Research Topics
| W PanSummaryAffiliation: University of Minnesota Country: USA Publications
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Detail Information
Publications
Functional group-based linkage analysis of gene expression trait lociNa Li
Division of Biostatistics, University of Minnesota, A460 Mayo Building MMC 303, 420 Delaware Street Southeast, Minneapolis, Minnesota 55126, USA
BMC Proc 1:S117. 2007..Future research is needed to develop rigorous methods in mapping of genes affecting the expression of a group of transcripts...- Genome-wide localization of mobile elements: experimental, statistical and biological considerationsBetsy M Martinez-Vaz
Department of Biochemistry, Molecular Biology and Biophysics and BioTechnology Institute, University of Minnesota, Saint Paul, MN 55108, USA
BMC Genomics 6:81. 2005.... - Operon information improves gene expression estimation for cDNA microarraysGuanghua Xiao
Division of Biostatistics, School of Public Health, University of Minnesota, A460 Mayo Building, Minneapolis, MN 55455 0378, USA
BMC Genomics 7:87. 2006..Therefore, techniques that can improve such estimations, and moreover are based on sound biological premises, are expected to benefit the field of microarray data analysis.. - Network-based support vector machine for classification of microarray samplesYanni Zhu
Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55455, USA
BMC Bioinformatics 10:S21. 2009..The main idea of this paper is to take full advantage of the biological observation that neighboring genes in a network tend to function together in biological processes and to embed this information into a formal statistical framework... - A comparative study of discriminating human heart failure etiology using gene expression profilesXiaohong Huang
Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA
BMC Bioinformatics 6:205. 2005..In this paper we consider discriminating the etiologies of heart failure using gene expression libraries from two separate institutions... 
Incorporating gene functions as priors in model-based clustering of microarray gene expression dataWei Pan
Division of Biostatistics, MMC 303, School of Public Health, University of Minnesota, Minneapolis, MN 55455 0392, USA
Bioinformatics 22:795-801. 2006..However, most existing methods, including model-based clustering, ignore known gene functions in clustering...- Statistical tests of genetic association in the presence of gene-gene and gene-environment interactionsWei Pan
Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minn 55455 0392, USA
Hum Hered 69:131-42. 2010..Unfortunately, Wang et al. did not include in their evaluations several powerful tests just recently discovered for analyzing multiple SNPs in a candidate gene or region... - Adaptive tests for association analysis of rare variantsWei Pan
Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN 55455 0392, USA
Genet Epidemiol 35:381-8. 2011..Our proposed tests are also general and flexible with the ability to incorporate weights on RVs and to adjust for covariates... - A mixture model approach to detecting differentially expressed genes with microarray dataWei Pan
Division of Biostatistics, School of Public Health, University of Minnesota, A460 Mayo, MMC 303, 420 Delaware Street SE, Minneapolis, MN 55455 0378, USA
Funct Integr Genomics 3:117-24. 2003..Several methods are proposed to effectively control the false positives. The methodology is applied to a data set containing expression levels of 1,176 genes of rats with and without pneumococcal middle ear infection... - Semi-supervised learning via penalized mixture model with application to microarray sample classificationWei Pan
Division of Biostatistics, School of Public Health, University of Minnesota, MN, USA
Bioinformatics 22:2388-95. 2006..The penalized mixture model seems to be promising for high-dimensional data with the capability of novel class discovery and automatic feature selection... - Incorporating gene networks into statistical tests for genomic data via a spatially correlated mixture modelPeng Wei
Division of Biostatistics, School of Public Health, University of Minnesota, A460 Mayo Building MMC 303, Minneapolis, MN 55455 0378, USA
Bioinformatics 24:404-11. 2008..We applied the two approaches to a real ChIP-chip dataset (and simulated data) to identify the transcriptional target genes of TF GCN4. The new method was found to be more powerful in discovering the target genes... - Network-based model weighting to detect multiple loci influencing complex diseasesWei Pan
Division of Biostatistics, MMC 303, School of Public Health, University of Minnesota, Minneapolis, MN 55455 0392, USA
Hum Genet 124:225-34. 2008.... - Asymptotic tests of association with multiple SNPs in linkage disequilibriumWei Pan
Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55455 0392, USA
Genet Epidemiol 33:497-507. 2009..We recommend the routine use of two of the new tests, along with several other tests, to detect disease associations with multiple linked SNPs... - Network-based multiple locus linkage analysis of expression traitsWei Pan
Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN 55455 0378, USA
Bioinformatics 25:1390-6. 2009..RESULTS: An analysis of a mouse dataset and simulation studies clearly demonstrate the advantage of the proposed method over a standard approach that ignores biological knowledge of gene networks... - Incorporating predictor network in penalized regression with application to microarray dataWei Pan
Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55455, USA
Biometrics 66:474-84. 2010.... - A unified framework for detecting genetic association with multiple SNPs in a candidate gene or region: contrasting genotype scores and LD patterns between cases and controlsWei Pan
Division of Biostatistics, MMC 303, School of Public Health, University of Minnesota, Minneapolis, MN 55455 0392, USA
Hum Hered 69:1-13. 2010.... 
Test selection with application to detecting disease association with multiple SNPsWei Pan
Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minn 55455 0392, USA
Hum Hered 69:120-30. 2010....- Small-sample adjustments in using the sandwich variance estimator in generalized estimating equationsWei Pan
Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN 55455 0378, USA
Stat Med 21:1429-41. 2002..In addition to hypothesis testing, our result has a clear implication on constructing Wald-type confidence intervals or regions... - Sample size and power calculations with correlated binary dataW Pan
Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA
Control Clin Trials 22:211-27. 2001..The given formulas are based on using the robust variance estimator in GEE. We believe that these formulas will facilitate the practice in planning two-arm clinical trials with correlated binary outcome data... - Linear regression for bivariate censored data via multiple imputationW Pan
Division of Biostatistics, School of Public Health, University of Minnesota, A460 Mayo Building, Box 303, 420 Delaware Street SE, Minneapolis, MN 55455 0378, USA
Stat Med 18:3111-21. 1999..The methods are applied to a data set from an otitis media clinical trial... - Estimating survival curves with left-truncated and interval-censored data under monotone hazardsW Pan
Division of Biostatistics, University of Minnesota, Minneapolis 55455 0378, USA
Biometrics 54:1053-60. 1998..The methodology is illustrated with the application to the Wisconsin Epidemiological Study of Diabetic Retinopathy data to estimate the probability of incidence of retinopathy... - A two-sample test with interval censored data via multiple imputationW Pan
Division of Biostatistics, School of Public Health, University of Minnesota, A460 Mayo Building Box 303, Minneapolis, MN 55455 0378, USA
Stat Med 19:1-11. 2000..The method is illustrated by reanalysing the Breast Cosmesis Study data set... - A linear mixed-effects model for multivariate censored dataW Pan
Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis 55455 0378, USA
Biometrics 56:160-6. 2000..From simulation studies, this approach compares favorably with the marginal independence approach, especially when there is a strong within-cluster correlation... - A multiple imputation approach to regression analysis for doubly censored data with application to AIDS studiesW Pan
Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis 55455 0378, USA
Biometrics 57:1245-50. 2001..Here we illustrate our method with an application to a formal goodness-of-fit test and a graphical check for the proportional hazards model for doubly censored data. We reanalyze a well-known AIDS data set... - Smooth estimation of the survival function for interval censored dataW Pan
Division of Biostatistics, School of Public Health, University of Minnesota, A460 Mayo Building Box 303, Minneapolis, MN 55455 0378, USA
Stat Med 19:2611-24. 2000..The methods are illustrated by reanalysing the Breast Cosmesis Study data set... - Graphical model checking with correlated response dataW Pan
Division of Biostatistics, School of Public Health, University of Minnesota, A460 Mayo Building, Box 303, 420 Delaware Street SE, Minneapolis, MN 55455 0378, USA
Stat Med 20:2935-49. 2001..The usefulness of the methodology is demonstrated through application to a correlated binary data set drawn from a clinical trial, the Lung Health Study... - How many replicates of arrays are required to detect gene expression changes in microarray experiments? A mixture model approachWei Pan
Division of Biostatistics, School of Public Health, University of Minnesota, 420 Delaware Street, Minneapolis, MN 55455 0378, USA
Genome Biol 3:research0022. 2002..Here, we discuss how to calculate the number of replicates in the context of applying a nonparametric statistical method, the normal mixture model approach, to detect changes in gene expression... - Akaike's information criterion in generalized estimating equationsW Pan
Division of Biostatistics, University of Minnesota, Minneapolis 55455, USA
Biometrics 57:120-5. 2001..Its performance is investigated through simulation studies. For illustration, the method is applied to a real data set... - Model selection in estimating equationsW Pan
Division of Biostatistics, University of Minnesota, Minneapolis 55455, USA
Biometrics 57:529-34. 2001..For illustration, the method is applied to a real data set taken from a study of the development of ewe embryos... - A multiple imputation approach to Cox regression with interval-censored dataW Pan
University of Minnesota School of Public Health, Division of Biostatistics, Minneapolis 55455 0392, USA
Biometrics 56:199-203. 2000..Our proposal is easily implemented by taking advantage of existing computer programs for right-censored data... - Using frailties in the accelerated failure time modelW Pan
Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA
Lifetime Data Anal 7:55-64. 2001..Through simulation it is shown that its performance compares favorably with that of the marginal independence approach. For illustration we reanalyze a real data set... - Estimation in the cox proportional hazards model with left-truncated and interval-censored dataWei Pan
Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis 55455, USA
Biometrics 58:64-70. 2002..Simulations were conducted to assess their performance. The methods are applied to the Massachusetts Health Care Panel Study data set to compare the probabilities of losing functional independence for male and female seniors... - Model-based cluster analysis of microarray gene-expression dataWei Pan
Division of Biostatistics, School of Public Health, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455 0378, USA
Genome Biol 3:RESEARCH0009. 2002..Here, we introduce and illustrate its use in detecting differentially expressed genes. In particular, we do not cluster gene-expression patterns but a summary statistic, the t-statistic... - A multiple imputation approach to linear regression with clustered censored dataW Pan
Division of Biostatistics, School of Public Health, A460 Mayo Building, University of Minnesota, Minneapolis, MN 55455, USA
Lifetime Data Anal 7:111-23. 2001..1993), which ignores the within-cluster correlation in estimating the regression coefficient. Our proposal is easy to implement by using existing softwares... - A comparative review of statistical methods for discovering differentially expressed genes in replicated microarray experimentsWei Pan
Division of Biostatistics, School of Public Health, University of Minnesota, A460 Mayo, MMC 303, 420 Delaware Street SE, Minneapolis, MN 55455 0378, USA
Bioinformatics 18:546-54. 2002..J. Am. Stat. Assoc., to appear, 2001) and the Significance Analysis of Microarray (SAM) method of Tusher et al. (PROC: Natl Acad. Sci. USA, 98, 5116-5121, 2001)... - Using weighted permutation scores to detect differential gene expression with microarray dataXu Guo
Division of Biostatistics, School of Public Health, University of Minnesota, A460 Mayo Building, MMC 303, Minneapolis, MN 55455-0378, USA
J Bioinform Comput Biol 3:989-1006. 2005..Using simulated data and real data for time-course microarray experiments, we show the improved performance of the proposed methods when implemented in MMM, EB and SAM... - A note on using permutation-based false discovery rate estimates to compare different analysis methods for microarray dataYang Xie
Division of Biostatistics, School of Public Health, University of Minnesota Minneapolis, MN 55455, USA
Bioinformatics 21:4280-8. 2005..In addition, our proposed FDR estimation method is simple and outperforms the standard method... - Machine safety evaluation in small metal working facilities: an evaluation of inter-rater reliability in the quantification of machine-related hazardsKaizad Munshi
Park Nicollet Institute, Minneapolis, Minnesota, USA
Am J Ind Med 48:381-8. 2005..Machinists and safety professionals may use this scoring system as a means of reproducible assessment of machine safety... - A Bayesian approach to joint modeling of protein-DNA binding, gene expression and sequence dataYang Xie
Division of Biostatistics, Department of Clinical Sciences, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
Stat Med 29:489-503. 2010.... - Statistical significance analysis of longitudinal gene expression dataXu Guo
Division of Biostatistics, School of Public Health, University of Minnesota, A460 Mayo Building, MMC 303, Minneapolis, MN 55455-0378, USA
Bioinformatics 19:1628-35. 2003..Using simulated data, we also show pitfalls in drawing statistical inference when the within-subject correlation in longitudinal gene expression data is ignored... - Linear regression and two-class classification with gene expression dataXiaohong Huang
Division of Biostatistics, School of Public Health, University of Minnesota, A460 Mayo Building (MMC 303, Minneapolis, MN 55455-0378, USA
Bioinformatics 19:2072-8. 2003..Using two real data sets, we show the competitive performance of our new methods when compared with the other three methods... - Combining gene annotations and gene expression data in model-based clustering: weighted methodDesheng Huang
Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, 55455, USA
OMICS 10:28-39. 2006..We use simulated data and real data to demonstrate the feasibility and advantages of the proposed method... - Incorporating prior knowledge of predictors into penalized classifiers with multiple penalty termsFeng Tai
Division of Biostatistics, School of Public Health, University of Minnesota, A460 Mayo Building MMC 303, Minneapolis, MN 55455 0378, USA
Bioinformatics 23:1775-82. 2007.... - Modified nonparametric approaches to detecting differentially expressed genes in replicated microarray experimentsYanli Zhao
Division of Biostatistics, School of Public Health, University of Minnesota, MMC 303, A460 Mayo Building, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Bioinformatics 19:1046-54. 2003..In the context of MMM, the improved performance of the modified methods is demonstrated using simulated data. In addition, our numerical results also provide evidence to support the utility and effectiveness of MMM... - Incorporating prior information via shrinkage: a combined analysis of genome-wide location data and gene expression dataYang Xie
Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA
Stat Med 26:2258-75. 2007..This method can also be used to incorporate other information, such as gene ontology (GO), to microarray data analysis to detect differentially expressed genes... - Incorporating prior knowledge of gene functional groups into regularized discriminant analysis of microarray dataFeng Tai
Division of Biostatistics, School of Public Health, University of Minnesota, A460 Mayo Building MMC 303, Minneapolis, MN 55455 0378, USA
Bioinformatics 23:3170-7. 2007..We show that one of the proposed methods performed better than PAM and SCRDA in a simulation study and several real data examples... - On the use of permutation in and the performance of a class of nonparametric methods to detect differential gene expressionWei Pan
Division of Biostatistics, School of Public Health, University of Minnesota, A460 Mayo Building MMC 303, Minneapolis, MN 55455 0378, USA
Bioinformatics 19:1333-40. 2003..Finally, by combining the idea of SAM and MMM, we outline a simple nonparametric method based on the direct use of a test statistic and a null statistic... - Modeling the relationship between LVAD support time and gene expression changes in the human heart by penalized partial least squaresXiaohong Huang
Division of Biostatistics, School of Public Health, University of Minnesota, A460 Mayo Building, MMC 303, Minneapolis, MN 55455-0378, USA
Bioinformatics 20:888-94. 2004..Compared with partial least squares and Breiman's random forest method, PPLS gives the best prediction results for the LVAD data... - Incorporating gene functions into regression analysis of DNA-protein binding data and gene expression data to construct transcriptional networksPeng Wei
Division of Biostatistics, School of Public Health, University of Minnesota, A460 Mayo Building, MMC 303, Minneapolis, MN 55455 0378, USA
IEEE/ACM Trans Comput Biol Bioinform 5:401-15. 2008..In particular, we find that the shrinkage method consistently works well under various scenarios. We recommend the use of the shrinkage method as a useful alternative to the existing methods... - Mapping safety interventions in metalworking shopsLisa M Brosseau
Division of Environmental Health Sciences, University of Minnesota, School of Public Health, Minneapolis, MN 55455, USA
J Occup Environ Med 49:338-45. 2007..This paper describes the selection of intervention activities designed to lower machine-related hazards and amputations in small metal fabrication businesses... - Effectiveness of a worksite intervention to reduce an occupational exposure: the Minnesota wood dust studyDeAnn Lazovich
Division of Epidemiology, University of Minnesota, Minneapolis, Minneapolis, MN 55454, USA
Am J Public Health 92:1498-505. 2002..This study assessed the effectiveness of an intervention to reduce wood dust, a carcinogen, by approximately 26% in small woodworking businesses... - Analysis by cDNA microarrays of altered gene expression in middle ears of rats following pneumococcal infectionJizhen Lin
Department of Otolaryngology, University of Minnesota Otitis Media Research Center, University of Minnesota School of Medicine, 2001 Sixth Street S E, Room 216, Minneapolis, MN 55455, USA
Int J Pediatr Otorhinolaryngol 65:203-11. 2002..The purpose of this study is to explore the cellular and molecular basis that remains on a longer time after acute pneucmococcal middle ear infection and potentiates development of thick effusion in the middle ear... - A comparison of the perceptions and beliefs of workers and owners with regard to workplace safety in small metal fabrication businessesDavid Parker
Park Nicollet Institute, Minneapolis, Minnesota 55426, USA
Am J Ind Med 50:999-1009. 2007..Problems of improving safety in small business establishments may include a lack of resources, limited unionization, and an informal management structure... - The Research Diagnostic Criteria for Temporomandibular Disorders. V: methods used to establish and validate revised Axis I diagnostic algorithmsEric L Schiffman
Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN 55455, USA
J Orofac Pain 24:63-78. 2010..Cutoff points for target validity were sensitivity > or = 0.70 and specificity > or = 0.95. Reliability of revised algorithms was assessed in 27 study participants... - A randomized, controlled intervention of machine guarding and related safety programs in small metal-fabrication businessesDavid L Parker
Park Nicollet Institute, Minneapolis, MN, USA
Public Health Rep 124:90-100. 2009..The absence of machine guarding and related programs such as lockout/tagout may result in serious injury or death. The purpose of this study was to improve machine-related safety in small metal-fabrication businesses... - Variable selection in penalized model-based clustering via regularization on grouped parametersBenhuai Xie
Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55455, USA
Biometrics 64:921-30. 2008..Simulation studies and applications to microarray gene expression data for cancer subtype discovery demonstrate the advantage of the new proposal over several existing approaches... - Identification of gene expression profiles in rat ears with cDNA microarraysJizhen Lin
Department of Otolaryngology, University of Minnesota Medical School, Division of Biostatistics, Minneapolis, MN 55455, USA
Hear Res 175:2-13. 2003.... - Gene function prediction by a combined analysis of gene expression data and protein-protein interaction dataGuanghua Xiao
Division of Biostatistics, School of Public Health, University of Minnesota, A460 Mayo Building (MMC 303, Minneapolis, MN 55455-0378, USA
J Bioinform Comput Biol 3:1371-89. 2005..Finally, we propose a logistic regression method that is flexible enough to combine information from any number of data sources while maintaining computational feasibility... - A data-adaptive sum test for disease association with multiple common or rare variantsFang Han
Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN 55455 0392, USA
Hum Hered 70:42-54. 2010..We show that the proposed test has high power across a wide range of scenarios with either common or rare variants, or both. In particular, in some situations the proposed test performs better than several commonly used methods... - Penalized mixtures of factor analyzers with application to clustering high-dimensional microarray dataBenhuai Xie
Division of Biostatistics, School of Public Health and School of Statistics, University of Minnesota, Minneapolis, MN, USA
Bioinformatics 26:501-8. 2010..We use simulated data and real microarray data to illustrate the utility and advantages of the proposed method over several existing ones... - Binomial mixture model-based association tests under genetic heterogeneityHui Zhou
Division of Biostatistics, University of Minnesota, Minneapolis, MN 55455, USA
Ann Hum Genet 73:614-30. 2009..We show with a wide spectrum of numerical examples that under genetic heterogeneity the proposed tests are more powerful than some commonly used association tests... - Comparing three methods for variance estimation with duplicated high density oligonucleotide arraysXiaohong Huang
Division of Biostatistics, School of Public Health, University of Minnesota, A460 Mayo Building (MMC 303, Minneapolis 55455-0378, USA
Funct Integr Genomics 2:126-33. 2002..Our results indicate that the three methods give variance estimates close to each other. Due to its simplicity and generality, we recommend the use of the smoothed sample variance for data with a small number of replicates... - Borrowing information from relevant microarray studies for sample classification using weighted partial least squaresXiaohong Huang
Division of Biostatistics, School of Public Health, University of Minnesota, A460 Mayo Building (MMC 303, Minneapolis, MN 55455-0378, USA
Comput Biol Chem 29:204-11. 2005..Second, WPLS/WPPLS performs better than the standard approach of combining multiple classifiers. Third, WPPLS can improve over WPLS, just as PPLS does over PLS for a single dataset... - Identification of genes responsible for osteoblast differentiation from human mesodermal progenitor cellsHuilin Qi
Stem Cell Institute, Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55445, USA
Proc Natl Acad Sci U S A 100:3305-10. 2003..These studies indicate that in vitro differentiation cultures in which MPCs are induced to one of multiple cell fates should be very useful for defining signals important for lineage-specific differentiation... - Profile of machine safety in small metal fabrication businessesYogindra Samant
Park Nicollet Institute, Minneapolis, Minnesota, USA
Am J Ind Med 49:352-9. 2006..The data also suggest that safety committees are an important component in improving machine safety and related programs in small businesses... - Differential endothelial cell gene expression by African Americans versus Caucasian Americans: a possible contribution to health disparity in vascular disease and cancerP Wei
Vascular Biology Center, Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN 55455, USA
BMC Med 9:2. 2011.... - Small-sample performance of the robust score test and its modifications in generalized estimating equationsXu Guo
Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA
Stat Med 24:3479-95. 2005..Finally, we demonstrate the utility of our proposal by applying it to a group-randomized clinical trial, trying alternative cafeteria options in schools (TACOS)... - A practical question based on cross-platform microarray data normalization: are BOEC more like large vessel or microvascular endothelial cells or neither of them?Aixiang Jiang
Division of Cancer Biostatistics, Department of Biostatistics, Vanderbilt University, Nashville, TN 37232, USA
J Bioinform Comput Biol 5:875-93. 2007..Based on all the common genes between the two platforms, SVM analysis further confirmed this conclusion... - Organizational characteristics of small metal-fabricating businesses in MinnesotaYogindra Samant
Norwegian Authority of Labor Inspection, Trondheim, Norway
Int J Occup Environ Health 13:160-6. 2007..Financial capability had no bearing on ability of a small business to mount an OHS programs. Non-unionized small businesses may be more vulnerable to occupational injuries... - Does it always help to adjust for misclassification of a binary outcome in logistic regression?Xianqun Luan
Division of Biostatistics and Epidemiology, The Children s Hospital of Philadelphia, 3535 Market St, 14th Floor, Philadelphia, PA 19104, USA
Stat Med 24:2221-34. 2005..In the context of a data set on agricultural injuries, numerical evidence is provided through simulation studies... - An examination of the process of relapse prevention therapy designed to aid smoking cessationBertram Stöffelmayr
Department of Psychiatry, Michigan State University, East Lansing, MI 48824, USA
Addict Behav 28:1351-8. 2003.... - Alternate arrangement of PpL B3 domain and SpA D domain creates synergistic double-site binding to VH3 and Vkappa regions of fabShaohua H Jiang
Department of Microbiology, Second Military Medical University, Shanghai, China
DNA Cell Biol 27:423-31. 2008..The demonstration of this novel binding property would promote to achieve the designed hybrid IBPs for useful immunological applications... - Persistence of the effect of the Lung Health Study (LHS) smoking intervention over eleven yearsRobert P Murray
Department of Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada R3A 1R9
Prev Med 35:314-9. 2002..This paper examined the quitting behavior of individuals who were randomized to a smoking cessation intervention (SI) or to usual care (UC), at a point approximately 11 years later... - Incorporating biological knowledge into distance-based clustering analysis of microarray gene expression dataDesheng Huang
Department of Mathematics, China Medical University Shenyang, China
Bioinformatics 22:1259-68. 2006..A simulation study and an application to gene function prediction for the yeast demonstrate the advantage of our proposal over the standard method... - [Differential expression of mitochondrial proteins in hepatoma cells analyzed using two-dimensional electrophoresis]Xing Li
Department of Medical Laboratory, Chongqing University of Medical Sciences, Chongqing, 400016, PR China
Ai Zheng 24:1327-31. 2005..CONCLUSION: A set of differentially expressed protein spots are detected in mitochondria of QGY-7703 cells with density gradient centrifugation and 2-DE... - [Serum levels of IFN-gamma and IL-4 in children with Mycoplasmal pneumonia at the acute phase]Wei Pan
Department of Pediatrics, Second Clinical Hospital, Jilin University, Changchun 130041, China
Zhongguo Dang Dai Er Ke Za Zhi 8:373-5. 2006..40 pg/mL respectively; P < 0.05). CONCLUSIONS: There was an imbalance in cytokine secretion in children with Mycoplasmal pneumonia at the acute phase, suggesting that adjuvant immunological therapy is needed for Mycoplasmal pneumonia... - Immune responses against SARS-coronavirus nucleocapsid protein induced by DNA vaccinePing Zhao
Department of Microbiology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China
Virology 331:128-35. 2005..The results indicate that the N protein may be of potential value in vaccine development for specific prophylaxis and treatment against SARS... - Statins are associated with a reduced incidence of perioperative mortality after coronary artery bypass graft surgeryWei Pan
Division of Cardiovascular Anesthesiology, Texas Heart Institute, St. Luke's Episcopal Hospital, Houston, Tex 77030, USA
Circulation 110:II45-9. 2004..1% versus 4.6%; P<0.05). CONCLUSIONS: Preoperative statin therapy may reduce the risk of early mortality after primary CABG surgery with CPB... - Myc-ARF (alternate reading frame) interaction inhibits the functions of MycAbhishek Datta
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, 900 S Ashland Avenue, Chicago, IL 60607, USA
J Biol Chem 279:36698-707. 2004..Our results strongly suggest that cMyc is a bona fide target of ARF and that ARF attenuates c-Myc independently of the ARF-p53 axis... - Inhibition of EGFP expression by siRNA in EGFP-stably expressing Huh-7 cellsMingmei Cao
Department of Microbiology, Second Military Medical University, Shanghai 200433, China
J Virol Methods 119:189-94. 2004..This Huh-7-N/EGFP specific siRNA system has been proved reliable and convenient, and can also be applied widely as control in other RNA interference studies... - Expression of human soluble gp190 in yeast Pichia pastorisGang Li
Department of Genetics and Eugenics, Chongqing Medical University, Chongqing 400016, China
Yi Chuan Xue Bao 31:1182-9. 2004..Biological activity assay showed that purified sgp190 could inhibit the effect of LIF on hCG biosynthesis of cytotrophoblast in vitro... - Simultaneous confidence bounds for low-dose risk assessment with nonquantal dataWalter W Piegorsch
Department of Statistics, University of South Carolina, Columbia, South Carolina, USA
J Biopharm Stat 15:17-31. 2005..From the simultaneous confidence bounds, simultaneous lower limits on the benchmark dose associated with a particular risk are also constructed... - Proactive telephone counseling as an adjunct to minimal intervention for smoking cessation: a meta-analysisWei Pan
Division of Educational Studies, University of Cincinnati, Cincinnati, OH 45221, USA
Health Educ Res 21:416-27. 2006..The results of this meta-analytic review imply that researchers and health care providers may need to focus on participants as much as on intervention process to obtain more effective interventions... - Genistein stimulates the osteoblastic differentiation via NO/cGMP in bone marrow cultureWei Pan
Institute of Clinical Pharmacology, Central South University, Changsha 410078, China
J Cell Biochem 94:307-16. 2005..Gen has estrogen-like activity and stimulates the proliferation and osteoblastic differentiation of mouse BMSCs at least in part through NO/cGMP pathway... - 1,25-dihydroxyvitamin D3 suppresses renin gene transcription by blocking the activity of the cyclic AMP response element in the renin gene promoterWeihua Yuan
Department of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, Illinois 60637, USA
J Biol Chem 282:29821-30. 2007..These data indicate that 1,25(OH)(2)D(3) suppresses renin gene expression at least in part by blocking the formation of CRE-CREB-CBP complex... - Genetic endothelial systems biology of sickle stroke riskLiming Chang Milbauer
Vascular Biology Center and Division of Hematology Oncology Transplantation, Department of Medicine, University of Minnesota Medical School, and Minneapolis Children s Hospital 55455, USA
Blood 111:3872-9. 2008.... - Family protection and prevention of alcohol use among Hispanic youth at high riskElizabeth Sale
Missouri Institute of Mental Health, 5400 Arsenal Street, St Louis, MO 63139, USA
Am J Community Psychol 36:195-205. 2005..Longitudinal growth curve analyses indicate that improving the connections that young Hispanic females have to their parents can have positive long-term effects on delaying or reducing their alcohol use... - Analysis of reflection-peak wavelengths of sampled fiber Bragg gratings with large chirpXihua Zou
School of Information Science and Technology, Southwest Jiaotong University, Chengdu, 610031, China
Appl Opt 47:4729-34. 2008..Finally, the RPWs of SFBGs-LC can be achieved by combining the wavelength shift and the RPWs of equivalent U-SFBGs. Several simulations are shown to numerically confirm these predicted RPWs of SFBGs-LC... - [Two-dimensional gel electrophoresis of subcellular fractions of hepatoma cells]Xing Li
Department of Laboratory Sciences, Chongqing University of Medical Sciences, Chongqing 400016, China
Zhonghua Gan Zang Bing Za Zhi 13:271-3. 2005.... - Small interfering RNA inhibits SARS-CoV nucleocapsid gene expression in cultured cells and mouse musclesPing Zhao
Department of Microbiology, Second Military Medical University, Shanghai, China
FEBS Lett 579:2404-10. 2005..Our findings suggest that the siRNA should provide the basis for prophylaxis and therapy of SARS-CoV infection in human... - Small interfering RNA-mediated inhibition of hepatitis G virus gene expression in human hepatoma cell Huh-7Mingmei Cao
Department of Microbiology, Second Military Medical University, Shanghai 200433, China
Sci China C Life Sci 48:61-9. 2005..In conclusion, the Huh-7-EH cells expressing HGV structural proteins stably can be used as a cell model for studying the replication of HGV and RNAi and the enlargement of RNAi may exist, in mammalian cells... - ApoA-I structure on discs and spheres. Variable helix registry and conformational statesHui Hua Li
Department of Pathology, The Wake Forest University Baptist Medical Center, Winston Salem, North Carolina 27157, USA
J Biol Chem 277:39093-101. 2002..Therefore, we conclude that as lipid-bound apoA-I adjusts from a discoidal to a spherical surface its intermolecular interactions are significantly reduced presumably to cover the increased surface area of the particle...
Research Grants
- Model Building--Marginal Regression with Dependent DataWei Pan; Fiscal Year: 2004..All the techniques will be implemented in the commonly used statistical language S-Plus and made freely available to practitioners. ..
- Statistical Methods for Genomic and Proteomic DataWei Pan; Fiscal Year: 2007..We will extend PPLS to combine microarray data from multiple studies. We plan to implement the proposed statistical methods in R and make the software publicly and freely available. ..
- Statistical Methods for Genomic and Proteomic DataWei Pan; Fiscal Year: 2009....
- Statistical Methods for Genomic and Proteomic DataWei Pan; Fiscal Year: 2010....