RICHARD PALMITER

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Distinguishing whether dopamine regulates liking, wanting, and/or learning about rewards
    Siobhan Robinson
    Neurobiology and Behavior Program, University of Washington, Seattle, WA, USA
    Behav Neurosci 119:5-15. 2005
  2. pmc Long-term memory for pavlovian fear conditioning requires dopamine in the nucleus accumbens and basolateral amygdala
    Jonathan P Fadok
    Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 5:e12751. 2010
  3. pmc Parkin-deficient mice are not more sensitive to 6-hydroxydopamine or methamphetamine neurotoxicity
    Francisco A Perez
    Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, WA 98195, USA
    BMC Neurosci 6:71. 2005
  4. pmc ZnT-3, a putative transporter of zinc into synaptic vesicles
    R D Palmiter
    Howard Hughes Medical Institute, University of Washington, Seattle 98195, USA
    Proc Natl Acad Sci U S A 93:14934-9. 1996
  5. pmc Dopamine signaling in the dorsal striatum is essential for motivated behaviors: lessons from dopamine-deficient mice
    Richard D Palmiter
    Howard Hughes Medical Institute and Department of Biochemistry, Box 357370, University of Washington, Seattle, WA 98195, USA
    Ann N Y Acad Sci 1129:35-46. 2008
  6. ncbi request reprint Is dopamine a physiologically relevant mediator of feeding behavior?
    Richard D Palmiter
    Howard Hughes Medical Institute, Department of Biochemistry, University of Washington, Seattle, WA 98195 7370, USA
    Trends Neurosci 30:375-81. 2007
  7. pmc Reduced levels of neurotransmitter-degrading enzyme PRCP promote a lean phenotype. [corrected]
    Richard D Palmiter
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    J Clin Invest 119:2130-3. 2009
  8. ncbi request reprint Efflux and compartmentalization of zinc by members of the SLC30 family of solute carriers
    Richard D Palmiter
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Box 357370, Seattle, WA 98195, USA
    Pflugers Arch 447:744-51. 2004
  9. pmc Protection against zinc toxicity by metallothionein and zinc transporter 1
    Richard D Palmiter
    Howard Hughes Medical Institute and Department of Biochemistry, Box 357370, University of Washington, Seattle, WA 98195 7370, USA
    Proc Natl Acad Sci U S A 101:4918-23. 2004
  10. pmc The elusive function of metallothioneins
    R D Palmiter
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Box 357370, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 95:8428-30. 1998

Research Grants

  1. Effect of Killing or Removing GABA from NPY/AgRP Neurons
    RICHARD PALMITER; Fiscal Year: 2007
  2. Effect of Killing or Removing GABA from NPY/AgRP Neurons
    RICHARD PALMITER; Fiscal Year: 2009
  3. Effect of Killing or Removing GABA from NPY/AgRP Neurons
    Richard D Palmiter; Fiscal Year: 2010
  4. GENETICS OF NEUROPEPTIDE Y FUNCTION
    RICHARD PALMITER; Fiscal Year: 2001

Detail Information

Publications80

  1. ncbi request reprint Distinguishing whether dopamine regulates liking, wanting, and/or learning about rewards
    Siobhan Robinson
    Neurobiology and Behavior Program, University of Washington, Seattle, WA, USA
    Behav Neurosci 119:5-15. 2005
    ....
  2. pmc Long-term memory for pavlovian fear conditioning requires dopamine in the nucleus accumbens and basolateral amygdala
    Jonathan P Fadok
    Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 5:e12751. 2010
    ..These data provide crucial insight into the dopamine-dependent circuitry involved in the formation of fear-related memory...
  3. pmc Parkin-deficient mice are not more sensitive to 6-hydroxydopamine or methamphetamine neurotoxicity
    Francisco A Perez
    Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, WA 98195, USA
    BMC Neurosci 6:71. 2005
    ..Because Parkin function has been linked to many of the pathways involved in METH and 6-OHDA toxicity, we predicted that Parkin-deficient mice would be more sensitive to the neurotoxic effects of these agents...
  4. pmc ZnT-3, a putative transporter of zinc into synaptic vesicles
    R D Palmiter
    Howard Hughes Medical Institute, University of Washington, Seattle 98195, USA
    Proc Natl Acad Sci U S A 93:14934-9. 1996
    ..We propose that ZnT-3 facilitates the accumulation of zinc in synaptic vesicles...
  5. pmc Dopamine signaling in the dorsal striatum is essential for motivated behaviors: lessons from dopamine-deficient mice
    Richard D Palmiter
    Howard Hughes Medical Institute and Department of Biochemistry, Box 357370, University of Washington, Seattle, WA 98195, USA
    Ann N Y Acad Sci 1129:35-46. 2008
    ..The results suggest that dopamine facilitates the output from dorsal striatum, which provides a permissive signal allowing feeding and other goal-directed behaviors...
  6. ncbi request reprint Is dopamine a physiologically relevant mediator of feeding behavior?
    Richard D Palmiter
    Howard Hughes Medical Institute, Department of Biochemistry, University of Washington, Seattle, WA 98195 7370, USA
    Trends Neurosci 30:375-81. 2007
    ..Here, I discuss the predictions and implications of these new findings as they relate to dopamine signaling and the physiology of appetite control...
  7. pmc Reduced levels of neurotransmitter-degrading enzyme PRCP promote a lean phenotype. [corrected]
    Richard D Palmiter
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    J Clin Invest 119:2130-3. 2009
    ..Their studies indicate that PRCP expression promotes obesity, while inhibitors of the enzyme counteract obesity...
  8. ncbi request reprint Efflux and compartmentalization of zinc by members of the SLC30 family of solute carriers
    Richard D Palmiter
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Box 357370, Seattle, WA 98195, USA
    Pflugers Arch 447:744-51. 2004
    ..No mutations in human counterparts of any of the members of the SLC30 family have been described...
  9. pmc Protection against zinc toxicity by metallothionein and zinc transporter 1
    Richard D Palmiter
    Howard Hughes Medical Institute and Department of Biochemistry, Box 357370, University of Washington, Seattle, WA 98195 7370, USA
    Proc Natl Acad Sci U S A 101:4918-23. 2004
    ..However, if Mt genes can be expressed, then they are preferentially amplified. Thus, both ZnT1 and MT genes contribute to zinc resistance in BHK cells, whereas ZnT1 plays a larger role in regulating free zinc levels...
  10. pmc The elusive function of metallothioneins
    R D Palmiter
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Box 357370, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 95:8428-30. 1998
    ....
  11. ncbi request reprint Dysregulation of dopamine signaling in the dorsal striatum inhibits feeding
    Bethany N Sotak
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Health Sciences Building, Room J661D, 1959 NE Pacific Street, Box 357370, Seattle, WA 98195 7370, USA
    Brain Res 1061:88-96. 2005
    ....
  12. ncbi request reprint A role for dopamine in feeding responses produced by orexigenic agents
    Thomas S Hnasko
    Neurobiology and Behavior Graduate Program, University of Washington, Seattle, WA 98195, USA
    Brain Res 1023:309-18. 2004
    ..Since dopamine signaling in the CPu is not sufficient for glucoprivation-induced feeding, we propose that this feeding behavior may be mediated by dopamine in an anatomically distinct brain region...
  13. pmc Restricting dopaminergic signaling to either dorsolateral or medial striatum facilitates cognition
    Martin Darvas
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 30:1158-65. 2010
    ....
  14. ncbi request reprint Viral restoration of dopamine signaling to the dorsal striatum restores instrumental conditioning to dopamine-deficient mice
    Siobhan Robinson
    Graduate Program in Neurobiology and Behavior, Howard Hughes Medical Institute, University of Washington, Seattle, WA, 98195, USA
    Psychopharmacology (Berl) 191:567-78. 2007
    ..Instrumental responding was evaluated to determine whether mice lacking dopamine [dopamine-deficient mice (DD mice)] could learn to preferentially press a visually cued, active lever for food reward over an inactive lever...
  15. ncbi request reprint The role of dopamine in learning, memory, and performance of a water escape task
    Victor H Denenberg
    Department of Biochemistry, University of Washington, Box 357370, Seattle, WA 98195 7370, USA
    Behav Brain Res 148:73-8. 2004
    ....
  16. ncbi request reprint Cocaine-conditioned place preference by dopamine-deficient mice is mediated by serotonin
    Thomas S Hnasko
    Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 27:12484-8. 2007
    ..These findings are consistent with the hypothesis that, in the absence of dopamine, cocaine-mediated SERT blockade activates dopamine neurons, which then release some other neurotransmitter that contributes to cocaine reward in DD mice...
  17. ncbi request reprint Expression of mutant NMDA receptors in dopamine D1 receptor-containing cells prevents cocaine sensitization and decreases cocaine preference
    Carrie L Heusner
    Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 25:6651-7. 2005
    ..These data suggest that intact NMDA receptor signaling in D1R-containing cells is required for the manifestation of behaviors associated with repeated drug exposure...
  18. pmc Absence of NMDA receptors in dopamine neurons attenuates dopamine release but not conditioned approach during Pavlovian conditioning
    Jones G Parker
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle WA 98195, USA
    Proc Natl Acad Sci U S A 107:13491-6. 2010
    ....
  19. pmc Mice with chronic norepinephrine deficiency resemble amphetamine-sensitized animals
    David Weinshenker
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 99:13873-7. 2002
    ..We conclude that in contrast to acute alpha1AR blockade, chronic NE deficiency induces changes similar to sensitization, perhaps by altering DA-signaling pathways...
  20. ncbi request reprint Role of noradrenergic signaling by the nucleus tractus solitarius in mediating opiate reward
    Valerie G Olson
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Science 311:1017-20. 2006
    ..Morphine-induced locomotion was partially restored by DBH expression in either brain region. These data suggest that NE signaling by the nucleus tractus solitarius is necessary for morphine reward...
  21. ncbi request reprint Dopamine-dependent desensitization of dopaminergic signaling in the developing mouse striatum
    Douglas S Kim
    Molecular and Cellular Biology Program, University of Washington, Seattle, Washington 98195 7370, USA
    J Neurosci 22:9841-9. 2002
    ..Dopaminoceptive neurons appear to reduce their sensitivity to dopamine as dopaminergic terminals innervate the striatum and functional neurotransmission begins...
  22. pmc Restriction of dopamine signaling to the dorsolateral striatum is sufficient for many cognitive behaviors
    Martin Darvas
    Department of Biochemistry, University of Washington, Howard Hughes Medical Institute, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 106:14664-9. 2009
    ..These results indicate that dopaminergic signaling in the ventromedial striatum is not absolutely necessary for mastery of these behaviors, but may facilitate them...
  23. pmc Cre recombinase-mediated restoration of nigrostriatal dopamine in dopamine-deficient mice reverses hypophagia and bradykinesia
    Thomas S Hnasko
    Graduate Program in Neurobiology and Behavior, Department of Biochemistry, and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 103:8858-63. 2006
    ..This approach offers numerous advantages compared with previous models aimed at examining dopamine signaling in discrete dopaminergic circuits...
  24. ncbi request reprint Altered sleep latency and arousal regulation in mice lacking norepinephrine
    Melissa S Hunsley
    Howard Hughes Medical Institute and Department of Biochemistry, Box 357370, University of Washington, Seattle, WA 98195 7370, USA
    Pharmacol Biochem Behav 78:765-73. 2004
    ..The results presented here suggest that NE promotes wakefulness during transitions between sleep and wake under conditions involving mild stress and SD, but not under baseline circumstances...
  25. ncbi request reprint Dopamine modulates release from corticostriatal terminals
    Nigel S Bamford
    Department of Neurology, University of Washington, USA
    J Neurosci 24:9541-52. 2004
    ..Microdialysis revealed that basal extracellular striatal glutamate was normal in DD mice. These data indicate that dopamine deficiency results in morphologically normal corticostriatal terminals with hypersensitive D2 receptors...
  26. pmc Parkin-deficient mice are not a robust model of parkinsonism
    Francisco A Perez
    Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 102:2174-9. 2005
    ..Understanding why Parkin-deficient mice do not exhibit robust signs of parkinsonism could advance knowledge and treatment of PD...
  27. pmc Disruption of NMDAR-dependent burst firing by dopamine neurons provides selective assessment of phasic dopamine-dependent behavior
    Larry S Zweifel
    Department of Psychology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 106:7281-8. 2009
    ....
  28. ncbi request reprint Morphine reward in dopamine-deficient mice
    Thomas S Hnasko
    Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, Washington 98195, USA
    Nature 438:854-7. 2005
    ....
  29. pmc Dopamine is necessary for cue-dependent fear conditioning
    Jonathan P Fadok
    Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 29:11089-97. 2009
    ..These findings indicate that DA acting on multiple receptor subtypes within multiple target regions facilitates the stabilization of fear memory...
  30. ncbi request reprint Attenuation of diabetic hyperphagia in neuropeptide Y--deficient mice
    Dana K Sindelar
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetes 51:778-83. 2002
    ....
  31. pmc Adenosine receptor blockade reverses hypophagia and enhances locomotor activity of dopamine-deficient mice
    Douglas S Kim
    Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195 7275, USA
    Proc Natl Acad Sci U S A 100:1346-51. 2003
    ..This study of a genetic model of dopamine depletion provides evidence that A(2A) receptor antagonists could ameliorate the hypokinetic symptoms of advanced Parkinson's disease patients without inducing excessive motor activity...
  32. ncbi request reprint Interaction of dopamine and adenosine receptor function in behavior: studies with dopamine-deficient mice
    Douglas S Kim
    Molecular and Cellular Biology Program, University of Washington, Seattle, Washington 98195, USA
    Front Biosci 13:2311-8. 2008
    ....
  33. ncbi request reprint Neonatal 6-hydroxydopamine administration to mice is fatal
    Michelle D Brot
    Department of Orthodontics, University of Washington, Seattle, Wash 98195 7370, USA
    Dev Neurosci 24:531-8. 2002
    ..Some treated mice were raised in a heated chamber to help them conserve energy. The results demonstrate that regardless of genotype or environmental temperature, bilateral neonatal 6-OHDA lesions are lethal to mice...
  34. pmc A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
    Linda Madisen
    Allen Institute for Brain Science, Seattle, Washington, USA
    Nat Neurosci 13:133-40. 2010
    ..Our expression data are displayed in a public online database to help researchers assess the utility of various Cre-driver lines for cell-type-specific genetic manipulation...
  35. ncbi request reprint Viral restoration of dopamine to the nucleus accumbens is sufficient to induce a locomotor response to amphetamine
    Carrie L Heusner
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Brain Res 980:266-74. 2003
    ..These data support previous studies in which accumbal dopamine is required for producing a normal locomotor response to amphetamine and further show that release of dopamine restricted to the NAc is sufficient for this response..
  36. pmc Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking
    Benjamin B Land
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 106:19168-73. 2009
    ..These results suggest that the adverse effects of stress may converge on the serotonergic system and offers an approach to controlling stress-induced dysphoria and relapse...
  37. ncbi request reprint Lack of neuropeptide Y attenuates the somatic signs of opiate withdrawal
    Valerie G Olson
    Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    Synapse 60:553-6. 2006
    ..Here we report that mice lacking the NPY gene show normal conditioned place aversion to opiate withdrawal, but show attenuated opiate withdrawal somatic signs...
  38. pmc Deletion of GAD67 in dopamine receptor-1 expressing cells causes specific motor deficits
    Carrie L Heusner
    Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    Genesis 46:357-67. 2008
    ..We show that these mice are deficient in some types of motor skills, but normal for others, suggesting a differential role for GABA release from D1 receptor-containing neurons...
  39. ncbi request reprint NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates
    Serge Luquet
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Box 357370, Seattle, WA 98195, USA
    Science 310:683-5. 2005
    ..These results suggest that network-based compensatory mechanisms can develop after the ablation of NPY/AgRP neurons in neonates but do not readily occur when these neurons become essential in adults...
  40. pmc Modulation of neuropeptide Y expression in adult mice does not affect feeding
    Linda Ste Marie
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 102:18632-7. 2005
    ..These observations suggest that pharmacological inhibition of NPY signaling is unlikely to have long-lasting effects on body weight...
  41. pmc Role of NMDA receptors in dopamine neurons for plasticity and addictive behaviors
    Larry S Zweifel
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Neuron 59:486-96. 2008
    ..These findings provide evidence for a role of NMDAR signaling in DA neurons for specific behavioral modifications associated with drug seeking behaviors...
  42. ncbi request reprint Reward without dopamine
    Claire Matson Cannon
    Department of Biochemistry and Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195 7370, USA
    J Neurosci 23:10827-31. 2003
    ..Thus, DA is not required for mice to learn to consume sweet solutions preferentially. We conclude that DA is not required to find the sweet tastes of sucrose or saccharin rewarding...
  43. ncbi request reprint Local dopamine production in the dorsal striatum restores goal-directed behavior in dopamine-deficient mice
    Siobhan Robinson
    Neurobiology and Behavior Program, University of Washington, Seattle, WA 98195, USA
    Behav Neurosci 120:196-200. 2006
    ..The authors conclude that finely tuned dopaminergic signaling within the dorsal striatum is sufficient for performance of goal-directed behavior...
  44. pmc Complex I deficiency due to loss of Ndufs4 in the brain results in progressive encephalopathy resembling Leigh syndrome
    Albert Quintana
    Department of Biochemistry, Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 107:10996-1001. 2010
    ..These data suggest that dysfunctional complex I in specific brain regions results in progressive glial activation that promotes neuronal death that ultimately results in mortality...
  45. ncbi request reprint Dysregulation of striatal dopamine signaling by amphetamine inhibits feeding by hungry mice
    Claire Matson Cannon
    Department of Biochemistry and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Neuron 44:509-20. 2004
    ..We suggest that, at this moderate dose of AMPH, dysregulation of striatal DA is the primary cause of AMPH-induced hypophagia and that regulated striatal dopaminergic signaling may be necessary for normal feeding behaviors...
  46. ncbi request reprint Regulation of norepinephrine transporter abundance by catecholamines and desipramine in vivo
    David Weinshenker
    Howard Hughes Medical Institute, Box 357370, University of Washington, Seattle 98195, USA
    Brain Res 946:239-46. 2002
    ..There are some qualitative and quantitative differences in the down-regulation of the NET by catecholamine depletion and DMI treatment, suggesting that different mechanisms may be involved...
  47. ncbi request reprint Mice lacking dopamine D1 receptors express normal lithium chloride-induced conditioned taste aversion for salt but not sucrose
    Claire Matson Cannon
    Department of Biochemistry and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195 7370, USA
    Eur J Neurosci 21:2600-4. 2005
    ..2 m NaCl). Our results suggest that activation of D1 receptors might contribute to the strength of an aversive gustatory association, but might not be required for the formation of a CTA in general...
  48. ncbi request reprint Norepinephrine-deficient mice exhibit normal sleep-wake states but have shorter sleep latency after mild stress and low doses of amphetamine
    Melissa S Hunsley
    Howard Hughes Medical Institute, University of Washington, Seattle 98195 7370, USA
    Sleep 26:521-6. 2003
    ..Mice lacking the ability to make norepinephrine (NE) were used to investigate how NE may be involved in regulating sleep and sleep latency under normal conditions and as a response to mild stress or varying doses of amphetamine...
  49. pmc Firing properties of dopamine neurons in freely moving dopamine-deficient mice: effects of dopamine receptor activation and anesthesia
    Siobhan Robinson
    Neurobiology and Behavior Program, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 101:13329-34. 2004
    ..These data suggest that restoration of endogenous dopamine signaling activates hypersensitive long-loop feedback pathways that serve to limit dopamine release and underscore the importance of recording from awake animals...
  50. ncbi request reprint NPY/AgRP neurons are not essential for feeding responses to glucoprivation
    Serge Luquet
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Box 357370, Seattle, WA 98195, United States
    Peptides 28:214-25. 2007
    ..We conclude that NPY/AgRP neurons are not necessary for generating or mediating the orexigenic response to glucose deficiency, but they are essential for the feeding response to ghrelin and refeeding on standard chow after a fast...
  51. pmc Ablation of neurons expressing agouti-related protein activates fos and gliosis in postsynaptic target regions
    Qi Wu
    Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 28:9218-26. 2008
    ..Furthermore, glial cell activation in target areas of AgRP neurons appears to be a result of excitotoxicity...
  52. ncbi request reprint Norepinephrine- and epinephrine-deficient mice gain weight normally on a high-fat diet
    Linda Ste Marie
    Department of Biochemistry, Howard Hughes Medical Institute, Box 357370, University of Washington, Seattle, WA 98195, USA
    Obes Res 13:1518-22. 2005
    ..We characterized the response of Dbh-null and control mice to a HFD...
  53. ncbi request reprint Norepinephrine and epinephrine-deficient mice are hyperinsulinemic and have lower blood glucose
    Linda Ste Marie
    Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    Endocrinology 144:4427-32. 2003
    ..We suggest that the primary difference in Dbh-/- mice is chronic hyperinsulinemia associated with an altered glucose set point. However, these animals compensate for NE/Epi-mediated glycogenolysis and feeding...
  54. ncbi request reprint Attenuated feeding responses to circadian and palatability cues in mice lacking neuropeptide Y
    Dana K Sindelar
    Department of Medicine, University of Washington, Harborview Hospital, Division of Endocrinology, Box 359757, 325 9th Avenue, Seattle, WA 98104, USA
    Peptides 26:2597-602. 2005
    ....
  55. ncbi request reprint Neuropeptide Y is required for hyperphagic feeding in response to neuroglucopenia
    Dana K Sindelar
    Department of Medicine, Harborview Medical Centr, Howard Hughes Medical Institute, University of Washington, Seattle 98195, USA
    Endocrinology 145:3363-8. 2004
    ..We conclude that NPY signaling is required for hyperphagic feeding, but not neuroendocrine responses to moderate hypoglycemia...
  56. pmc Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat
    Won Seok Choi
    Toxicology Program, Department of Environmental and Occupational Health Sciences, Graduate Program in Neurobiology and Behavior, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195 7234, USA
    Proc Natl Acad Sci U S A 105:15136-41. 2008
    ..In fact, the dopaminergic neurons were more sensitive to rotenone. These data suggest that dopaminergic neuron death induced by treatment with rotenone, MPP(+), or paraquat is independent of complex I inhibition...
  57. ncbi request reprint Genetic disruption of dopamine production results in pituitary adenomas and severe prolactinemia
    Thomas S Hnasko
    Graduate Program in Neurobiology and Behavior, Children s Hospital and Regional Medical Center, University of Washington, Seattle, WA 98195, USA
    Neuroendocrinology 86:48-57. 2007
    ..Dopamine release from tuberoinfundibular dopamine neurons into the median eminence activates dopamine-D2 receptors in the pituitary gland where it inhibits lactotroph function...
  58. ncbi request reprint Role of agouti-related protein-expressing neurons in lactation
    Colin T Phillips
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Endocrinology 149:544-50. 2008
    ..We also show that constitutive inactivation of Npy and Agrp genes does not prevent pregnancy or lactation, nor does it protect lactating dams from diphtheria toxin-induced starvation...
  59. pmc Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy
    Shane E Kruse
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Cell Metab 7:312-20. 2008
    ..Nonetheless, total oxygen consumption and muscle ATP and phosphocreatine concentrations measured in vivo were within normal parameters...
  60. pmc Starvation after AgRP neuron ablation is independent of melanocortin signaling
    Qi Wu
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Box 357370, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 105:2687-92. 2008
    ..These results indicate that both the appetitive and consummatory aspects of feeding become impaired in a melanocortin-independent manner after AgRP neuron ablation...
  61. pmc Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation
    Qi Wu
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Cell 137:1225-34. 2009
    ..Chronic delivery of bretazenil during loss of AgRP neurons provides time to establish compensatory mechanisms that eventually allow mice to eat...
  62. ncbi request reprint Chronic neuropeptide Y infusion into the lateral ventricle induces sustained feeding and obesity in mice lacking either Npy1r or Npy5r expression
    Paula D Raposinho
    Division of Pediatric Endocrinology and Diabetology, University of Geneva School of Medicine, 1211 Geneva 14, Switzerland
    Endocrinology 145:304-10. 2004
    ..Taken together, these data strongly suggest biological redundancies between Y1 and Y5 receptor signaling in the NPY-mediated control of food intake...
  63. ncbi request reprint Dbh(-/-) mice are hypotensive, have altered circadian rhythms, and have abnormal responses to dieting and stress
    Steven J Swoap
    Department of Biology, Williams College, Williamstown, MA 01267, USA
    Am J Physiol Regul Integr Comp Physiol 286:R108-13. 2004
    ..In contrast, Epi and NE are required for the tachycardia in an open field but are not required for the increase in blood pressure...
  64. pmc Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis
    Philip Seeman
    Pharmacology Department, Medical Science Building, Room 4344, University of Toronto, 1 King s College Circle, Toronto, ON, Canada M5S 1A8
    Proc Natl Acad Sci U S A 102:3513-8. 2005
    ..If many types of brain impairment cause dopamine behavioral supersensitivity and a common increase in D2High states, it suggests that there are many pathways to psychosis, any one of which can be disrupted...
  65. ncbi request reprint Neuropeptide Y protects against methamphetamine-induced neuronal apoptosis in the mouse striatum
    Nathalie Thiriet
    Centre National de la Recherche Scientifique 6187, University of Poitiers, 86000 Poitiers, France
    J Neurosci 25:5273-9. 2005
    ..Given the similarity between the cell death patterns induced by METH and by disorders such as Huntington's disease, our results suggest that NPY analogs might be useful therapeutic agents against some neurodegenerative processes...
  66. ncbi request reprint Role of metallothionein-III following central nervous system damage
    Javier Carrasco
    Institute of Neurosciences and Department of Cellular Biology, Physiology and Immunology, Animal Physiology Unit, Faculty of Sciences, Autonomous University of Barcelona, Bellaterra, Barcelona, Spain 08193
    Neurobiol Dis 13:22-36. 2003
    ....
  67. pmc Dopamine controls the firing pattern of dopamine neurons via a network feedback mechanism
    Carlos A Paladini
    Vollum Institute, Oregon Health and Science University, Portland, OR 97201, USA
    Proc Natl Acad Sci U S A 100:2866-71. 2003
    ..These data suggest that endogenously released dopamine plays a critical role in the afferent control of dopamine neuron bursting activity and that this control is exerted via a network feedback mechanism...
  68. ncbi request reprint Dopamine depletion does not protect against acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in vivo
    Daphne M Hasbani
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 25:9428-33. 2005
    ..These results suggest that DA does not contribute to acute MPTP toxicity in vivo...
  69. pmc Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice
    Joo Yong Lee
    National Creative Research Initiative Center for the Study of Central Nervous System Zinc and Department of Neurology, University of Ulsan College of Medicine, Seoul 138 736, Korea
    Proc Natl Acad Sci U S A 99:7705-10. 2002
    ..Hence, of endogenous metals, synaptic zinc contributes predominantly to amyloid deposition in hAPP(+) mice...
  70. ncbi request reprint Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease
    Avi L Friedlich
    Laboratory for Oxidation Biology, Genetics and Aging Research Unit, Massachusetts General Hospital, and Department of Psychiatry, Harvard Medical School, Charlestown, Massachusetts 02129 4404, USA
    J Neurosci 24:3453-9. 2004
    ..ZnT3 was not detected in the cerebral vessel walls or in blood components of wild-type mice. Thus, synaptic ZnT3 activity may promote CAA by indirectly raising exchangeable Zn2+ concentrations in the perivascular spaces of the brain...
  71. ncbi request reprint Zinc released from metallothionein-iii may contribute to hippocampal CA1 and thalamic neuronal death following acute brain injury
    Joo Yong Lee
    National Creative Research Initiative Center for the Study of CNS Zinc and Department of Neurology, University of Ulsan College of Medicine, 138 736, Seoul, Korea
    Exp Neurol 184:337-47. 2003
    ..These results suggest that intracellular zinc release from MT-III may contribute substantially to zinc-mediated neuronal death in certain brain areas, including the hippocampal CA1 region and the thalamus...
  72. pmc GAD67-mediated GABA synthesis and signaling regulate inhibitory synaptic innervation in the visual cortex
    Bidisha Chattopadhyaya
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Neuron 54:889-903. 2007
    ..Since intracellular GABA levels are modulated by neuronal activity, our results implicate GAD67-mediated GABA synthesis in activity-dependent regulation of inhibitory innervation patterns...
  73. ncbi request reprint Endogenous neurotensin attenuates dopamine-dependent locomotion and stereotypy
    Elena H Chartoff
    Department of Psychiatry, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Brain Res 1022:71-80. 2004
    ....
  74. pmc Induction of metallothionein I by phenolic antioxidants requires metal-activated transcription factor 1 (MTF-1) and zinc
    Yongyi Bi
    Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
    Biochem J 380:695-703. 2004
    ..These findings establish that phenolic antioxidants activate Mt1 transcription by a zinc-dependent mechanism, which involves MTF-1 binding to metal regulator elements in the Mt1 gene promoter...
  75. ncbi request reprint Estrogen decreases zinc transporter 3 expression and synaptic vesicle zinc levels in mouse brain
    Joo Yong Lee
    National Creative Research Initiative Center for the Study of Central Nervous System Zinc, and Department of Neurology, University of Ulsan College of Medicine, Seoul 138 736, Korea
    J Biol Chem 279:8602-7. 2004
    ....
  76. doi request reprint Dopamine is necessary to endogenous morphine formation in mammalian brain in vivo
    Carla Neri
    Institute of Medicine and Public Health, University of Verona, Verona, Italy
    J Neurochem 106:2337-44. 2008
    ..Thus, dopamine and endogenous opiates/opioid peptides may be interconnected in the physiological processes; yet, endogenous morphine may represent a basic link of this chain...
  77. ncbi request reprint The d subunit of the vacuolar ATPase (Atp6d) is essential for embryonic development
    Grant I Miura
    Transgenic Res 12:131-3. 2003
  78. ncbi request reprint Mouse zinc transporter 1 gene provides an essential function during early embryonic development
    Glen K Andrews
    Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7421, USA
    Genesis 40:74-81. 2004
    ....
  79. ncbi request reprint Dopamine is not required for the hyperlocomotor response to NMDA receptor antagonists
    Elena H Chartoff
    Department of Psychiatry, Harvard Medical School, McLean Hospital Belmont, MA, USA
    Neuropsychopharmacology 30:1324-33. 2005
    ..These results suggest that glutamate, rather than dopamine, is required for the locomotor and molecular effects of NMDA receptor antagonists, but that glutamate and dopamine can act cooperatively...
  80. pmc The NK1 receptor mediates both the hyperalgesia and the resistance to morphine in mice lacking noradrenaline
    Luc Jasmin
    Department of Neurological Surgery, University of California, San Francisco, CA 94143 0112, USA
    Proc Natl Acad Sci U S A 99:1029-34. 2002
    ..We conclude that when unopposed by NA, substance P acting at the NK1 receptor causes chronic thermal hyperalgesia, and that the reduced opioid efficacy associated with a lack of NA is due to increased NK1-receptor stimulation...

Research Grants6

  1. Effect of Killing or Removing GABA from NPY/AgRP Neurons
    RICHARD PALMITER; Fiscal Year: 2007
    ..These experiments should provide insight into the neural circuits and signaling molecules that are critical for feeding. ..
  2. Effect of Killing or Removing GABA from NPY/AgRP Neurons
    RICHARD PALMITER; Fiscal Year: 2009
    ..These experiments should provide insight into the neural circuits and signaling molecules that are critical for feeding. ..
  3. Effect of Killing or Removing GABA from NPY/AgRP Neurons
    Richard D Palmiter; Fiscal Year: 2010
    ..These experiments should provide insight into the neural circuits and signaling molecules that are critical for feeding. ..
  4. GENETICS OF NEUROPEPTIDE Y FUNCTION
    RICHARD PALMITER; Fiscal Year: 2001
    ..These genetic experiments should help rationalize the current disparate results obtained by permanent NPY gene silencing and by acute intervention of NPY signaling. ..