Bradley M Palmer

Summary

Affiliation: University of Vermont
Country: USA

Publications

  1. pmc An inverse power-law distribution of molecular bond lifetimes predicts fractional derivative viscoelasticity in biological tissue
    Bradley M Palmer
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT, USA
    Biophys J 104:2540-52. 2013
  2. pmc Elevated rates of force development and MgATP binding in F764L and S532P myosin mutations causing dilated cardiomyopathy
    Bradley M Palmer
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
    J Mol Cell Cardiol 57:23-31. 2013
  3. pmc Distribution of myosin attachment times predicted from viscoelastic mechanics of striated muscle
    Bradley M Palmer
    Department of Molecular Physiology and Biophysics, University of Vermont, 122 HSRF, Beaumont Avenue, Burlington, VT 05405, USA
    J Biomed Biotechnol 2011:592343. 2011
  4. pmc Roles for cardiac MyBP-C in maintaining myofilament lattice rigidity and prolonging myosin cross-bridge lifetime
    Bradley M Palmer
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont, USA
    Biophys J 101:1661-9. 2011
  5. ncbi request reprint Effect of cardiac myosin binding protein-C on mechanoenergetics in mouse myocardium
    Bradley M Palmer
    Department of Molecular Physiology and Biophysics, University of Vermont College of Medicine, University of Vermont, Burlington, VT 05405, USA
    Circ Res 94:1615-22. 2004
  6. pmc Cardiac myosin isoforms exhibit differential rates of MgADP release and MgATP binding detected by myocardial viscoelasticity
    Yuan Wang
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
    J Mol Cell Cardiol 54:1-8. 2013
  7. doi request reprint Myofilament mechanical performance is enhanced by R403Q myosin in mouse myocardium independent of sex
    Bradley M Palmer
    Dept of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
    Am J Physiol Heart Circ Physiol 294:H1939-47. 2008
  8. pmc Zinc-induced cardiomyocyte relaxation in a rat model of hyperglycemia is independent of myosin isoform
    Ting Yi
    Department of Molecular Physiology and Biophysics, University of Vermont, 122 HSRF Beaumont Ave, Burlington, VT 05405, USA
    Cardiovasc Diabetol 11:135. 2012
  9. ncbi request reprint The essential light chain N-terminal extension alters force and fiber kinetics in mouse cardiac muscle
    Mark S Miller
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont 05405, USA
    J Biol Chem 280:34427-34. 2005
  10. ncbi request reprint Reduced cross-bridge dependent stiffness of skinned myocardium from mice lacking cardiac myosin binding protein-C
    Bradley M Palmer
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
    Mol Cell Biochem 263:73-80. 2004

Collaborators

Detail Information

Publications33

  1. pmc An inverse power-law distribution of molecular bond lifetimes predicts fractional derivative viscoelasticity in biological tissue
    Bradley M Palmer
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT, USA
    Biophys J 104:2540-52. 2013
    ....
  2. pmc Elevated rates of force development and MgATP binding in F764L and S532P myosin mutations causing dilated cardiomyopathy
    Bradley M Palmer
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
    J Mol Cell Cardiol 57:23-31. 2013
    ..9s(-1) in F764L/+, 32.9±4.5s(-1) in S532P/+ and 18.2±1.7s(-1) in +/+). These results suggest that elevated rates of force development and MgATP binding are features of cardiac myofilament function that underlie the development of DCM...
  3. pmc Distribution of myosin attachment times predicted from viscoelastic mechanics of striated muscle
    Bradley M Palmer
    Department of Molecular Physiology and Biophysics, University of Vermont, 122 HSRF, Beaumont Avenue, Burlington, VT 05405, USA
    J Biomed Biotechnol 2011:592343. 2011
    ....
  4. pmc Roles for cardiac MyBP-C in maintaining myofilament lattice rigidity and prolonging myosin cross-bridge lifetime
    Bradley M Palmer
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont, USA
    Biophys J 101:1661-9. 2011
    ..Although the presence of cMyBP-C also provides longitudinal rigidity, phosphorylation of the N-terminus is not necessary to maintain longitudinal rigidity of the lattice, in contrast to radial rigidity...
  5. ncbi request reprint Effect of cardiac myosin binding protein-C on mechanoenergetics in mouse myocardium
    Bradley M Palmer
    Department of Molecular Physiology and Biophysics, University of Vermont College of Medicine, University of Vermont, Burlington, VT 05405, USA
    Circ Res 94:1615-22. 2004
    ....
  6. pmc Cardiac myosin isoforms exhibit differential rates of MgADP release and MgATP binding detected by myocardial viscoelasticity
    Yuan Wang
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
    J Mol Cell Cardiol 54:1-8. 2013
    ....
  7. doi request reprint Myofilament mechanical performance is enhanced by R403Q myosin in mouse myocardium independent of sex
    Bradley M Palmer
    Dept of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
    Am J Physiol Heart Circ Physiol 294:H1939-47. 2008
    ..The sex-dependent development of HCM due to the R403Q myosin may then be inhibited by female sex hormones, which may additionally underlie the observed sex differences for pCa(50) and unloaded shortening velocity...
  8. pmc Zinc-induced cardiomyocyte relaxation in a rat model of hyperglycemia is independent of myosin isoform
    Ting Yi
    Department of Molecular Physiology and Biophysics, University of Vermont, 122 HSRF Beaumont Ave, Burlington, VT 05405, USA
    Cardiovasc Diabetol 11:135. 2012
    ..Investigations into the effects of Zn2+ on these mechanisms are now underway...
  9. ncbi request reprint The essential light chain N-terminal extension alters force and fiber kinetics in mouse cardiac muscle
    Mark S Miller
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont 05405, USA
    J Biol Chem 280:34427-34. 2005
    ..Our results strongly suggest that an interaction between residues 5-14 of the ELC N terminus and the C-terminal residues of actin enhances cardiac performance...
  10. ncbi request reprint Reduced cross-bridge dependent stiffness of skinned myocardium from mice lacking cardiac myosin binding protein-C
    Bradley M Palmer
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
    Mol Cell Biochem 263:73-80. 2004
    ....
  11. pmc Mechanisms underlying skeletal muscle weakness in human heart failure: alterations in single fiber myosin protein content and function
    Mark S Miller
    Departments of Molecular Physiology and Biophysics and Medicine, University of Vermont, College of Medicine, Burlington, VT, USA
    Circ Heart Fail 2:700-6. 2009
    ..Patients with chronic heart failure (HF) frequently experience skeletal muscle weakness that limits physical function. The mechanisms underlying muscle weakness, however, have not been clearly defined...
  12. pmc Thick-to-thin filament surface distance modulates cross-bridge kinetics in Drosophila flight muscle
    Bertrand C W Tanner
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont, USA
    Biophys J 103:1275-84. 2012
    ..Together, these structural changes may provide a mechanism for altering cross-bridge performance throughout a contraction-relaxation cycle...
  13. pmc Effects of cardiac myosin isoform variation on myofilament function and crossbridge kinetics in transgenic rabbits
    Takeki Suzuki
    Department of Medicine, Cardiology Unit, Fletcher Allen Health Care, Burlington, VT 05401, USA
    Circ Heart Fail 2:334-41. 2009
    ..This study was undertaken to identify a myofilament-based mechanism underlying tachycardia-induced cardiomyopathy protection and to extrapolate the impact of MHC isoform variation on myofilament function in human hearts...
  14. pmc Erythropoietin induces positive inotropic and lusitropic effects in murine and human myocardium
    David Hefer
    The Department of Medicine Cardiac Unit, University of Vermont, College of Medicine, Burlington, VT, USA
    J Mol Cell Cardiol 52:256-63. 2012
    ..These effects are mediated through PI3-K and PKCε isoform signaling to directly affect both calcium release dynamics and myofilament function...
  15. pmc Cardiac myosin binding protein-C is essential for thick-filament stability and flexural rigidity
    Lori R Nyland
    Department of Biology, University of Vermont, Burlington, Vermont 05405, USA
    Biophys J 96:3273-80. 2009
    ..These results provide what we consider a new understanding for the critical role of cMyBP-C in defining normal cardiac output by sustaining force and muscle stiffness...
  16. pmc Two-state model of acto-myosin attachment-detachment predicts C-process of sinusoidal analysis
    Bradley M Palmer
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont, USA
    Biophys J 93:760-9. 2007
    ..Experimental results from activated cardiac muscle examined at different temperatures and containing predominately alpha- or beta-myosin heavy chain isoforms were found to be consistent with the above interpretation...
  17. ncbi request reprint Role of cardiac myosin binding protein C in sustaining left ventricular systolic stiffening
    Bradley M Palmer
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
    Circ Res 94:1249-55. 2004
    ..Abnormal sarcomere shortening velocity and abbreviated muscle stiffening may underlie development of cardiac dysfunction associated with deficient incorporation of cMyBP-C...
  18. ncbi request reprint Differential cross-bridge kinetics of FHC myosin mutations R403Q and R453C in heterozygous mouse myocardium
    Bradley M Palmer
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
    Am J Physiol Heart Circ Physiol 287:H91-9. 2004
    ....
  19. pmc Myosin cross-bridge dynamics in patients with hypertension and concentric left ventricular remodeling
    Cameron Donaldson
    Cardiology Unit, University of Vermont, Burlington, VT, USA
    Circ Heart Fail 5:803-11. 2012
    ..HTN and concentric remodeling are also common precursors to heart failure with a preserved ejection fraction. It is not known whether the myofilament contributes to diastolic dysfunction in patients with concentric remodeling...
  20. pmc Identifying cellular mechanisms of zinc-induced relaxation in isolated cardiomyocytes
    Ting Yi
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont
    Am J Physiol Heart Circ Physiol 305:H706-15. 2013
    ..The use of the low-Ca(2+)-affinity Fura-2FF likely prevented the detection of changes in diastolic Ca(2+) and SERCA2a function. Other strategies to detect diastolic Ca(2+) in the presence of Zn(2+) are essential for future work. ..
  21. ncbi request reprint Effect of heart failure on skeletal muscle myofibrillar protein content, isoform expression and calcium sensitivity
    Michael J Toth
    Department of Medicine, University of Vermont, Burlington, VT 05405, United States
    Int J Cardiol 107:211-9. 2006
    ..To address this issue, we examined the effect of heart failure on skeletal muscle myofibrillar protein content, isoform distribution and Ca2+ sensitivity...
  22. pmc Chronic heart failure decreases cross-bridge kinetics in single skeletal muscle fibres from humans
    Mark S Miller
    Department of Molecular Physiology, University of Vermont, Burlington, VT 05405, USA
    J Physiol 588:4039-53. 2010
    ..Additionally, we uncovered a unique kinetic property of MHC I fibres, a potential indication of two distinct populations of cross-bridges, which may have important physiological consequences...
  23. ncbi request reprint Thick filament proteins and performance in human heart failure
    Bradley M Palmer
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
    Heart Fail Rev 10:187-97. 2005
    ....
  24. ncbi request reprint Acto-myosin crossbridge kinetics in humans with coronary artery disease: influence of sex and diabetes mellitus
    Naomi K Fukagawa
    Department of Medicine, University of Vermont College of Medicine, 89 Beaumont Avenue, Given C 207, Burlington, VT 05405 0068, USA
    J Mol Cell Cardiol 39:743-53. 2005
    ..These sex-related differences were absent in DM, suggesting that differences in the properties of cardiac muscle contribute to reported sex differences in the incidence and mortality of HF in DM...
  25. pmc Age-related slowing of myosin actin cross-bridge kinetics is sex specific and predicts decrements in whole skeletal muscle performance in humans
    Mark S Miller
    Department of Molecular Physiology and Biophysics, University of Vermont, College of Medicine, Burlington, Vermont
    J Appl Physiol (1985) 115:1004-14. 2013
    ..Thus these results support our hypothesis that age-related alterations in the myosin molecule contribute to skeletal muscle dysfunction and physical disability and indicate that this effect is stronger in women. ..
  26. pmc Tachycardia-induced diastolic dysfunction and resting tone in myocardium from patients with a normal ejection fraction
    Donald E Selby
    Cardiology Division and Department of Physiology, University of Vermont College of Medicine, Burlington, Vermont 05401, USA
    J Am Coll Cardiol 58:147-54. 2011
    ..The purpose of this study is to evaluate tachycardia-induced relaxation abnormalities in myocardium from patients with a normal ejection fraction...
  27. ncbi request reprint Intracellular distributions of essential elements in cardiomyocytes
    Bradley M Palmer
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, 05405, USA
    J Struct Biol 155:12-21. 2006
    ....
  28. doi request reprint Effects of testosterone on cardiomyocyte calcium homeostasis and contractile function in female rats
    Ronald D Beesley
    Department of Obstetrics and Gynecology, University of Vermont College of Medicine, Burlington, VT, USA
    Exp Physiol 98:161-71. 2013
    ..Our results argue against acute or chronic effects of T on cardiomyocyte shortening dynamics, calcium cycling or myosin heavy chain expression, arguing against any direct effect of T on cardiomyocyte function in adult females...
  29. pmc Measuring myosin cross-bridge attachment time in activated muscle fibers using stochastic vs. sinusoidal length perturbation analysis
    Bertrand C W Tanner
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont, USA
    J Appl Physiol (1985) 110:1101-8. 2011
    ..This study demonstrates that white noise analysis can detect underlying molecular processes associated with dynamic muscle contraction comparable to sinusoidal analysis, but in a fraction of the time...
  30. pmc Resistance training alters skeletal muscle structure and function in human heart failure: effects at the tissue, cellular and molecular levels
    Michael J Toth
    Health Science Research Facility 126B, 149 Beaumont Ave, University of Vermont, Burlington, VT 05405, USA
    J Physiol 590:1243-59. 2012
    ..More broadly, these data highlight novel cellular and molecular adaptations in muscle structure and function that contribute to the resistance-trained phenotype...
  31. pmc A strain-dependency of Myosin off-rate must be sensitive to frequency to predict the B-process of sinusoidal analysis
    Bradley M Palmer
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
    Adv Exp Med Biol 682:57-75. 2010
    ....
  32. ncbi request reprint Cardiomyocyte function associated with hyperactivity and/or hypertension in genetic models of LV hypertrophy
    Bradley M Palmer
    Dept of Molecular Physiology and Biophysics, Univ of Vermont, Burlington, VT 05405, USA
    Am J Physiol Heart Circ Physiol 290:H463-73. 2006
    ....
  33. pmc Fibroblast cytoskeletal remodeling contributes to connective tissue tension
    Helene M Langevin
    Department of Neurology, University of Vermont, Burlington, Vermont 05405, USA
    J Cell Physiol 226:1166-75. 2011
    ....