Research Topics
Species | MICHAEL PANGBURNSummaryAffiliation: University of Texas Health Center Country: USA Publications
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Publications
Cutting edge: localization of the host recognition functions of complement factor H at the carboxyl-terminal: implications for hemolytic uremic syndromeMichael K Pangburn
Department of Biochemistry, University of Texas Health Science Center, Tyler 75708, USA
J Immunol 169:4702-6. 2002..The resulting uncontrolled activation of complement on susceptible host tissues appears to be the initiating event behind the acute renal failure of familial HUS patients...
Discrimination between host and pathogens by the complement systemMichael K Pangburn
Department of Biochemistry, Center for Biomedical Research, University of Texas Health Science Center, Tyler, TX 75708, USA
Vaccine 26:I15-21. 2008....- Polyanion-induced self-association of complement factor HMichael K Pangburn
Department of Biochemistry, Center for Biomedical Research, University of Texas Health Science Center, Tyler, TX 75708, USA
J Immunol 182:1061-8. 2009..The results suggest that recognition of polyanionic markers on host cells and tissues by factor H, and the resulting regulation of complement activation, may involve formation of dimers and tetramers of factor H... - Critical role of the C-terminal domains of factor H in regulating complement activation at cell surfacesViviana P Ferreira
Department of Biochemistry, Center for Biomedical Research, University of Texas, Health Science Center, Tyler, TX 75708, USA
J Immunol 177:6308-16. 2006.... - The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndromeViviana P Ferreira
Department of Biochemistry, Center for Biomedical Research, University of Texas Health Science Center, Tyler, TX 75708, USA
J Immunol 182:7009-18. 2009..Taken together, our data suggest that disruption of a complex fH-self-surface recognition process, involving a balance of affinities for protein and physiological carbohydrate ligands, predisposes to aHUS... - Role of the C3b-binding site on C4b-binding protein in regulating classical pathway C5 convertaseNenoo Rawal
Department of Biochemistry, University of Texas Health Science Center, 11937 US Highway 271, Tyler, TX 75708 3154, USA
Mol Immunol 44:1105-14. 2007..Although deposition of additional C3b molecules is necessary to convert a C3 convertase to a high affinity C5 convertase, the additional C3b molecules play no role in the regulation of C5 convertase by C4BP... - Formation of high affinity C5 convertase of the classical pathway of complementNenoo Rawal
Department of Biochemistry, University of Texas Health Science Center, Tyler, Texas 75703, USA
J Biol Chem 278:38476-83. 2003.... - Factor H mediated cell surface protection from complement is critical for the survival of PNH erythrocytesViviana P Ferreira
Department of Biochemistry, Center for Biomedical Research, University of Texas Health Science Center, Tyler, TX 75708, USA
Blood 110:2190-2. 2007..The results indicate that cells deficient in surface-bound regulators are protected for extended periods of time by factor H... - Interaction of human factor H with PspC of Streptococcus pneumoniaeSandhya Dave
Departments of Microbiology, The University of Texas Health Science Center, Tyler, TX 75708, USA
Indian J Med Res 119:66-73. 2004..Thus, binding of FH to PspC might be an important mechanism by which S. pneumoniae resist complement activation and opsonophagocytosis... - A novel vector for the expression of SCR domains in insect cellsM Nurul Alam
Department of Biochemistry, University of Texas Health Science Center, 11937 U.S. Hwy 271, Tyler, TX 75703, USA
J Immunol Methods 293:107-13. 2004..As a demonstration of its usefulness, the constitutive extracellular expression of five SCR-containing proteins derived from complement factor H is presented... - Digestion of native proteins for proteomics using a thermocyclerObolbek A Turapov
Department of Biochemistry, Center for Biomedical Research, University of Texas Health Science Center, Tyler, Texas 75708, USA
Anal Chem 80:6093-9. 2008..Samples were directly spotted on the MALDI-TOF target plate, without additional purification, thus reducing losses on reversed-phase resins... - Dual roles of PspC, a surface protein of Streptococcus pneumoniae, in binding human secretory IgA and factor HSandhya Dave
Department of Microbiology, University of Mississippi Medical Center, Jackson, MS 39216, USA
J Immunol 173:471-7. 2004..These PspC variants bind FH yet fail to bind sIgA. Thus, we conclude that FH and sIgA can bind concurrently to the alpha-helical region of PspC... - Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphismAndrew P Herbert
Edinburgh Biomolecular NMR Unit, School of Chemistry and School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, Scotland, United Kingdom
J Biol Chem 282:18960-8. 2007.... - In vivo binding of complement regulator factor H by Streptococcus pneumoniaeLisa R Quin
Department of Microbiology, University of Mississippi Medical Center, Jackson, MS 39216, USA
J Infect Dis 192:1996-2003. 2005..These results suggest that the interaction between PspC and FH contributes to pneumococcal virulence... - Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variationsHenry G Hocking
Edinburgh Biomolecular NMR Unit, Schools of Chemistry and Biological Sciences, Joseph Black Chemistry Bldg, University of Edinburgh, West Mains Road, Edinburgh, United Kingdom
J Biol Chem 283:9475-87. 2008.... - Disease-associated sequence variations in factor H: a structural biology approachAndrew P Herbert
School of Chemistry/Institute of Structural and Molecular Biology, University of Edinburgh, King's Buildings, Edinburgh EH9 3JJ, UK
Adv Exp Med Biol 586:313-27. 2006 - Herpes simplex virus type 1 and 2 glycoprotein C prevents complement-mediated neutralization induced by natural immunoglobulin M antibodyLauren M Hook
Infectious Disease Division, Department of Medicine, 502 Johnson Pavilion, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6073, USA
J Virol 80:4038-46. 2006..These findings indicate that humans differ in the ability of their innate immune systems to neutralize HSV-1 or HSV-2 gC-null virus and that a critical function of gC1 and gC2 is to prevent C5 activation... - Disease-associated sequence variations congregate in a polyanion recognition patch on human factor H revealed in three-dimensional structureAndrew P Herbert
Edinburgh Biomolecular NMR Unit, University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, United Kingdom
J Biol Chem 281:16512-20. 2006..It is intriguing that a single nucleotide polymorphism predisposing to age-related macular degeneration occupies another region of factor H that harbors a polyanion-binding site...
Research Grants
- ACTIVATION OF THE ALTERNATIVE PATHWAY OF COMPLEMENTMICHAEL PANGBURN; Fiscal Year: 2007..Recent discoveries point to the alternative pathway of complement as a major contributor to these diseases. This proposal will examine the molecular events leading to tissue damage in these and other diseases. ..
- ACTIVATION OF THE ALTERNATIVE PATHWAY OF COMPLEMENTMICHAEL PANGBURN; Fiscal Year: 2006..abstract_text> ..
- ACTIVATION OF THE ALTERNATIVE PATHWAY OF COMPLEMENTMICHAEL PANGBURN; Fiscal Year: 1992..The model would be useful in predicting effects of complement depletion and deficiencies, in simulating anaphylatoxin release, in modeling changes in acute phase proteins and in the design and evaluation of drugs which affect complement...
- ACTIVATION OF THE ALTERNATIVE PATHWAY OF COMPLEMENTMichael K Pangburn; Fiscal Year: 2010..Recent discoveries point to the alternative pathway of complement as a major contributor to these diseases. This proposal will examine the molecular events leading to tissue damage in these and other diseases. ..