M K Pangburn

Summary

Affiliation: University of Texas Health Center
Country: USA

Publications

  1. ncbi Molecular mechanisms of target recognition in an innate immune system: interactions among factor H, C3b, and target in the alternative pathway of human complement
    M K Pangburn
    Department of Biochemistry, University of Texas Health Science Center, Tyler, TX 75708, USA
    J Immunol 164:4742-51. 2000
  2. ncbi Host recognition and target differentiation by factor H, a regulator of the alternative pathway of complement
    M K Pangburn
    Department of Biochemistry, University of Texas Health Science Center, Tyler 75708, USA
    Immunopharmacology 49:149-57. 2000
  3. ncbi Critical role of the C-terminal domains of factor H in regulating complement activation at cell surfaces
    Viviana P Ferreira
    Department of Biochemistry, Center for Biomedical Research, University of Texas, Health Science Center, Tyler, TX 75708, USA
    J Immunol 177:6308-16. 2006
  4. ncbi Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism
    Andrew P Herbert
    Edinburgh Biomolecular NMR Unit, School of Chemistry and School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, Scotland, United Kingdom
    J Biol Chem 282:18960-8. 2007
  5. ncbi Factor H mediated cell surface protection from complement is critical for the survival of PNH erythrocytes
    Viviana P Ferreira
    Department of Biochemistry, Center for Biomedical Research, University of Texas Health Science Center, Tyler, TX 75708, USA
    Blood 110:2190-2. 2007
  6. ncbi In vivo binding of complement regulator factor H by Streptococcus pneumoniae
    Lisa R Quin
    Department of Microbiology, University of Mississippi Medical Center, Jackson, MS 39216, USA
    J Infect Dis 192:1996-2003. 2005
  7. ncbi Role of the C3b-binding site on C4b-binding protein in regulating classical pathway C5 convertase
    Nenoo Rawal
    Department of Biochemistry, University of Texas Health Science Center, 11937 US Highway 271, Tyler, TX 75708 3154, USA
    Mol Immunol 44:1105-14. 2007
  8. ncbi Interaction of human factor H with PspC of Streptococcus pneumoniae
    Sandhya Dave
    Departments of Microbiology, The University of Texas Health Science Center, Tyler, TX 75708, USA
    Indian J Med Res 119:66-73. 2004
  9. ncbi Dual roles of PspC, a surface protein of Streptococcus pneumoniae, in binding human secretory IgA and factor H
    Sandhya Dave
    Department of Microbiology, University of Mississippi Medical Center, Jackson, MS 39216, USA
    J Immunol 173:471-7. 2004
  10. ncbi Formation of high affinity C5 convertase of the classical pathway of complement
    Nenoo Rawal
    Department of Biochemistry, University of Texas Health Science Center, Tyler, Texas 75703, USA
    J Biol Chem 278:38476-83. 2003

Collaborators

  • S Meri
  • M Lyon
  • Nenoo Rawal
  • David Kavanagh
  • Sven Hammerschmidt
  • Andrew P Herbert
  • Viviana P Ferreira
  • Paul N Barlow
  • Sandhya Dave
  • Henry G Hocking
  • Dusan Uhrin
  • Larry S McDaniel
  • Obolbek A Turapov
  • Dinesh C Soares
  • Lauren M Hook
  • Lisa R Quin
  • Stephanie Carmicle
  • M Nurul Alam
  • Galina V Mukamolova
  • Andrew R Bottrill
  • Bärbel S Blaum
  • Jon A Deakin
  • Claire Egan
  • Christoph Q Schmidt
  • Ming Jiang
  • John M Lubinski
  • Harvey M Friedman
  • Jason P Evenhuis
  • Corunda Pruitt
  • Aftabul Haque
  • Maladi Sreedhar

Detail Information

Publications17

  1. ncbi Molecular mechanisms of target recognition in an innate immune system: interactions among factor H, C3b, and target in the alternative pathway of human complement
    M K Pangburn
    Department of Biochemistry, University of Texas Health Science Center, Tyler, TX 75708, USA
    J Immunol 164:4742-51. 2000
    ..The results reveal a complex molecular mechanism of discrimination between microbes and host in this ancient innate defense system and help explain the different rates and intensities of APC activation on different biological particles...
  2. ncbi Host recognition and target differentiation by factor H, a regulator of the alternative pathway of complement
    M K Pangburn
    Department of Biochemistry, University of Texas Health Science Center, Tyler 75708, USA
    Immunopharmacology 49:149-57. 2000
    ..Organisms using one or more of these evasive techniques include Neisseria gonorrhoeae, Streptococcus pyogenes, Yersinia enterocolitica, Trypanosoma cruzi, and the HIV virus...
  3. ncbi Critical role of the C-terminal domains of factor H in regulating complement activation at cell surfaces
    Viviana P Ferreira
    Department of Biochemistry, Center for Biomedical Research, University of Texas, Health Science Center, Tyler, TX 75708, USA
    J Immunol 177:6308-16. 2006
    ....
  4. ncbi Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism
    Andrew P Herbert
    Edinburgh Biomolecular NMR Unit, School of Chemistry and School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, Scotland, United Kingdom
    J Biol Chem 282:18960-8. 2007
    ....
  5. ncbi Factor H mediated cell surface protection from complement is critical for the survival of PNH erythrocytes
    Viviana P Ferreira
    Department of Biochemistry, Center for Biomedical Research, University of Texas Health Science Center, Tyler, TX 75708, USA
    Blood 110:2190-2. 2007
    ..The results indicate that cells deficient in surface-bound regulators are protected for extended periods of time by factor H...
  6. ncbi In vivo binding of complement regulator factor H by Streptococcus pneumoniae
    Lisa R Quin
    Department of Microbiology, University of Mississippi Medical Center, Jackson, MS 39216, USA
    J Infect Dis 192:1996-2003. 2005
    ..These results suggest that the interaction between PspC and FH contributes to pneumococcal virulence...
  7. ncbi Role of the C3b-binding site on C4b-binding protein in regulating classical pathway C5 convertase
    Nenoo Rawal
    Department of Biochemistry, University of Texas Health Science Center, 11937 US Highway 271, Tyler, TX 75708 3154, USA
    Mol Immunol 44:1105-14. 2007
    ..Although deposition of additional C3b molecules is necessary to convert a C3 convertase to a high affinity C5 convertase, the additional C3b molecules play no role in the regulation of C5 convertase by C4BP...
  8. ncbi Interaction of human factor H with PspC of Streptococcus pneumoniae
    Sandhya Dave
    Departments of Microbiology, The University of Texas Health Science Center, Tyler, TX 75708, USA
    Indian J Med Res 119:66-73. 2004
    ..Thus, binding of FH to PspC might be an important mechanism by which S. pneumoniae resist complement activation and opsonophagocytosis...
  9. ncbi Dual roles of PspC, a surface protein of Streptococcus pneumoniae, in binding human secretory IgA and factor H
    Sandhya Dave
    Department of Microbiology, University of Mississippi Medical Center, Jackson, MS 39216, USA
    J Immunol 173:471-7. 2004
    ..These PspC variants bind FH yet fail to bind sIgA. Thus, we conclude that FH and sIgA can bind concurrently to the alpha-helical region of PspC...
  10. ncbi Formation of high affinity C5 convertase of the classical pathway of complement
    Nenoo Rawal
    Department of Biochemistry, University of Texas Health Science Center, Tyler, Texas 75703, USA
    J Biol Chem 278:38476-83. 2003
    ....
  11. ncbi Cutting edge: localization of the host recognition functions of complement factor H at the carboxyl-terminal: implications for hemolytic uremic syndrome
    Michael K Pangburn
    Department of Biochemistry, University of Texas Health Science Center, Tyler 75708, USA
    J Immunol 169:4702-6. 2002
    ..The resulting uncontrolled activation of complement on susceptible host tissues appears to be the initiating event behind the acute renal failure of familial HUS patients...
  12. ncbi Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations
    Henry G Hocking
    Edinburgh Biomolecular NMR Unit, Schools of Chemistry and Biological Sciences, Joseph Black Chemistry Bldg, University of Edinburgh, West Mains Road, Edinburgh, United Kingdom
    J Biol Chem 283:9475-87. 2008
    ....
  13. ncbi Disease-associated sequence variations in factor H: a structural biology approach
    Andrew P Herbert
    School of Chemistry/Institute of Structural and Molecular Biology, University of Edinburgh, King's Buildings, Edinburgh EH9 3JJ, UK
    Adv Exp Med Biol 586:313-27. 2006
  14. ncbi Herpes simplex virus type 1 and 2 glycoprotein C prevents complement-mediated neutralization induced by natural immunoglobulin M antibody
    Lauren M Hook
    Infectious Disease Division, Department of Medicine, 502 Johnson Pavilion, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6073, USA
    J Virol 80:4038-46. 2006
    ..These findings indicate that humans differ in the ability of their innate immune systems to neutralize HSV-1 or HSV-2 gC-null virus and that a critical function of gC1 and gC2 is to prevent C5 activation...
  15. ncbi Disease-associated sequence variations congregate in a polyanion recognition patch on human factor H revealed in three-dimensional structure
    Andrew P Herbert
    Edinburgh Biomolecular NMR Unit, University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, United Kingdom
    J Biol Chem 281:16512-20. 2006
    ..It is intriguing that a single nucleotide polymorphism predisposing to age-related macular degeneration occupies another region of factor H that harbors a polyanion-binding site...
  16. ncbi A novel vector for the expression of SCR domains in insect cells
    M Nurul Alam
    Department of Biochemistry, University of Texas Health Science Center, 11937 U.S. Hwy 271, Tyler, TX 75703, USA
    J Immunol Methods 293:107-13. 2004
    ..As a demonstration of its usefulness, the constitutive extracellular expression of five SCR-containing proteins derived from complement factor H is presented...
  17. ncbi Digestion of native proteins for proteomics using a thermocycler
    Obolbek A Turapov
    Department of Biochemistry, Center for Biomedical Research, University of Texas Health Science Center, Tyler, Texas 75708, USA
    Anal Chem 80:6093-9. 2008
    ..Samples were directly spotted on the MALDI-TOF target plate, without additional purification, thus reducing losses on reversed-phase resins...