Genomes and Genes
Affiliation: University of Rochester
- Glutathiolation regulates tumor necrosis factor-alpha-induced caspase-3 cleavage and apoptosis: key role for glutaredoxin in the death pathwayShi Pan
Cardiovascular Research Institute and Department of Medicine, University of Rochester, NY 14642, USA
Circ Res 100:213-9. 2007..Furthermore, Grx association with caspase-3 was decreased by tumor necrosis factor-alpha. These findings demonstrate a novel mechanism of caspase-3 regulation by Grx in tumor necrosis factor-alpha-induced apoptosis...
- Molecular mechanisms responsible for the atheroprotective effects of laminar shear stressShi Pan
Aab Cardiovascular Research Institute, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
Antioxid Redox Signal 11:1669-82. 2009..Thus, high laminar shear stress plays a key role in the prevention of atherosclerosis through its regulation of vascular tone and long-term maintenance of the integrity and function of endothelial cells...
- Glutaredoxin mediates Akt and eNOS activation by flow in a glutathione reductase-dependent mannerJing Wang
University of Rochester, Cardiovascular Research Institute and Department of Medicine, 601 Elmwood Ave, Rochester, NY 14642, USA
Arterioscler Thromb Vasc Biol 27:1283-8. 2007..Because steady laminar flow exerts an antioxidant effect, we hypothesized that Grx mediates flow induced Akt and eNOS phosphorylation in a GR dependent manner...
- Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cellsShi Pan
Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Arterioscler Thromb Vasc Biol 29:895-901. 2009..Because tyrosine phosphorylation is a key regulatory pathway for VEGF-mediated endothelial cell (EC) responses, we investigated tyrosine phosphorylation of G6PD and the role of the nonreceptor tyrosine kinase Src...
- Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cellsHideyuki Yamawaki
Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
J Clin Invest 115:733-8. 2005..The data suggest that TXNIP and TRX are key components of biomechanical signal transduction and establish them as potentially novel regulators of TNF signaling and inflammation in ECs...
- Flow activates ERK1/2 and endothelial nitric oxide synthase via a pathway involving PECAM1, SHP2, and Tie2Lung Kuo Tai
Cardiovascular Research Institute and Department of Medicine, University of Rochester, New York 14642, USA
J Biol Chem 280:29620-4. 2005..These results establish Tie2 transactivation via PECAM1 as an early event in flow-mediated mechanotransduction and suggest an important role for a PECAM1-SHP2-Tie2 pathway in flow-mediated signal transduction...
- Cyclophilin A mediates vascular remodeling by promoting inflammation and vascular smooth muscle cell proliferationKimio Satoh
Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA
Circulation 117:3088-98. 2008....
- Etk/Bmx as a tumor necrosis factor receptor type 2-specific kinase: role in endothelial cell migration and angiogenesisShi Pan
Center for Cardiovascular Research, University of Rochester Medical Center, Rochester, New York 14642, USA
Mol Cell Biol 22:7512-23. 2002..While most TNF actions have been attributed to TNFR1, our studies demonstrate that Etk is a TNFR2-specific kinase involved in TNF-induced angiogenic events...