REYNOLD ALEXANDER PANETTIERI

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc 20-HETE mediates ozone-induced, neutrophil-independent airway hyper-responsiveness in mice
    Philip R Cooper
    Department of Medicine and the Airways Biology Initiative, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 5:e10235. 2010
  2. pmc An RGS4-mediated phenotypic switch of bronchial smooth muscle cells promotes fixed airway obstruction in asthma
    Gautam Damera
    Airways Biology Initiative, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e28504. 2012
  3. pmc Anaphylatoxin C3a receptors in asthma
    Hydar Ali
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, 240 South 40th Street, Philadelphia, PA 19104, USA
    Respir Res 6:19. 2005
  4. pmc Expression and activation of the oxytocin receptor in airway smooth muscle cells: Regulation by TNFalpha and IL-13
    Yassine Amrani
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, TRL Suite 1200, 125 South 31st Street, Philadelphia, PA 19104, USA
    Respir Res 11:104. 2010
  5. pmc Regulation of the cd38 promoter in human airway smooth muscle cells by TNF-alpha and dexamethasone
    Krishnaswamy G Tirumurugaan
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St, Paul, MN, USA
    Respir Res 9:26. 2008
  6. pmc Susceptibility to ozone-induced airway inflammation is associated with decreased levels of surfactant protein D
    S Kierstein
    University of Pennsylvania, Philadelphia, PA, USA
    Respir Res 7:85. 2006
  7. pmc The effect of IL-13 and IL-13R130Q, a naturally occurring IL-13 polymorphism, on the gene expression of human airway smooth muscle cells
    Farhat Syed
    Centocor Inc, 200 Great Valley Parkway, Malvern, PA 19355, USA
    Respir Res 6:9. 2005
  8. pmc Chronic obstructive pulmonary disease and inhaled steroids alter surfactant protein D (SP-D) levels: a cross-sectional study
    Michael W Sims
    Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Respir Res 9:13. 2008
  9. ncbi request reprint Effects of corticosteroids on structural cells in asthma and chronic obstructive pulmonary disease
    Reynold A Panettieri
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania Medical Center, 421 Curie Boulevard, BRB II III, Philadelphia, PA 19104 6160, USA
    Proc Am Thorac Soc 1:231-4. 2004
  10. ncbi request reprint Airway smooth muscle: immunomodulatory cells that modulate airway remodeling?
    Reynold A Panettieri
    Pulmonary, Allergy and Critical Care Division, University of Pennsylvania Medical Center, 421 Curie Boulevard, 805 BRB II III, Philadelphia, Pennsylvania, PA 19104 6160, USA
    Respir Physiol Neurobiol 137:277-93. 2003

Research Grants

Collaborators

Detail Information

Publications88

  1. pmc 20-HETE mediates ozone-induced, neutrophil-independent airway hyper-responsiveness in mice
    Philip R Cooper
    Department of Medicine and the Airways Biology Initiative, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 5:e10235. 2010
    ..We postulate oxidized lipids mediate in vivo ozone-induced AHR in murine airways...
  2. pmc An RGS4-mediated phenotypic switch of bronchial smooth muscle cells promotes fixed airway obstruction in asthma
    Gautam Damera
    Airways Biology Initiative, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e28504. 2012
    ..These studies indicate that increased RGS4 expression promotes a phenotypic switch of ASM, evoking irreversible airway obstruction in subjects with severe asthma...
  3. pmc Anaphylatoxin C3a receptors in asthma
    Hydar Ali
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, 240 South 40th Street, Philadelphia, PA 19104, USA
    Respir Res 6:19. 2005
    ..Therefore, C3a likely plays an important role in asthma primarily by regulating mast cell-ASM cell interaction...
  4. pmc Expression and activation of the oxytocin receptor in airway smooth muscle cells: Regulation by TNFalpha and IL-13
    Yassine Amrani
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, TRL Suite 1200, 125 South 31st Street, Philadelphia, PA 19104, USA
    Respir Res 11:104. 2010
    ..The purpose of this study was to define the role of oxytocin in modulating human airway smooth muscle (HASMCs) function in the presence and absence of IL-13 and TNFalpha, cytokines known to be important in asthma...
  5. pmc Regulation of the cd38 promoter in human airway smooth muscle cells by TNF-alpha and dexamethasone
    Krishnaswamy G Tirumurugaan
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St, Paul, MN, USA
    Respir Res 9:26. 2008
    ..In this study, we determined whether the transcriptional regulation of CD38 expression in HASM cells involves response elements within the promoter region of this gene...
  6. pmc Susceptibility to ozone-induced airway inflammation is associated with decreased levels of surfactant protein D
    S Kierstein
    University of Pennsylvania, Philadelphia, PA, USA
    Respir Res 7:85. 2006
    ..We have shown previously that SP-D plays a protective role in a mouse model of allergic airway inflammation. Here we studied the role and regulation of SP-D in O3-induced inflammatory changes in the lung...
  7. pmc The effect of IL-13 and IL-13R130Q, a naturally occurring IL-13 polymorphism, on the gene expression of human airway smooth muscle cells
    Farhat Syed
    Centocor Inc, 200 Great Valley Parkway, Malvern, PA 19355, USA
    Respir Res 6:9. 2005
    ..In this report, we hypothesize that IL-13 may participate in the pathogenesis of asthma by activating a set of "pro-asthmatic" genes in airway smooth muscle (ASM) cells...
  8. pmc Chronic obstructive pulmonary disease and inhaled steroids alter surfactant protein D (SP-D) levels: a cross-sectional study
    Michael W Sims
    Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Respir Res 9:13. 2008
    ..Deficiency of this molecule induces emphysematous changes in murine lungs, but its significance in human COPD remains unclear...
  9. ncbi request reprint Effects of corticosteroids on structural cells in asthma and chronic obstructive pulmonary disease
    Reynold A Panettieri
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania Medical Center, 421 Curie Boulevard, BRB II III, Philadelphia, PA 19104 6160, USA
    Proc Am Thorac Soc 1:231-4. 2004
    ..Therapeutic approaches designed to modulate chemokine and cytokine secretion by structural cells may offer new opportunities to treat diseases characterized by airway obstruction...
  10. ncbi request reprint Airway smooth muscle: immunomodulatory cells that modulate airway remodeling?
    Reynold A Panettieri
    Pulmonary, Allergy and Critical Care Division, University of Pennsylvania Medical Center, 421 Curie Boulevard, 805 BRB II III, Philadelphia, Pennsylvania, PA 19104 6160, USA
    Respir Physiol Neurobiol 137:277-93. 2003
    ....
  11. doi request reprint Natural history of asthma: persistence versus progression-does the beginning predict the end?
    Reynold A Panettieri
    Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, Philadelphia, PA 19104 3403, USA
    J Allergy Clin Immunol 121:607-13. 2008
    ..These findings, however, might not apply to adults, and further study in adults is needed to determine the effect of inhaled corticosteroid therapy on disease progression...
  12. doi request reprint Asthma persistence versus progression: does airway smooth muscle function predict irreversible airflow obstruction?
    Reynold A Panettieri
    Pulmonary, Allergy and Critical Care Division, Airways Biology Initiative, University of Pennsylvania, Philadelphia, Pennsylvania 19104 3403, USA
    Allergy Asthma Proc 30:103-8. 2009
    ....
  13. ncbi request reprint Comparison of the efficacy and safety of arformoterol 15 microg twice daily and arformoterol 30 microg once daily in COPD: a single-dose, multicenter, randomized, modified-blind, two-way crossover study
    Reynold A Panettieri
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 3403, USA
    Clin Ther 31:1716-23. 2009
    ....
  14. ncbi request reprint Patients' and primary care physicians' beliefs about asthma control and risk
    Reynold A Panettieri
    Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Allergy Asthma Proc 30:519-28. 2009
    ..Gaps exist between patients' understanding of asthma control and their use of controller and quick-relief medications. Many patients and physicians fail to recognize that, even with symptom abatement, serious asthma risks remain...
  15. pmc β2-adrenergic receptor agonists modulate human airway smooth muscle cell migration via vasodilator-stimulated phosphoprotein
    Elena A Goncharova
    Airways Biology Initiative, Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Pennsylvania, Philadelphia, 19104, USA
    Am J Respir Cell Mol Biol 46:48-54. 2012
    ....
  16. ncbi request reprint Cellular and molecular mechanisms regulating airway smooth muscle proliferation and cell adhesion molecule expression
    R A Panettieri
    Pulmonary and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Respir Crit Care Med 158:S133-40. 1998
    ....
  17. ncbi request reprint Mechanisms of cytokine effects on G protein-coupled receptor-mediated signaling in airway smooth muscle
    R M Pascual
    Division of Critical Care, Pulmonary, Allergic, and Immunological Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Physiol Lung Cell Mol Physiol 281:L1425-35. 2001
    ..These data demonstrate disparity in the requirement and sufficiency of COX-2 induction in promoting different functional effects of IL-1 beta and TNF-alpha in HASM...
  18. ncbi request reprint Ozone inhalation induces exacerbation of eosinophilic airway inflammation and hyperresponsiveness in allergen-sensitized mice
    S Kierstein
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 3403, USA
    Allergy 63:438-46. 2008
    ..We used a murine model to characterize the effects of O(3) on allergic airway inflammation and hyperresponsiveness and to identify factors that might contribute to the O(3)-induced exacerbation of asthma...
  19. ncbi request reprint TGF-beta 1 modulates EGF-stimulated phosphatidylinositol 3-kinase activity in human airway smooth muscle cells
    V P Krymskaya
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Am J Physiol 273:L1220-7. 1997
    ....
  20. ncbi request reprint Arrestin specificity for G protein-coupled receptors in human airway smooth muscle
    R B Penn
    Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 276:32648-56. 2001
    ....
  21. ncbi request reprint CD40-mediated signal transduction in human airway smooth muscle
    A L Lazaar
    Department of Medicine, Hospital of University of Pennsylvania, Philadelphia 19104, USA
    J Immunol 161:3120-7. 1998
    ..Together, these results suggest a mechanism whereby T cell/smooth muscle cell interactions may potentiate airway inflammation...
  22. ncbi request reprint Airway smooth muscle as an immunomodulatory cell: a new target for pharmacotherapy?
    A L Lazaar
    Pulmonary, Allergy and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia 19104 6160, USA
    Curr Opin Pharmacol 1:259-64. 2001
    ..The cellular and molecular mechanisms that regulate the immunomodulatory functions of airway smooth muscle may offer new and important therapeutic targets in treating this common lung disease...
  23. pmc Activation of tumor necrosis factor receptor 1 in airway smooth muscle: a potential pathway that modulates bronchial hyper-responsiveness in asthma?
    Y Amrani
    Pulmonary, Allergy and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6160, USA
    Respir Res 1:49-53. 2000
    ....
  24. ncbi request reprint Tumor necrosis factor receptor (TNFR) 1, but not TNFR2, mediates tumor necrosis factor-alpha-induced interleukin-6 and RANTES in human airway smooth muscle cells: role of p38 and p42/44 mitogen-activated protein kinases
    Y Amrani
    Department of Medicine, Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6160, USA
    Mol Pharmacol 60:646-55. 2001
    ..Our data suggest that despite the presence of functional TNFR2, TNFR1 associated with MAPK-dependent and -independent pathways is the primary signaling pathway involved in TNF alpha-induced synthetic functions in ASM cells...
  25. ncbi request reprint Interferon-gamma modulates cysteinyl leukotriene receptor-1 expression and function in human airway myocytes
    Y Amrani
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6160, USA
    Am J Respir Crit Care Med 164:2098-101. 2001
    ..Our data suggest that increased levels of IFN-gamma in asthmatic individuals may promote airway hyperresponsiveness and asthma exacerbations by directly modulating contractile responses of HASM...
  26. ncbi request reprint Aspergillus fumigatus-induced allergic airway inflammation alters surfactant homeostasis and lung function in BALB/c mice
    A Haczku
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Am J Respir Cell Mol Biol 25:45-50. 2001
    ..These changes may contribute significantly to the pathophysiology of Af-induced allergic airway hyperresponsiveness...
  27. ncbi request reprint Up-regulation of ICAM-1 by cytokines in human tracheal smooth muscle cells involves an NF-kappa B-dependent signaling pathway that is only partially sensitive to dexamethasone
    Y Amrani
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    J Immunol 163:2128-34. 1999
    ..Together, these data demonstrate that cytokine-mediated NF-kappa B activation and ICAM-1 expression involve activation of a steroid-insensitive pathway...
  28. ncbi request reprint Activation of p55 tumor necrosis factor-alpha receptor-1 coupled to tumor necrosis factor receptor-associated factor 2 stimulates intercellular adhesion molecule-1 expression by modulating a thapsigargin-sensitive pathway in human tracheal smooth muscle c
    Y Amrani
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia 19104 6160, USA
    Mol Pharmacol 58:237-45. 2000
    ..These data suggest that TNFR1, through a TNF receptor-associated factor 2-NF-kappaB signaling pathway, mediates TNFalpha-induced expression of ICAM-1 on ASM cells by involving a thapsigargin-sensitive signaling pathway...
  29. ncbi request reprint Activation of class IA PI3K stimulates DNA synthesis in human airway smooth muscle cells
    V P Krymskaya
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Am J Physiol Lung Cell Mol Physiol 280:L1009-18. 2001
    ..Collectively, these data suggest that class IA PI3K is activated by thrombin and is sufficient to induce ASM cell growth...
  30. pmc Vitamin D inhibits growth of human airway smooth muscle cells through growth factor-induced phosphorylation of retinoblastoma protein and checkpoint kinase 1
    G Damera
    University of Pennsylvania, Philadelphia, 19104 3403, USA
    Br J Pharmacol 158:1429-41. 2009
    ..We hypothesized that calcitriol, a secosteroidal vitamin D receptor (VDR) modulator, would inhibit growth factor-induced myocyte proliferation...
  31. ncbi request reprint Pharmacological inhibition of protein kinases in intact cells: antagonism of beta adrenergic receptor ligand binding by H-89 reveals limitations of usefulness
    R B Penn
    Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Pharmacol Exp Ther 288:428-37. 1999
    ..Results from additional pharmacological and biochemical analyses of various protein kinase inhibitors further established the need for careful characterization of pharmacological inhibitors when used in intact cell models...
  32. ncbi request reprint A small animal model of regional alveolar ventilation using HP 3He MRI1
    Z Z Spector
    Department of Radiology, University of Pennsylvania School of Medicine, Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    Acad Radiol 11:1171-9. 2004
    ..The aim of this study was to establish a standardized procedure for the measurement of regional fractional ventilation in a healthy rat model as a baseline for further studies of pulmonary disorder models...
  33. ncbi request reprint IL-13 and IL-4 cause eotaxin release in human airway smooth muscle cells: a role for ERK
    Paul E Moore
    Physiology Program, Harvard School of Public Health, 665 Huntington Ave, Bldg 1 Rm 311, Boston, MA 02115, USA
    Am J Physiol Lung Cell Mol Physiol 282:L847-53. 2002
    ....
  34. ncbi request reprint Cooperative mitogenic signaling by G protein-coupled receptors and growth factors is dependent on G(q/11)
    Kok Choi Kong
    Department of Internal Medicine and Center for Human Genomics, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, North Carolina 27157, USA
    FASEB J 20:1558-60. 2006
    ..Thus, G(q/11)-coupled receptors are the principal GPCR subfamily mediating cooperative mitogenic signaling in ASM, acting through Gbetagamma-dependent, and Src/arrestin-independent activation of PI3K and p70S6K...
  35. ncbi request reprint Airway smooth muscle as a regulator of immune responses and bronchomotor tone
    Aili L Lazaar
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania Medical Center, BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104 6160, USA
    Clin Chest Med 27:53-69, vi. 2006
    ..This article also discusses how altered synthetic function contributes to airway remodeling...
  36. ncbi request reprint Adenoviral mediated anti-sense CD38 attenuates TNF-alpha-induced changes in calcium homeostasis of human airway smooth muscle cells
    Bit Na Kang
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
    Can J Physiol Pharmacol 83:799-804. 2005
    ..001). These results provide evidence for the feasibility of using adenoviral vectors for gene transfer to down regulate gene expression, and confirm the role of CD38 in calcium homeostatis in ASM cells...
  37. ncbi request reprint Cooperative regulation of p70S6 kinase by receptor tyrosine kinases and G protein-coupled receptors augments airway smooth muscle growth
    Charlotte K Billington
    Department of Internal Medicine, Wake Forest University Health Sciences Center, Winston Salem, North Carolina 27157, USA
    Biochemistry 44:14595-605. 2005
    ..These data suggest that PI3K-dependent T389/T229 phosphorylation is limiting in late-phase p70S6K activation by EGF and contributes to the cooperative effect of GPCRs on p70S6K activity and cell growth...
  38. ncbi request reprint Hyperpolarized 3He MRI in asthma measurements of regional ventilation following allergic sensitization and challenge in mice--preliminary results
    Angela Haczku
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104 6100, USA
    Acad Radiol 12:1362-70. 2005
    ..The objective of this study was to investigate regional ventilation changes in the mouse lung following allergen sensitization and challenge...
  39. ncbi request reprint Cytokines regulate beta-2-adrenergic receptor responsiveness in airway smooth muscle via multiple PKA- and EP2 receptor-dependent mechanisms
    Manhong Guo
    Department of Internal Medicine and Center for Human Genomics, Wake Forest University Health Sciences Center, Winston Salem, NC 27157, USA
    Biochemistry 44:13771-82. 2005
    ..These findings identify EP2 receptor- and PKA-dependent mechanisms as the principal effectors of cytokine-mediated beta2AR desensitization in ASM...
  40. ncbi request reprint TGF-beta potentiates airway smooth muscle responsiveness to bradykinin
    Jenny H Kim
    Pulmonary, Allergy, and Critical Care Division, Dept of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Physiol Lung Cell Mol Physiol 289:L511-20. 2005
    ....
  41. ncbi request reprint Cyclic mechanical strain-induced proliferation and migration of human airway smooth muscle cells: role of EMMPRIN and MMPs
    Nadia A Hasaneen
    Department of Medicine and Research, VAMC Northport, Northport, New York, USA
    FASEB J 19:1507-9. 2005
    ..This increase in proliferation and migration is through an increase in MMP release and activation. Pharmacological MMPIs should be considered in the pursuit of therapeutic options for airway remodeling in asthma...
  42. ncbi request reprint Expression and muscarinic receptor coupling of Lyn kinase in cultured human airway smooth muscle cells
    Thomas Pertel
    Dept of Anesthesiology, College of Physicians and Surgeons of Columbia Univ, 630 W 168th St, P and S Box 46, New York, NY 10032, USA
    Am J Physiol Lung Cell Mol Physiol 290:L492-500. 2006
    ....
  43. ncbi request reprint Functional expression of the GABAB receptor in human airway smooth muscle
    Yoko Osawa
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, 630 W 168th St, P and S Box 46, New York, NY 10032, USA
    Am J Physiol Lung Cell Mol Physiol 291:L923-31. 2006
    ..Functional GABA(B) receptors are expressed in HASM. GABA may modulate an uncharacterized signaling cascade via GABA(B) receptors coupled to the G(i) protein in airway smooth muscle...
  44. ncbi request reprint Regulation of inflammation by airway smooth muscle
    Omar Tliba
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania, Philadelphia, PA 19104 3403, USA
    Curr Allergy Asthma Rep 8:262-8. 2008
    ....
  45. pmc Essential role of IFNbeta and CD38 in TNFalpha-induced airway smooth muscle hyper-responsiveness
    Deepika Jain
    Pulmonary and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Immunobiology 213:499-509. 2008
    ..These data provide the first evidence that ASM-derived IFNbeta and CD38 may play a significant role in the development of TNFalpha-associated AHR...
  46. pmc Glucocorticoid regulation of CD38 expression in human airway smooth muscle cells: role of dual specificity phosphatase 1
    Bit Na Kang
    Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, Minnesota 55108, USA
    Am J Physiol Lung Cell Mol Physiol 295:L186-93. 2008
    ..The glucocorticoid effects on decreased CD38 expression and function result from regulation through transcription and transcript stability...
  47. ncbi request reprint Sphingosine-1-phosphate stimulates contraction of human airway smooth muscle cells
    Hans M Rosenfeldt
    Department of Biochemistry, Medical College of Virginia Campus, Virginia Commonwealth University, 2 011 Sanger Hall, 1101 E Marshall St, Richmond, Virginia 23298 0614, USA
    FASEB J 17:1789-99. 2003
    ..Collectively, our results suggest that S1P may regulate HASM contractility, important in the pathobiology of asthma...
  48. doi request reprint Is airway smooth muscle the "missing link" modulating airway inflammation in asthma?
    Omar Tliba
    Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, 125 South 31st St, Philadelphia, PA 19104 3403, USA
    Chest 133:236-42. 2008
    ..This review addresses the immunomodulatory function of ASM and highlights how such function may have therapeutic implications in the management of asthma...
  49. ncbi request reprint Interferon beta augments tuberous sclerosis complex 2 (TSC2)-dependent inhibition of TSC2-null ELT3 and human lymphangioleiomyomatosis-derived cell proliferation
    Elena A Goncharova
    Department of Medicine, University of Pennsylvania, TRL Suite 1200, 125 South 31st Street, Philadelphia, PA 19104, USA
    Mol Pharmacol 73:778-88. 2008
    ....
  50. ncbi request reprint Inhibition of human airway smooth muscle cell proliferation by beta 2-adrenergic receptors and cAMP is PKA independent: evidence for EPAC involvement
    Karen M Kassel
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5800, USA
    Am J Physiol Lung Cell Mol Physiol 294:L131-8. 2008
    ....
  51. ncbi request reprint Mitogenic effects of cytokines on smooth muscle are critically dependent on protein kinase A and are unmasked by steroids and cyclooxygenase inhibitors
    Anna M Misior
    Wake Forest University Health Sciences Center, Center for Human Genomics, Medical Center Blvd, Winston Salem NC 27157, USA
    Mol Pharmacol 73:566-74. 2008
    ....
  52. ncbi request reprint Angiogenesis is induced by airway smooth muscle strain
    Nadia A Hasaneen
    The Department of Medicine and Research, Veterans Affairs Medical Center, Northport, New York, USA
    Am J Physiol Lung Cell Mol Physiol 293:L1059-68. 2007
    ..VEGF release by mechanical strain of HASM may contribute to the angiogenesis seen with repeated exacerbation of asthma and COPD...
  53. ncbi request reprint Phosphodiesterases regulate airway smooth muscle function in health and disease
    Vera P Krymskaya
    Department of Medicine, Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Curr Top Dev Biol 79:61-74. 2007
    ..This chapter will focus on recent advances in our understanding of the role of PDE in regulating ASM function...
  54. ncbi request reprint Cross-talk between tuberin, calmodulin, and estrogen signaling pathways
    Brian York
    Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    FASEB J 19:1202-4. 2005
    ..Cumulatively, data presented here support the hypothesis that interactions between tuberin, ERalpha, and CaM may play a critical role in the pathology of LAM disease...
  55. ncbi request reprint Isoproterenol induces actin depolymerization in human airway smooth muscle cells via activation of an Src kinase and GS
    Carol A Hirshman
    Dept of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Am J Physiol Lung Cell Mol Physiol 288:L924-31. 2005
    ....
  56. ncbi request reprint Regulation of TNF-alpha- and IFN-gamma-induced CXCL10 expression: participation of the airway smooth muscle in the pulmonary inflammatory response in chronic obstructive pulmonary disease
    Elizabeth L Hardaker
    GlaxoSmithKline, Respiratory and Inflammation, Centre for Excellence in Drug Discovery, King of Prussia, Pennsylvania 19406, USA
    FASEB J 18:191-3. 2004
    ..These data demonstrate a potential active role for hASM in pulmonary inflammatory diseases such as COPD by producing CXCL10...
  57. ncbi request reprint Tumor necrosis factor alpha modulates airway smooth muscle function via the autocrine action of interferon beta
    Omar Tliba
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 278:50615-23. 2003
    ..Together these data show that TNFalpha, via the autocrine action of IFNbeta, differentially regulates the expression of proinflammatory genes and DNA synthesis...
  58. ncbi request reprint Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)
    Elena A Goncharova
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania, 421 Curie Boulevard, 847 BRB II III, Philadelphia, PA 19104, USA
    J Biol Chem 277:30958-67. 2002
    ..These data demonstrate that tuberin negatively regulates the activity of S6 and p70S6K specifically, and suggest a potential mechanism for abnormal cell growth in LAM...
  59. ncbi request reprint TNF-[alpha] modulates murine tracheal rings responsiveness to G-protein-coupled receptor agonists and KCl
    Hang Chen
    Deparment of Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 1904, USA
    J Appl Physiol (1985) 95:864-72; discussion 863. 2003
    ..Taken together, these data suggest that TNF-alpha may participate in the development of airway hyperresponsiveness in asthma via the modulation of ASM responsiveness to both contractile and beta-adrenoceptor GPCR agonists...
  60. ncbi request reprint Effect of dexamethasone on beta2-adrenergic desensitization in airway smooth muscle: role of the ARG19 polymorphism
    Paul E Moore
    Departments of Pediatrics and Pharmacology Dr Moore and Mr Calder, Vanderbilt University School of Medicine, Nashville, TN 37232 2586, USA
    Chest 123:368S-9S. 2003
  61. ncbi request reprint Receptors and pathways mediating the effects of prostaglandin E2 on airway tone
    Stephen L Tilley
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill, 27599 7248, USA
    Am J Physiol Lung Cell Mol Physiol 284:L599-606. 2003
    ..This segregation of EP receptor function within the airway suggests that PGE(2) analogs that selectively activate the EP2 receptor without activating the EP1/EP3 receptors might prove useful in the treatment of asthma...
  62. ncbi request reprint Cyclic AMP-mobilizing agents and glucocorticoids modulate human smooth muscle cell migration
    Elena A Goncharova
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    Am J Respir Cell Mol Biol 29:19-27. 2003
    ..Collectively, these findings demonstrate that cAMP-mobilizing agents and steroids modulate human smooth muscle cell migration, likely by distinct mechanisms...
  63. ncbi request reprint Bradykinin induces interleukin-6 production in human airway smooth muscle cells: modulation by Th2 cytokines and dexamethasone
    Chien Da Huang
    Department of Thoracic Medicine II, Chang Gung Memorial Hospital, Taipei, Taiwan
    Am J Respir Cell Mol Biol 28:330-8. 2003
    ..Moreover, IL-6 secretion by BK is sensitive to corticosteroids and is regulated by Th(2)-derived cytokines...
  64. ncbi request reprint IFN-gamma inhibits human airway smooth muscle cell proliferation by modulating the E2F-1/Rb pathway
    Yassine Amrani
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Am J Physiol Lung Cell Mol Physiol 284:L1063-71. 2003
    ....
  65. ncbi request reprint Interleukin-9 influences chemokine release in airway smooth muscle: role of ERK
    Simonetta Baraldo
    Physiology Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Physiol Lung Cell Mol Physiol 284:L1093-102. 2003
    ..Our results indicate that airway smooth muscle is a target for IL-9 and that IL-9 amplifies the potential for these cells to recruit eosinophils and neutrophils into the airways by a mechanism involving ERK...
  66. ncbi request reprint Airway smooth muscle: contraction and beyond
    Yassine Amrani
    Department of Medicine, University of Pennsylvania Medical Center, Pulmonary, Allergy and Critical Care Division, 848 BRB II III 421 Curie Boulevard, Philadelphia PA 19104, USA
    Int J Biochem Cell Biol 35:272-6. 2003
    ..Displays phenotypic modulation of mechanical, synthetic and proliferative responses. 5. Secretes cytokines, chemokines and extracellular matrix proteins. 6. May serve as a potential new target for the treatment of chronic lung diseases...
  67. ncbi request reprint CD38/cyclic ADP-ribose-mediated Ca2+ signaling contributes to airway smooth muscle hyper-responsiveness
    Deepak A Deshpande
    Department of Veterinary Pathobiology, University of Minnesota, St Paul, Minnesota 55108, USA
    FASEB J 17:452-4. 2003
    ..This study provides the first demonstration of a role for CD38-cADPR signaling in a model of inflammatory airway disease...
  68. ncbi request reprint Airway smooth muscle: an immunomodulatory cell
    Reynold A Panettieri
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, PA 19104 6160, USA
    J Allergy Clin Immunol 110:S269-74. 2002
    ..The cellular and molecular mechanisms that regulate the immunomodulatory functions of airway smooth muscle may offer new and important therapeutic targets in treating these common lung diseases...
  69. ncbi request reprint Effect of IL-1beta on CRE-dependent gene expression in human airway smooth muscle cells
    Thomas Lahiri
    Physiology Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Physiol Lung Cell Mol Physiol 283:L1239-46. 2002
    ....
  70. ncbi request reprint PI3K is required for proliferation and migration of human pulmonary vascular smooth muscle cells
    Elena A Goncharova
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6160, USA
    Am J Physiol Lung Cell Mol Physiol 283:L354-63. 2002
    ..These results demonstrate that PI3K signaling is both necessary and sufficient to mediate human PVSM cell proliferation and migration and suggest that the activation of PI3K may play an important role in vascular remodeling...
  71. pmc IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscle
    Omar Tliba
    Department of Medicine, Pulmonary Allergy and Critical Care Division, University of Pennsylvania, BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Br J Pharmacol 140:1159-62. 2003
    ..The present study demonstrates that IL-13 may promote BHR by directly modulating ASM contractility, an effect that may be due to enhanced G protein-coupled receptor (GPCR)-associated calcium signaling...
  72. ncbi request reprint Is airway remodeling clinically relevant in asthma?
    Aili L Lazaar
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Med 115:652-9. 2003
    ....
  73. ncbi request reprint CD38/cyclic ADP-ribose signaling: role in the regulation of calcium homeostasis in airway smooth muscle
    Deepak A Deshpande
    Dept of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, MN 55108, USA
    Am J Physiol Lung Cell Mol Physiol 288:L773-88. 2005
    ....
  74. ncbi request reprint Airway smooth muscle cells enhance C3a-induced mast cell degranulation following cell-cell contact
    E Berla Thangam
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104 6002, USA
    FASEB J 19:798-800. 2005
    ....
  75. ncbi request reprint Oncostatin M causes eotaxin-1 release from airway smooth muscle: synergy with IL-4 and IL-13
    Debora S Faffe
    Physiology Program, Harvard School of Public Health, Boston, Mass 02115, USA
    J Allergy Clin Immunol 115:514-20. 2005
    ..Eotaxin is implicated in asthmatic eosinophilia. Oncostatin M (OSM) causes eotaxin release from fibroblasts...
  76. ncbi request reprint Src is necessary and sufficient for human airway smooth muscle cell proliferation and migration
    Vera P Krymskaya
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, 421 Curie Blvd, BRB II III, Philadelphia, PA 19104 6160, USA
    FASEB J 19:428-30. 2005
    ....
  77. ncbi request reprint Phosphatidylinositol 3-kinase but not tuberin is required for PDGF-induced cell migration
    Carla Irani
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Am J Physiol Lung Cell Mol Physiol 282:L854-62. 2002
    ..These data suggest that PI 3-kinase is required for growth factor-induced cell migration and loss of tuberin appears to have little effect on cell migration...
  78. ncbi request reprint Airway smooth muscle: immunomodulatory cells?
    Reynold A Panettieri
    Pulmonary, Allergy and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6160, USA
    Allergy Asthma Proc 25:381-6. 2004
    ....
  79. ncbi request reprint Oncostatin M causes VEGF release from human airway smooth muscle: synergy with IL-1beta
    Debora S Faffe
    Physiology Program, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Am J Physiol Lung Cell Mol Physiol 288:L1040-8. 2005
    ..This is the first description of a role for OSM on IL-1R1 expression in any cell type. OSM may contribute to airway remodeling observed in chronic airway disease...
  80. ncbi request reprint Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth muscle cells: modulation by glucocorticoids and beta-agonists
    Alaina J Ammit
    Faculty of Pharmacy, University of Sydney, Sydney, Australia
    Am J Respir Cell Mol Biol 26:465-74. 2002
    ....
  81. ncbi request reprint Modulation of calcium homeostasis as a mechanism for altering smooth muscle responsiveness in asthma
    Yassine Amrani
    Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, 848 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Curr Opin Allergy Clin Immunol 2:39-45. 2002
    ..Studies using isolated bronchial preparations or cultured cells show that inflammatory mediators and cytokines may alter calcium homeostasis in airway smooth muscle and render the cells nonspecifically hyperreactive to agonists...
  82. ncbi request reprint Synthetic responses in airway smooth muscle
    Peter H Howarth
    Respiratory Cell and Molecular Biology, Southampton General Hospital, Southampton, United Kingdom
    J Allergy Clin Immunol 114:S32-50. 2004
    ..Combinations of long-acting beta(2)-agonists and corticosteroids appear to have additive and/or synergistic effects in inhibiting inflammatory mediator release and the migration and proliferation of ASM cells...
  83. ncbi request reprint Tumor necrosis factor-alpha differentially regulates the expression of proinflammatory genes in human airway smooth muscle cells by activation of interferon-beta-dependent CD38 pathway
    Omar Tliba
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6160, USA
    Mol Pharmacol 66:322-9. 2004
    ..Our study is the first to demonstrate that IFNbeta-dependent activation of CD38 pathway is a novel component by which TNFalpha differentially regulates the expression of inflammatory genes in ASM cells...
  84. ncbi request reprint Bronchial hyperresponsiveness: insights into new signaling molecules
    Yassine Amrani
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Curr Opin Pharmacol 4:230-4. 2004
    ..Thus, a better understanding of these signaling molecules that alter calcium signaling and contractility of ASM might provide new insight into novel therapeutic targets for the control of bronchial hyperresponsiveness...
  85. ncbi request reprint Transgenic smooth muscle expression of the human CysLT1 receptor induces enhanced responsiveness of murine airways to leukotriene D4
    Guochang Yang
    Center for Experimental Therapeutics, Rm 814BRBII III, Univ of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104 6160, USA
    Am J Physiol Lung Cell Mol Physiol 286:L992-1001. 2004
    ..These results indicate that a selective hCysLT(1)R-induced contractile mechanism synergizes with allergic AHR. We speculate that hCysLT(1)R signaling contributes to a hypercontractile state of the airway smooth muscle...
  86. ncbi request reprint Modulation of calcium signaling by interleukin-13 in human airway smooth muscle: role of CD38/cyclic adenosine diphosphate ribose pathway
    Deepak A Deshpande
    Department of Veterinary Pathobiology, University of Minnesota, St Paul, MN, USA
    Am J Respir Cell Mol Biol 31:36-42. 2004
    ..These findings indicate that the CD38/cADPR-dependent pathway has a major role in IL-13-induced modulation of calcium signaling in human ASM...
  87. pmc Attenuated allergic airway hyperresponsiveness in C57BL/6 mice is associated with enhanced surfactant protein (SP)-D production following allergic sensitization
    Elena N Atochina
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia, PA, USA
    Respir Res 4:15. 2003
    ..We hypothesized that an elevated SP-D production is associated with the impaired ability of C57BL/6 mice to develop allergic AHR...
  88. ncbi request reprint Mast cell chymase modifies cell-matrix interactions and inhibits mitogen-induced proliferation of human airway smooth muscle cells
    Aili L Lazaar
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 169:1014-20. 2002
    ..These data suggest that the local release of mast cell chymase may have profound effects on ASM cell function and airway remodeling...

Research Grants26

  1. MECHANISMS REGULATING FUNCTIONS OF AIRWAY SMOOTH MUSCLE
    Reynold Panettieri; Fiscal Year: 2002
    ..By understanding the mechanisms by which ASM synthetic responses are regulated, new issues in the pathogenesis of asthma will be addressed and therapeutic measures to prevent these alterations can be developed. ..
  2. RGS: A Molecular Switch Regulating Irreversible ASM Growth/Contraction in Asthma
    REYNOLD ALEXANDER PANETTIERI; Fiscal Year: 2010
    ..Our studies will identify the key mechanisms by which RGS proteins regulate ASM growth and contractility while providing insight into therapeutic targets to abrogate ASM hyperplasia and hyperresponsiveness in asthma. (End of Abstract) ..
  3. MECHANISMS REGULATING AIRWAY MUSCLE GROWTH
    Reynold Panettieri; Fiscal Year: 2001
    ..These studies will define the mechanism by which agonists induce ASM cell growth such that new issues in the pathogenesis of asthma will be addressed and therapeutic measures to prevent these alterations can be developed. ..
  4. MECHANISMS REGULATING FUNCTIONS OF AIRWAY SMOOTH MUSCLE
    Reynold Panettieri; Fiscal Year: 2000
    ..By understanding the mechanisms by which ASM synthetic responses are regulated, new issues in the pathogenesis of asthma will be addressed and therapeutic measures to prevent these alterations can be developed. ..
  5. MECHANISMS REGULATING FUNCTIONS OF AIRWAY SMOOTH MUSCLE
    Reynold Panettieri; Fiscal Year: 1999
    ..By understanding the mechanisms by which ASM synthetic responses are regulated, new issues in the pathogenesis of asthma will be addressed and therapeutic measures to prevent these alterations can be developed. ..
  6. Interferons Modulate Airway Smooth Muscle Growth
    Reynold Panettieri; Fiscal Year: 2006
    ....
  7. Mechanisms of VEGF modulation of smooth muscle function
    Reynold Panettieri; Fiscal Year: 2009
    ..abstract_text> ..
  8. RGS: A Molecular Switch Regulating Irreversible ASM Growth/Contraction in Asthma
    Reynold Panettieri; Fiscal Year: 2009
    ..Our studies will identify the key mechanisms by which RGS proteins regulate ASM growth and contractility while providing insight into therapeutic targets to abrogate ASM hyperplasia and hyperresponsiveness in asthma. (End of Abstract) ..
  9. Mechanisms Regulation Functions of Airway Smooth Muscle
    Reynold Panettieri; Fiscal Year: 2007
    ..Thus, understanding the transcriptional mechanisms regulating the expression of inflammatory genes in ASM will likely lead to new therapeutic approaches for the treatment of asthma. ..
  10. Ozone ALTERS Airway Smooth Muscle FUNCTION IN ASTHMA
    Reynold Panettieri; Fiscal Year: 2007
    ..These studies will identify the mechanisms by which ozone enhances allergen-induced AHR and provide insight into new therapeutic targets to prevent asthma exacerbations and decrease asthma morbidity and mortality. ..
  11. Mechanisms of VEGF modulation of smooth muscle function
    Reynold Panettieri; Fiscal Year: 2007
    ....
  12. Interferons Modulate Airway Smooth Muscle Growth
    Reynold Panettieri; Fiscal Year: 2007
    ....
  13. Ozone ALTERS Airway Smooth Muscle FUNCTION IN ASTHMA
    Reynold Panettieri; Fiscal Year: 2006
    ..These studies will identify the mechanisms by which ozone enhances allergen-induced AHR and provide insight into new therapeutic targets to prevent asthma exacerbations and decrease asthma morbidity and mortality. ..
  14. MECHANISMS REGULATING AIRWAY MUSCLE GROWTH
    Reynold Panettieri; Fiscal Year: 1999
    ..By understanding the mechanisms of ASM cell growth, new issues in the pathogenesis of asthma will be addressed and therapeutic measures to prevent these alterations can be developed. ..
  15. MECHANISMS REGULATING AIRWAY MUSCLE GROWTH
    Reynold Panettieri; Fiscal Year: 2000
    ..These studies will define the mechanism by which agonists induce ASM cell growth such that new issues in the pathogenesis of asthma will be addressed and therapeutic measures to prevent these alterations can be developed. ..
  16. MECHANISMS REGULATING FUNCTIONS OF AIRWAY SMOOTH MUSCLE
    Reynold Panettieri; Fiscal Year: 2001
    ..By understanding the mechanisms by which ASM synthetic responses are regulated, new issues in the pathogenesis of asthma will be addressed and therapeutic measures to prevent these alterations can be developed. ..
  17. MECHANISMS REGULATING AIRWAY MUSCLE GROWTH
    Reynold Panettieri; Fiscal Year: 2002
    ..These studies will define the mechanism by which agonists induce ASM cell growth such that new issues in the pathogenesis of asthma will be addressed and therapeutic measures to prevent these alterations can be developed. ..
  18. MECHANISMS REGULATING AIRWAY MUSCLE GROWTH
    Reynold Panettieri; Fiscal Year: 2003
    ..These studies will define the mechanism by which agonists induce ASM cell growth such that new issues in the pathogenesis of asthma will be addressed and therapeutic measures to prevent these alterations can be developed. ..
  19. Ozone ALTERS Airway Smooth Muscle FUNCTION IN ASTHMA
    Reynold Panettieri; Fiscal Year: 2005
    ..These studies will identify the mechanisms by which ozone enhances allergen-induced AHR and provide insight into new therapeutic targets to prevent asthma exacerbations and decrease asthma morbidity and mortality. ..
  20. Interferons Modulate Airway Smooth Muscle Growth
    Reynold Panettieri; Fiscal Year: 2005
    ....