Research Topics
| John PanepintoSummaryAffiliation: University of Illinois at Chicago Country: USA Publications
Research Grants
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Detail Information
Publications
Binding of serum mannan binding lectin to a cell integrity-defective Cryptococcus neoformans ccr4Delta mutantJohn C Panepinto
University of Illinois at Chicago, Section of Infectious Diseases, Chicago, IL 60612, USA
Infect Immun 75:4769-79. 2007..Interestingly, treatment of wild-type cells with caspofungin also increased MBL binding to C. neoformans. These results suggest that both the presence of capsule and wild-type cell wall architecture preclude MBL binding to C. neoformans...- The DEAD-box RNA helicase Vad1 regulates multiple virulence-associated genes in Cryptococcus neoformansJohn Panepinto
Section of Infectious Diseases, Department of Medicine, University of Illinois at Chicago College of Medicine, Chicago, Illinois 60612, USA
J Clin Invest 115:632-41. 2005.... 
Intersection of fungal fitness and virulence in Cryptococcus neoformansJohn C Panepinto
Section of Infectious Diseases, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
FEMS Yeast Res 6:489-98. 2006..Vacuolar function, copper homeostasis, mitochondrial function and carbon repression are covered...- Role of a CUF1/CTR4 copper regulatory axis in the virulence of Cryptococcus neoformansScott R Waterman
Section of Infectious Diseases, Department of Medicine, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA
J Clin Invest 117:794-802. 2007.... - The Hsp70 member, Ssa1, acts as a DNA-binding transcriptional co-activator of laccase in Cryptococcus neoformansShirong Zhang
Section of Infectious Diseases, Department of Medicine, University of Illinois at Chicago College of Medicine, Chicago, IL, USA
Mol Microbiol 62:1090-101. 2006..Furthermore, deletion of Ssa1 results in reduced laccase and attenuated virulence using a mouse model. These results indicate that Hsp70 functions as a stress-related transcriptional co-activator required for fungal virulence... - PI3K signaling of autophagy is required for starvation tolerance and virulenceof Cryptococcus neoformansGuowu Hu
Section of Infectious Diseases, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
J Clin Invest 118:1186-97. 2008..Moreover, the data show that molecular dissection of such pathogen stress-response pathways may identify new approaches for chemotherapeutic interventions... - Cell wall targeting of laccase of Cryptococcus neoformans during infection of miceScott R Waterman
Section of Infectious Diseases, Department of Medicine, University of Illinois at Chicago College of Medicine, Chicago, IL 60612, USA
Infect Immun 75:714-22. 2007.... 
Sec6-dependent sorting of fungal extracellular exosomes and laccase of Cryptococcus neoformansJohn Panepinto
Section of Infectious Diseases, Department of Medicine, University of Illinois at Chicago College of Medicine, Chicago, IL, USA
Mol Microbiol 71:1165-76. 2009..These results provide the first molecular evidence for the existence of fungal exosomes and associate these vesicles with the virulence of C. neoformans...- Role of a VPS41 homologue in starvation response, intracellular survival and virulence of Cryptococcus neoformansXiaoguang Liu
Section of Infectious Diseases, Department of Medicine, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA
Mol Microbiol 61:1132-46. 2006..Our results indicate that VPS41 plays a key role in regulating starvation response in this pathogenic organism and that defects in cell cycle arrest are associated with attenuated pathogenic fitness in mammalian hosts... - Deletion of the regulatory subunit of protein kinase A in Aspergillus fumigatus alters morphology, sensitivity to oxidative damage, and virulenceWei Zhao
Department of Pathology and Laboratory Medicine, University of Cincinnati, P O Box 670529, Cincinnati, Ohio 45267 0529, USA
Infect Immun 74:4865-74. 2006..Unregulated PKA signaling is detrimental to the virulence of A. fumigatus, perhaps through the reduced susceptibility of the mutant to damage by oxidizing agents and reduced growth kinetics... - Disruption of the Aspergillus fumigatus gene encoding nucleolar protein CgrA impairs thermotolerant growth and reduces virulenceRuchi Bhabhra
Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, 231 Bethesda Ave, OH 45267-0529, USA
Infect Immun 72:4731-40. 2004..Together, these findings establish the intracellular localization of CgrA in A. fumigatus and demonstrate that cgrA is required for thermotolerant growth and wild-type virulence of the organism... - Aspergillus fumigatus rasA and rasB regulate the timing and morphology of asexual developmentJarrod R Fortwendel
Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45267-0529, USA
Fungal Genet Biol 41:129-39. 2004..DArasB expression led to reduced conidiation. RasA and RasB appear to play different, but overlapping, roles in the vegetative growth and asexual development of A. fumigatus... - Deletion of the Aspergillus fumigatus gene encoding the Ras-related protein RhbA reduces virulence in a model of Invasive pulmonary aspergillosisJohn C Panepinto
Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
Infect Immun 71:2819-26. 2003..The mutant showed enhanced sensitivity to the TOR kinase inhibitor rapamycin. These findings establish the importance of rhbA for A. fumigatus virulence and suggest a role for rhbA in nutrient sensing... - Expression of the Aspergillus fumigatus rheb homologue, rhbA, is induced by nitrogen starvationJohn C Panepinto
Department of Pathology and Laboratory Medicine, University of Cincinnati, P.O. Box 670529, Cincinnati, OH 45267-0529, USA
Fungal Genet Biol 36:207-14. 2002..The rhbA gene was able to complement the canavanine hypersensitivity of Saccharomyces cerevisiae Deltarhb1 mutants, suggesting that the two proteins share overlapping function... - Cloning and expression of pkaC and pkaR, the genes encoding the cAMP-dependent protein kinase of Aspergillus fumigatusBrian G Oliver
Department of Pathology and Laboratory Medicine, University of Cincinnati, OH 45267-0529, USA
Mycopathologia 154:85-91. 2002..Both subunit mRNAs are expressed throughout the asexual life cycle of A. fumigatus. Message levels of pkaR and pkaC are higher during co-cultivation with alveolar epithelial cells than during culture alone...
Research Grants
- NOT1 in stress tolerance of Cryptococcus neoformansJohn Panepinto; Fiscal Year: 2005..Exploring the NOT1 dependent stress response may reveal novel virulence factors in C. neoformans. ..