Research Topics
Species | Matthew S PanizzonSummaryAffiliation: University of California Country: USA Publications
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Publications
Distinct genetic influences on cortical surface area and cortical thicknessMatthew S Panizzon
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Cereb Cortex 19:2728-35. 2009..We conclude that using volume in a genetically informative study, or as an endophenotype for a disorder, may confound the underlying genetic architecture of brain structure...
Genetic architecture of learning and delayed recall: a twin study of episodic memoryMatthew S Panizzon
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Neuropsychology 25:488-98. 2011....
Genetic and environmental influences of white and gray matter signal contrast: a new phenotype for imaging genetics?Matthew S Panizzon
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Neuroimage 60:1686-95. 2012..The lack of significant genetic correlations with cortical thickness suggests that this measure potentially represents a unique source of genetic variance, one that has yet to be explored by the field of imaging genetics...
Genetic influences on hippocampal volume differ as a function of testosterone level in middle-aged menMatthew S Panizzon
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Neuroimage 59:1123-31. 2012..To the best of our knowledge, this is the first study to demonstrate that the heritability of a brain structure in adults may be modified by an endogenous biological factor...
Testosterone modifies the effect of APOE genotype on hippocampal volume in middle-aged menM S Panizzon
Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 9293 0738, USA
Neurology 75:874-80. 2010..The aim of the present study was to examine the potential interaction of testosterone and APOE genotype with respect to hippocampal volume in middle age...
A comparison of heritability maps of cortical surface area and thickness and the influence of adjustment for whole brain measures: a magnetic resonance imaging twin studyLisa T Eyler
Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
Twin Res Hum Genet 15:304-14. 2012..Implications regarding brain phenotypes for future genetic association studies are discussed...
Cross-sectional and 35-year longitudinal assessment of salivary cortisol and cognitive functioning: the Vietnam Era twin study of agingCarol E Franz
University of California San Diego, Department of Psychiatry, 9500 Gilman Drive, MC0738, La Jolla, CA 92093, USA
Psychoneuroendocrinology 36:1040-52. 2011..The results also suggest that the direction of effect is complex...
Presence of ApoE ε4 allele associated with thinner frontal cortex in middle ageChristine Fennema-Notestine
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0738, USA
J Alzheimers Dis 26:49-60. 2011..Ongoing follow-up of the VETSA sample may shed light on the potential for age- and disease-related mediation of the influence of ApoE allele status...
Genetic architecture of context processing in late middle age: more than one underlying mechanismWilliam S Kremen
Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, USA
Psychol Aging 26:852-63. 2011..In contrast, the reactive control component was unrelated to general cognitive ability...
Genetic and environmental influences on the size of specific brain regions in midlife: the VETSA MRI studyWilliam S Kremen
Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive MC 0738, La Jolla, CA 92093, USA
Neuroimage 49:1213-23. 2010..Longitudinal analysis will be needed to determine whether the degree of genetic and environmental influences changes for different ROIs from midlife to later life...
Factor structure of planning and problem-solving: a behavioral genetic analysis of the Tower of London task in middle-aged twinsWilliam S Kremen
Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, La Jolla, CA 92093 0738, USA
Behav Genet 39:133-44. 2009..The different phenotypic and genetic factor results suggest that relying solely on the former could obscure genetic associations...
Genetic influences on cortical regionalization in the human brainChi Hua Chen
Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
Neuron 72:537-44. 2011..Broad similarities in genetic patterning between rodents and humans might suggest a conservation of cortical patterning mechanisms, whereas dissimilarities might reflect the functionalities most essential to each species...
Hierarchical genetic organization of human cortical surface areaChi Hua Chen
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Science 335:1634-6. 2012..We also found that the results were consistent with human-specific regions being subdivisions of previously described, genetically based lobar regionalization patterns...
Heritability of brain ventricle volume: converging evidence from inconsistent resultsWilliam S Kremen
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Neurobiol Aging 33:1-8. 2012..These conclusions have implications for the basic understanding of the genetic and environmental underpinnings of normative and pathological brain aging...
Genetic and environmental contributions to regional cortical surface area in humans: a magnetic resonance imaging twin studyLisa T Eyler
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Cereb Cortex 21:2313-21. 2011....
Salivary cortisol and prefrontal cortical thickness in middle-aged men: A twin studyWilliam S Kremen
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Neuroimage 53:1093-102. 2010..Longitudinal assessments are underway to elucidate the direction of the associations and the genetic underpinnings of longitudinal phenotypes for changes in cortisol and brain morphology...
Genetic patterns of correlation among subcortical volumes in humans: results from a magnetic resonance imaging twin studyLisa T Eyler
Department of Psychiatry, University of California, San Diego, La Jolla, California, USA
Hum Brain Mapp 32:641-53. 2011....
A 35-year longitudinal assessment of cognition and midlife depression symptoms: the Vietnam Era Twin Study of AgingCarol E Franz
Department of Psychiatry, University of California, San Diego, 92093, USA
Am J Geriatr Psychiatry 19:559-70. 2011....
Adult romantic attachment, negative emotionality, and depressive symptoms in middle aged men: a multivariate genetic analysisCarol E Franz
Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0738, USA
Behav Genet 41:488-98. 2011..41, indicating some, but not complete overlap of genetic factors. Genetically informative longitudinal studies on attachment relationship dimensions can help to illuminate the role of relationship-based risk factors in healthy aging...
Cortical thickness is influenced by regionally specific genetic factorsLars M Rimol
Department of Radiology, University of California, San Diego, La Jolla, California 92093 0738, USA
Biol Psychiatry 67:493-9. 2010..Yet, little is known about the patterning of those genetic influences, i.e., whether the same genes influence structure throughout the brain or whether there are regionally specific sets of genes...
Storage and executive components of working memory: integrating cognitive psychology and behavior genetics in the study of agingWilliam S Kremen
Department of Psychiatry, Center for Behavioral Genomics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA
J Gerontol B Psychol Sci Soc Sci 63:P84-91. 2008..We discuss the findings in the context of research suggesting that new genetic influences come into play if demand continues to increase beyond a certain threshold, a threshold that may change with task difficulty and with age...
A twin study of spatial and non-spatial delayed response performance in middle ageWilliam S Kremen
Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, La Jolla, CA 92093 0738, USA
Brain Cogn 76:43-51. 2011..Compared with findings from small, selected control samples, high "failure" rates in this community-based sample raise concerns about interpretation of brain dysfunction in elderly or patient samples...
Genetic and environmental multidimensionality of well- and ill-being in middle aged twin menCarol E Franz
Department of Psychiatry, University of California San Diego, MC0738, La Jolla, CA 92093, USA
Behav Genet 42:579-91. 2012..All measures had specific unique environmental influences. Results indicate that well-being is genetically and environmentally multidimensional and that ill-being has partial overlap with both latent factors...
