James N Palmer

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Bacterial biofilms: do they play a role in chronic sinusitis?
    James N Palmer
    Division of Rhinology, Department of Otolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, 5 Ravdin Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Otolaryngol Clin North Am 38:1193-201, viii. 2005
  2. ncbi request reprint Medical management in functional endoscopic sinus surgery failures
    James N Palmer
    Division of Rhinology, Department of Otorhinolaryngology Head and Neck Surgery, 5 Ravdin, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Curr Opin Otolaryngol Head Neck Surg 11:6-12. 2003
  3. ncbi request reprint Historical perspective on image-guided sinus surgery
    James N Palmer
    Department of Otolaryngology Head and Neck Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Otolaryngol Clin North Am 38:419-28. 2005
  4. doi request reprint Radiographic enhancement of the nasoseptal flap does not predict postoperative cerebrospinal fluid leaks in endoscopic skull base reconstruction
    Nithin D Adappa
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
    Laryngoscope 122:1226-34. 2012
  5. doi request reprint Prevalence of biofilm-forming bacteria in chronic rhinosinusitis
    Anthony A Prince
    The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Rhinol 22:239-45. 2008
  6. doi request reprint Baby shampoo nasal irrigations for the symptomatic post-functional endoscopic sinus surgery patient
    Alexander G Chiu
    Division of Rhinology, Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Rhinol 22:34-7. 2008
  7. doi request reprint Genetics of the taste receptor T2R38 correlates with chronic rhinosinusitis necessitating surgical intervention
    Nithin D Adappa
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Int Forum Allergy Rhinol 3:184-7. 2013
  8. doi request reprint Medical therapy vs surgery for chronic rhinosinusitis: a prospective, multi-institutional study with 1-year follow-up
    Timothy L Smith
    Division of Rhinology and Sinus Surgery, Oregon Sinus Center, Department of Otolaryngology Head and Neck Surgery, Portland, OR 97239, USA
    Int Forum Allergy Rhinol 3:4-9. 2013
  9. doi request reprint Physiologic alterations in the murine model after nasal fungal antigenic exposure
    Ayesha N Khalid
    Division of Otolaryngology Head and Neck Surgery, Pennsylvania State College of Medicine, Philadelphia, PA, USA
    Otolaryngol Head Neck Surg 139:695-701. 2008
  10. doi request reprint Clinical factors associated with bacterial biofilm formation in chronic rhinosinusitis
    Zi Zhang
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Otolaryngol Head Neck Surg 144:457-62. 2011

Collaborators

Detail Information

Publications81

  1. ncbi request reprint Bacterial biofilms: do they play a role in chronic sinusitis?
    James N Palmer
    Division of Rhinology, Department of Otolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, 5 Ravdin Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Otolaryngol Clin North Am 38:1193-201, viii. 2005
    ..New directions in therapy aimed at biofilms may provide some success in treatment for patients with chronic sinusitis...
  2. ncbi request reprint Medical management in functional endoscopic sinus surgery failures
    James N Palmer
    Division of Rhinology, Department of Otorhinolaryngology Head and Neck Surgery, 5 Ravdin, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Curr Opin Otolaryngol Head Neck Surg 11:6-12. 2003
    ..Therefore, we strongly recommend that chronic rhinosinusitis be viewed as a medical disease in which surgery plays a therapeutic role. Frequently, persistent inflammation slowly settles down over time with appropriate medical management...
  3. ncbi request reprint Historical perspective on image-guided sinus surgery
    James N Palmer
    Department of Otolaryngology Head and Neck Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Otolaryngol Clin North Am 38:419-28. 2005
    ..Further integrations of surgical instrumentation, the ability to update images intraoperatively, and advancements in real-time imaging and robotics are likely to continue ata rapid rate...
  4. doi request reprint Radiographic enhancement of the nasoseptal flap does not predict postoperative cerebrospinal fluid leaks in endoscopic skull base reconstruction
    Nithin D Adappa
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
    Laryngoscope 122:1226-34. 2012
    ..Our aim was to identify whether nasoseptal flap enhancement contributed to reduction of postoperative CSF leak rates...
  5. doi request reprint Prevalence of biofilm-forming bacteria in chronic rhinosinusitis
    Anthony A Prince
    The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Rhinol 22:239-45. 2008
    ..We sought to determine the prevalence of biofilm-forming cultures obtained from patients with CRS and clinical factors that may contribute to biofilm formation...
  6. doi request reprint Baby shampoo nasal irrigations for the symptomatic post-functional endoscopic sinus surgery patient
    Alexander G Chiu
    Division of Rhinology, Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Rhinol 22:34-7. 2008
    ....
  7. doi request reprint Genetics of the taste receptor T2R38 correlates with chronic rhinosinusitis necessitating surgical intervention
    Nithin D Adappa
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Int Forum Allergy Rhinol 3:184-7. 2013
    ..Based on this data, we hypothesize that supertasters are less likely to require sinus surgery compared with heterozygous or nontasters and that supertasters have improved surgical outcomes...
  8. doi request reprint Medical therapy vs surgery for chronic rhinosinusitis: a prospective, multi-institutional study with 1-year follow-up
    Timothy L Smith
    Division of Rhinology and Sinus Surgery, Oregon Sinus Center, Department of Otolaryngology Head and Neck Surgery, Portland, OR 97239, USA
    Int Forum Allergy Rhinol 3:4-9. 2013
    ..In addition, some patients initially enrolled in the medical treatment arm crossed over to the surgery arm during the study period and their respective outcomes are evaluated...
  9. doi request reprint Physiologic alterations in the murine model after nasal fungal antigenic exposure
    Ayesha N Khalid
    Division of Otolaryngology Head and Neck Surgery, Pennsylvania State College of Medicine, Philadelphia, PA, USA
    Otolaryngol Head Neck Surg 139:695-701. 2008
    ..To determine whether a recently developed murine model of fungus-induced sinonasal inflammation demonstrated alterations in ciliary activity and expression of inflammatory cytokines...
  10. doi request reprint Clinical factors associated with bacterial biofilm formation in chronic rhinosinusitis
    Zi Zhang
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Otolaryngol Head Neck Surg 144:457-62. 2011
    ..However, the mechanism behind biofilm formation in chronic rhinosinusitis remains poorly defined. The aim of this study is to evaluate clinical factors that may be associated with bacterial biofilm formation in chronic rhinosinusitis...
  11. doi request reprint Clinical correlation between irrigation bottle contamination and clinical outcomes in post-functional endoscopic sinus surgery patients
    Kevin C Welch
    Loyola University Medical Center, Department of Otolaryngology Head and Neck Surgery, Maywood, Illinois 60125, USA
    Am J Rhinol Allergy 23:401-4. 2009
    ..Therefore, we investigated whether irrigation bottles used postoperatively become contaminated and have any potential association with immediate postsurgical infection and outcomes...
  12. ncbi request reprint Reversal of chronic rhinosinusitis-associated sinonasal ciliary dysfunction
    Bei Chen
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Rhinol 21:346-53. 2007
    ....
  13. doi request reprint An in vitro model of Pseudomonas aeruginosa biofilms on viable airway epithelial cell monolayers
    Bradford A Woodworth
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania, USA
    Am J Rhinol 22:235-8. 2008
    ..To better understand the interactions of bacterial biofilms with respiratory epithelium, we describe an in vitro model of biofilm sinusitis by establishing mature biofilms on airway epithelial air-liquid interface cultures...
  14. pmc T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection
    Robert J Lee
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Clin Invest 122:4145-59. 2012
    ..These data suggest that T2R38 is an upper airway sentinel in innate defense and that genetic variation contributes to individual differences in susceptibility to respiratory infection...
  15. doi request reprint One-way valve bottle contamination rates in the immediate post-functional endoscopic sinus surgery period
    Jennifer M Kofonow
    Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Rhinol Allergy 25:393-6. 2011
    ..An alternative delivery system uses a one-way valve to reduce saline backflow and may limit bottle contamination. Our sole objective was to determine whether this system in post-FESS patients eliminates microbial bottle contamination...
  16. doi request reprint Biofilms correlate with TH1 inflammation in the sinonasal tissue of patients with chronic rhinosinusitis
    Adrianna M Hekiert
    Department of Otorhinolaryngology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Otolaryngol Head Neck Surg 141:448-53. 2009
    ..Determine the prevalence of bacterial biofilms in surgical chronic rhinosinusitis (CRS) patients and characterize the inflammatory response associated with biofilm CRS...
  17. doi request reprint Indications for external frontal sinus procedures for inflammatory sinus disease
    Samuel Hahn
    Division of Rhinology, Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Rhinol Allergy 23:342-7. 2009
    ..Our goal was to characterize these patients and propose indications for the use of an external approach alone or in combination with functional ESS (FESS) for frontal sinus inflammatory disease...
  18. doi request reprint Vasoactive intestinal peptide regulates sinonasal mucociliary clearance and synergizes with histamine in stimulating sinonasal fluid secretion
    Robert J Lee
    1Department of Otorhinolaryngology, Head and Neck Surgery, Hospital of the University of Pennsylvania, Ravdin Bldg, 5th Floor, 3400 Spruce St, Philadelphia, PA 19104, USA
    FASEB J 27:5094-103. 2013
    ..Conversely, a loss of VIP-activated secretion in patients with CF may impair mucociliary transport, contributing to increased incidences of sinonasal infections and rhinosinusitis...
  19. ncbi request reprint MR imaging evaluation of endoscopic cranial base reconstruction with pedicled nasoseptal flap following endoscopic endonasal skull base surgery
    Kim O Learned
    Department of Radiology Neuroradiology Division, University of Pennsylvania Health System, University of Pennsylvania Perelman School of Medicine, Hospital of the University of Pennsylvania, 219 Dulles Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Eur J Radiol 82:544-51. 2013
    ..EEA robustly expands in surgical arena, yet postoperative imaging evaluation remains poorly studied. This work illustrates normal MR imaging appearance of skull base reconstruction utilizing NSFs during immediate postoperative period...
  20. doi request reprint Safety evaluation of sinus surfactant solution on respiratory cilia function
    Alexander G Chiu
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, USA
    Int Forum Allergy Rhinol 1:280-3. 2011
    ..This study evaluates the safety of this solution on respiratory cilia function...
  21. ncbi request reprint Altered sinonasal ciliary dynamics in chronic rhinosinusitis
    Bei Chen
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Rhinol 20:325-9. 2006
    ..Additionally, these studies have only analyzed basal CBF. The goal of this study was to compare the basal as well as the stimulated sinonasal CBF in patients with CRS versus controls...
  22. ncbi request reprint Biofilms
    Jeffrey D Suh
    Department of Otorhinolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, Ravdin Building 5th Floor, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Otolaryngol Clin North Am 43:521-30, viii. 2010
    ..Future research will determine if topical antimicrobials, surfactants, and other adjuvant therapies can be used to treat biofilm-associated chronic rhinosinusitis...
  23. doi request reprint The effects of serum and urinary cortisol levels of topical intranasal irrigations with budesonide added to saline in patients with recurrent polyposis after endoscopic sinus surgery
    Kevin C Welch
    Department of Otolaryngology Head and Neck Surgery, Loyola University Medical Center, Maywood, Illinois, USA
    Am J Rhinol Allergy 24:26-8. 2010
    ..Therefore, we investigated whether irrigation with budesonide solution was associated with any increase in serum cortisol and 24-hour urinary cortisol levels...
  24. doi request reprint Laser-welded endoscopic endoluminal repair of iatrogenic esophageal perforation: an animal model
    Benjamin S Bleier
    Department of Otorhinolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Otolaryngol Head Neck Surg 139:713-7. 2008
    ..To test the feasibility of laser tissue welding (LTW) in creating an endoscopic transluminal repair of esophageal perforation...
  25. doi request reprint Planum, tubercular, sellar and clival defects
    Calvin C Wei
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania School of Medicine, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Adv Otorhinolaryngol 74:119-29. 2013
    ..Future refinements in skull base reconstruction techniques will allow better management of patients at high risk for a postoperative CSF leak, especially those who have been previously irradiated and/or require revision surgery...
  26. doi request reprint Medical therapy vs surgery for chronic rhinosinusitis: a prospective, multi-institutional study
    Timothy L Smith
    Division of Rhinology and Sinus Surgery, Oregon Sinus Center, Department of Otolaryngology Head and Neck Surgery, Oregon Health and Science University, Portland, OR, USA
    Int Forum Allergy Rhinol 1:235-41. 2011
    ..This study evaluates outcomes in patients who failed initial medical management and elect a subsequent treatment option, either continued medical management or endoscopic sinus surgery (ESS) coupled with continued medical management...
  27. ncbi request reprint Clinical outcomes of endoscopic and endoscopic-assisted resection of inverted papillomas: a 15-year experience
    Bradford A Woodworth
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    Am J Rhinol 21:591-600. 2007
    ..The aim of this retrospective study was to review the experience with the endoscopic and endoscopic-assisted resection of IPs at a major academic tertiary care facility and assess long-term outcomes...
  28. doi request reprint Chitosan glycerophosphate-based semirigid dexamethasone eluting biodegradable stent
    Benjamin S Bleier
    Department of Otorhinolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Rhinol Allergy 23:76-9. 2009
    ..The purpose of this study was to optimize the chitosan formulation to produce a pliable sheet, to assess the innate longevity and inflammatory potential of the polymer, and to study the in vivo rate of dexamethasone release over time...
  29. ncbi request reprint Intraoperative IGS/CT updates for complex endoscopic frontal sinus surgery
    Sri Kiran Chennupati
    Division of Rhinology, Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, USA
    ORL J Otorhinolaryngol Relat Spec 70:268-70. 2008
    ..We describe the potential applications of xCAT, a new intraoperative mobile volume CT scanner and its utility in providing surgical navigation updates in the operating room...
  30. doi request reprint Endoscopic repair of supraorbital ethmoid cerebrospinal fluid leaks
    Michael T Purkey
    Division of Rhinology, Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    ORL J Otorhinolaryngol Relat Spec 71:93-8. 2009
    ..To examine the clinical and anatomical characteristics of patients with supraorbital ethmoid (SOE) cerebrospinal fluid (CSF) leaks and encephaloceles and identify specific considerations unique to their management...
  31. doi request reprint Septal dislocation for endoscopic access of the anterolateral maxillary sinus and infratemporal fossa
    Vijay R Ramakrishnan
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, USA
    Am J Rhinol Allergy 25:128-30. 2011
    ..The aim of this study is to examine the effectiveness of septal dislocation for anterolateral reach in extended endoscopic sinus surgery...
  32. doi request reprint Endoscopic closure of CSF rhinorrhea: 193 cases over 21 years
    Caroline A Banks
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, PA, USA
    Otolaryngol Head Neck Surg 140:826-33. 2009
    ..Endoscopic repair of cerebrospinal fluid (CSF) leaks has become a routine approach. This study describes endoscopic closure of a large series over 21 years, focusing on management, surgical technique, and long-term outcomes...
  33. ncbi request reprint Informed consent in sinus surgery: link between demographics and patient desires
    Rodney J Taylor
    Department of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Laryngoscope 115:826-31. 2005
    ..To evaluate and understand differences in expectations according to patient demographics during the informed consent process for functional endoscopic sinus surgery (FESS)...
  34. doi request reprint Endoscopic versus open resection of tuberculum sellae meningiomas: a decision analysis
    Leif Erik Bohman
    Department of Neurosurgery, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
    ORL J Otorhinolaryngol Relat Spec 74:255-63. 2012
    ..Tuberculum sellae meningiomas (TSMs) are challenging tumors for surgical resection. Endoscopic endonasal (EE) approaches to these lesions have not been directly compared to open craniotomy in a controlled trial...
  35. doi request reprint Assessing risk/benefit of lumbar drain use for endoscopic skull-base surgery
    Evan R Ransom
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Int Forum Allergy Rhinol 1:173-7. 2011
    ..The objective of this work was to characterize the risks, benefits, and resource utilization associated with LD use in endoscopic anterior skull-base surgery...
  36. doi request reprint Spontaneous CSF leaks: a paradigm for definitive repair and management of intracranial hypertension
    Bradford A Woodworth
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, PA 19104 4206, USA
    Otolaryngol Head Neck Surg 138:715-20. 2008
    ..To report our outcomes with the repair of spontaneous cerebrospinal fluid (CSF) leaks and to demonstrate how management of underlying intracranial hypertension improves outcomes...
  37. ncbi request reprint The incidence of concurrent osteitis in patients with chronic rhinosinusitis: a clinicopathological study
    Jivianne T Lee
    Division of Rhinology, Department of Otorhinolaryngology, University of Pennsylvania, School of Medicine, 3400 Spruce St, 5 Ravdin, Philadelphia, PA 19104, USA
    Am J Rhinol 20:278-82. 2006
    ..The purpose of this study was to determine the clinical incidence rate of osteitis in patients with CRS undergoing functional endoscopic sinus surgery...
  38. ncbi request reprint Endonasal laser tissue welding: first human experience
    Benjamin S Bleier
    Department of Otorhinolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Am J Rhinol Allergy 24:244-6. 2010
    ..The objective of this study is to assess the safety and technical feasibility of endoscopic LTW in human sinonasal mucosa...
  39. ncbi request reprint Regional analysis of sinonasal ciliary beat frequency
    Jeffrey Shaari
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Rhinol 20:150-4. 2006
    ..We analyzed CBF from the inferior turbinate, uncinate process, and sphenoethmoid recess in nonsinusitis patients to determine regional variability of ciliary activity within the sinonasal cavity...
  40. ncbi request reprint Evaluation of the in vivo efficacy of topical tobramycin against Pseudomonas sinonasal biofilms
    Alexander G Chiu
    Division of Rhinology, Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, USA
    J Antimicrob Chemother 59:1130-4. 2007
    ..This is the first study to evaluate the effects of a topical antibiotic on Pseudomonas biofilms in an animal model of sinusitis...
  41. doi request reprint Global and disease-specific health-related quality of life after complete endoscopic resection of anterior skull base neoplasms
    Evan R Ransom
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, USA
    Am J Rhinol Allergy 26:76-9. 2012
    ..The relative effect of endoscopic procedures, however, has not been described in terms of disease-specific and global health-related quality of life (QoL)...
  42. doi request reprint Nasal irrigation with or without drugs: the evidence
    Nithin D Adappa
    Department of Otorhinolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Otolaryngol Head Neck Surg 20:53-7. 2012
    ....
  43. doi request reprint Reliability of preoperative assessment of cerebrospinal fluid pressure in the management of spontaneous cerebrospinal fluid leaks and encephaloceles
    Vijay R Ramakrishnan
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Int Forum Allergy Rhinol 1:201-5. 2011
    ..However, preoperative measurement of CSF pressure may be inaccurate secondary to active drainage. The purpose of this study is to determine the accuracy of preoperative CSF pressure measurement in the setting of active CSF rhinorrhea...
  44. ncbi request reprint Murine tracheal and nasal septal epithelium for air-liquid interface cultures: a comparative study
    Bradford A Woodworth
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    Am J Rhinol 21:533-7. 2007
    ..Our hypothesis is that the murine nasal septum is a better source of ciliated respiratory epithelium to develop respiratory epithelial air-liquid interface models...
  45. doi request reprint Biofilms in chronic rhinosinusitis: a review
    Michael Cohen
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    Am J Rhinol Allergy 23:255-60. 2009
    ..Thus, bacterial biofilms were hypothesized to contribute to the progression and persistence of chronic rhinosinusitis...
  46. ncbi request reprint The bitter taste receptor T2R38 is an independent risk factor for chronic rhinosinusitis requiring sinus surgery
    Nithin D Adappa
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA
    Int Forum Allergy Rhinol 4:3-7. 2014
    ....
  47. ncbi request reprint Surgical decisions in the management of frontal sinus osteomas
    Alexander G Chiu
    Department of Otorhinolaryngology Head and Neck Surgery, Division of Rhinology, University of Pennsylvania, Philadelphia, Pennsylvania 19103, USA
    Am J Rhinol 19:191-7. 2005
    ..The aim of this study is to review our recent experience with the surgical management of frontal sinus osteomas, and the anatomic features that make specific lesions more or less amenable to endoscopic resection...
  48. ncbi request reprint Endoscopic management of frontal sinus mucoeceles with anterior table erosion
    Bradford A Woodworth
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Rhinology 46:231-7. 2008
    ..To describe the endoscopic management of frontal sinus mucoeceles with anterior table erosion. Previous hardware exposure and subsequent contour defects were also assessed...
  49. doi request reprint Intraoperative emergencies during endoscopic sinus surgery: CSF leak and orbital hematoma
    Kevin C Welch
    Department of Otorhinolaryngology, Division of Rhinology, University of Pennsylvania Health System, 5 Ravdin, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Otolaryngol Clin North Am 41:581-96, ix-x. 2008
    ..Intraoperative orbital hematoma is discussed and a stepwise approach to reduce complications is provided...
  50. ncbi request reprint Familial aggregation of sinonasal polyps correlates with severity of disease
    Noam A Cohen
    Department of Otorhinolaryngology, Head and Neck Surgery, Division of Rhinology, University of Pennsylvania, Philadelphia, PA, USA
    Otolaryngol Head Neck Surg 134:601-4. 2006
    ..Investigate familial aggregation of sinonasal polyps (NP) and correlate the severity of chronic rhinosinusitis (CRS) with a family history of NP...
  51. doi request reprint Molecular modulation of airway epithelial ciliary response to sneezing
    Ke Qing Zhao
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    FASEB J 26:3178-87. 2012
    ..Apical ATP release with subsequent calcium mobilization and PKA activation are involved in sinonasal ciliary response to sneezing, which is blunted in patients with upper-airway disease...
  52. doi request reprint In vivo laser tissue welding in the rabbit maxillary sinus
    Benjamin S Bleier
    Department of Otorhinolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104 4206, USA
    Am J Rhinol 22:625-8. 2008
    ..We performed this study to determine whether LTW can create durable tissue bonds in sinonasal mucosa that support normal wound healing and produce minimal collateral thermal injury...
  53. doi request reprint Laser tissue welding in lung and tracheobronchial repair: an animal model
    Benjamin S Bleier
    Division of Rhinology, Department of Otolaryngology Head and Neck Surgery, Medical University of South Carolina, Charleston, SC 29425, USA
    Chest 138:345-9. 2010
    ..Laser tissue welding (LTW) is an alternative method that produces wound repairs that are significantly stronger than those of fibrin glue and may be used to repair air leaks...
  54. doi request reprint Current management of juvenile nasopharyngeal angiofibroma: a tertiary center experience 1999-2007
    Benjamin S Bleier
    Department of Otorhinolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104 4206, USA
    Am J Rhinol Allergy 23:328-30. 2009
    ..The purpose of this study was to report on a series of patients presenting with JNA in an effort to further define an optimal treatment algorithm and improve outcomes...
  55. doi request reprint Cranial-base repair using endoscopic laser welding
    Benjamin S Bleier
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania School of Medicine, 1324 Pinewood Road, Villanova, Philadelphia, PA 19085, USA
    Otolaryngol Clin North Am 42:901-6, xi. 2009
    ..Laser welding is a novel technology that can be performed endoscopically and offers the potential of producing instantaneous, watertight repairs using a chromophore-doped biologic solder...
  56. doi request reprint Biofilms in chronic rhinosinusitis
    Jeffrey D Suh
    Division of Rhinology, Department of ORL HNS, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Otolaryngol Head Neck Surg 18:27-31. 2010
    ..We will discuss these changes as well as emerging treatment options...
  57. ncbi request reprint Primary sinonasal undifferentiated carcinoma presenting with bilateral retrobulbar optic neuropathy
    Madhura A Tamhankar
    Division of Neuro ophthalmology, Scheie Eye Institute, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, 51 North 39th Street, Philadelphia, PA 19104, USA
    J Neuroophthalmol 27:189-92. 2007
    ..Endoscopic biopsy showed a high-grade neoplasm consistent with sinonasal undifferentiated carcinoma. This case report highlights an unusual clinical presentation for this rare and aggressive neoplasm...
  58. ncbi request reprint Ecthyma gangrenosum mimicking acute invasive fungal sinusitis in an immunocompromised patient
    Adrianna M Hekiert
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Ear Nose Throat J 89:262-7. 2010
    ..To the best of our knowledge, this represents the first case of ecthyma gangrenosum affecting the sinonasal mucosa to be reported in the literature...
  59. doi request reprint Surfactants in the management of rhinopathologies
    Philip L Rosen
    Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Rhinol Allergy 27:177-80. 2013
    ..Because of these unique physical properties several in vitro, ex vivo, and human trials have examined the role of surfactants as stand-alone or adjunct therapy in recalcitrant chronic rhinosinusitis (CRS)...
  60. ncbi request reprint Endoscopic-assisted reduction of anterior table frontal sinus fractures
    Jacob D Steiger
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Laryngoscope 116:1978-81. 2006
    ..When no flow phenomena are observed and no flap salvage is deemed possible, aggressive treatment such as a second free flap or next pedicle flap should be chosen as soon as possible to avoid any delay in postoperative treatment...
  61. ncbi request reprint Epidermoids of the paranasal sinuses and beyond: endoscopic management
    Rakesh K Chandra
    Department of Otolaryngology Head and Neck Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, 38163, USA
    Am J Rhinol 20:441-4. 2006
    ..Epidermoid tumors of the craniofacial skeleton are uncommon, with the exception of acquired cholesteatoma of the temporal bone. These lesions may be primary embryologic in origin or, less frequently, may be iatrogenic or posttraumatic...
  62. doi request reprint Endoscopic, endonasal, transclival resection of a pontine cavernoma: case report
    Matthew R Sanborn
    Department of Neurosurgery, Perelman School of Medicine, Hospital of University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Neurosurgery 71:198-203. 2012
    ..We present the successful purely endoscopic, endonasal, transclival resection of a symptomatic cavernoma located in the ventromedial pons...
  63. doi request reprint Molecular basis of tobacco-induced bacterial biofilms: an in vitro study
    Marcelo B Antunes
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, USA
    Otolaryngol Head Neck Surg 147:876-84. 2012
    ..To evaluate changes in the expression of biofilm-related genes when exposed to tobacco smoke and oxidative stress...
  64. ncbi request reprint Evidence of bacterial biofilms in a rabbit model of sinusitis
    Joel R Perloff
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Rhinol 19:1-6. 2005
    ..We hypothesize that bacterial biofilms are present on the mucosa of animals with sinuses experimentally infected with Pseudomonas aeruginosa...
  65. ncbi request reprint Olfactory groove meningioma
    Nithin D Adappa
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania School of Medicine, Hospital of the University of Pennsylvania, Ravdin Building 5th Floor, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Otolaryngol Clin North Am 44:965-80, ix. 2011
    ..These options include radiotherapy, stereotactic radiosurgery, and chemotherapy. In addition, we discuss the current on going research in molecular targeting agents for meningioma treatment...
  66. ncbi request reprint Radiographic and histologic analysis of the bone underlying inverted papillomas
    Alexander G Chiu
    Division of Rhinology, Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Laryngoscope 116:1617-20. 2006
    ..In this article, histopathologic specimens and preoperative radiologic studies are prospectively examined to better understand the involvement of the bone underlying an inverted papilloma...
  67. ncbi request reprint Tension pneumocephalus after endoscopic sinus surgery: case report of repair and management in absence of obvious skull base defect
    Robert G Whitmore
    Department of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Ear Nose Throat J 87:96-9. 2008
    ..We discuss management of this complication and preventive measures for avoiding pneumocephalus after functional endoscopic sinus surgery...
  68. ncbi request reprint Endoscopic-assisted reduction of anterior table frontal sinus fractures
    Jacob D Steiger
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Laryngoscope 116:1936-9. 2006
  69. ncbi request reprint Evidence of bacterial biofilms on frontal recess stents in patients with chronic rhinosinusitis
    Joel R Perloff
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4206, USA
    Am J Rhinol 18:377-80. 2004
    ..We believe that frontal sinus stents may serve as a reservoir for biofilms. EXPERIMENT: We studied silicone frontal sinus stents removed from six patients 1 to 4 weeks after FESS with scanning electron microscopy (SEM)...
  70. ncbi request reprint Laser-assisted cerebrospinal fluid leak repair: an animal model to test feasibility
    Benjamin S Bleier
    Department of Otorhinolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19104 4206, USA
    Otolaryngol Head Neck Surg 137:810-4. 2007
    ..To test the feasibility of laser tissue welding as a method of creating an endonasal tissue bond for the purpose of cerebrospinal fluid leak repair...
  71. ncbi request reprint Quantification of ciliary beat frequency in sinonasal epithelial cells using differential interference contrast microscopy and high-speed digital video imaging
    Ioana Schipor
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Rhinol 20:124-7. 2006
    ..This is the first report of sinonasal epithelial CBF analysis performed using high-speed video digital analysis...
  72. ncbi request reprint Evidence of bacterial biofilms in human chronic sinusitis
    Jonathan Cryer
    Division of Rhinology, Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, USA
    ORL J Otorhinolaryngol Relat Spec 66:155-8. 2004
    ..The presence of bacterial biofilms may explain the recalcitrant nature of some forms of chronic sinusitis...
  73. ncbi request reprint Transseptal suture to secure middle meatal spacers
    Neil G Hockstein
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania Health System, 34th and Spruce Sts, 5 Ravdin, Philadelphia, PA 19104, USA
    Ear Nose Throat J 85:47-8. 2006
    ..During follow-up of 2 to 10 months, we found no evidence of injury to the septum at the site of the transseptal suture. We conclude that the transseptal suture is a safe and cosmetically superior method of securing middle meatal spacers...
  74. ncbi request reprint Use of image-guided computed tomography-magnetic resonance fusion for complex endoscopic sinus and skull base surgery
    Alexander G Chiu
    Division of Rhinology, Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Laryngoscope 115:753-5. 2005
  75. ncbi request reprint Cerebrospinal fluid pressure monitoring after repair of cerebrospinal fluid leaks
    Rodney J Schlosser
    Department of Otolaryngology Head and Neck Surgery, Medical University of South Carolina, Charleston, SC 29425, USA
    Otolaryngol Head Neck Surg 130:443-8. 2004
    ..To measure intracranial pressures (ICPs) via lumbar drains after surgical repair of cerebrospinal fluid (CSF) leaks...
  76. doi request reprint Use of intraoperative CT scanning in endoscopic sinus surgery: a preliminary report
    Alexis H Jackman
    Department of Otorhinolaryngology, Albert Einstein College of Medicine Montefiore Medical Center, Bronx, New York 10467, USA
    Am J Rhinol 22:170-4. 2008
    ..The purpose of this study is to show the technical feasibility and the potential impact of intraoperative CT scanning in conjunction with real-time update of computer-assisted navigation during ESS...
  77. ncbi request reprint Endoscopic management of failed frontal sinus obliteration
    Rakesh K Chandra
    Department of Otolaryngology Head and Neck Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Am J Rhinol 18:279-84. 2004
    ..However, this procedure has been associated with failure in 5-10% of cases. Advances in surgical instrumentation and image-guided surgical navigation have permitted endoscopic management of these failures...
  78. ncbi request reprint Informed consent in endoscopic sinus surgery: the patient perspective
    Jeffrey S Wolf
    Department of Otolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Laryngoscope 115:492-4. 2005
    ..To understand patient expectations during the informed consent process for functional endoscopic sinus surgery (FESS)...
  79. ncbi request reprint Frontal sinus complications after frontal craniotomy
    Keith Meetze
    Department of Otolaryngology Head and Neck Surgery, Medical University of South Carolina, Charleston, 29425, USA
    Laryngoscope 114:945-8. 2004
    ..To review frontal sinus complications following frontal craniotomy and to describe management strategies...
  80. ncbi request reprint Proteolysis of beta-trace Protein?
    Neil G Hockstein
    Otolaryngol Head Neck Surg 133:310; author reply 310-1. 2005
  81. ncbi request reprint Factors associated with failure of frontal sinusotomy in the early follow-up period
    Rakesh K Chandra
    Department of Otolarygology Head and Neck Surgery, University of Tennessee School of Medicine, Memphis, USA
    Otolaryngol Head Neck Surg 131:514-8. 2004
    ..To understand factors associated with failure of endoscopic frontal sinusotomy...