MICHAEL PANGBURN

Summary

Affiliation: University of Texas Health Center
Country: USA

Publications

  1. ncbi request reprint Cutting edge: localization of the host recognition functions of complement factor H at the carboxyl-terminal: implications for hemolytic uremic syndrome
    Michael K Pangburn
    Department of Biochemistry, University of Texas Health Science Center, Tyler 75708, USA
    J Immunol 169:4702-6. 2002
  2. pmc Discrimination between host and pathogens by the complement system
    Michael K Pangburn
    Department of Biochemistry, Center for Biomedical Research, University of Texas Health Science Center, Tyler, TX 75708, USA
    Vaccine 26:I15-21. 2008
  3. pmc Polyanion-induced self-association of complement factor H
    Michael K Pangburn
    Department of Biochemistry, Center for Biomedical Research, University of Texas Health Science Center, Tyler, TX 75708, USA
    J Immunol 182:1061-8. 2009
  4. ncbi request reprint Critical role of the C-terminal domains of factor H in regulating complement activation at cell surfaces
    Viviana P Ferreira
    Department of Biochemistry, Center for Biomedical Research, University of Texas, Health Science Center, Tyler, TX 75708, USA
    J Immunol 177:6308-16. 2006
  5. pmc The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome
    Viviana P Ferreira
    Department of Biochemistry, Center for Biomedical Research, University of Texas Health Science Center, Tyler, TX 75708, USA
    J Immunol 182:7009-18. 2009
  6. ncbi request reprint Role of the C3b-binding site on C4b-binding protein in regulating classical pathway C5 convertase
    Nenoo Rawal
    Department of Biochemistry, University of Texas Health Science Center, 11937 US Highway 271, Tyler, TX 75708 3154, USA
    Mol Immunol 44:1105-14. 2007
  7. ncbi request reprint Formation of high affinity C5 convertase of the classical pathway of complement
    Nenoo Rawal
    Department of Biochemistry, University of Texas Health Science Center, Tyler, Texas 75703, USA
    J Biol Chem 278:38476-83. 2003
  8. pmc Factor H mediated cell surface protection from complement is critical for the survival of PNH erythrocytes
    Viviana P Ferreira
    Department of Biochemistry, Center for Biomedical Research, University of Texas Health Science Center, Tyler, TX 75708, USA
    Blood 110:2190-2. 2007
  9. ncbi request reprint Interaction of human factor H with PspC of Streptococcus pneumoniae
    Sandhya Dave
    Departments of Microbiology, The University of Texas Health Science Center, Tyler, TX 75708, USA
    Indian J Med Res 119:66-73. 2004
  10. ncbi request reprint A novel vector for the expression of SCR domains in insect cells
    M Nurul Alam
    Department of Biochemistry, University of Texas Health Science Center, 11937 U S Hwy 271, Tyler, TX 75703, USA
    J Immunol Methods 293:107-13. 2004

Research Grants

  1. ACTIVATION OF THE ALTERNATIVE PATHWAY OF COMPLEMENT
    MICHAEL PANGBURN; Fiscal Year: 2007
  2. ACTIVATION OF THE ALTERNATIVE PATHWAY OF COMPLEMENT
    MICHAEL PANGBURN; Fiscal Year: 2006
  3. ACTIVATION OF THE ALTERNATIVE PATHWAY OF COMPLEMENT
    MICHAEL PANGBURN; Fiscal Year: 1992
  4. ACTIVATION OF THE ALTERNATIVE PATHWAY OF COMPLEMENT
    Michael K Pangburn; Fiscal Year: 2010

Collaborators

  • Viviana P Ferreira
  • Paul N Barlow
  • David Kavanagh
  • M Lyon
  • Sven Hammerschmidt
  • Nenoo Rawal
  • Andrew P Herbert
  • Sandhya Dave
  • Dusan Uhrin
  • Larry S McDaniel
  • Henry G Hocking
  • Obolbek A Turapov
  • Dinesh C Soares
  • Lauren M Hook
  • Lisa R Quin
  • Stephanie Carmicle
  • M Nurul Alam
  • Andrew R Bottrill
  • Galina V Mukamolova
  • Bärbel S Blaum
  • Christoph Q Schmidt
  • Jon A Deakin
  • Claire Egan
  • Ming Jiang
  • Harvey M Friedman
  • John M Lubinski
  • Jason P Evenhuis
  • Corunda Pruitt
  • Maladi Sreedhar
  • Aftabul Haque

Detail Information

Publications18

  1. ncbi request reprint Cutting edge: localization of the host recognition functions of complement factor H at the carboxyl-terminal: implications for hemolytic uremic syndrome
    Michael K Pangburn
    Department of Biochemistry, University of Texas Health Science Center, Tyler 75708, USA
    J Immunol 169:4702-6. 2002
    ..The resulting uncontrolled activation of complement on susceptible host tissues appears to be the initiating event behind the acute renal failure of familial HUS patients...
  2. pmc Discrimination between host and pathogens by the complement system
    Michael K Pangburn
    Department of Biochemistry, Center for Biomedical Research, University of Texas Health Science Center, Tyler, TX 75708, USA
    Vaccine 26:I15-21. 2008
    ....
  3. pmc Polyanion-induced self-association of complement factor H
    Michael K Pangburn
    Department of Biochemistry, Center for Biomedical Research, University of Texas Health Science Center, Tyler, TX 75708, USA
    J Immunol 182:1061-8. 2009
    ..The results suggest that recognition of polyanionic markers on host cells and tissues by factor H, and the resulting regulation of complement activation, may involve formation of dimers and tetramers of factor H...
  4. ncbi request reprint Critical role of the C-terminal domains of factor H in regulating complement activation at cell surfaces
    Viviana P Ferreira
    Department of Biochemistry, Center for Biomedical Research, University of Texas, Health Science Center, Tyler, TX 75708, USA
    J Immunol 177:6308-16. 2006
    ....
  5. pmc The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome
    Viviana P Ferreira
    Department of Biochemistry, Center for Biomedical Research, University of Texas Health Science Center, Tyler, TX 75708, USA
    J Immunol 182:7009-18. 2009
    ..Taken together, our data suggest that disruption of a complex fH-self-surface recognition process, involving a balance of affinities for protein and physiological carbohydrate ligands, predisposes to aHUS...
  6. ncbi request reprint Role of the C3b-binding site on C4b-binding protein in regulating classical pathway C5 convertase
    Nenoo Rawal
    Department of Biochemistry, University of Texas Health Science Center, 11937 US Highway 271, Tyler, TX 75708 3154, USA
    Mol Immunol 44:1105-14. 2007
    ..Although deposition of additional C3b molecules is necessary to convert a C3 convertase to a high affinity C5 convertase, the additional C3b molecules play no role in the regulation of C5 convertase by C4BP...
  7. ncbi request reprint Formation of high affinity C5 convertase of the classical pathway of complement
    Nenoo Rawal
    Department of Biochemistry, University of Texas Health Science Center, Tyler, Texas 75703, USA
    J Biol Chem 278:38476-83. 2003
    ....
  8. pmc Factor H mediated cell surface protection from complement is critical for the survival of PNH erythrocytes
    Viviana P Ferreira
    Department of Biochemistry, Center for Biomedical Research, University of Texas Health Science Center, Tyler, TX 75708, USA
    Blood 110:2190-2. 2007
    ..The results indicate that cells deficient in surface-bound regulators are protected for extended periods of time by factor H...
  9. ncbi request reprint Interaction of human factor H with PspC of Streptococcus pneumoniae
    Sandhya Dave
    Departments of Microbiology, The University of Texas Health Science Center, Tyler, TX 75708, USA
    Indian J Med Res 119:66-73. 2004
    ..The present study was carried out to map the binding regions on PspC and FH, and to assess the functional activity of FH upon binding to PspC...
  10. ncbi request reprint A novel vector for the expression of SCR domains in insect cells
    M Nurul Alam
    Department of Biochemistry, University of Texas Health Science Center, 11937 U S Hwy 271, Tyler, TX 75703, USA
    J Immunol Methods 293:107-13. 2004
    ..As a demonstration of its usefulness, the constitutive extracellular expression of five SCR-containing proteins derived from complement factor H is presented...
  11. pmc Digestion of native proteins for proteomics using a thermocycler
    Obolbek A Turapov
    Department of Biochemistry, Center for Biomedical Research, University of Texas Health Science Center, Tyler, Texas 75708, USA
    Anal Chem 80:6093-9. 2008
    ..Samples were directly spotted on the MALDI-TOF target plate, without additional purification, thus reducing losses on reversed-phase resins...
  12. ncbi request reprint Dual roles of PspC, a surface protein of Streptococcus pneumoniae, in binding human secretory IgA and factor H
    Sandhya Dave
    Department of Microbiology, University of Mississippi Medical Center, Jackson, MS 39216, USA
    J Immunol 173:471-7. 2004
    ..These PspC variants bind FH yet fail to bind sIgA. Thus, we conclude that FH and sIgA can bind concurrently to the alpha-helical region of PspC...
  13. ncbi request reprint Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism
    Andrew P Herbert
    Edinburgh Biomolecular NMR Unit, School of Chemistry and School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, Scotland, United Kingdom
    J Biol Chem 282:18960-8. 2007
    ....
  14. ncbi request reprint In vivo binding of complement regulator factor H by Streptococcus pneumoniae
    Lisa R Quin
    Department of Microbiology, University of Mississippi Medical Center, Jackson, MS 39216, USA
    J Infect Dis 192:1996-2003. 2005
    ..These results suggest that the interaction between PspC and FH contributes to pneumococcal virulence...
  15. pmc Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations
    Henry G Hocking
    Edinburgh Biomolecular NMR Unit, Schools of Chemistry and Biological Sciences, Joseph Black Chemistry Bldg, University of Edinburgh, West Mains Road, Edinburgh, United Kingdom
    J Biol Chem 283:9475-87. 2008
    ....
  16. ncbi request reprint Disease-associated sequence variations in factor H: a structural biology approach
    Andrew P Herbert
    School of Chemistry Institute of Structural and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JJ, UK
    Adv Exp Med Biol 586:313-27. 2006
  17. pmc Herpes simplex virus type 1 and 2 glycoprotein C prevents complement-mediated neutralization induced by natural immunoglobulin M antibody
    Lauren M Hook
    Infectious Disease Division, Department of Medicine, 502 Johnson Pavilion, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6073, USA
    J Virol 80:4038-46. 2006
    ..These findings indicate that humans differ in the ability of their innate immune systems to neutralize HSV-1 or HSV-2 gC-null virus and that a critical function of gC1 and gC2 is to prevent C5 activation...
  18. ncbi request reprint Disease-associated sequence variations congregate in a polyanion recognition patch on human factor H revealed in three-dimensional structure
    Andrew P Herbert
    Edinburgh Biomolecular NMR Unit, University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, United Kingdom
    J Biol Chem 281:16512-20. 2006
    ..It is intriguing that a single nucleotide polymorphism predisposing to age-related macular degeneration occupies another region of factor H that harbors a polyanion-binding site...

Research Grants16

  1. ACTIVATION OF THE ALTERNATIVE PATHWAY OF COMPLEMENT
    MICHAEL PANGBURN; Fiscal Year: 2007
    ..Recent discoveries point to the alternative pathway of complement as a major contributor to these diseases. This proposal will examine the molecular events leading to tissue damage in these and other diseases. ..
  2. ACTIVATION OF THE ALTERNATIVE PATHWAY OF COMPLEMENT
    MICHAEL PANGBURN; Fiscal Year: 2006
    ..abstract_text> ..
  3. ACTIVATION OF THE ALTERNATIVE PATHWAY OF COMPLEMENT
    MICHAEL PANGBURN; Fiscal Year: 1992
    ..The model would be useful in predicting effects of complement depletion and deficiencies, in simulating anaphylatoxin release, in modeling changes in acute phase proteins and in the design and evaluation of drugs which affect complement...
  4. ACTIVATION OF THE ALTERNATIVE PATHWAY OF COMPLEMENT
    Michael K Pangburn; Fiscal Year: 2010
    ..Recent discoveries point to the alternative pathway of complement as a major contributor to these diseases. This proposal will examine the molecular events leading to tissue damage in these and other diseases. ..