Ghanshyam N Pandey

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. pmc Toll-like receptors in the depressed and suicide brain
    Ghanshyam N Pandey
    University of Illinois at Chicago, Department of Psychiatry MC 912, 1601 West Taylor Street, Chicago, IL 60612, USA Electronic address
    J Psychiatr Res 53:62-8. 2014
  2. ncbi request reprint Signal transduction abnormalities in suicide: focus on phosphoinositide signaling system
    Ghanshyam N Pandey
    Department of Psychiatry University of Illinois at Chicago, MC 912, 1601 W Taylor Street, Chicago, IL 60612, USA
    CNS Neurol Disord Drug Targets 12:941-53. 2013
  3. pmc Biological basis of suicide and suicidal behavior
    Ghanshyam N Pandey
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Bipolar Disord 15:524-41. 2013
  4. ncbi request reprint Serotonin receptors in platelets of bipolar and schizoaffective patients: effect of lithium treatment
    Ghanshyam N Pandey
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA
    Psychopharmacology (Berl) 170:115-23. 2003
  5. ncbi request reprint Altered expression and phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in postmortem brain of suicide victims with or without depression
    Ghanshyam N Pandey
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    J Psychiatr Res 37:421-32. 2003
  6. doi request reprint Brain-derived neurotrophic factor gene and protein expression in pediatric and adult depressed subjects
    Ghanshyam N Pandey
    University of Illinois at Chicago, Department of Psychiatry MC 912, 1601 West Taylor Street, Chicago, IL 60612, United States
    Prog Neuropsychopharmacol Biol Psychiatry 34:645-51. 2010
  7. doi request reprint Glycogen synthase kinase-3beta in the platelets of patients with mood disorders: effect of treatment
    Ghanshyam N Pandey
    The Psychiatric Institute, University of Illinois at Chicago, Department of Psychiatry, Chicago, IL 60612, USA
    J Psychiatr Res 44:143-8. 2010
  8. doi request reprint Brain-derived neurotrophic factor and tyrosine kinase B receptor signalling in post-mortem brain of teenage suicide victims
    Ghanshyam N Pandey
    Department of Psychiatry, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA
    Int J Neuropsychopharmacol 11:1047-61. 2008
  9. pmc Neurotrophin receptor activation and expression in human postmortem brain: effect of suicide
    Yogesh Dwivedi
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Biol Psychiatry 65:319-28. 2009
  10. ncbi request reprint Brain region specific alterations in the protein and mRNA levels of protein kinase A subunits in the post-mortem brain of teenage suicide victims
    Ghanshyam N Pandey
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuropsychopharmacology 30:1548-56. 2005

Detail Information

Publications49

  1. pmc Toll-like receptors in the depressed and suicide brain
    Ghanshyam N Pandey
    University of Illinois at Chicago, Department of Psychiatry MC 912, 1601 West Taylor Street, Chicago, IL 60612, USA Electronic address
    J Psychiatr Res 53:62-8. 2014
    ..To our knowledge, this is the first study of TLRs in the brain of psychiatric subjects. ..
  2. ncbi request reprint Signal transduction abnormalities in suicide: focus on phosphoinositide signaling system
    Ghanshyam N Pandey
    Department of Psychiatry University of Illinois at Chicago, MC 912, 1601 W Taylor Street, Chicago, IL 60612, USA
    CNS Neurol Disord Drug Targets 12:941-53. 2013
    ..These studies may lead to new therapeutic agents targeting specific sites in this signaling cascade. ..
  3. pmc Biological basis of suicide and suicidal behavior
    Ghanshyam N Pandey
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Bipolar Disord 15:524-41. 2013
    ..However, very little is known about the neurobiology of suicide. Recent research has provided some understanding of the neurobiology of suicide, which is the topic of this review...
  4. ncbi request reprint Serotonin receptors in platelets of bipolar and schizoaffective patients: effect of lithium treatment
    Ghanshyam N Pandey
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA
    Psychopharmacology (Berl) 170:115-23. 2003
    ..However, the role of 5HT2A receptors in bipolar disorders and in the mechanism of action of lithium is unclear...
  5. ncbi request reprint Altered expression and phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in postmortem brain of suicide victims with or without depression
    Ghanshyam N Pandey
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    J Psychiatr Res 37:421-32. 2003
    ....
  6. doi request reprint Brain-derived neurotrophic factor gene and protein expression in pediatric and adult depressed subjects
    Ghanshyam N Pandey
    University of Illinois at Chicago, Department of Psychiatry MC 912, 1601 West Taylor Street, Chicago, IL 60612, United States
    Prog Neuropsychopharmacol Biol Psychiatry 34:645-51. 2010
    ....
  7. doi request reprint Glycogen synthase kinase-3beta in the platelets of patients with mood disorders: effect of treatment
    Ghanshyam N Pandey
    The Psychiatric Institute, University of Illinois at Chicago, Department of Psychiatry, Chicago, IL 60612, USA
    J Psychiatr Res 44:143-8. 2010
    ....
  8. doi request reprint Brain-derived neurotrophic factor and tyrosine kinase B receptor signalling in post-mortem brain of teenage suicide victims
    Ghanshyam N Pandey
    Department of Psychiatry, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA
    Int J Neuropsychopharmacol 11:1047-61. 2008
    ....
  9. pmc Neurotrophin receptor activation and expression in human postmortem brain: effect of suicide
    Yogesh Dwivedi
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Biol Psychiatry 65:319-28. 2009
    ..This study examines whether expression and activation of Trk receptors and expression of p75(NTR) are altered in brain of these subjects...
  10. ncbi request reprint Brain region specific alterations in the protein and mRNA levels of protein kinase A subunits in the post-mortem brain of teenage suicide victims
    Ghanshyam N Pandey
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuropsychopharmacology 30:1548-56. 2005
    ..Whether these changes in PKA subunits are related to suicidal behavior or are a result of suicide or are specific to suicide is not clear at this point...
  11. ncbi request reprint Decreased catalytic activity and expression of protein kinase C isozymes in teenage suicide victims: a postmortem brain study
    Ghanshyam N Pandey
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    Arch Gen Psychiatry 61:685-93. 2004
    ....
  12. ncbi request reprint Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects
    Yogesh Dwivedi
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    Arch Gen Psychiatry 60:804-15. 2003
    ....
  13. ncbi request reprint Lower phosphoinositide 3-kinase (PI 3-kinase) activity and differential expression levels of selective catalytic and regulatory PI 3-kinase subunit isoforms in prefrontal cortex and hippocampus of suicide subjects
    Yogesh Dwivedi
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuropsychopharmacology 33:2324-40. 2008
    ....
  14. ncbi request reprint Cyclic AMP response element-binding protein in post-mortem brain of teenage suicide victims: specific decrease in the prefrontal cortex but not the hippocampus
    Ghanshyam N Pandey
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Int J Neuropsychopharmacol 10:621-9. 2007
    ....
  15. doi request reprint GSK-3beta gene expression in human postmortem brain: regional distribution, effects of age and suicide
    Ghanshyam N Pandey
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA
    Neurochem Res 34:274-85. 2009
    ..The decrease observed in the mRNA levels in teenage suicide but not in adult suicide victims may represent a neurodevelopmentally associated decrease and may be important in the pathophysiology of teenage suicide...
  16. ncbi request reprint Brain-derived neurotrophic factor gene expression in pediatric bipolar disorder: effects of treatment and clinical response
    Ghanshyam N Pandey
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Am Acad Child Adolesc Psychiatry 47:1077-85. 2008
    ..The observed structural abnormality in the brains of patients with mood disorders has been related to abnormal brain-derived neurotrophic factor (BDNF) function, suggesting an important role for BDNF in these disorders...
  17. ncbi request reprint Differential and brain region-specific regulation of Rap-1 and Epac in depressed suicide victims
    Yogesh Dwivedi
    Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    Arch Gen Psychiatry 63:639-48. 2006
    ..Rap-1 is also activated directly by cyclic adenosine monophosphate through Epac, and thus participates in mediating physiologic functions independent of protein kinase A...
  18. ncbi request reprint Higher expression of serotonin 5-HT(2A) receptors in the postmortem brains of teenage suicide victims
    Ghanshyam N Pandey
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    Am J Psychiatry 159:419-29. 2002
    ..The authors examined whether 5-HT(2A) receptor subtypes are altered in the postmortem brains of teenage suicide victims...
  19. ncbi request reprint Abnormal expression and functional characteristics of cyclic adenosine monophosphate response element binding protein in postmortem brain of suicide subjects
    Yogesh Dwivedi
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    Arch Gen Psychiatry 60:273-82. 2003
    ....
  20. ncbi request reprint Protein kinase A in postmortem brain of depressed suicide victims: altered expression of specific regulatory and catalytic subunits
    Yogesh Dwivedi
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 W Taylor Street, Chicago, IL 60612, USA
    Biol Psychiatry 55:234-43. 2004
    ..Here we examined the molecular basis of these alterations and whether these findings can be replicated in another cohort...
  21. pmc Selective deficits in erythrocyte docosahexaenoic acid composition in adult patients with bipolar disorder and major depressive disorder
    Robert K McNamara
    Department of Psychiatry, Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH 45219 0516, USA
    J Affect Disord 126:303-11. 2010
    ..However, there is limited comparative information available regarding the n-3 fatty acid status and associated mood symptoms in medication-free patients with major depressive disorder (MDD) and bipolar disorder (BD)...
  22. pmc Lower docosahexaenoic acid concentrations in the postmortem prefrontal cortex of adult depressed suicide victims compared with controls without cardiovascular disease
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Medical Science Building, 231 Albert Sabin Way, Cincinnati, OH 45267 0559, USA
    J Psychiatr Res 47:1187-91. 2013
    ....
  23. pmc Modulation in activation and expression of phosphatase and tensin homolog on chromosome ten, Akt1, and 3-phosphoinositide-dependent kinase 1: further evidence demonstrating altered phosphoinositide 3-kinase signaling in postmortem brain of suicide subject
    Yogesh Dwivedi
    Department of Psychiatry, Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA
    Biol Psychiatry 67:1017-25. 2010
    ....
  24. ncbi request reprint Protein kinase C and phospholipase C activity and expression of their specific isozymes is decreased and expression of MARCKS is increased in platelets of bipolar but not in unipolar patients
    Ghanshyam N Pandey
    Psychiatric Institute, Department of Psychiatry College of Medicine, University of Illinois at Chicago, 60612, USA
    Neuropsychopharmacology 26:216-28. 2002
    ..These results suggest that alterations in PKC, PLC, and MARCKS may be involved in the pathophysiology of bipolar illness...
  25. ncbi request reprint Aberrant extracellular signal-regulated kinase (ERK)1/2 signalling in suicide brain: role of ERK kinase 1 (MEK1)
    Yogesh Dwivedi
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Int J Neuropsychopharmacol 12:1337-54. 2009
    ..Our results demonstrate abnormalities in MEK1 at multiple levels and suggest that these abnormalities in MEK1 are crucial for aberrant ERK1/2 signalling in suicide brain...
  26. pmc Decreased protein kinase C (PKC) in platelets of pediatric bipolar patients: effect of treatment with mood stabilizing drugs
    Ghanshyam N Pandey
    University of Illinois at Chicago, Department of Psychiatry, 1601 West Taylor Street, Chicago, IL 60612, USA
    J Psychiatr Res 42:106-16. 2008
    ....
  27. ncbi request reprint Hippocampal cell proliferation regulation by repeated stress and antidepressants
    Hu Chen
    Department of Psychiatry, Psychiatric Institute, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Neuroreport 17:863-7. 2006
    ..Both fluoxetine and desipramine significantly increased the number of cells/cluster. Our results suggest modified hippocampal neurogenesis in prolonged depression and in the mechanism of antidepressant action...
  28. ncbi request reprint Focus on protein kinase A and protein kinase C, critical components of signal transduction system, in mood disorders and suicide
    Ghanshyam N Pandey
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Int J Neuropsychopharmacol 8:1-4. 2005
  29. ncbi request reprint Aberrant extracellular signal-regulated kinase (ERK) 5 signaling in hippocampus of suicide subjects
    Yogesh Dwivedi
    Department of Psychiatry, Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuropsychopharmacology 32:2338-50. 2007
    ....
  30. doi request reprint MicroRNA expression in rat brain exposed to repeated inescapable shock: differential alterations in learned helplessness vs. non-learned helplessness
    Neil R Smalheiser
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Int J Neuropsychopharmacol 14:1315-25. 2011
    ..Thus, miRNAs participate in the alterations of gene expression networks that underlie the normal (NLH) as well as aberrant (LH) response to repeated shocks...
  31. pmc Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims
    Ghanshyam N Pandey
    Department of Psychiatry, University of Illinois at Chicago, 1601 W Taylor Street, Chicago, IL 60612, USA
    J Psychiatr Res 46:57-63. 2012
    ..These results suggest an important role for IL-1β, IL-6, and TNF-α in the pathophysiology of suicidal behavior and that proinflammatory cytokines may be an appropriate target for developing therapeutic agents...
  32. doi request reprint Postmortem brain tissue of depressed suicides reveals increased Gs alpha localization in lipid raft domains where it is less likely to activate adenylyl cyclase
    Robert J Donati
    Department of Physiology and, University of Illinois at Chicago, College of Medicine, Chicago, Illinois 60612 7342, USA
    J Neurosci 28:3042-50. 2008
    ..Raft localization of Gs alpha in human peripheral tissue may thus serve as a biomarker for depression and as a harbinger of antidepressant responsiveness...
  33. ncbi request reprint Differential effects of haloperidol and clozapine on [(3)H]cAMP binding, protein kinase A (PKA) activity, and mRNA and protein expression of selective regulatory and catalytic subunit isoforms of PKA in rat brain
    Yogesh Dwivedi
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Pharmacol Exp Ther 301:197-209. 2002
    ....
  34. ncbi request reprint mRNA and protein expression of selective alpha subunits of G proteins are abnormal in prefrontal cortex of suicide victims
    Yogesh Dwivedi
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, 60612, USA
    Neuropsychopharmacology 27:499-517. 2002
    ..Our results suggest that there are defects in the expression of selective G protein alpha subunits in prefrontal cortex of adult and teenage suicide subjects, which appear to be related to mental disorders...
  35. doi request reprint Altered Wnt signalling in the teenage suicide brain: focus on glycogen synthase kinase-3β and β-catenin
    Xinguo Ren
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Int J Neuropsychopharmacol 16:945-55. 2013
    ..The observation that there is a decrease in β-catenin and pGSK-3β-ser(9) in the PFC and hippocampus of teenage suicide victims does indicate a disturbance in the Wnt signalling pathway in teenage suicide...
  36. doi request reprint Fatty acid composition of the postmortem prefrontal cortex of adolescent male and female suicide victims
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Medical Science Building, 231 Albert Sabin Way, Cincinnati, OH 45267 0559, USA
    Prostaglandins Leukot Essent Fatty Acids 80:19-26. 2009
    ....
  37. pmc Elucidating biological risk factors in suicide: role of protein kinase A
    Yogesh Dwivedi
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA
    Prog Neuropsychopharmacol Biol Psychiatry 35:831-41. 2011
    ..These studies suggest the interesting possibility that PKA and related signaling molecules may serve as important neurobiological factors in suicide and may be relevant in target-specific therapeutic interventions for these disorders...
  38. ncbi request reprint Regional distribution and relative abundance of serotonin(2c) receptors in human brain: effect of suicide
    Ghanshyam N Pandey
    The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA
    Neurochem Res 31:167-76. 2006
    ....
  39. ncbi request reprint Single and repeated stress-induced modulation of phospholipase C catalytic activity and expression: role in LH behavior
    Yogesh Dwivedi
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuropsychopharmacology 30:473-83. 2005
    ..Our results suggest different responsiveness at the level of PI-PLC after single vs repeated stress, and that reductions in PLC may be critical in the pathophysiology of depression and other stress-related disorders...
  40. pmc Alteration of cyclic-AMP response element binding protein in the postmortem brain of subjects with bipolar disorder and schizophrenia
    Xinguo Ren
    University of Illinois at Chicago, Department of Psychiatry, Chicago, IL 60612, USA
    J Affect Disord 152:326-33. 2014
    ..To further elucidate the role of CREB in these disorders, we studied CREB expression and function in two brain areas implicated in these disorders, i.e., dorsolateral prefrontal cortex (DLPFC) and cingulate gyrus (CG)...
  41. pmc Region-specific alterations in glucocorticoid receptor expression in the postmortem brain of teenage suicide victims
    Ghanshyam N Pandey
    University of Illinois at Chicago, Department of Psychiatry, Chicago, IL 60612, USA Electronic address
    Psychoneuroendocrinology 38:2628-39. 2013
    ..We therefore determined the protein and gene expression of glucocorticoid (GR) and mineralocorticoid receptors (MR) in the postmortem brain of teenage suicide victims and matched normal controls...
  42. pmc Cyclic-AMP response element binding protein (CREB) in the neutrophils of depressed patients
    Xinguo Ren
    Department of Psychiatry, University of Illinois at Chicago, College of Medicine, Chicago, IL 60612, USA
    Psychiatry Res 185:108-12. 2011
    ..Neutrophil CREB levels may also serve as a useful biomarker for patients with MDD...
  43. ncbi request reprint Noradrenergic function in suicide
    Ghanshyam N Pandey
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago 60612, USA
    Arch Suicide Res 11:235-46. 2007
    ..More studies are needed in order to examine extensively the role of noradrenergic function in suicidal behavior...
  44. pmc Adult medication-free schizophrenic patients exhibit long-chain omega-3 Fatty Acid deficiency: implications for cardiovascular disease risk
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45219 0516, USA
    Cardiovasc Psychiatry Neurol 2013:796462. 2013
    ..008) and female (+22%, P = 0.04) SZ patients. These results suggest that the majority of SZ patients exhibit low LCn - 3 fatty acid levels which may place them at increased risk for cardiovascular morbidity and mortality...
  45. pmc 5-Lipoxygenase in the Prefrontal Cortex of Suicide Victims
    Tolga Uz
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL
    Open Neuropsychopharmacol J 1:1-5. 2008
    ..We propose that further studies of brain 5-LOX are needed to elucidate the functional implications of the protein alterations observed in our present study, and to further explore a putative role of 5-LOX in depression and suicide...
  46. ncbi request reprint [(3)H]cAMP binding sites and protein kinase a activity in the prefrontal cortex of suicide victims
    Yogesh Dwivedi
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    Am J Psychiatry 159:66-73. 2002
    ..To examine the role of this enzyme in suicidal behavior, the authors examined the catalytic and regulatory activities of protein kinase A in the postmortem brain of suicide victims...
  47. ncbi request reprint The regional and cellular expression profile of the melatonin receptor MT1 in the central dopaminergic system
    Tolga Uz
    Department of Psychiatry, Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, M C 912, Chicago, IL 60612, USA
    Brain Res Mol Brain Res 136:45-53. 2005
    ..Further research is needed to understand the regional/cellular functional role of melatonin receptors in the regulation of dopaminergic behaviors, using models such as melatonin receptor knockout mice...
  48. pmc Pharmacological Characterization of Inositol 1,4,5-tris Phosphate Receptors in Human Platelet Membranes
    Yogesh Dwivedi
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA
    Cardiovasc Psychiatry Neurol 2009:618586. 2009
    ....
  49. pmc Adenylyl cyclase-cyclicAMP signaling in mood disorders: Role of the crucial phosphorylating enzyme protein kinase A
    Yogesh Dwivedi
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago Chicago, Illinois 60612, USA
    Neuropsychiatr Dis Treat 4:161-76. 2008
    ....

Research Grants1

  1. PI and Wnt Signaling in Postmortem Brain of Biopolar and Schizophrenia Subjects
    Ghanshyam Pandey; Fiscal Year: 2007
    ..This may eventually lead to i better understanding of the pathophysiology of BP or SZ illnesses and may aid in the development of more appropriate therapeutic agents for the treatment of these disorders. ..