Jerry P Palmer
Affiliation: University of Washington
- Identification of autoantibody-negative autoimmune type 2 diabetic patientsBarbara M Brooks-Worrell
Department of Medicine, University of Washington, Seattle, Washington, USA
Diabetes Care 34:168-73. 2011..In this study, we investigated whether islet reactive T cells might also be present in type 2 diabetic patients and how islet reactive T cells correlate with β-cell function...
- Is latent autoimmune diabetes in adults distinct from type 1 diabetes or just type 1 diabetes at an older age?Jerry P Palmer
Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, USA
Diabetes 54:S62-7. 2005..These patients appear to be similar to type 1.5 patients in having decreased stimulated C-peptide values. These immunological differences between type 1 and type 1.5 diabetes suggest at least partially distinct disease processes...
- C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: report of an ADA workshop, 21-22 October 2001Jerry P Palmer
Department of Medicine, University of Washington, and DVA Puget Sound Health Care System, Seattle, Washington 98108, USA
Diabetes 53:250-64. 2004..The development of therapies for addressing this important unmet clinical need will be facilitated by trials that are carefully designed with beta-cell function as determined by C-peptide measurement as the primary efficacy outcome...
- C-peptide in the natural history of type 1 diabetesJerry P Palmer
Department of Medicine, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, WA, USA
Diabetes Metab Res Rev 25:325-8. 2009....
- Beta cell rest and recovery--does it bring patients with latent autoimmune diabetes in adults to euglycemia?Jerry P Palmer
VA Puget Sound Health Care System, Department of Medicine, University of Washington, Seattle, Washington 98198, USA
Ann N Y Acad Sci 958:89-98. 2002....
- Equivalent insulin resistance in latent autoimmune diabetes in adults (LADA) and type 2 diabetic patientsHarvey K Chiu
Veterans Affairs Puget Sound Health Care System, Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington Seattle, WA, United States
Diabetes Res Clin Pract 77:237-44. 2007..As complications and treatment regimens specific to LADA are realized, improved means of identification of LADA will become increasingly important...
- T-cell responses to islet antigens improves detection of autoimmune diabetes and identifies patients with more severe beta-cell lesions in phenotypic type 2 diabetesAmit Goel
Veterans Affairs Puget Sound Health Care System, Department of Medicine, Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, WA 98108, USA
Diabetes 56:2110-5. 2007....
- Autoimmunity and clinical course in children with type 1, type 2, and type 1.5 diabetesLisa K Gilliam
Department of Medicine, University of Washington, 1959 N E Pacific St, Box 357710, Seattle, 98195, USA
J Autoimmun 25:244-50. 2005..We examined the relationship between diabetes autoantibodies (DAA), human leukocyte antigen (HLA), and clinical course in subjects grouped by clinical diabetes type...
- Autoimmunity to islet proteins in children diagnosed with new-onset diabetesBarbara M Brooks-Worrell
Department of Medicine, University of Washington, Seattle, Washington 98195, USA
J Clin Endocrinol Metab 89:2222-7. 2004..Moreover, the presence of obesity or acanthosis nigracans does not reliably distinguish children with or without islet cell autoimmunity...
- Parenteral insulin suppresses T cell proliferation to islet antigensCarla J Greenbaum
Benaroya Research Institute, Seattle, WA, USA
Pediatr Diabetes 12:150-5. 2011..Further study is needed to determine whether a therapy that results in sustained suppression of T cell proliferation could yield a measurable clinical benefit...
- Islet cell antibodies and glutamic acid decarboxylase antibodies, but not the clinical phenotype, help to identify type 1(1/2) diabetes in patients presenting with type 2 diabetesR Juneja
Department of Medicine, University of Washington, Seattle, WA 98108, USA
Metabolism 50:1008-13. 2001..We therefore conclude that screening with antibodies, mainly ICA and GAD, but not age, BMI, or clinical presentation should be used to identify type 1(1/2) diabetes...
- Fall in C-peptide during first 2 years from diagnosis: evidence of at least two distinct phases from composite Type 1 Diabetes TrialNet dataCarla J Greenbaum
Benaroya Research Institute, Seattle, Washington, USA
Diabetes 61:2066-73. 2012..The robust data on the C-peptide obtained under clinical trial conditions should be used in planning and interpretation of clinical trials...
- Successful prospective prediction of type 1 diabetes in schoolchildren through multiple defined autoantibodies: an 8-year follow-up of the Washington State Diabetes Prediction StudyJames M LaGasse
Pacific Northwest Research Institute, Seattle, Washington 98122, USA
Diabetes Care 25:505-11. 2002..Almost 90% of type 1 diabetes appears in individuals without a close family history. We sought to evaluate the best current predictive strategy, multiple defined autoantibodies, in a long-term prospective study in the general population...
- Precursor frequencies of T-cells reactive to insulin in recent onset type 1 diabetes mellitusRamachandra G Naik
Department of Medicine, Division of Metabolism, Endocrinology, and Nutrition, University of Washington and Department of Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
J Autoimmun 23:55-61. 2004..Consequently the precursor frequency of insulin autoreactive cells in patients and their siblings is probably much higher than calculated...
- Improved T cell assay for identification of type 1 diabetes patientsBarbara Brooks-Worrell
Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
J Immunol Methods 344:79-83. 2009..This improved T cell assay, which directly measures islet reactive T cell responses in autoimmune diabetes patients with excellent sensitivity and specificity, will likely improve patient follow-up during intervention studies...
- Multiple factors affect the loss of measurable C-peptide over 6 years in newly diagnosed 15- to 35-year-old diabetic subjectsRichard A Jensen
Department of Biostatistics, University of Washington, Seattle, WA, USA
J Diabetes Complications 21:205-13. 2007..The aim of this study is to identify risk factors for the loss of measurable plasma C-peptide in newly diagnosed 15- to 35-year-old diabetic subjects...
- Intermolecular antigen spreading occurs during the preclinical period of human type 1 diabetesB Brooks-Worrell
Department of Medicine, University of Washington, Seattle, WA 98195, USA
J Immunol 166:5265-70. 2001..Our data strongly support the conclusion that intermolecular spreading of T cell and Ab responses to islet proteins occurs during the preclinical period of type 1 diabetes...
- Relationship of beta-cell function and autoantibodies to progression and nonprogression of subclinical type 1 diabetes: follow-up of the Seattle Family StudyC J Greenbaum
Department of Medicine, University of Washington, Seattle, USA
Diabetes 48:170-5. 1999..In addition, there are a group of ICA+ relatives with low AIRg and/or multiple antibodies who have not progressed to diabetes over the course of the study...
- Autoimmune diabetes: more than just one flavor?H K Chiu
Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, VA Puget Sound Health Care System, Seattle, WA, USA
J Endocrinol Invest 27:480-4. 2004
- Improving the quality of outpatient care for older patients with diabetes: lessons from a comparison of rural and urban communitiesR A Rosenblatt
University of Washington, Department of Family Medicine, Box 354696, Seattle, WA 98195 4696, USA
J Fam Pract 50:676-80. 2001..Our goal was to compare the quality of diabetic care received by patients in rural and urban communities...
- Type 1 1/2 diabetes: myth or reality?R Juneja
Department of Veteran Affairs Puget Sound Health Care System, University of Washington, Endocrinology, Seattle 98108, USA
Autoimmunity 29:65-83. 1999....
- Cellular immune responses to human islet proteins in antibody-positive type 2 diabetic patientsB M Brooks-Worrell
Department of Medicine, Department of Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
Diabetes 48:983-8. 1999..Some subjects demonstrate PBMC responses similar to those of "classic" type 1 diabetic patients, whereas others have PBMC responses potentially distinct from type 1 diabetic patients...
- Nitric oxide mediates IL-1beta stimulation of heat shock protein but not IL-1beta inhibition of glutamic acid decarboxylaseW Hao
Department of Medicine, University of Washington, Department of Veteran Affairs Puget Sound Health Care System, Seattle 98108, USA
Autoimmunity 29:93-101. 1999..Our findings indicate that the effect of IL-1beta on HSP-70 expression is mediated by NO production, whereas a NO-independent pathway is involved in the effect of IL-1beta on GAD-65 expression and insulin secretion...
- The association between the PTPN22 1858C>T variant and type 1 diabetes depends on HLA risk and GAD65 autoantibodiesM Maziarz
Department of Biostatistics, University of Washington, Seattle, WA 98195 7232, USA
Genes Immun 11:406-15. 2010..We hypothesize that the altered T-cell function because of the PTPN22(1858C>T) polymorphism is exclusively associated with GADA-positive T1D at diagnosis...
- Immunogenetic analysis suggests different pathogenesis for obese and lean African-Americans with diabetic ketoacidosisG E Umpierrez
Department of Medicine, Emory University, Atlanta, Georgia 30312, USA
Diabetes Care 22:1517-23. 1999..The aim of this study was to determine whether obese African-American patients with DKA could be determined to have type 1 or type 2 diabetes based on insulin secretion or the presence of immunological and genetic markers...
- Gestational diabetes: antepartum characteristics that predict postpartum glucose intolerance and type 2 diabetes in Latino womenT A Buchanan
Department of Medicine, University of Southern California School of Medicine, Los Angeles, USA
Diabetes 47:1302-10. 1998....
- Biomarkers and immune-modulating therapies for type 2 diabetesBarbara Brooks-Worrell
Department of Medicine, University of Washington, VA Puget Sound Health Care System, Seattle, WA 98108, USA
Trends Immunol 33:546-53. 2012....
- Tyramine-mediated activation of sympathetic nerves inhibits insulin secretion in humansLisa K Gilliam
Department of Medicine, University of Washington, 1959 N E Pacific Street, Box 357710, Seattle, Washington 98195, USA
J Clin Endocrinol Metab 92:4035-8. 2007..However, a direct test of the hypothesis that moderate and selective activation of these nerves is sufficient to inhibit insulin secretion in humans is lacking...
- Is diabetes mellitus a continuous spectrum?Barbara Brooks-Worrell
Department of Medicine, DVA Puget Sound Health Care System, Seattle, WA 98108, USA
Clin Chem 57:158-61. 2011..Diabetes mellitus has been historically divided into type 1 and type 2 diabetes, with type 1 being an autoimmune disease and type 2 being primarily a metabolic disease...
- Inhaled insulin and insulin antibodies: a new twist to an old debateJames A Stoever
Department of Endocrinology, Diabetes and Metabolism, VA Puget Sound Health Care System, University of Washington, 1660 South Colombian Way, Seattle, WA 98108, USA
Diabetes Technol Ther 4:157-61. 2002..This review will discuss the potential implications of elevated insulin antibody levels, the role insulin antibodies play in the metabolic control of diabetes and the effect inhaled insulin may have on the immune system...
- Lipoprotein lipase and hepatic lipase: their relationship with HDL subspecies Lp(A-I) and Lp(A-I,A-II)Marian C Cheung
Department of Medicine, University of Washington, Seattle, WA 98103, USA
J Lipid Res 44:1552-8. 2003..Furthermore, select correlations of LPL and/or HL with the apoA-I, cholesterol, and triglyceride of Lp(A-I) but not Lp(A-I,A-II) imply that the apoA-I and lipid of Lp(A-I) and Lp(A-I,A-II) are not fully equilibrated...
- Therapeutic targets for the prevention of type 1 diabetes mellitusN Singh
Department of Medicine, Division of Endocrinology and Metabolism, Veterans Affairs Puget Sound Healthcare System, Seattle, Washington 98108, USA
Curr Drug Targets Immune Endocr Metabol Disord 5:227-36. 2005..Animal studies and small short-term human trials with these compounds have suggested that they may be effective interventions in patients recently diagnosed with type 1 diabetes...
- Relationship of family history of type 2 diabetes, hypoglycemia, and autoantibodies to weight gain and lipids with intensive and conventional therapy in the Diabetes Control and Complications TrialJonathan Q Purnell
Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health and Science University, Portland, Oregon 97201, USA
Diabetes 52:2623-9. 2003..These data support the hypothesis that increased weight gain with intensive therapy might be explained, in part, by genetic traits...
- Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetesJinko Graham
Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, Canada
Diabetes 51:1346-55. 2002..We conclude that age and genetic factors such as HLA-DQ and INS VNTR need to be combined with islet autoantibody markers when evaluating the risk for type 1 diabetes development...
- Specific human leukocyte antigen DQ influence on expression of antiislet autoantibodies and progression to type 1 diabetesMaria J Redondo
Department of Endocrinology, University Clinic of Navarra, 31008 Pamplona, Spain
J Clin Endocrinol Metab 91:1705-13. 2006..Human leukocyte antigen (HLA) DQ haplotypes have the strongest genetic association with type 1 diabetes (T1DM) risk...
- Patterns of metabolic progression to type 1 diabetes in the Diabetes Prevention Trial-Type 1Jay M Sosenko
Division of Endocrinology, University of Miami, PO Box 016960 D110, Miami, FL 33101, USA
Diabetes Care 29:643-9. 2006..The goal of this study was to utilize data from the Diabetes Prevention Trial-Type 1 (DPT-1) to obtain a picture of the metabolic progression to type 1 diabetes over a period of approximately 2.5 years before its diagnosis...
- Screening strategies for the identification of multiple antibody-positive relatives of individuals with type 1 diabetesJeffrey P Krischer
H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612 9497, USA
J Clin Endocrinol Metab 88:103-8. 2003..Further follow-up and analysis of actual progression to diabetes will be essential to define actual diabetes risk in this large cohort...
- What's in a name: latent autoimmune diabetes of adults, type 1.5, adult-onset, and type 1 diabetesJerry P Palmer
Diabetes Care 26:536-8. 2003
- A risk score for type 1 diabetes derived from autoantibody-positive participants in the diabetes prevention trial-type 1Jay M Sosenko
Division of Endocrinology, University of Miami, P O Box 016960 D110, Miami, FL 33101, USA
Diabetes Care 31:528-33. 2008..The accurate prediction of type 1 diabetes is essential for appropriately identifying prevention trial participants. Thus, we have developed a risk score for the prediction of type 1 diabetes...
- Increasing the accuracy of oral glucose tolerance testing and extending its application to individuals with normal glucose tolerance for the prediction of type 1 diabetes: the Diabetes Prevention Trial-Type 1Jay M Sosenko
Division of Endocrinology, University of Miami, P O Box 016960 D110, Miami, FL 33101, USA
Diabetes Care 30:38-42. 2007....
- Visceral obesity, hepatic lipase activity, and dyslipidemia in type 1 diabetesShalamar D Sibley
Division of Endocrinology and Diabetes, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Clin Endocrinol Metab 88:3379-84. 2003..DCCT-related weight gain positively correlated with subsequent IAF...
- Analysis of T-cell assays to measure autoimmune responses in subjects with type 1 diabetes: results of a blinded controlled studyVicki Seyfert-Margolis
Immune Teolerance Network, Bethesda, Maryland, USA
Diabetes 55:2588-94. 2006..They may be useful for assessment of cellular autoimmune responses involved in type 1 diabetes...
- Role of insulin resistance in predicting progression to type 1 diabetesPing Xu
Pediatrics Epidemiology Center, University of South Florida, Tampa, Florida 33612, USA
Diabetes Care 30:2314-20. 2007..The purpose of this study was to determine whether insulin resistance is a risk factor for the development of type 1 diabetes in autoantibody-positive first-degree relatives of diabetic family members...
- Standardization of C-peptide measurementsRandie R Little
Diabetes Diagnostic Laboratory, Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, MO 65212, USA
Clin Chem 54:1023-6. 2008..We assessed within- and between-laboratory imprecision of C-peptide assays and determined whether serum calibrators with values assigned by mass spectrometry could be used to harmonize C-peptide results...
- Latent autoimmune diabetes in adults (LADA)Ramachandra G Naik
Consultant Endocrinologist, Bombay Hospital and Medical Research Center, 12 New Marine Lines, Mumbai, India 400 020
Rev Endocr Metab Disord 4:233-41. 2003
- Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial--Type 1Jay S Skyler
University of Miami, PO Box 016960 D 110, Miami, FL 33101 6960, USA
Diabetes Care 28:1068-76. 2005..This randomized, double-masked, placebo-controlled clinical trial tested whether oral insulin administration could delay or prevent type 1 diabetes in nondiabetic relatives at risk for diabetes...
- Manipulating the type 1 diabetes disease process, man versus mouseJerry P Palmer
Diabetes Care 25:1240-1. 2002
- International comparison of C-peptide measurementsHsiao Mei Wiedmeyer
Department of Pathology and Anatomical Sciences, University of Missouri Columbia School of Medicine, Columbia, MO 65212, USA
Clin Chem 53:784-7. 2007..We assessed the comparability of C-peptide results obtained with different methods and by different laboratories and determined whether C-peptide results could be harmonized by normalization with a WHO reference reagent or with plasma...
- Identification of Islet Proteins Stimulatory to T Cells from Autoimmune DiabeticJerry Palmer; Fiscal Year: 2007..Identification of the stimulatory islet proteins will allow for these proteins to be used for diagnostic as well as have clinical applications for monitoring immunomodulatory therapies. ..
- DIABETES ENDOCRINOLOGY RESEARCH CENTERJerry Palmer; Fiscal Year: 2007..abstract_text> ..
- Identification of Islet Proteins Stimulatory for T Cells from Diabetes PatientsJerry P Palmer; Fiscal Year: 2010..Subsequent identification of potential islet proteins will be useful in the development of new antigen based intervention strategies and new assays to monitor immunomodulatory therapies for treating autoimmune diabetes. ..