Zeev Pancer

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Diversity and function of adaptive immune receptors in a jawless vertebrate
    Matthew N Alder
    Howard Hughes Medical Institute, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Science 310:1970-3. 2005
  2. pmc Structure of a lamprey variable lymphocyte receptor in complex with a protein antigen
    C Alejandro Velikovsky
    Center for Advanced Research in Biotechnology, WM Keck Laboratory for Structural Biology, University of Maryland Biotechnology Institute, Rockville, Maryland, USA
    Nat Struct Mol Biol 16:725-30. 2009
  3. ncbi request reprint The evolution of adaptive immunity
    Zeev Pancer
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21202, USA
    Annu Rev Immunol 24:497-518. 2006
  4. pmc High-affinity lamprey VLRA and VLRB monoclonal antibodies
    Satoshi Tasumi
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD 21202, USA
    Proc Natl Acad Sci U S A 106:12891-6. 2009
  5. ncbi request reprint The immune gene repertoire encoded in the purple sea urchin genome
    Taku Hibino
    Sunnybrook Research Institute and Department of Medical Biophysics, University of Toronto, 2075 Bayview Ave, Room S 126B, Toronto, Ontario, Canada M4N 3M5
    Dev Biol 300:349-65. 2006
  6. ncbi request reprint Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey
    Zeev Pancer
    Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nature 430:174-80. 2004
  7. pmc Variable lymphocyte receptors in hagfish
    Zeev Pancer
    Division of Developmental and Clinical Immunology, Department of Medicine, University of Alabama, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 102:9224-9. 2005
  8. ncbi request reprint Evolution and diversification of lamprey antigen receptors: evidence for involvement of an AID-APOBEC family cytosine deaminase
    Igor B Rogozin
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
    Nat Immunol 8:647-56. 2007
  9. pmc The amphioxus genome illuminates vertebrate origins and cephalochordate biology
    Linda Z Holland
    Marine Biology Research Division, Scripps Institution of Oceanography, La Jolla, California 92093 0202, USA
    Genome Res 18:1100-11. 2008
  10. pmc Prototypic T cell receptor and CD4-like coreceptor are expressed by lymphocytes in the agnathan sea lamprey
    Zeev Pancer
    Department of Medicine, Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, AL 35294 3300, USA
    Proc Natl Acad Sci U S A 101:13273-8. 2004

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Diversity and function of adaptive immune receptors in a jawless vertebrate
    Matthew N Alder
    Howard Hughes Medical Institute, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Science 310:1970-3. 2005
    ..These findings reveal that two strikingly different modes of antigen recognition through rearranged lymphocyte receptors have evolved in the jawless and jawed vertebrates...
  2. pmc Structure of a lamprey variable lymphocyte receptor in complex with a protein antigen
    C Alejandro Velikovsky
    Center for Advanced Research in Biotechnology, WM Keck Laboratory for Structural Biology, University of Maryland Biotechnology Institute, Rockville, Maryland, USA
    Nat Struct Mol Biol 16:725-30. 2009
    ..We further demonstrated that VLRs can be affinity-matured by 13-fold to affinities as high as those of IgG antibodies, making VLRs potential alternatives to antibodies for biotechnology applications...
  3. ncbi request reprint The evolution of adaptive immunity
    Zeev Pancer
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21202, USA
    Annu Rev Immunol 24:497-518. 2006
    ....
  4. pmc High-affinity lamprey VLRA and VLRB monoclonal antibodies
    Satoshi Tasumi
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD 21202, USA
    Proc Natl Acad Sci U S A 106:12891-6. 2009
    ..VLRs may be useful natural single-chain alternatives to conventional antibodies for biotechnology applications...
  5. ncbi request reprint The immune gene repertoire encoded in the purple sea urchin genome
    Taku Hibino
    Sunnybrook Research Institute and Department of Medical Biophysics, University of Toronto, 2075 Bayview Ave, Room S 126B, Toronto, Ontario, Canada M4N 3M5
    Dev Biol 300:349-65. 2006
    ..The genome sequence provides immediate opportunities to apply the advantages of the sea urchin model toward problems in developmental and evolutionary immunobiology...
  6. ncbi request reprint Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey
    Zeev Pancer
    Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nature 430:174-80. 2004
    ..Different evolutionary strategies were thus used to generate highly diverse lymphocyte receptors through rearrangement of LRR modules in agnathans (jawless fish) and of immunoglobulin gene segments in gnathostomes (jawed vertebrates)...
  7. pmc Variable lymphocyte receptors in hagfish
    Zeev Pancer
    Division of Developmental and Clinical Immunology, Department of Medicine, University of Alabama, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 102:9224-9. 2005
    ..The development of two very different strategies for receptor diversification at the dawn of vertebrate evolution approximately 500 million years ago attests to the fitness value of a lymphocyte-based system of anticipatory immunity...
  8. ncbi request reprint Evolution and diversification of lamprey antigen receptors: evidence for involvement of an AID-APOBEC family cytosine deaminase
    Igor B Rogozin
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
    Nat Immunol 8:647-56. 2007
    ..Vertebrate acquired immunity could have therefore originated from lymphocyte receptor diversification by an ancestral AID-like DNA cytosine deaminase...
  9. pmc The amphioxus genome illuminates vertebrate origins and cephalochordate biology
    Linda Z Holland
    Marine Biology Research Division, Scripps Institution of Oceanography, La Jolla, California 92093 0202, USA
    Genome Res 18:1100-11. 2008
    ..Our results indicate that the amphioxus genome is elemental to an understanding of the biology and evolution of nonchordate deuterostomes, invertebrate chordates, and vertebrates...
  10. pmc Prototypic T cell receptor and CD4-like coreceptor are expressed by lymphocytes in the agnathan sea lamprey
    Zeev Pancer
    Department of Medicine, Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, AL 35294 3300, USA
    Proc Natl Acad Sci U S A 101:13273-8. 2004
    ..Thus, the TCR-like gene cannot account for the receptor diversity that is required for the immune responses reported for lamprey, but it could have been easily modified to serve as an evolutionary precursor of modern TCR and Ig genes...