Research Topics
Species | Quintin PanSummaryAffiliation: University of Michigan Country: USA Publications
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Detail Information
Publications
RhoC GTPase expression as a potential marker of lymph node metastasis in squamous cell carcinomas of the head and neckCelina G Kleer
Department of Pathology, University of Michigan, Ann Arbor, 48109, USA
Clin Cancer Res 12:4485-90. 2006..This study evaluated the expression of RhoC in head and neck carcinoma and investigated the prognostic use of this marker on a large cohort of previously untreated patients with SCCHN...- Protein kinase C epsilon is a predictive biomarker of aggressive breast cancer and a validated target for RNA interference anticancer therapyQuintin Pan
Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Health System, Ann Arbor, Michigan 48109, USA
Cancer Res 65:8366-71. 2005..Taken together, these results revealed that PKC epsilon plays a critical and causative role in promoting an aggressive metastatic breast cancer phenotype and as a target for anticancer therapy... - Targeted disruption of protein kinase C epsilon reduces cell invasion and motility through inactivation of RhoA and RhoC GTPases in head and neck squamous cell carcinomaQuintin Pan
Division of Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, University of Michigan Health System, Ann Arbor, MI 48109, USA
Cancer Res 66:9379-84. 2006..Our study shows, for the first time, that PKC epsilon is involved in a coordinated regulation of RhoA and RhoC activation, possibly through direct post-translational phosphorylation... - Tetrathiomolybdate promotes tumor necrosis and prevents distant metastases by suppressing angiogenesis in head and neck cancerBasil Hassouneh
Department of Otolaryngology Head and Neck Surgery, University of Michigan, 1500 East Medical Centre Drive, 1904 Taubman Center, Ann Arbor, MI 48109, USA
Mol Cancer Ther 6:1039-45. 2007..Taken together, these results show that tetrathiomolybdate can act long-term as a suppressor of vascularity and inhibit the growth of metastasis in this model of HNSCC... - WISP3 and RhoC guanosine triphosphatase cooperate in the development of inflammatory breast cancerCelina G Kleer
Department of Pathology, Univeristy of Michigan, Ann Arbor, MI, USA
Breast Cancer Res 6:R110-5. 2004..This provides further evidence that these two genes act in concert to give rise to the highly aggressive IBC phenotype. We propose a model of this interaction as a starting point for further investigations... 
WISP3 and RhoC guanosine triphosphatase cooperate in the development of inflammatory breast cancerCelina G Kleer
Department of Pathology, University of Michigan, Ann Arbor, MI, USA
Breast Cancer Res 6:R110-5. 2004..We propose a model of this interaction as a starting point for further investigations...- Tetrathiomolybdate inhibits angiogenesis and metastasis through suppression of the NFkappaB signaling cascadeQuintin Pan
Department of Internal Medicine, Division of Hematology and Oncology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Mol Cancer Res 1:701-6. 2003..Taken together, these results strongly support that suppression of NFkappaB is the major mechanism used by TM to inhibit angiogenesis and metastasis... - Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancerKenneth L van Golen
Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, Ann Arbor 48109 0948, USA
Clin Exp Metastasis 19:301-11. 2002..We found that activation of the MAPK pathway was responsible for motility, invasion and production of angiogenic factors. In contrast, growth under anchorage independent conditions was dependent on the PI3K pathway... - Phase II trial of copper depletion with tetrathiomolybdate as an antiangiogenesis strategy in patients with hormone-refractory prostate cancerN Lynn Henry
Department of Internal Medicine, Division of Hematology, University of Michigan School of Medicine, Ann Arbor, Mich, USA
Oncology 71:168-75. 2006..There was no correlation between prostate-specific antigen and levels of angiogenesis factors. CONCLUSIONS: Copper depletion with TM did not delay disease progression in patients with asymptomatic metastatic HRPC... - The effect of tetrathiomolybdate on cytokine expression, angiogenesis, and tumor growth in squamous cell carcinoma of the head and neckTheodoros N Teknos
Department of Otolaryngology Head and Neck Surgery, University of Michigan Medical Center, Ann Arbor, MI 48103, USA
Arch Otolaryngol Head Neck Surg 131:204-11. 2005..To assess the effect of tetrathiomolybdate on cytokine expression, angiogenesis, and tumor growth rate in human squamous cell carcinoma (SCC)... - Inhibition of CCN6 (WISP3) expression promotes neoplastic progression and enhances the effects of insulin-like growth factor-1 on breast epithelial cellsYanhong Zhang
Department of Pathology, University of Michigan Medical Center, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
Breast Cancer Res 7:R1080-9. 2005..We hypothesized that inhibition of CCN6 might result in the loss of a growth regulatory function that protects mammary epithelial cells from the tumorigenic effects of growth factors, particularly IGF-1... 
Pomegranate fruit extract impairs invasion and motility in human breast cancerGazala N Khan
Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
Integr Cancer Ther 8:242-53. 2009..Because nuclear transcription factor-kB (NF-kB) is known to regulate cell survival, proliferation, tumorigenesis, and inflammation, it was postulated that PFEs may exert anticancer effects at least in part by modulating NF-kB activity...- WISP3 (CCN6) is a secreted tumor-suppressor protein that modulates IGF signaling in inflammatory breast cancerCelina G Kleer
Department of Pathology, Division of Hematology and Oncology, University of Michigan Medical Center, Ann Arbor, MI 48108, USA
Neoplasia 6:179-85. 2004.... - Preclinical development of a bifunctional cancer cell homing, PKCepsilon inhibitory peptide for the treatment of head and neck cancerLiWei Bao
Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, Michigan, USA
Cancer Res 69:5829-34. 2009..02) retards the growth of UMSCC1 xenografts in nude mice. Our work indicates that the bifunctional HN1-PKCepsilon inhibitory peptide represents a promising novel therapeutic strategy for HNSCC... - Antiangiogenic tetrathiomolybdate enhances the efficacy of doxorubicin against breast carcinomaQuintin Pan
Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Mol Cancer Ther 2:617-22. 2003..4 +/- 14.3% greater than that in doxorubicin-treated mice. These results suggest that TM may enhance the rate of pathological complete response when used in combination with an anthracycline in neoadjuvant therapy of breast carcinoma... - Copper deficiency induced by tetrathiomolybdate suppresses tumor growth and angiogenesisQuintin Pan
Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Cancer Res 62:4854-9. 2002..Our study suggests that a major mechanism of the antiangiogenic effect of copper deficiency induced by TM is suppression of NFkappaB, contributing to a global inhibition of NFkappaB-mediated transcription of proangiogenic factors... - Phase II trial of tetrathiomolybdate in patients with advanced kidney cancerBruce G Redman
Division of Hematology and Oncology, University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor 48109 0948, USA
Clin Cancer Res 9:1666-72. 2003..Tetrathiomolybdate (TM), a copper-lowering agent, has been shown in preclinical murine tumor models to be antiangiogenic. We evaluated the antitumor activity of TM in patients with advanced kidney cancer in a Phase II trial... - Prognostic factors in oral cavity and oropharyngeal squamous cell carcinomaBenjamin Marcus
Department of Otolaryngology-Head and Neck Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48103, USA
Cancer 101:2779-87. 2004..0001). CONCLUSIONS: Primary tumor macrophage content is a strong predictor of tumor aggressiveness in HNSCC... - Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimicsLori W Lee
Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
Bioorg Med Chem Lett 19:6233-6. 2009..Addition of the small molecules leads to decreased expression of the cell surface growth receptor ErbB2(Her2) in ErbB2-positive cancer cells and, correspondingly, decreased proliferation... - WISP3 is a novel tumor suppressor gene of inflammatory breast cancerCelina G Kleer
Department of Pathology, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0054, USA
Oncogene 21:3172-80. 2002..Our data demonstrate that WISP3 acts as a tumor suppressor gene in the breast. Loss of WISP3 expression contributes to the phenotype of IBC by regulating tumor cell growth, invasion and angiogenesis... - Rap1GAP promotes invasion via induction of matrix metalloproteinase 9 secretion, which is associated with poor survival in low N-stage squamous cell carcinomaRaj S Mitra
Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, University of Michigan Medical School, USA
Cancer Res 68:3959-69. 2008..015). In conclusion, Rap1GAP inhibits tumor growth but induces MMP2- and MMP9-mediated SCC invasion and tumor progression, suggesting a role for this protein as a biomarker for early N-stage, aggressive SCCs...