Quintin Pan

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint RhoC GTPase expression as a potential marker of lymph node metastasis in squamous cell carcinomas of the head and neck
    Celina G Kleer
    Department of Pathology, University of Michigan, Ann Arbor, 48109, USA
    Clin Cancer Res 12:4485-90. 2006
  2. ncbi request reprint Protein kinase C epsilon is a predictive biomarker of aggressive breast cancer and a validated target for RNA interference anticancer therapy
    Quintin Pan
    Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Health System, Ann Arbor, Michigan 48109, USA
    Cancer Res 65:8366-71. 2005
  3. ncbi request reprint Targeted disruption of protein kinase C epsilon reduces cell invasion and motility through inactivation of RhoA and RhoC GTPases in head and neck squamous cell carcinoma
    Quintin Pan
    Division of Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Cancer Res 66:9379-84. 2006
  4. ncbi request reprint Tetrathiomolybdate promotes tumor necrosis and prevents distant metastases by suppressing angiogenesis in head and neck cancer
    Basil Hassouneh
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, 1500 East Medical Centre Drive, 1904 Taubman Center, Ann Arbor, MI 48109, USA
    Mol Cancer Ther 6:1039-45. 2007
  5. ncbi request reprint WISP3 and RhoC guanosine triphosphatase cooperate in the development of inflammatory breast cancer
    Celina G Kleer
    Department of Pathology, Univeristy of Michigan, Ann Arbor, MI, USA
    Breast Cancer Res 6:R110-5. 2004
  6. ncbi request reprint The effect of tetrathiomolybdate on cytokine expression, angiogenesis, and tumor growth in squamous cell carcinoma of the head and neck
    Theodoros N Teknos
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Medical Center, Ann Arbor, MI 48103, USA
    Arch Otolaryngol Head Neck Surg 131:204-11. 2005
  7. pmc WISP3 and RhoC guanosine triphosphatase cooperate in the development of inflammatory breast cancer
    Celina G Kleer
    Department of Pathology, University of Michigan, Ann Arbor, MI, USA
    Breast Cancer Res 6:R110-5. 2004
  8. ncbi request reprint Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer
    Kenneth L van Golen
    Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, Ann Arbor 48109 0948, USA
    Clin Exp Metastasis 19:301-11. 2002
  9. ncbi request reprint Tetrathiomolybdate inhibits angiogenesis and metastasis through suppression of the NFkappaB signaling cascade
    Quintin Pan
    Department of Internal Medicine, Division of Hematology and Oncology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Mol Cancer Res 1:701-6. 2003
  10. ncbi request reprint Phase II trial of copper depletion with tetrathiomolybdate as an antiangiogenesis strategy in patients with hormone-refractory prostate cancer
    N Lynn Henry
    Department of Internal Medicine, Division of Hematology, University of Michigan School of Medicine, Ann Arbor, Mich, USA
    Oncology 71:168-75. 2006

Collaborators

Detail Information

Publications21

  1. ncbi request reprint RhoC GTPase expression as a potential marker of lymph node metastasis in squamous cell carcinomas of the head and neck
    Celina G Kleer
    Department of Pathology, University of Michigan, Ann Arbor, 48109, USA
    Clin Cancer Res 12:4485-90. 2006
    ..This study evaluated the expression of RhoC in head and neck carcinoma and investigated the prognostic use of this marker on a large cohort of previously untreated patients with SCCHN...
  2. ncbi request reprint Protein kinase C epsilon is a predictive biomarker of aggressive breast cancer and a validated target for RNA interference anticancer therapy
    Quintin Pan
    Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Health System, Ann Arbor, Michigan 48109, USA
    Cancer Res 65:8366-71. 2005
    ..Taken together, these results revealed that PKC epsilon plays a critical and causative role in promoting an aggressive metastatic breast cancer phenotype and as a target for anticancer therapy...
  3. ncbi request reprint Targeted disruption of protein kinase C epsilon reduces cell invasion and motility through inactivation of RhoA and RhoC GTPases in head and neck squamous cell carcinoma
    Quintin Pan
    Division of Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Cancer Res 66:9379-84. 2006
    ..Our study shows, for the first time, that PKC epsilon is involved in a coordinated regulation of RhoA and RhoC activation, possibly through direct post-translational phosphorylation...
  4. ncbi request reprint Tetrathiomolybdate promotes tumor necrosis and prevents distant metastases by suppressing angiogenesis in head and neck cancer
    Basil Hassouneh
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, 1500 East Medical Centre Drive, 1904 Taubman Center, Ann Arbor, MI 48109, USA
    Mol Cancer Ther 6:1039-45. 2007
    ..Taken together, these results show that tetrathiomolybdate can act long-term as a suppressor of vascularity and inhibit the growth of metastasis in this model of HNSCC...
  5. ncbi request reprint WISP3 and RhoC guanosine triphosphatase cooperate in the development of inflammatory breast cancer
    Celina G Kleer
    Department of Pathology, Univeristy of Michigan, Ann Arbor, MI, USA
    Breast Cancer Res 6:R110-5. 2004
    ..We have demonstrated that WISP3 has tumor growth and angiogenesis inhibitory functions in IBC. We proposed that RhoC and WISP3 cooperate in the development of IBC...
  6. ncbi request reprint The effect of tetrathiomolybdate on cytokine expression, angiogenesis, and tumor growth in squamous cell carcinoma of the head and neck
    Theodoros N Teknos
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Medical Center, Ann Arbor, MI 48103, USA
    Arch Otolaryngol Head Neck Surg 131:204-11. 2005
    ..To assess the effect of tetrathiomolybdate on cytokine expression, angiogenesis, and tumor growth rate in human squamous cell carcinoma (SCC)...
  7. pmc WISP3 and RhoC guanosine triphosphatase cooperate in the development of inflammatory breast cancer
    Celina G Kleer
    Department of Pathology, University of Michigan, Ann Arbor, MI, USA
    Breast Cancer Res 6:R110-5. 2004
    ..We have demonstrated that WISP3 has tumor growth and angiogenesis inhibitory functions in IBC. We hypothesized that RhoC and WISP3 cooperate in the development of IBC...
  8. ncbi request reprint Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer
    Kenneth L van Golen
    Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, Ann Arbor 48109 0948, USA
    Clin Exp Metastasis 19:301-11. 2002
    ..We found that activation of the MAPK pathway was responsible for motility, invasion and production of angiogenic factors. In contrast, growth under anchorage independent conditions was dependent on the PI3K pathway...
  9. ncbi request reprint Tetrathiomolybdate inhibits angiogenesis and metastasis through suppression of the NFkappaB signaling cascade
    Quintin Pan
    Department of Internal Medicine, Division of Hematology and Oncology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Mol Cancer Res 1:701-6. 2003
    ..Taken together, these results strongly support that suppression of NFkappaB is the major mechanism used by TM to inhibit angiogenesis and metastasis...
  10. ncbi request reprint Phase II trial of copper depletion with tetrathiomolybdate as an antiangiogenesis strategy in patients with hormone-refractory prostate cancer
    N Lynn Henry
    Department of Internal Medicine, Division of Hematology, University of Michigan School of Medicine, Ann Arbor, Mich, USA
    Oncology 71:168-75. 2006
    ..In tumor models, the copper-chelating agent tetrathiomolybdate (TM) has been shown to be antiangiogenic. We evaluated the antitumor activity of TM in patients with hormone-refractory prostate cancer (HRPC)...
  11. pmc Inhibition of CCN6 (WISP3) expression promotes neoplastic progression and enhances the effects of insulin-like growth factor-1 on breast epithelial cells
    Yanhong Zhang
    Department of Pathology, University of Michigan Medical Center, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    Breast Cancer Res 7:R1080-9. 2005
    ..We hypothesized that inhibition of CCN6 might result in the loss of a growth regulatory function that protects mammary epithelial cells from the tumorigenic effects of growth factors, particularly IGF-1...
  12. doi request reprint Pomegranate fruit extract impairs invasion and motility in human breast cancer
    Gazala N Khan
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Integr Cancer Ther 8:242-53. 2009
    ..Because nuclear transcription factor-kB (NF-kB) is known to regulate cell survival, proliferation, tumorigenesis, and inflammation, it was postulated that PFEs may exert anticancer effects at least in part by modulating NF-kB activity...
  13. pmc WISP3 (CCN6) is a secreted tumor-suppressor protein that modulates IGF signaling in inflammatory breast cancer
    Celina G Kleer
    Department of Pathology, Division of Hematology and Oncology, University of Michigan Medical Center, Ann Arbor, MI 48108, USA
    Neoplasia 6:179-85. 2004
    ....
  14. pmc Preclinical development of a bifunctional cancer cell homing, PKCepsilon inhibitory peptide for the treatment of head and neck cancer
    LiWei Bao
    Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Cancer Res 69:5829-34. 2009
    ..02) retards the growth of UMSCC1 xenografts in nude mice. Our work indicates that the bifunctional HN1-PKCepsilon inhibitory peptide represents a promising novel therapeutic strategy for HNSCC...
  15. ncbi request reprint Antiangiogenic tetrathiomolybdate enhances the efficacy of doxorubicin against breast carcinoma
    Quintin Pan
    Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Mol Cancer Ther 2:617-22. 2003
    ..4 +/- 14.3% greater than that in doxorubicin-treated mice. These results suggest that TM may enhance the rate of pathological complete response when used in combination with an anthracycline in neoadjuvant therapy of breast carcinoma...
  16. ncbi request reprint Copper deficiency induced by tetrathiomolybdate suppresses tumor growth and angiogenesis
    Quintin Pan
    Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Cancer Res 62:4854-9. 2002
    ..Our study suggests that a major mechanism of the antiangiogenic effect of copper deficiency induced by TM is suppression of NFkappaB, contributing to a global inhibition of NFkappaB-mediated transcription of proangiogenic factors...
  17. ncbi request reprint Phase II trial of tetrathiomolybdate in patients with advanced kidney cancer
    Bruce G Redman
    Division of Hematology and Oncology, University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor 48109 0948, USA
    Clin Cancer Res 9:1666-72. 2003
    ..Tetrathiomolybdate (TM), a copper-lowering agent, has been shown in preclinical murine tumor models to be antiangiogenic. We evaluated the antitumor activity of TM in patients with advanced kidney cancer in a Phase II trial...
  18. ncbi request reprint Prognostic factors in oral cavity and oropharyngeal squamous cell carcinoma
    Benjamin Marcus
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48103, USA
    Cancer 101:2779-87. 2004
    ..The authors hypothesized that tumor-associated macrophages contribute to HNSCC aggressiveness, and the objective of the current study was to prove this hypothesis using mRNA expression analysis and a large cohort of clinical specimens...
  19. pmc Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics
    Lori W Lee
    Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
    Bioorg Med Chem Lett 19:6233-6. 2009
    ..Addition of the small molecules leads to decreased expression of the cell surface growth receptor ErbB2(Her2) in ErbB2-positive cancer cells and, correspondingly, decreased proliferation...
  20. ncbi request reprint WISP3 is a novel tumor suppressor gene of inflammatory breast cancer
    Celina G Kleer
    Department of Pathology, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0054, USA
    Oncogene 21:3172-80. 2002
    ..Our data demonstrate that WISP3 acts as a tumor suppressor gene in the breast. Loss of WISP3 expression contributes to the phenotype of IBC by regulating tumor cell growth, invasion and angiogenesis...
  21. doi request reprint Rap1GAP promotes invasion via induction of matrix metalloproteinase 9 secretion, which is associated with poor survival in low N-stage squamous cell carcinoma
    Raj S Mitra
    Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, University of Michigan Medical School, USA
    Cancer Res 68:3959-69. 2008
    ..015). In conclusion, Rap1GAP inhibits tumor growth but induces MMP2- and MMP9-mediated SCC invasion and tumor progression, suggesting a role for this protein as a biomarker for early N-stage, aggressive SCCs...