James Pankow

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Periodontitis and coronary artery calcification: the Atherosclerosis Risk in Communities (ARIC) study
    Sarah A Nakib
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA
    J Periodontol 75:505-10. 2004
  2. pmc The transcription factor 7-like 2 (TCF7L2) polymorphism may be associated with focal arteriolar narrowing in Caucasians with hypertension or without diabetes: the ARIC Study
    Yu Yan
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    BMC Endocr Disord 10:9. 2010
  3. ncbi request reprint Insulin resistance and cardiovascular disease risk factors in children of parents with the insulin resistance (metabolic) syndrome
    James S Pankow
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55454, USA
    Diabetes Care 27:775-80. 2004
  4. ncbi request reprint Familial aggregation and genome-wide linkage analysis of carotid artery plaque: the NHLBI family heart study
    James S Pankow
    Division of Epidemiology, University of Minnesota, 1300 South Second Street, Ste 300, Minneapolis, MN 55454, USA
    Hum Hered 57:80-9. 2004
  5. ncbi request reprint Fasting plasma free fatty acids and risk of type 2 diabetes: the atherosclerosis risk in communities study
    James S Pankow
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55454, USA
    Diabetes Care 27:77-82. 2004
  6. ncbi request reprint Cardiometabolic risk in impaired fasting glucose and impaired glucose tolerance: the Atherosclerosis Risk in Communities Study
    James S Pankow
    Division of EpidemiologyCommunity Health, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454, USA
    Diabetes Care 30:325-31. 2007
  7. ncbi request reprint Further evidence of a quantitative trait locus on chromosome 18 influencing postural change in systolic blood pressure: the Hypertension Genetic Epidemiology Network (HyperGEN) Study
    James S Pankow
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota 55454, USA
    Am J Hypertens 18:672-8. 2005
  8. ncbi request reprint B-mode ultrasound-detected carotid artery lesions with and without acoustic shadowing and their association with markers of inflammation and endothelial activation: the atherosclerosis risk in communities study
    Kelly J Hunt
    CVD Program, Department of Epidemiology, School of Public Health, University of North Carolina, 137 E Franklin St, Bank of America, Suite 306, Chapel Hill, NC, USA
    Atherosclerosis 162:145-55. 2002
  9. ncbi request reprint Risk factors for peripheral arterial disease incidence in persons with diabetes: the Atherosclerosis Risk in Communities (ARIC) Study
    Keattiyoat Wattanakit
    Division of Epidemiology, School of Public Health, University of Minnesota, Suite 300, 1300 South 2nd Street, Minneapolis, MN 55454 1015, USA
    Atherosclerosis 180:389-97. 2005
  10. ncbi request reprint Risk of atherosclerosis: interaction of smoking and glutathione S-transferase genes
    Andrew F Olshan
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Epidemiology 14:321-7. 2003

Research Grants

  1. INFLAMMATORY PRECURSORS OF TYPE 2 DIABETES
    James Pankow; Fiscal Year: 2001
  2. MESA Family Study
    James Pankow; Fiscal Year: 2007
  3. INFLAMMATORY PRECURSORS OF TYPE 2 DIABETES
    James Pankow; Fiscal Year: 2007
  4. Identifying Susceptibility Genes for Metabolic Syndrome
    James Pankow; Fiscal Year: 2007
  5. INFLAMMATORY PRECURSORS OF TYPE 2 DIABETES
    James Pankow; Fiscal Year: 2006
  6. MESA Family Study
    James Pankow; Fiscal Year: 2006
  7. INFLAMMATORY PRECURSORS OF TYPE 2 DIABETES
    James Pankow; Fiscal Year: 2005
  8. MESA Family Study
    James Pankow; Fiscal Year: 2005
  9. TRAINING GRANT IN CVD GENETIC EPIDEMIOLOGY
    James Pankow; Fiscal Year: 2005
  10. GENCAC - Minnesota Field Center
    James Pankow; Fiscal Year: 2004

Detail Information

Publications72

  1. ncbi request reprint Periodontitis and coronary artery calcification: the Atherosclerosis Risk in Communities (ARIC) study
    Sarah A Nakib
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA
    J Periodontol 75:505-10. 2004
    ..Coronary artery calcification (CAC) is an emerging marker for atherosclerosis, and past studies suggest that it predicts incident CHD in asymptomatic populations...
  2. pmc The transcription factor 7-like 2 (TCF7L2) polymorphism may be associated with focal arteriolar narrowing in Caucasians with hypertension or without diabetes: the ARIC Study
    Yu Yan
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    BMC Endocr Disord 10:9. 2010
    ..We therefore aimed to investigate the association between the transcription factor 7-like 2 (TCF7L2) rs7903146 polymorphism and retinal microvascular phenotypes in the Atherosclerosis Risk in Communities (ARIC) Study (1993-1995)...
  3. ncbi request reprint Insulin resistance and cardiovascular disease risk factors in children of parents with the insulin resistance (metabolic) syndrome
    James S Pankow
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55454, USA
    Diabetes Care 27:775-80. 2004
    ..To evaluate whether children of parents with the insulin resistance syndrome (IRS) themselves have greater insulin resistance and unfavorable patterns of cardiovascular disease (CVD) risk factors...
  4. ncbi request reprint Familial aggregation and genome-wide linkage analysis of carotid artery plaque: the NHLBI family heart study
    James S Pankow
    Division of Epidemiology, University of Minnesota, 1300 South Second Street, Ste 300, Minneapolis, MN 55454, USA
    Hum Hered 57:80-9. 2004
    ..To evaluate familial and genetic influences on carotid artery plaque, a qualitative marker of the systemic burden of atherosclerosis...
  5. ncbi request reprint Fasting plasma free fatty acids and risk of type 2 diabetes: the atherosclerosis risk in communities study
    James S Pankow
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55454, USA
    Diabetes Care 27:77-82. 2004
    ..To evaluate whether plasma levels of free fatty acids (FFAs) are independently associated with incidence of type 2 diabetes...
  6. ncbi request reprint Cardiometabolic risk in impaired fasting glucose and impaired glucose tolerance: the Atherosclerosis Risk in Communities Study
    James S Pankow
    Division of EpidemiologyCommunity Health, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454, USA
    Diabetes Care 30:325-31. 2007
    ..We compared and contrasted cardiovascular disease (CVD) risk factors, subclinical manifestations of CVD, incident coronary heart disease (CHD), and all-cause mortality by categories of impaired glucose regulation in nondiabetic individuals...
  7. ncbi request reprint Further evidence of a quantitative trait locus on chromosome 18 influencing postural change in systolic blood pressure: the Hypertension Genetic Epidemiology Network (HyperGEN) Study
    James S Pankow
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota 55454, USA
    Am J Hypertens 18:672-8. 2005
    ..The objective of this study was to characterize further a possible quantitative trait locus on chromosome 18q21 influencing SBP response to a postural challenge...
  8. ncbi request reprint B-mode ultrasound-detected carotid artery lesions with and without acoustic shadowing and their association with markers of inflammation and endothelial activation: the atherosclerosis risk in communities study
    Kelly J Hunt
    CVD Program, Department of Epidemiology, School of Public Health, University of North Carolina, 137 E Franklin St, Bank of America, Suite 306, Chapel Hill, NC, USA
    Atherosclerosis 162:145-55. 2002
    ..38 (95% CI: 1.10, 1.74)], a marker of endothelial activation. Associations with endothelial adhesion molecules were inconsistent. Further studies aimed at elucidating the mechanisms of arterial mineralization are warranted...
  9. ncbi request reprint Risk factors for peripheral arterial disease incidence in persons with diabetes: the Atherosclerosis Risk in Communities (ARIC) Study
    Keattiyoat Wattanakit
    Division of Epidemiology, School of Public Health, University of Minnesota, Suite 300, 1300 South 2nd Street, Minneapolis, MN 55454 1015, USA
    Atherosclerosis 180:389-97. 2005
    ..Some risk factors for peripheral arterial disease (PAD) have been identified, but little information is available on PAD risk factors in individuals with diabetes...
  10. ncbi request reprint Risk of atherosclerosis: interaction of smoking and glutathione S-transferase genes
    Andrew F Olshan
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Epidemiology 14:321-7. 2003
    ..Enzymes including glutathione S-transferase mu (GSTM1) and theta (GSTT1) are involved in the metabolism of tobacco smoke chemicals and are expressed in human vessels and smooth muscle cells...
  11. ncbi request reprint Sex-specific effects of ACE I/D and AGT-M235T on pulse pressure: the HyperGEN Study
    Amy I Lynch
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA
    Hum Genet 122:33-40. 2007
    ..This evidence for a genotype-by-sex interaction helps our understanding of the complex genetic underpinnings of blood pressure phenotypes...
  12. ncbi request reprint Genome-wide linkage scans for loci affecting total cholesterol, HDL-C, and triglycerides: the Family Blood Pressure Program
    Suzette J Bielinski
    University of Minnesota, Division of Epidemiology and Community Health, West Bank Office Building Suite 300, 1300 South 2nd Street, Minneapolis, MN 55454, USA
    Hum Genet 120:371-80. 2006
    ..The identification of these loci affecting lipid phenotypes and the apparent congruence with previous linkage results provides increased support that these regions contain genes influencing lipid levels...
  13. pmc Association of sICAM-1 and MCP-1 with coronary artery calcification in families enriched for coronary heart disease or hypertension: the NHLBI Family Heart Study
    Weihong Tang
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
    BMC Cardiovasc Disord 7:30. 2007
    ..In the follow-up exam of the NHLBI Family Heart Study, we evaluated whether plasma levels of sICAM-1 and MCP-1 were associated with coronary artery calcification (CAC), a measure of the burden of coronary atherosclerosis...
  14. pmc Variation in TCF7L2 and increased risk of colon cancer: the Atherosclerosis Risk in Communities (ARIC) Study
    Aaron R Folsom
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Suite 300, 1300 S Second St, Minneapolis, MN 55454 1015, USA
    Diabetes Care 31:905-9. 2008
    ..The purpose of this study was to determine whether a variation in the transcription factor 7-like 2 (TCF7L2) gene, which influences diabetes risk, is associated with incidence of cancers...
  15. ncbi request reprint Racial differences in the association of coronary calcified plaque with left ventricular hypertrophy: the National Heart, Lung, and Blood Institute Family Heart Study and Hypertension Genetic Epidemiology Network
    Weihong Tang
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA
    Am J Cardiol 97:1441-8. 2006
    ....
  16. doi request reprint A whole-genome scan for stroke or myocardial infarction in family blood pressure program families
    Richard Sherva
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, USA
    Stroke 39:1115-20. 2008
    ..Using data from the Family Blood Pressure Program, we tested for chromosomal regions linked to the composite phenotype of stroke or myocardial infarction in a large set of hypertensive families...
  17. pmc Influence of waist on adiponectin and insulin sensitivity in adolescence
    Laura J Rasmussen-Torvik
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA
    Obesity (Silver Spring) 17:156-61. 2009
    ..These results support the hypothesis that adiponectin may contribute to the association of waist and insulin sensitivity...
  18. pmc Circulating soluble ICAM-1 levels shows linkage to ICAM gene cluster region on chromosome 19: the NHLBI Family Heart Study follow-up examination
    Suzette J Bielinski
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA
    Atherosclerosis 199:172-8. 2008
    ..Through additional genotyping we were able to rule out rs5491 as the cause of the linkage finding. This study provides preliminary evidence linking genetic variation in the ICAM1 structural gene to circulating sICAM-1 levels...
  19. pmc ICAM1 and VCAM1 polymorphisms, coronary artery calcium, and circulating levels of soluble ICAM-1: the multi-ethnic study of atherosclerosis (MESA)
    Suzette J Bielinski
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA
    Atherosclerosis 201:339-44. 2008
    ..Our results identified ICAM1 polymorphisms that were significantly associated with sICAM-1 level but not CAC, a subclinical marker of atherosclerosis...
  20. doi request reprint Changes in insulin resistance and cardiovascular risk during adolescence: establishment of differential risk in males and females
    Antoinette Moran
    Department of Pediatrics, University of Minnesota, 516 Delaware St SE, Minneapolis, MN 55454, USA
    Circulation 117:2361-8. 2008
    ..Developmental changes in insulin resistance and cardiovascular risk were studied in youths 11 to 19 years of age...
  21. doi request reprint An alternative model for quantitative trait loci (QTL) analysis in general pedigrees
    Saonli Basu
    Division of Biostatistics, University of Minnesota, 55455, USA
    Ann Hum Genet 75:292-304. 2011
    ..The performance of these methods was also studied on a real dataset. We have demonstrated the usefulness of our approach in terms of power and robustness for linkage detection of quantitative traits in general pedigrees...
  22. pmc Genome-wide association study identifies novel loci for plasma levels of protein C: the ARIC study
    Weihong Tang
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA
    Blood 116:5032-6. 2010
    ..In summary, this first genome-wide scan for circulating protein C concentration identified both new and known loci in the general population. These findings may improve the understanding of physiologic mechanisms in protein C regulation...
  23. pmc High-molecular-weight adiponectin and the risk of type 2 diabetes in the ARIC study
    Na Zhu
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Suite 300, Minneapolis, Minnesota 55454, USA
    J Clin Endocrinol Metab 95:5097-104. 2010
    ..Adiponectin circulates in plasma as three oligomeric isoforms. High-molecular-weight (HMW) adiponectin is thought to be the most biologically active form of adiponectin in terms of glucose homeostasis...
  24. pmc Association of glycemic index and glycemic load with risk of incident coronary heart disease among Whites and African Americans with and without type 2 diabetes: the Atherosclerosis Risk in Communities study
    Dale S Hardy
    Division of Epidemiology, University of Texas School of Public Health, Houston, TX 77225, USA
    Ann Epidemiol 20:610-6. 2010
    ..In this study we examined whether high glycemic index (GI) and glycemic load (GL) diets are associated with increased risk of developing coronary heart disease (CHD) in Whites and African Americans with and without type 2 diabetes...
  25. pmc Familial aggregation of olfactory impairment and odor identification in older adults
    Laura A Raynor
    Department of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota 55454 1015, USA
    Laryngoscope 120:1614-8. 2010
    ..The objective of this analysis was to estimate the genetic contributions to olfactory impairment...
  26. pmc Preliminary report: No association between TCF7L2 rs7903146 and euglycemic-clamp-derived insulin sensitivity in a mixed-age cohort
    Laura J Rasmussen-Torvik
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454 1015, USA
    Metabolism 58:1369-71. 2009
    ..No significant associations were seen between rs7903146 and insulin sensitivity. Adjusted genotype means were consistent across races and generational subgroups...
  27. pmc Familial aggregation of age-related hearing loss in an epidemiological study of older adults
    Laura A Raynor
    Division of Epidemiology and Community Health, University of Minnesota, 1300 S Second Street, Minneapolis, MN 55454 1015, USA
    Am J Audiol 18:114-8. 2009
    ..To estimate the genetic contributions to presbycusis...
  28. pmc Suggestion for linkage of chromosome 1p35.2 and 3q28 to plasma adiponectin concentrations in the GOLDN Study
    Laura J Rasmussen-Torvik
    Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA
    BMC Med Genet 10:39. 2009
    ..Variance components analysis was used to estimate heritability and to perform genome-wide scans. Adiponectin was adjusted for age, sex, and field center. Additional models also included BMI adjustment...
  29. pmc The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents
    Laura J Rasmussen-Torvik
    Division of Epidemiology and Community Health, University of Minnesota School of Public Health, 1300 S Second St, Suite 300, Minneapolis, MN 55454 1015, USA
    Hum Genet 125:21-8. 2009
    ..There are several other variants in ADIPOQ, ADIPOR1, and ADIPOR2 that may influence insulin sensitivity and these variants should be further investigated in other populations...
  30. pmc HFE C282Y homozygotes have reduced low-density lipoprotein cholesterol: the Atherosclerosis Risk in Communities (ARIC) Study
    James S Pankow
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minn 55454, USA
    Transl Res 152:3-10. 2008
    ..Reduced LDL in C282Y homozygotes may be because of effects of excess iron on cholesterol metabolism and lipoprotein formation in the liver...
  31. pmc Lack of association between uncoupling protein-2 Ala55Val polymorphism and incident diabetes in the atherosclerosis risk in communities study
    Suzette J Bielinski
    Division of Epidemiology and Community Health, University of Minnesota, 1300 South 2nd Street, Suite 300, Minneapolis, MN 55454, USA
    Acta Diabetol 45:179-82. 2008
    ..The Ala55Val polymorphism of UCP2 was not associated with incident T2DM in the ARIC cohort...
  32. ncbi request reprint Familial clustering for features of the metabolic syndrome: the National Heart, Lung, and Blood Institute (NHLBI) Family Heart Study
    Weihong Tang
    Division of Epidemiology and Community Health, University of Minnesota, 1300 South Second St, Suite 300, Minneapolis, MN 55454, USA
    Diabetes Care 29:631-6. 2006
    ..We present a bivariate genetic analysis of MetS-related traits including both traditional and novel risk factors...
  33. ncbi request reprint Prediction of coronary heart disease in middle-aged adults with diabetes
    Aaron R Folsom
    University of Minnesota, School of Public Health, Division of Epidemiology, Minneapolis, Minnesota 55454 1015, USA
    Diabetes Care 26:2777-84. 2003
    ..To determine the 10-year probability of coronary heart disease (CHD) in diabetic adults and how well basic and novel risk factors predict CHD risk...
  34. ncbi request reprint Linkage analysis of a composite factor for the multiple metabolic syndrome: the National Heart, Lung, and Blood Institute Family Heart Study
    Weihong Tang
    Division of Epidemiology, University of Minnesota, Minneapolis 55454, USA
    Diabetes 52:2840-7. 2003
    ..34 at 240 cM. Suggestive linkage was also observed for regions on chromosomes 7, 12, 14, and 15. In summary, a genomic region on chromosome 2 may contain a pleiotropic locus contributing to the clustering of MMS-related phenotypes...
  35. ncbi request reprint Apolipoprotein E polymorphism modifies the alcohol-HDL association observed in the National Heart, Lung, and Blood Institute Family Heart Study
    Luc Djousse
    Section of Preventive Medicine and Epidemiology, Evans Department of Medicine, University of Minnesota, Minneapolis, USA
    Am J Clin Nutr 80:1639-44. 2004
    ....
  36. pmc Incidence and risk factors for cardiovascular disease in African Americans with diabetes: the Atherosclerosis Risk in Communities (ARIC) study
    Ayokanmi Adeniyi
    Division of Epidemiology, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA
    J Natl Med Assoc 94:1025-35. 2002
    ..In addition, several blood markers of hemostasis or inflammatory response and elevated serum creatinine also proved to be CVD risk factors in African Americans with diabetes...
  37. ncbi request reprint Relation of C-reactive protein to insulin resistance and cardiovascular risk factors in youth
    Antoinette Moran
    Deprtment of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Diabetes Care 28:1763-8. 2005
    ..Insulin resistance and C-reactive protein (CRP) levels are strongly correlated in adults. This study explored the relationship in youth...
  38. ncbi request reprint Family history of cancer and incidence of acute leukemia in adults
    Garth H Rauscher
    Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, Chicago, IL 60612, USA
    Am J Epidemiol 156:517-26. 2002
    ..Associations between family history of breast cancer and leukemia incidence may be the result of unmeasured, shared etiologies specific to these cancers...
  39. ncbi request reprint Plasma fatty acid composition and incidence of diabetes in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study
    Lu Wang
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454, USA
    Am J Clin Nutr 78:91-8. 2003
    ..The results of some epidemiologic studies conducted by using questionnaires suggest that dietary fat composition influences diabetes risk. Confirmation of this finding with use of a biomarker is warranted...
  40. ncbi request reprint Linkage analysis of diabetes status among hypertensive families: the Hypertension Genetic Epidemiology Network study
    Christy L Avery
    Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, NC 27514, USA
    Diabetes 53:3307-12. 2004
    ..The identification and replication of type 2 diabetes QTLs will bring us closer to the detection of functional genes that influence diabetes susceptibility...
  41. ncbi request reprint Adiponectin and the development of type 2 diabetes: the atherosclerosis risk in communities study
    Bruce B Duncan
    Graduate Studies Program in Epidemiology, UFRGS, Av Luiz Manoel Gonzaga, 630 8, Porto Alegre, RS 90470 280 Brazil
    Diabetes 53:2473-8. 2004
    ..01 for each). In conclusion, in this community-based sample of U.S. adults, higher adiponectin levels were associated with a lower incidence of diabetes...
  42. ncbi request reprint Coronary artery disease risk in familial combined hyperlipidemia and familial hypertriglyceridemia: a case-control comparison from the National Heart, Lung, and Blood Institute Family Heart Study
    Paul N Hopkins
    Cardiovascular Genetics Research, University of Utah, Salt Lake City, USA
    Circulation 108:519-23. 2003
    ..However, no population-based studies have critically addressed this issue...
  43. ncbi request reprint Evidence for a gene on chromosome 13 influencing postural systolic blood pressure change and body mass index
    Kari E North
    Department of Epidemiology, University of North Carolina Chapel Hill, Bank of America Center, 137 E Franklin St, Suite 306, Chapel Hill, NC 27514, USA
    Hypertension 43:780-4. 2004
    ..4 and 0.9, respectively). These findings suggest that a gene(s) on chromosome 13q jointly regulates the SBP response to postural change and BMI...
  44. ncbi request reprint Cardiovascular events in diabetic and nondiabetic adults with or without history of myocardial infarction
    Chong Do Lee
    Department of Sports and Exercise Sciences, West Texas A and M University, Canyon, Tex, USA
    Circulation 109:855-60. 2004
    ..We compared risks of CHD and stroke events and mortality from cardiovascular disease (CVD) in diabetic and nondiabetic men and women with and without a history of MI...
  45. ncbi request reprint Glutathione-S-transferase genotypes, smoking, and their association with markers of inflammation, hemostasis, and endothelial function: the atherosclerosis risk in communities (ARIC) study
    Eric A Miller
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    Atherosclerosis 171:265-72. 2003
    ..The results of this study provide some limited evidence that GSTM1 and GSTT1 polymorphisms modify the effect of smoking on inflammation, hemostasis, and endothelial function...
  46. pmc TCF7L2 variants associate with CKD progression and renal function in population-based cohorts
    Anna Kottgen
    Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland, USA
    J Am Soc Nephrol 19:1989-99. 2008
    ..In conclusion, several population-based samples suggest that variants in the TCF7L2 gene are associated with reduced kidney function or CKD progression, overall and specifically among participants without diabetes...
  47. pmc Blood viscosity and hematocrit as risk factors for type 2 diabetes mellitus: the atherosclerosis risk in communities (ARIC) study
    Leonardo J Tamariz
    Department of Medicine, University of Miami School of Medicine, Miami, Florida, USA
    Am J Epidemiol 168:1153-60. 2008
    ..63, 95% confidence interval: 1.49, 1.79) were over 60% more likely to develop diabetes. Therefore, elevated blood viscosity and hematocrit deserve attention as emerging risk factors for insulin resistance and type 2 diabetes mellitus...
  48. ncbi request reprint Evidence of QTL on 15q21 for high-density lipoprotein cholesterol: the National Heart, Lung, and Blood Institute Family Heart Study (NHLBI FHS)
    Mary F Feitosa
    Division of Statistical Genomics, Center for Genome Sciences, Washington University School of Medicine, 660 S Euclid, Campus Box 8067, St Louis, MO 63110 1093, USA
    Atherosclerosis 190:232-7. 2007
    ..A prominent candidate gene residing within the linkage region on 15q21 is hepatic lipase (HL), which has a major role in lipoprotein metabolism...
  49. ncbi request reprint Hepatitis C virus infection and incident type 2 diabetes
    Shruti H Mehta
    Department of Epidemiology, Johns Hopkins University, Baltimore, MD, USA
    Hepatology 38:50-6. 2003
    ..05-4.40). In conclusion, pre-existing HCV infection may increase the risk for type 2 diabetes in persons with recognized diabetes risk factors. Additional larger prospective evaluations are needed to confirm these preliminary findings...
  50. ncbi request reprint Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study
    Bruce B Duncan
    Graduate Studies Program in Epidemiology, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    Diabetes 52:1799-805. 2003
    ..7 (P for linear trend = 0.008). In conclusion, a low-grade inflammation predicts incident type 2 diabetes. The association is absent in smokers and African-Americans...
  51. ncbi request reprint Five common gene variants identify elevated genetic risk for coronary heart disease
    Lance A Bare
    Celera, Alameda, California 94502, USA
    Genet Med 9:682-9. 2007
    ....
  52. doi request reprint Genome-wide admixture mapping for coronary artery calcification in African Americans: the NHLBI Family Heart Study
    Qunyuan Zhang
    Division of Statistical Genomics, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Genet Epidemiol 32:264-72. 2008
    ..On the basis of the results from this and other independent studies, the location of D6S1053 at 80cM on chromosome 6 (6q12) seems to harbor a highly promising quantitative trait loci for atherosclerosis...
  53. ncbi request reprint Quantitative trait loci for metabolic syndrome in the Hypertension Genetic Epidemiology Network study
    Aldi T Kraja
    Division of Biostatistics, Washington University School of Medicine, Campus Box 8067, 660 South Euclid Avenue, St Louis, MO 63110 1093, USA
    Obes Res 13:1885-90. 2005
    ..The most promising candidate loci on 11q24 for lipids-INS and 13p12 for obesity-INS in blacks, 8p23 for lipids-INS, 14q24 for obesity-INS, and 15q15 for BP in whites warrant further investigation...
  54. ncbi request reprint Genetic variation of the renin-angiotensin system and chronic kidney disease progression in black individuals in the atherosclerosis risk in communities study
    Charles Chia Chuen Hsu
    Department of Epidemiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    J Am Soc Nephrol 17:504-12. 2006
    ..The AT1R C1166 allele may increase susceptibility but only in the presence of hypertension...
  55. ncbi request reprint Genome scans for blood pressure and hypertension: the National Heart, Lung, and Blood Institute Family Heart Study
    Steven C Hunt
    Cardiovascular Genetics Program, Cardiology Division, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Hypertension 40:1-6. 2002
    ..These results overlap other published scans, particularly regions on chromosomes 1 and 6, which have been implicated in familial combined hyperlipidemia...
  56. ncbi request reprint Apolipoprotein E and progression of chronic kidney disease
    Charles C Hsu
    Department of Epidemiology, The Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins Medical Institutions, Baltimore, MD 21205 2223, USA
    JAMA 293:2892-9. 2005
    ..APOE allelic associations with chronic kidney disease beyond diabetic nephropathy are unknown, with no studies reported in high-risk African American populations...
  57. ncbi request reprint Association of coronary artery calcified plaque with clinical coronary heart disease in the National Heart, Lung, and Blood Institute's Family Heart Study
    Paul N Hopkins
    Cardiovascular Genetics Research, University of Utah, Salt Lake City, Utah, USA
    Am J Cardiol 97:1564-9. 2006
    ..In conclusion, CAC was strongly associated with CHD even after adjustment for standard risk factors and family history contributed independently to CHD risk...
  58. ncbi request reprint Association study of CRP gene polymorphisms with serum CRP level and cardiovascular risk in the NHLBI Family Heart Study
    Qingwei Wang
    Cardiovascular Research Institute, Atlanta, GA 30310, USA
    Am J Physiol Heart Circ Physiol 291:H2752-7. 2006
    ....
  59. ncbi request reprint Influence of saturated fat and linolenic acid on the association between intake of dairy products and blood pressure
    Luc Djousse
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Hypertension 48:335-41. 2006
    ..This suggests that consumption of low-fat dairy products might be more beneficial for preventing HTN...
  60. ncbi request reprint Vital capacity as a predictor of incident type 2 diabetes: the Atherosclerosis Risk in Communities study
    Hsin Chieh Yeh
    The Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, 2024 E Monument St, Suite 2 600, Baltimore, MD 21205, USA
    Diabetes Care 28:1472-9. 2005
    ..To test the hypothesis that lower vital capacity is cross-sectionally associated with features of insulin resistance and is an independent predictor of incident type 2 diabetes...
  61. ncbi request reprint Parity and risk of type 2 diabetes: the Atherosclerosis Risk in Communities Study
    Wanda K Nicholson
    Johns Hopkins School of Medicine, 600 N Wolfe St, Phipps 247, Baltimore, MD 21287, USA
    Diabetes Care 29:2349-54. 2006
    ..Our objectives were to estimate the magnitude of association between parity and diabetes and to determine if higher parity is predictive of future risk of diabetes...
  62. ncbi request reprint Increased risk of type 2 diabetes from a family history of coronary heart disease and type 2 diabetes
    Edwina H Yeung
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Diabetes Care 30:154-6. 2007
  63. ncbi request reprint Relation of the metabolic syndrome to calcified atherosclerotic plaque in the coronary arteries and aorta
    R Curtis Ellison
    Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Cardiol 95:1180-6. 2005
    ..We conclude that the metabolic syndrome and most of its components are associated with a higher prevalence of calcified atherosclerotic plaque in the coronary arteries and abdominal aorta in white and African-American men and women...
  64. ncbi request reprint A prospective study of plasma ferritin level and incident diabetes: the Atherosclerosis Risk in Communities (ARIC) Study
    Megan L Jehn
    Department of Epidemiology, Welch Center for Prevention, Epidemiology, and Clinical Research, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Epidemiol 165:1047-54. 2007
    ..Longitudinal studies with repeated measurements of glucose and iron metabolism parameters are needed to establish the role of iron stores and plasma ferritin in diabetes development...
  65. ncbi request reprint Prediction of coronary heart disease risk using a genetic risk score: the Atherosclerosis Risk in Communities Study
    Alanna C Morrison
    Human Genetics Center and Division of Epidemiology, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Am J Epidemiol 166:28-35. 2007
    ..This study demonstrates the concept of aggregating information from multiple single nucleotide polymorphisms into a risk score and indicates that it can improve prediction of incident CHD in the ARIC study...
  66. ncbi request reprint Dietary linolenic acid is associated with a lower prevalence of hypertension in the NHLBI Family Heart Study
    Luc Djousse
    Section of Preventive Medicine and Epidemiology, Evans Department of Medicine, Boston University School of Medicine, Massachusetts 02118, USA
    Hypertension 45:368-73. 2005
    ..These data suggest that dietary linolenic acid is associated with a lower prevalence of hypertension and lower systolic blood pressure in white subjects...
  67. pmc Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies
    Hua Tang
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Am J Hum Genet 76:268-75. 2005
    ..S. population. Implications of this genetic structure for case-control association studies are discussed...
  68. pmc Regarding "Testing for population subdivision and association in four case-control studies"
    James S Pankow
    Am J Hum Genet 71:1478-80. 2002
  69. ncbi request reprint Re: "(Mis)use of factor analysis in the study of insulin resistance syndrome"
    Weihong Tang
    Am J Epidemiol 162:921-2; author reply 923. 2005
  70. pmc Cross-sectional and prospective study of lung function in adults with type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) study
    Hsin Chieh Yeh
    Department of Epidemiology, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Diabetes Care 31:741-6. 2008
    ..The aim of this study was to test the hypothesis that diabetes is independently associated with reduced lung function, both cross-sectionally and longitudinally...
  71. ncbi request reprint Identifying individuals at high risk for diabetes: The Atherosclerosis Risk in Communities study
    Maria Ines Schmidt
    Graduate Studies Program in Epidemiology, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    Diabetes Care 28:2013-8. 2005
    ..To develop and evaluate clinical rules to predict risk for diabetes in middle-aged adults...
  72. ncbi request reprint Retinal arteriolar narrowing and risk of diabetes mellitus in middle-aged persons
    Tien Yin Wong
    Department of Ophthalmology, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260
    JAMA 287:2528-33. 2002
    ..Microvascular processes have been hypothesized to play a role in the pathogenesis of type 2 diabetes mellitus, but prospective clinical data regarding this hypothesis are unavailable...

Research Grants16

  1. INFLAMMATORY PRECURSORS OF TYPE 2 DIABETES
    James Pankow; Fiscal Year: 2001
    ....
  2. MESA Family Study
    James Pankow; Fiscal Year: 2007
    ....
  3. INFLAMMATORY PRECURSORS OF TYPE 2 DIABETES
    James Pankow; Fiscal Year: 2007
    ..abstract_text> ..
  4. Identifying Susceptibility Genes for Metabolic Syndrome
    James Pankow; Fiscal Year: 2007
    ..Identification of genes influencing the MS will not only further the understanding of etiologic pathways that explain the clustering of abnormalities, but also may offer novel strategies for screening and prevention. ..
  5. INFLAMMATORY PRECURSORS OF TYPE 2 DIABETES
    James Pankow; Fiscal Year: 2006
    ..abstract_text> ..
  6. MESA Family Study
    James Pankow; Fiscal Year: 2006
    ....
  7. INFLAMMATORY PRECURSORS OF TYPE 2 DIABETES
    James Pankow; Fiscal Year: 2005
    ..abstract_text> ..
  8. MESA Family Study
    James Pankow; Fiscal Year: 2005
    ....
  9. TRAINING GRANT IN CVD GENETIC EPIDEMIOLOGY
    James Pankow; Fiscal Year: 2005
    ..End of Abstract) ..
  10. GENCAC - Minnesota Field Center
    James Pankow; Fiscal Year: 2004
    ..abstract_text> ..
  11. MESA Family Study
    James Pankow; Fiscal Year: 2004
    ....
  12. NHLBI FAMILY BLOOD PRESSURE PROGRAM-HYPERGEN-MPLS FC
    James Pankow; Fiscal Year: 2004
    ..The resulting synthesis of ideas and amassed data permits rigorous hypothesis testing not otherwise possible and will hasten understanding of the previously elusive genetic variation responsible for disease risk. ..
  13. INFLAMMATORY PRECURSORS OF TYPE 2 DIABETES
    James Pankow; Fiscal Year: 2002
    ....
  14. Identifying Susceptibility Genes for Metabolic Syndrome
    James Pankow; Fiscal Year: 2009
    ..Identification of genes influencing the MS will not only further the understanding of etiologic pathways that explain the clustering of abnormalities, but also may offer novel strategies for screening and prevention. ..