S C Pandey

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. ncbi request reprint Anxiety and alcohol abuse disorders: a common role for CREB and its target, the neuropeptide Y gene
    Subhash C Pandey
    The Psychiatric Institute, Department of Psychiatry, Anatomy and Cell Biology, University of Illinois at Chicago and VA Chicago Health Care System, 820 South Damen Avenue M C 151, Chicago, IL 60612, USA
    Trends Pharmacol Sci 24:456-60. 2003
  2. ncbi request reprint CREB gene transcription factors: role in molecular mechanisms of alcohol and drug addiction
    Subhash C Pandey
    Department of Psychiatry, University of Illinois at Chicago and Jesse Brown VA Medical Center, Chicago, Illinois 60612, USA
    Alcohol Clin Exp Res 29:176-84. 2005
  3. pmc TLR4-MyD88 signalling: a molecular target for alcohol actions
    Subhash C Pandey
    Department of Psychiatry, University of Illinois at Chicago and Jesse Brown VA Medical Center, Chicago, IL 60612, USA
    Br J Pharmacol 165:1316-8. 2012
  4. ncbi request reprint Partial deletion of the cAMP response element-binding protein gene promotes alcohol-drinking behaviors
    Subhash C Pandey
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago and Veterans Affairs Chicago Health Care System, Chicago, Illinois 60612, USA
    J Neurosci 24:5022-30. 2004
  5. ncbi request reprint Central and medial amygdaloid brain-derived neurotrophic factor signaling plays a critical role in alcohol-drinking and anxiety-like behaviors
    Subhash C Pandey
    Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Neurosci 26:8320-31. 2006
  6. ncbi request reprint The decreased phosphorylation of cyclic adenosine monophosphate (cAMP) response element binding (CREB) protein in the central amygdala acts as a molecular substrate for anxiety related to ethanol withdrawal in rats
    Subhash C Pandey
    Department of Psychiatry, University of Illinois at Chicago, and VA Chicago Health Care System West Side Division, 820 South Damen Avenue M C 151, Chicago, IL 60612, USA
    Alcohol Clin Exp Res 27:396-409. 2003
  7. ncbi request reprint Neuropeptide y and alcoholism: genetic, molecular, and pharmacological evidence
    Subhash C Pandey
    Department of Psychiatry, Psychiatric Institute, University of Illinois, IL 60612, USA
    Alcohol Clin Exp Res 27:149-54. 2003
  8. doi request reprint Effector immediate-early gene arc in the amygdala plays a critical role in alcoholism
    Subhash C Pandey
    Department of Psychiatry, University of Illinois at Chicago, and Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60612, USA
    J Neurosci 28:2589-600. 2008
  9. doi request reprint Brain chromatin remodeling: a novel mechanism of alcoholism
    Subhash C Pandey
    Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Neurosci 28:3729-37. 2008
  10. ncbi request reprint The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and negative affective states of alcohol addiction
    Subhash C Pandey
    Department of Psychiatry, Anatomy, and Cell Biology, University of Illinois at Chicago, 820 South Damen Avenue M C 151, Chicago, IL 60612, United States
    Pharmacol Ther 104:47-58. 2004

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Anxiety and alcohol abuse disorders: a common role for CREB and its target, the neuropeptide Y gene
    Subhash C Pandey
    The Psychiatric Institute, Department of Psychiatry, Anatomy and Cell Biology, University of Illinois at Chicago and VA Chicago Health Care System, 820 South Damen Avenue M C 151, Chicago, IL 60612, USA
    Trends Pharmacol Sci 24:456-60. 2003
    ....
  2. ncbi request reprint CREB gene transcription factors: role in molecular mechanisms of alcohol and drug addiction
    Subhash C Pandey
    Department of Psychiatry, University of Illinois at Chicago and Jesse Brown VA Medical Center, Chicago, Illinois 60612, USA
    Alcohol Clin Exp Res 29:176-84. 2005
    ..Chartoff; (3) CREB-Haplodeficient Mice: Role in Anxiety and Alcohol-Drinking Behaviors, by Subhash C. Pandey; and (4) A Role for CREB in Stress and Drug Addiction, by Julie A. Blendy...
  3. pmc TLR4-MyD88 signalling: a molecular target for alcohol actions
    Subhash C Pandey
    Department of Psychiatry, University of Illinois at Chicago and Jesse Brown VA Medical Center, Chicago, IL 60612, USA
    Br J Pharmacol 165:1316-8. 2012
    ..These results clearly suggest that TLR4-MyD88 signalling may play a causal role in the mediation of the behavioural effects of acute alcohol...
  4. ncbi request reprint Partial deletion of the cAMP response element-binding protein gene promotes alcohol-drinking behaviors
    Subhash C Pandey
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago and Veterans Affairs Chicago Health Care System, Chicago, Illinois 60612, USA
    J Neurosci 24:5022-30. 2004
    ..Furthermore, alcohol drinking and anxiety-like behaviors in CREB-haplodeficient mice may possibly be related to decreased expression of NPY and BDNF in the brains of these mice...
  5. ncbi request reprint Central and medial amygdaloid brain-derived neurotrophic factor signaling plays a critical role in alcohol-drinking and anxiety-like behaviors
    Subhash C Pandey
    Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Neurosci 26:8320-31. 2006
    ..These novel results suggest that decreased BDNF levels in the CeA and MeA, but not in the BLA, are crucial in regulating alcohol-drinking and anxiety-like behaviors in rats...
  6. ncbi request reprint The decreased phosphorylation of cyclic adenosine monophosphate (cAMP) response element binding (CREB) protein in the central amygdala acts as a molecular substrate for anxiety related to ethanol withdrawal in rats
    Subhash C Pandey
    Department of Psychiatry, University of Illinois at Chicago, and VA Chicago Health Care System West Side Division, 820 South Damen Avenue M C 151, Chicago, IL 60612, USA
    Alcohol Clin Exp Res 27:396-409. 2003
    ..This study investigated the molecular mechanisms in the amygdaloid neurocircuitry governing anxiety related to ethanol withdrawal and also the phenomenon of alcohol preference...
  7. ncbi request reprint Neuropeptide y and alcoholism: genetic, molecular, and pharmacological evidence
    Subhash C Pandey
    Department of Psychiatry, Psychiatric Institute, University of Illinois, IL 60612, USA
    Alcohol Clin Exp Res 27:149-54. 2003
    ..Pandey; (4) Involvement of NPY in alcohol dependence: from animal models to human genetics, by Markus Heilig; and (5) Association of neuropeptide Y polymorphism with the occurrence of type 1 and type 2 alcoholism, by Erkki Ilveskoski...
  8. doi request reprint Effector immediate-early gene arc in the amygdala plays a critical role in alcoholism
    Subhash C Pandey
    Department of Psychiatry, University of Illinois at Chicago, and Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60612, USA
    J Neurosci 28:2589-600. 2008
    ..These results revealed that BDNF-Arc signaling and the associated DSD in the CeA, and possibly in the MeA, may be involved in the molecular processes of alcohol dependence and comorbidity of anxiety and alcohol-drinking behaviors...
  9. doi request reprint Brain chromatin remodeling: a novel mechanism of alcoholism
    Subhash C Pandey
    Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Neurosci 28:3729-37. 2008
    ..These results reveal a novel role for amygdaloid chromatin remodeling in the process of alcohol addiction and further suggest that HDAC inhibitors may be potential therapeutic agents in treating alcohol withdrawal symptoms...
  10. ncbi request reprint The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and negative affective states of alcohol addiction
    Subhash C Pandey
    Department of Psychiatry, Anatomy, and Cell Biology, University of Illinois at Chicago, 820 South Damen Avenue M C 151, Chicago, IL 60612, United States
    Pharmacol Ther 104:47-58. 2004
    ..This review article highlights the current findings on the role of nucleus accumbal and amygdaloid CREB signaling in behavioral consequences of alcohol use and abuse...
  11. ncbi request reprint Regulation of AP-1 gene transcription factor binding activity in the rat brain during nicotine dependence
    S C Pandey
    Department of Psychiatry, Psychiatric Institute, College of Medicine, University of Illinois, Chicago, USA
    Neurosci Lett 264:21-4. 1999
    ..Thus, these findings suggest that desensitization of cortical AP-1 DNA binding activity may be involved in the neuroadaptational mechanisms to nicotine dependence...
  12. ncbi request reprint Involvement of the cyclic AMP-responsive element binding protein gene transcription factor in genetic preference for alcohol drinking behavior
    S C Pandey
    Department of Psychiatry, College of Medicine, University of Illinois and the VA Chicago Health Care System, 60612, USA
    Alcohol Clin Exp Res 23:1425-34. 1999
    ....
  13. ncbi request reprint Effects of chronic ethanol intake and its withdrawal on the expression and phosphorylation of the creb gene transcription factor in rat cortex
    S C Pandey
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Pharmacol Exp Ther 296:857-68. 2001
    ....
  14. ncbi request reprint Effects of protracted nicotine exposure and withdrawal on the expression and phosphorylation of the CREB gene transcription factor in rat brain
    S C Pandey
    The Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, 60612, USA
    J Neurochem 77:943-52. 2001
    ..These results provide the first evidence that decreased CREB activity and/or expression in specific cortical and amygdaloid brain structures may be involved in the underlying molecular mechanisms of nicotine dependence...
  15. ncbi request reprint cAmp signaling cascade: a promising role in ethanol tolerance and dependence
    S C Pandey
    University of Illinois Department of Psychiatry, and VA Chicago Health Care System, Chicago, Illinois 60612, USA
    Alcohol Clin Exp Res 25:46S-48S. 2001
    ..Sohma; (3) The role of the CREB gene transcription factor in ethanol dependence and preference, by Subhash C. Pandey; and (4) The efficacy of adenylyl cyclase signal transduction to the nucleus in primary alcoholics, by M. E. Götz...
  16. ncbi request reprint The decreased cyclic-AMP dependent-protein kinase A function in the nucleus accumbens: a role in alcohol drinking but not in anxiety-like behaviors in rats
    Kaushik Misra
    Department of Psychiatry, University of Illinois at Chicago, Jesse Brown VA Medical Center, Chicago, IL 60612, USA
    Neuropsychopharmacology 31:1406-19. 2006
    ..Furthermore, decreased function of PKA may regulate alcohol drinking behaviors via CREB-mediated decreased expression of NPY in the NAc shell of rats...
  17. doi request reprint Innate differences in the expression of brain-derived neurotrophic factor in the regions within the extended amygdala between alcohol preferring and nonpreferring rats
    Anand Prakash
    Department of Psychiatry, University of Illinois at Chicago, Jesse Brown VA Medical Center, Chicago, Illinois 60612, USA
    Alcohol Clin Exp Res 32:909-20. 2008
    ..Therefore, we examined the basal expression of BDNF in the extended amygdala of alcohol naive P and NP rats...
  18. ncbi request reprint Effects of voluntary ethanol intake on the expression of Ca(2+) /calmodulin-dependent protein kinase IV and on CREB expression and phosphorylation in the rat nucleus accumbens
    K Misra
    Department of Psychiatry, University of Illinois at Chicago, IL 60612, USA
    Neuroreport 12:4133-7. 2001
    ..This is the first evidence to suggest that decreased CaM kinase IV-dependent CREB phosphorylation in the shell region of NAc may play a role in the reward mechanisms of alcohol drinking...
  19. ncbi request reprint The decreased cellular expression of neuropeptide Y protein in rat brain structures during ethanol withdrawal after chronic ethanol exposure
    Adip Roy
    Department of Psychiatry, The Psychiatric Institute, University of Illinois, and the Veterans Affairs Chicago Health Care System West Side Division, Chicago 60612, USA
    Alcohol Clin Exp Res 26:796-803. 2002
    ..Neuropeptide Y (NPY) has been implicated in the alcohol-drinking behaviors of rodents. This study investigated the possible involvement of NPY in the neuroadaptational mechanisms to chronic ethanol exposure and its withdrawal...
  20. ncbi request reprint Modulation of cellular expression of glucocorticoid receptor and glucocorticoid response element-DNA binding in rat brain during alcohol drinking and withdrawal
    Adip Roy
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    J Pharmacol Exp Ther 301:774-84. 2002
    ..It is possible that decreased GR expression in PVN may be responsible for the abnormal HPA axis during ethanol exposure and withdrawal...
  21. ncbi request reprint Estrogen modulation of the cyclic AMP response element-binding protein pathway. Effects of long-term and acute treatments
    L Carlstrom
    Department of Anatomy and Cell Biology, University of Illinois at Chicago, 808 South Wood Street, Chicago, IL 60612, USA
    Neuroendocrinology 74:227-43. 2001
    ..Our study indicates that both long-term and acute treatments with estrogens influence the function of CREB in specific brain structures...
  22. pmc Neuroscience of alcoholism: molecular and cellular mechanisms
    Sachin Moonat
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA
    Cell Mol Life Sci 67:73-88. 2010
    ..This review outlines progressive neuroscience research into molecular and epigenetic mechanisms of alcoholism...
  23. pmc Effects of estrogen treatment on expression of brain-derived neurotrophic factor and cAMP response element-binding protein expression and phosphorylation in rat amygdaloid and hippocampal structures
    Jin Zhou
    Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuroendocrinology 81:294-310. 2005
    ....
  24. pmc Neuropeptide Y signaling in the central nucleus of amygdala regulates alcohol-drinking and anxiety-like behaviors of alcohol-preferring rats
    Huaibo Zhang
    Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Alcohol Clin Exp Res 34:451-61. 2010
    ..In this study, we investigated the molecular mechanisms by which NPY in the CeA regulates anxiety and alcohol drinking behaviors using alcohol-preferring (P) rats as an animal model...
  25. ncbi request reprint Effects of PKA modulation on the expression of neuropeptide Y in rat amygdaloid structures during ethanol withdrawal
    Huaibo Zhang
    Department of Psychiatry, The Psychiatric Institute, University of Illinois, Chicago, IL 60612, USA
    Peptides 24:1397-402. 2003
    ..These results suggest that the decreased cellular expression of NPY in the central amygdala may play an important role in the CREB-mediated regulation of anxiety-like behaviors during ethanol withdrawal...
  26. ncbi request reprint Beta-adrenergic receptor subtypes in stress-induced behavioral depression
    S C Pandey
    Department of Psychiatry, College of Medicine, University of Illinois at Chicago 60612, USA
    Pharmacol Biochem Behav 51:339-44. 1995
    ....
  27. ncbi request reprint Hyperactive phosphoinositide signaling pathway in platelets of depressed patients: effect of desipramine treatment
    G N Pandey
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 W Taylor Street, Chicago, IL 60612, USA
    Psychiatry Res 105:23-32. 2001
    ....
  28. ncbi request reprint Higher expression of serotonin 5-HT(2A) receptors in the postmortem brains of teenage suicide victims
    Ghanshyam N Pandey
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    Am J Psychiatry 159:419-29. 2002
    ..The authors examined whether 5-HT(2A) receptor subtypes are altered in the postmortem brains of teenage suicide victims...
  29. ncbi request reprint Serotonin receptors in platelets of bipolar and schizoaffective patients: effect of lithium treatment
    Ghanshyam N Pandey
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA
    Psychopharmacology (Berl) 170:115-23. 2003
    ..However, the role of 5HT2A receptors in bipolar disorders and in the mechanism of action of lithium is unclear...
  30. pmc Deficits in amygdaloid cAMP-responsive element-binding protein signaling play a role in genetic predisposition to anxiety and alcoholism
    Subhash C Pandey
    Department of Psychiatry, Psychiatric Institute, University of Illinois at Chicago, and Jesse Brown VA Medical Center, Chicago, Illinois 60612, USA
    J Clin Invest 115:2762-73. 2005
    ..These novel results provide the first evidence to our knowledge that decreased CREB function in the CeA may be operative in maintaining the high anxiety and excessive alcohol-drinking behaviors of P rats...
  31. ncbi request reprint Differences in basal levels of CREB and NPY in nucleus accumbens regions between C57BL/6 and DBA/2 mice differing in inborn alcohol drinking behavior
    Kaushik Misra
    Department of Psychiatry, Anatomy, and Cell Biology, University of Illinois at Chicago and VA Chicago Health Care System, Chicago, Illinois 60612, USA
    J Neurosci Res 74:967-75. 2003
    ....
  32. ncbi request reprint Neuronal signaling systems and ethanol dependence
    S C Pandey
    Department of Psychiatry, College of Medicine, University of Illinois at Chicago, USA
    Mol Neurobiol 17:1-15. 1998
    ..These findings support the notion that alterations in the cAMP and the PI-signaling cascades during chronic ethanol exposure could be the critical molecular events associated with the development of ethanol dependence...
  33. ncbi request reprint Estrogen affects the expression of Ca2+/calmodulin-dependent protein kinase IV in amygdala
    J Zhou
    Department of Anatomy and Cell Biology, University of Illinois at Chicago, 808 South Wood Street (M/C 512, Chicago, IL 60612, USA
    Neuroreport 12:2987-90. 2001
    ..These results suggest that CaMK IV may act as a molecular target for actions of estrogen in the amygdala of rats...
  34. ncbi request reprint Modulation of CREB expression and phosphorylation in the rat nucleus accumbens during nicotine exposure and withdrawal
    Olivera Pluzarev
    Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Neurosci Res 77:884-91. 2004
    ..These results suggest the possibility that decreased CREB activity in the shell of NAc may be associated with abnormal reward mechanisms during nicotine withdrawal after chronic exposure...
  35. doi request reprint Dose and time effects of estrogen on expression of neuron-specific protein and cyclic AMP response element-binding protein and brain region volume in the medial amygdala of ovariectomized rats
    Lu Fan
    Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, Ill 60612, USA
    Neuroendocrinology 88:111-26. 2008
    ..5 microg for 4 days. No differences in these parameters were seen in CeA. These data indicate a neuroanatomical heterogeneity of a time effect of estrogen on cells expressing NeuN and pCREB in the MeA versus CeA...
  36. ncbi request reprint Low phosphoinositide-specific phospholipase C activity and expression of phospholipase C beta1 protein in the prefrontal cortex of teenage suicide subjects
    G N Pandey
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    Am J Psychiatry 156:1895-901. 1999
    ....
  37. ncbi request reprint Estrogen decreases levels of calcineurin in rat amygdala and hippocampus
    Jin Zhou
    Departments of Anatomy, University of Illinois at Chicago, 808 South Wood Street M C 512, Chicago, IL 60612, USA
    Neuroreport 15:2437-40. 2004
    ..These results indicate that E2 acts on calcineurin in a neuroanatomically specific manner and may be involved in estrogen-mediated regulation of gene expression...
  38. pmc Estrogen affects levels of Bcl-2 protein and mRNA in medial amygdala of ovariectomized rats
    Lu Fan
    Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Neurosci Res 86:3655-64. 2008
    ..The E-induced increase in protein and mRNA levels of Bcl-2 in MeA may be important for neuroprotection in this region...
  39. ncbi request reprint BIG news in alcohol addiction: new findings on growth factor pathways BDNF, insulin, and GDNF
    Patricia H Janak
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, California, USA
    Alcohol Clin Exp Res 30:214-21. 2006
    ..Dr. Pandey showed that amygdalar BDNF regulates alcohol's anxiolytic effects and preference. Finally, Dr. Janak presented evidence that increases in the expression of GDNF in the midbrain reduce alcohol self-administration in rats...
  40. ncbi request reprint Ethanol effects on cell signaling mechanisms
    A Leslie Morrow
    Department of Psychiatry, Center for Alcohol Studies, University of Chapel Hill at North Carolina, Chapel Hill, North Carolina 27599 7178, USA
    Alcohol Clin Exp Res 28:217-27. 2004