy of leukemia in mice using leukemia-specific T cells transduced with an interleukin-3/Bax fusion protein geneDaniel A Vallera
University of Minnesota Cancer Center, Department of Therapeutic Radiology, Section on Experimental Cancer Immunology, Minneapolis, MN 55455, USA
Hum Gene Ther 14:1787-98. 2003..Furthermore, the Bax construct may be particularly useful as a nonimmunogenic substitute for bacterial toxins in retIT... - Distribution of aerosols in mouse lobes by fluorescent imagingDandan Yi
Department of Pharmaceutics, University of Minnesota, Minneapolis, MN 55455, United States
Int J Pharm 426:108-15. 2012..This approach provides a rapid, economical means to obtain high resolution images of mouse lungs from which detailed analysis of the distribution of deposited aerosol particles can be obtained... - Elevation of intracellular cyclic AMP in alloreactive CD4(+) T Cells induces alloantigen-specific tolerance that can prevent GVHD lethality in vivoZong Ming Chen
University of Minnesota Cancer Center, Department of Pediatrics, Division of Bone Marrow Transplantation, Minneapolis, Minnesota 55455, USA
Biol Blood Marrow Transplant 13:530-42. 2007..Thus, our results provide the first preclinical evidence of using cAMP-elevating pharmaceutical reagents to achieve long-term alloantigen-specific T cell tolerance that is sufficient to prevent GVHD... - Murine and human IL-7 activate STAT5 and induce proliferation of normal human pro-B cellsSonja E Johnson
The Cancer Center, University of Minnesota Medical School, Minneapolis, MN 55455, USA
J Immunol 175:7325-31. 2005..Our results support a model wherein IL-7 transduces a replicative signal to normal human B-lineage cells that is complemented by additional stromal cell-derived signals essential for normal human B cell development... - IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generationChristoph Bucher
University of Minnesota Cancer Center and Department of Pediatrics, Division of BMT, Minneapolis, MN, USA
Blood 114:5375-84. 2009..Together, these data indicate that IL-21 suppresses inducible Treg conversion and further suggest that IL-21 blockade is an attractive strategy to reduce GVHD-induced injury... - Multipotent adult progenitor cells can suppress graft-versus-host disease via prostaglandin E2 synthesis and only if localized to sites of alloprimingSteven L Highfill
University of Minnesota Masonic Cancer Center and Department of Pediatrics, Division of Bone Marrow Transplantation, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Blood 114:693-701. 2009..Such data have implications for the use of allogeneic MAPCs and possibly other immunomodulatory nonhematopoietic stem cells for preventing GVHD in the clinic... - Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13Steven L Highfill
University of Minnesota Masonic Cancer Center, Minneapolis, MN, USA
Blood 116:5738-47. 2010..MDSC-IL-13 and pegylated form of human arginase-1 represent novel strategies to prevent GVHD that can be clinically translated... - Toll-like receptor-7 agonist administered subcutaneously in a prolonged dosing schedule in heavily pretreated recurrent breast, ovarian, and cervix cancersMelissa A Geller
Department of Obstetrics, Gynecology and Women s Health, University of Minnesota, MMC 395 420 Delaware St SE, Minneapolis, MN, 55455, USA
Cancer Immunol Immunother 59:1877-84. 2010..Secondary objectives included assessment of safety and immune system activation... - Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cellsRachelle G Veenstra
University of Minnesota Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation, Minneapolis, MN 55455, USA
Blood 120:682-90. 2012..Thus, although donor Tregs typically inhibit GVHD, under some conditions, such Tregs actually may contribute to GVHD by reducing activation-induced T-cell death... - Host factors that impact the biodistribution and persistence of multipotent adult progenitor cellsJakub Tolar
Pediatric Hematology Oncology Blood and Marrow Transplantation Program, MMC 366, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Blood 107:4182-8. 2006..Our data indicate that the biodistribution and persistence of reporter gene-labeled MAPCs are maximized after intra-arterial delivery or host irradiation and that T cells, B cells, and NK cells contribute to in vivo MAPC rejection... - Overexpression of murine TSLP impairs lymphopoiesis and myelopoiesisMark J Osborn
Department of Laboratory Medicine and Pathology, Division of Medical Technology, University of Minnesota, BSBE 6 118, 312 Church Street SE, Minneapolis, MN 55455, USA
Blood 103:843-51. 2004..The arrest in lymphopoiesis and the expansion of myeloid progenitor cells in TSLP transgenic mice suggest that TSLP has negative and positive regulatory effects on lymphoid and myeloid development, respectively... - Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethalityLisa K Jasperson
University of Minnesota Cancer Center and Department of Pediatrics, Division of Bone Marrow Transplantation, Minneapolis, MN 55455, USA
Blood 111:3257-65. 2008..These studies are the first to identify a function for IDO in GVHD lethality and indicate that modulation of the IDO pathway may be an effective strategy for treatment of this disease... - Immunotoxin pharmacokinetics: a comparison of the anti-glioblastoma bi-specific fusion protein (DTAT13) to DTAT and DTIL13Edward Rustamzadeh
Department of Neurosurgery, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
J Neurooncol 77:257-66. 2006..These studies show that DTAT13 has properties encompassing those of both DTIL13 and DTAT and warrants further consideration for clinical development... - Prolonged subcutaneous administration of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced hematologic malignanciesBrenda J Weigel
Department of Pediatrics, Division of Hematology Oncology, Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA
Am J Hematol 87:953-6. 2012..2 mg/m(2) twice weekly with evidence of sustained tolerability and clinical activity in hematologic malignancies. Systemic TLR agonists for the treatment of hematologic malignancies warrant further study... - A deimmunized bispecific ligand-directed toxin that shows an impressive anti-pancreatic cancer effect in a systemic nude mouse orthotopic modelSeunguk Oh
Department of Therapeutic Radiology, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
Pancreas 41:789-96. 2012..The objective was to test a bispecific ligand-directed toxin (BLT), with reduced immunogenicity for enhanced efficacy in targeting orthotopic pancreatic cancer in vivo... - Evidence for early fibrosis and increased airway resistance in bone marrow transplant recipient mice deficient in MMP12Kristen A England
Department of Pediatrics, Heme Onc BMT Division, University of Minnesota Cancer Center, USA
Am J Physiol Lung Cell Mol Physiol 301:L519-26. 2011..These data indicate that host-derived MMP12 may be important in limiting development of IPS by allowing proper remodeling of extracellular matrix and effective repair of BMT-related injury... - CD30/CD30 ligand (CD153) interaction regulates CD4+ T cell-mediated graft-versus-host diseaseBruce R Blazar
Cancer Center and Department of Pediatrics, Division of Bone Marrow Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
J Immunol 173:2933-41. 2004..Blockade of the CD30/CD153 pathway represents a new approach for preventing CD4(+) T cell-mediated GVHD... - Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancerJeffrey S Miller
Division Medical and Pediatric Hematology Oncology, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
Blood 105:3051-7. 2005..These findings suggest that haploidentical NK cells can persist and expand in vivo and may have a role in the treatment of selected malignancies used alone or as an adjunct to HCT... - Targeting glioblastoma multiforme with an IL-13/diphtheria toxin fusion protein in vitro and in vivo in nude miceChunbin Li
Department of Therapeutic Radiology-Radiation Oncology, Section on Experimental Cancer Immunology, University of Minnesota Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
Protein Eng 15:419-27. 2002..Together, these data suggest that DT(390)IL13 may provide an important, alternative therapy for brain cancer... - Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliteransMathangi Srinivasan
Masonic Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Blood 119:1570-80. 2012.... - Mactinin, a fragment of cytoskeletal alpha-actinin, is a novel inducer of heat shock protein (Hsp)-90 mediated monocyte activationSharon D Luikart
Hematology Oncology Section 111E, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
BMC Cell Biol 10:60. 2009..We therefore sought to determine the mechanism by which mactinin stimulates monocytes... - Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cellsKeli L Hippen
University of Minnesota Cancer Center and Department of Pediatrics, Division of Bone, Blood and Marrow Transplantation, Minneapolis, USA
Blood 112:2847-57. 2008..These data offer a novel approach for UCB Treg expansion using aAPCs, including those coexpressing OX40L or 4-1BBL... - Genetic alteration of a bispecific ligand-directed toxin targeting human CD19 and CD22 receptors resulting in improved efficacy against systemic B cell malignancyDaniel A Vallera
University of Minnesota Cancer Center, Section on Molecular Cancer Therapeutics, Department of Therapeutic Radiology Radiation Oncology, Minneapolis, MN 55455, USA
Leuk Res 33:1233-42. 2009..DT2219ARL represents a new class of bispecific biological that can be continually improved by genetic mutation... - Increasing anticarcinoma activity of an anti-erbB2 recombinant immunotoxin by the addition of an anti-EpCAM sFvBrad J Stish
Department of Therapeutic Radiology Radiation Oncology, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
Clin Cancer Res 13:3058-67. 2007..The goal of this study was to determine if genetically adding an sFv targeting epithelial cell adhesion molecule (EpCAM) to an anti-Her2 sFv immunotoxin would result in enhanced antitumor activity... - The host immune response is essential for the beneficial effect of adult stem cells after myocardial ischemiaJakub Tolar
Cancer Center and Department of Pediatrics, Division of Hematology Oncology, Blood and Marrow Transplantation, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Exp Hematol 35:682-90. 2007..Multipotent adult progenitor cells (MAPCs) are adult stem cells derived from bone marrow. We investigated the capacity of MAPCs to aid in tissue healing after myocardial ischemia in mice with different levels of immune competence... - A spontaneous CD8 T cell-dependent autoimmune disease to an antigen expressed under the human keratin 14 promoterMaureen A McGargill
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
J Immunol 169:2141-7. 2002..We discuss the potential relationship between autoimmunity and self-Ags that are expressed in stratified epithelium... - Diminished neo-antigen response to keyhole limpet hemocyanin (KLH) vaccines in patients after treatment with chemotherapy or hematopoietic cell transplantationJeffrey S Miller
Divisions of Medical and Pediatric Hematology Oncology and Transplantation, The Blood and Marrow Transplant Program, Department of Biostatistics, and The University of Minnesota Cancer Center, MN 55455, USA
Clin Immunol 117:144-51. 2005..KLH vaccines are safe and require only a single injection to test neo-antigen responses providing an optimal platform for definitive testing of strategies to improve diminished immune recovery after chemotherapy or post-HCT... - Cardiac functional and histopathologic findings in humans and mice with mucopolysaccharidosis type I: implications for assessment of therapeutic interventions in hurler syndromeElizabeth Braunlin
Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
Pediatr Res 59:27-32. 2006.... - Evaluation of a bispecific biological drug designed to simultaneously target glioblastoma and its neovasculature in the brainSeunguk Oh
Department of Therapeutic Radiology Radiation Oncology, Section on Molecular Cancer Therapeutics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Neurosurg 114:1662-71. 2011.... - A picornaviral 2A-like sequence-based tricistronic vector allowing for high-level therapeutic gene expression coupled to a dual-reporter systemMark J Osborn
Pediatrics, Hematology-Oncology, Blood and Marrow Transplant Program, Institute of Human Genetics, Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
Mol Ther 12:569-74. 2005.... - Bispecific and trispecific killer cell engagers directly activate human NK cells through CD16 signaling and induce cytotoxicity and cytokine productionMichelle K Gleason
Department of Therapeutic Radiology Radiation Oncology, University of Minnesota Masonic Cancer Center, Minneapolis, Minnesota, USA
Mol Cancer Ther 11:2674-84. 2012.... - Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9Michelle K Gleason
Adult Division of Hematology, Oncology and Transplantation, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
Blood 119:3064-72. 2012..In conclusion, we show that Tim-3 functions as a human NK-cell coreceptor to enhance IFN-γ production, which has important implications for control of infectious disease and cancer... - Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cellsE Ashley Moseman
University of Minnesota Cancer Center and Department of Pediatrics, and Division of Hematology, Oncology, and Bone Marrow Transplantation, Minneapolis, MN 55455, USA
J Immunol 173:4433-42. 2004..This study demonstrates that TLR9 stimulation can promote PDC-mediated generation of CD4(+)CD25(+) Treg cells and suggests PDCs may play an important role in the maintenance of immunological tolerance... - Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of agingDullei Min
Division of Stem Cell Transplantation, Department of Pediatrics, Stanford University, CA 94304, USA
Blood 109:2529-37. 2007..The result suggests that TEC damage is pathophysiologically important in thymic aging, and KGF therapy may be clinically useful in improving thymopoiesis and immune function in the elderly... - Radiotherapy of CD45-expressing Daudi tumors in nude mice with yttrium-90-labeled, PEGylated anti-CD45 antibodyDaniel A Vallera
Department of Therapeutic Radiology Radiation Oncology, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
Cancer Biother Radiopharm 22:488-500. 2007..Also, the final outcome may be impacted by the size of the PEG molecule used for the modification of the blood half-life... - Development of a decellularized lung bioreactor system for bioengineering the lung: the matrix reloadedAndrew P Price
Blood and Marrow Transplant Program, Division of Hematology Oncology, Department of Pediatrics, University of Minnesota Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
Tissue Eng Part A 16:2581-91. 2010..These data illustrate the potential of using decellularized lungs as a natural three-dimensional bioengineering matrix as well as provide a model for the study of lung regeneration from pulmonary stem cells... - Elevated cerebral spinal fluid cytokine levels in boys with cerebral adrenoleukodystrophy correlates with MRI severityTroy C Lund
Division of Pediatric Blood and Marrow Transplant, University of Minnesota, Minneapolis, Minnesota, United States of America
PLoS ONE 7:e32218. 2012..The most severe course of ALD progression is the cerebral inflammatory and demyelinating form of the disease, cALD. To date there is very little information on the cytokine mediators in the cerebral spinal fluid (CSF) of these boys... - Exuberant inflammation in nicotinamide adenine dinucleotide phosphate-oxidase-deficient mice after allogeneic marrow transplantationShuxia Yang
Department of Pediatrics, Divisions of Pulmonary and Critical Care and Bone Marrow Transplantation and Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
J Immunol 168:5840-7. 2002.... - IL-10 and TGF-beta induce alloreactive CD4+CD25- T cells to acquire regulatory cell functionZong-ming Chen
University of Minnesota Cancer Center and Department of Pediatrics, Division of Bone Marrow Transplantation, Minneapolis, MN 55455, USA
Blood 101:5076-83. 2003..The generation of immunoregulatory cells from a CD4+CD25- population during tolerization with IL-10 and TGF-beta provides an additional mechanism to prevent GVHD lethality by T cells that may escape full tolerance induction... - Mouse fetal and embryonic liver cells differentiate human umbilical cord blood progenitors into CD56-negative natural killer cell precursors in the absence of interleukin-15Valarie McCullar
Division of Medical, University of Minnesota Cancer Center, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Exp Hematol 36:598-608. 2008..Human natural killer (NK) cell maturation involves the orderly acquisition of NK cell receptors. Our aim was to understand how stromal interactions and cytokines are important in this developmental process... - A phase II study of allogeneic natural killer cell therapy to treat patients with recurrent ovarian and breast cancerMelissa A Geller
Obstetrics and Gynecology, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Cytotherapy 13:98-107. 2011..We evaluated the tumor response and in vivo expansion of allogeneic NK cells in recurrent ovarian and breast cancer... - Endothelial cell expression of tissue factor in sickle mice is augmented by hypoxia/reoxygenation and inhibited by lovastatinAnna Solovey
Vascular Biology Center and Divisions of Hematology Oncology Transplantation, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA
Blood 104:840-6. 2004..In addition to identifying tissue expression of endothelial TF in the sickle lung, these studies implicate reperfusion injury physiology in its expression and suggest a rationale for use of statins in sickle disease... - Sex-dependent attenuation of plaque growth after treatment with bone marrow mononuclear cellsWendy D Nelson
University of Minnesota, Minneapolis R and D Systems, Minneapolis, MN 55455, USA
Circ Res 101:1319-27. 2007..Our findings may have implications for clinical cell therapy trials for coronary artery disease. Further exploration of sex-based differences in atheroprotection and vascular repair is warranted... - Inflammatory cytokines and the development of pulmonary complications after allogeneic hematopoietic cell transplantation in patients with inherited metabolic storage disordersSandhya Kharbanda
University of Minnesota Cancer Center and Department of Pediatrics, Division of Pediatric Hematology/Oncology and Blood and Marrow Transplant, Minneapolis, 55455, USA
Biol Blood Marrow Transplant 12:430-7. 2006..Larger studies will be required to further elucidate etiologic mechanisms and predictive factors... - Measurement of the distribution of aerosols among mouse lobes by fluorescent imagingDandan Yi
Department of Pharmaceutics, University of Minnesota, Minneapolis, MN 55455, USA
Anal Biochem 403:88-93. 2010..This approach provides a quantitative means to determine the selectivity of drug delivery to mouse lower respiratory tract... - Targeting urokinase-type plasminogen activator receptor on human glioblastoma tumors with diphtheria toxin fusion protein DTATDaniel A Vallera
Section on Molecular Cancer Therapeutics, Department of Therapeutic Radiology Radiation Oncology, University of Minnesota Cancer Center, Minneapolis 55455, USA
J Natl Cancer Inst 94:597-606. 2002.... - Cerebrospinal fluid cytokine levels and cognitive impairment in cerebral malariaChandy C John
Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Am J Trop Med Hyg 78:198-205. 2008..34, P = 0.04) and working memory (Spearman rho, -0.32, P = 0.06) 6 months later. In children with cerebral malaria, central nervous system TNF-alpha production is associated with subsequent neurologic and cognitive morbidity... - Comparative analysis of murine marrow-derived dendritic cells generated by Flt3L or GM-CSF/IL-4 and matured with immune stimulatory agents on the in vivo induction of antileukemia responsesBrenda J Weigel
University of Minnesota Cancer Center and Department of Pediatrics, Division of Pediatric Hematology Oncology and Blood and Marrow Transplant, Minneapolis 55455, USA
Blood 100:4169-76. 2002..These data have important clinical implications and are the first to show that Flt3L-generated DCs can provide antitumor protection and that nontoxic agents such as CpGs and Flt3L may be useful in the clinical development of DC vaccines... - Minimally invasive versus open Roux-en-Y gastric bypass: effect on immune effector cellsBryan A Whitson
Department of Surgery, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Surg Obes Relat Dis 5:181-93. 2009..We hypothesized that the open approach to Roux-en-Y gastric bypass (RYGB) has a more deleterious, negative, quantifiable effect on the peripheral blood mononuclear cells than does the MIS approach... - A novel system for simultaneous in vivo tracking and biological assessment of leukemia cells and ex vivo generated leukemia-reactive cytotoxic T cellsMartin G Sauer
University of Minnesota Cancer Center and Department of Pediatrics, Minneapolis, Minnesota 55455, USA
Cancer Res 64:3914-21. 2004..This survival advantage was achieved with short-term expanded CTLs only. The site of treatment failure was mainly the central nervous system where no CTLs could be identified at AML sites... - Interferon-regulated chemokines as biomarkers of systemic lupus erythematosus disease activity: a validation studyJason W Bauer
University of Minnesota, Minneapolis, MN 55455, USA
Arthritis Rheum 60:3098-107. 2009..This study was designed to validate IFN-regulated chemokines as biomarkers of SLE disease activity in 267 SLE patients followed up longitudinally... - Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cellsBritt E Anderson
Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA
Blood 111:5242-51. 2008..Taken together, these data argue against the hypothesis that T(EM) fail to induce GVHD because of inefficient trafficking to LN and PP... - Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantationDullei Min
Division of Research Immunology BMT, Childrens Hospital Los Angeles, CA 90027, USA
Blood 99:4592-600. 2002..Furthermore, thymic injury and prolonged posttransplantation immune deficiency in BMT recipients can be prevented by KGF administration... - Administration of either anti-CD40 or interleukin-12 following lethal total body irradiation induces acute lethal toxicity affecting the gutJulie A Hixon
SAIC Frederick, NCI Frederick, Maryland 21702, USA
Biol Blood Marrow Transplant 8:316-25. 2002..These results suggest that both anti-CD40 MoAb and rmIL-12 induce an acute fatal toxicity characterized by similar intestinal pathology and mediated in part by IFN-gamma... - Peyer patches are not required for acute graft-versus-host disease after myeloablative conditioning and murine allogeneic bone marrow transplantationLisbeth A Welniak
Department of Microbiology and Immunology, University of Nevada School of Medicine, Mail Stop 199, Reno, NV 89557, USA
Blood 107:410-2. 2006..We conclude that neither PPs nor host TNF-alpha is required for the development of acute lethal GVHD in mice that undergo myeloablative conditioning and allogeneic BMT... - Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host diseaseChristian A Wysocki
Department of Medicine, Lineberger Comprehensive Cancer Center, Campus Box No 7295, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
Blood 106:3300-7. 2005.... - Abnormal T cell-dependent B-cell responses in SCID mice receiving allogeneic bone marrow in utero. Severe combined immune deficiencyThomas J Waldschmidt
Department of Pathology, University of Iowa College of Medicine, Iowa City 52246, USA
Blood 100:4557-64. 2002..Thus, although allogeneic BM transplantation results in complete recovery of the B-cell compartment, certain elements of the humoral response remain defective... - Differential roles for CCR5 expression on donor T cells during graft-versus-host disease based on pretransplant conditioningChristian A Wysocki
Department of Medicine and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
J Immunol 173:845-54. 2004..Our data indicate that the effects of inhibiting CCR5/ligand interaction on donor T cells during GVHD differ depending on conditioning of recipients, a finding with potentially important clinical significance... - The balance between donor T cell anergy and suppression versus lethal graft-versus-host disease is determined by host conditioningMercedes Gonzalez
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
J Immunol 169:5581-9. 2002..These findings underscore the decisive effect of the inflammatory environment created by irradiation in determining the ultimate fate and function of alloreactive T cells in vivo.. - Deficiency of P-selectin or P-selectin glycoprotein ligand-1 leads to accelerated development of glomerulonephritis and increased expression of CC chemokine ligand 2 in lupus-prone miceXiaodong He
Department of Genetics, University of Alabama at Birmingham, 720 South 20th Street, Birmingham, AL 35294, USA
J Immunol 177:8748-56. 2006.... - Inhibition of acute graft-versus-host disease with retention of graft-versus-tumor effects by the proteasome inhibitor bortezomibKai Sun
Department of Microbiology and Immunology, University of Nevada, Reno, NV 89557, USA
Proc Natl Acad Sci U S A 101:8120-5. 2004..Increased cytotoxic T cell killing of the tumor was also observed. Thus, the combination of proteasome inhibition with selective immune attack can markedly increase the efficacy of BMT in cancer...
Research Grants
- POST BMT LUNG INJURY PATHOPHYSIOLOGYAngela Panoskaltsis Mortari; Fiscal Year: 2009..These translatable approaches offer new avenues for the prevention and treatment of IPS. ..