Ning Pan

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc A novel Atoh1 "self-terminating" mouse model reveals the necessity of proper Atoh1 level and duration for hair cell differentiation and viability
    Ning Pan
    Department of Biology, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 7:e30358. 2012
  2. pmc Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti
    Ning Pan
    University of Iowa, Department of Biology, 143 BB, Iowa City, IA 52242, USA
    Hear Res 275:66-80. 2011
  3. pmc Expression of Neurog1 instead of Atoh1 can partially rescue organ of Corti cell survival
    Israt Jahan
    University of Iowa, Department of Biology, Iowa City, Iowa, United States of America
    PLoS ONE 7:e30853. 2012
  4. pmc Neurod1 suppresses hair cell differentiation in ear ganglia and regulates hair cell subtype development in the cochlea
    Israt Jahan
    Department of Biology, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 5:e11661. 2010
  5. doi request reprint Evolution and development of the tetrapod auditory system: an organ of Corti-centric perspective
    Bernd Fritzsch
    Department of Biology, University of Iowa, CLAS, 143 BB, Iowa City, IA, 52242, USA
    Evol Dev 15:63-79. 2013
  6. pmc Neurod1 regulates survival and formation of connections in mouse ear and brain
    Israt Jahan
    Department of Biology, College of Liberal Arts and Sciences, University of Iowa, Iowa City, IA 52242, USA
    Cell Tissue Res 341:95-110. 2010
  7. pmc Dissecting the molecular basis of organ of Corti development: Where are we now?
    Bernd Fritzsch
    Department of Biology, College of Liberal Arts and Sciences, 143 BB, University of Iowa, Iowa City, IA 52242, USA
    Hear Res 276:16-26. 2011
  8. pmc Understanding the evolution and development of neurosensory transcription factors of the ear to enhance therapeutic translation
    Ning Pan
    Department of Biology, University of Iowa, College of Liberal Arts and Sciences, Iowa City, IA 52242, USA
    Cell Tissue Res 349:415-32. 2012
  9. pmc The molecular basis of making spiral ganglion neurons and connecting them to hair cells of the organ of Corti
    Tian Yang
    Department of Biology, College of Liberal Arts and Sciences, University of Iowa, 143 BB, Iowa City, IA 52242, USA
    Hear Res 278:21-33. 2011
  10. pmc Beyond generalized hair cells: molecular cues for hair cell types
    Israt Jahan
    University of Iowa, Department of Biology, College of Liberal Arts and Sciences, 143 BB, Iowa City, IA 52242, USA
    Hear Res 297:30-41. 2013

Collaborators

Detail Information

Publications11

  1. pmc A novel Atoh1 "self-terminating" mouse model reveals the necessity of proper Atoh1 level and duration for hair cell differentiation and viability
    Ning Pan
    Department of Biology, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 7:e30358. 2012
    ..outer hair cell development. These genetically engineered Atoh1 CKO mice provide a novel model for establishing critical conditions needed to regenerate viable and functional hair cells with Atoh1 therapy...
  2. pmc Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti
    Ning Pan
    University of Iowa, Department of Biology, 143 BB, Iowa City, IA 52242, USA
    Hear Res 275:66-80. 2011
    ..This pattern of innervation by sensory neurons is maintained at least until P14, but fibers target the few Myo7a positive cells found in later stages...
  3. pmc Expression of Neurog1 instead of Atoh1 can partially rescue organ of Corti cell survival
    Israt Jahan
    University of Iowa, Department of Biology, Iowa City, Iowa, United States of America
    PLoS ONE 7:e30853. 2012
    ..In contrast to the previously demonstrated fate plasticity of neurons to differentiate as hair cells, hair cell precursors can be maintained for a limited time by Neurog1 but do not transdifferentiate as neurons...
  4. pmc Neurod1 suppresses hair cell differentiation in ear ganglia and regulates hair cell subtype development in the cochlea
    Israt Jahan
    Department of Biology, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 5:e11661. 2010
    ..Neurod1, regulated by both Neurog1 and Atoh1, could be the mediator of this cross-regulation...
  5. doi request reprint Evolution and development of the tetrapod auditory system: an organ of Corti-centric perspective
    Bernd Fritzsch
    Department of Biology, University of Iowa, CLAS, 143 BB, Iowa City, IA, 52242, USA
    Evol Dev 15:63-79. 2013
    ..Selection may explain the survival of the fittest auditory system, but only developmental genetics can explain the arrival of the fittest auditory system. [Modified after (Wagner 2011)]...
  6. pmc Neurod1 regulates survival and formation of connections in mouse ear and brain
    Israt Jahan
    Department of Biology, College of Liberal Arts and Sciences, University of Iowa, Iowa City, IA 52242, USA
    Cell Tissue Res 341:95-110. 2010
    ....
  7. pmc Dissecting the molecular basis of organ of Corti development: Where are we now?
    Bernd Fritzsch
    Department of Biology, College of Liberal Arts and Sciences, 143 BB, University of Iowa, Iowa City, IA 52242, USA
    Hear Res 276:16-26. 2011
    ..In summary, the emerging molecular complexity of organ of Corti development demands further study before a rational approach towards regeneration of unique types of hair cells in specific positions is possible...
  8. pmc Understanding the evolution and development of neurosensory transcription factors of the ear to enhance therapeutic translation
    Ning Pan
    Department of Biology, University of Iowa, College of Liberal Arts and Sciences, Iowa City, IA 52242, USA
    Cell Tissue Res 349:415-32. 2012
    ..We propose that appropriate manipulation of these TFs through their characterized binding sites may offer a solution by itself, or in conjunction with the two other approaches currently pursued by others, to restore the organ of Corti...
  9. pmc The molecular basis of making spiral ganglion neurons and connecting them to hair cells of the organ of Corti
    Tian Yang
    Department of Biology, College of Liberal Arts and Sciences, University of Iowa, 143 BB, Iowa City, IA 52242, USA
    Hear Res 278:21-33. 2011
    ....
  10. pmc Beyond generalized hair cells: molecular cues for hair cell types
    Israt Jahan
    University of Iowa, Department of Biology, College of Liberal Arts and Sciences, 143 BB, Iowa City, IA 52242, USA
    Hear Res 297:30-41. 2013
    ..Importantly, the molecular means to modify the Atoh1 expression are at least partially understood and can be readily implemented in the attempts to regenerate specific types of HCs...
  11. pmc Defects in the cerebella of conditional Neurod1 null mice correlate with effective Tg(Atoh1-cre) recombination and granule cell requirements for Neurod1 for differentiation
    Ning Pan
    Department of Biology, College of Liberal Arts and Sciences, University of Iowa, Iowa City, IA 52242, USA
    Cell Tissue Res 337:407-28. 2009
    ....