Research Topics
Species | Bradley M PalmerSummaryAffiliation: University of Vermont Country: USA Publications
| Collaborators
|
Detail Information
Publications
Elevated rates of force development and MgATP binding in F764L and S532P myosin mutations causing dilated cardiomyopathyBradley M Palmer
Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
J Mol Cell Cardiol 57:23-31. 2013..9s(-1) in F764L/+, 32.9±4.5s(-1) in S532P/+ and 18.2±1.7s(-1) in +/+). These results suggest that elevated rates of force development and MgATP binding are features of cardiac myofilament function that underlie the development of DCM...- Roles for cardiac MyBP-C in maintaining myofilament lattice rigidity and prolonging myosin cross-bridge lifetimeBradley M Palmer
Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont, USA
Biophys J 101:1661-9. 2011..Although the presence of cMyBP-C also provides longitudinal rigidity, phosphorylation of the N-terminus is not necessary to maintain longitudinal rigidity of the lattice, in contrast to radial rigidity... - Distribution of myosin attachment times predicted from viscoelastic mechanics of striated muscleBradley M Palmer
Department of Molecular Physiology and Biophysics, University of Vermont, 122 HSRF, Beaumont Avenue, Burlington, VT 05405, USA
J Biomed Biotechnol 2011:592343. 2011.... 
Effect of cardiac myosin binding protein-C on mechanoenergetics in mouse myocardiumBradley M Palmer
Department of Molecular Physiology and Biophysics, University of Vermont College of Medicine, University of Vermont, Burlington, VT 05405, USA
Circ Res 94:1615-22. 2004....
Myofilament mechanical performance is enhanced by R403Q myosin in mouse myocardium independent of sexBradley M Palmer
Dept of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
Am J Physiol Heart Circ Physiol 294:H1939-47. 2008..The sex-dependent development of HCM due to the R403Q myosin may then be inhibited by female sex hormones, which may additionally underlie the observed sex differences for pCa(50) and unloaded shortening velocity...- Zinc-induced cardiomyocyte relaxation in a rat model of hyperglycemia is independent of myosin isoformTing Yi
Department of Molecular Physiology and Biophysics, University of Vermont, 122 HSRF Beaumont Ave, Burlington, VT 05405, USA
Cardiovasc Diabetol 11:135. 2012..Investigations into the effects of Zn2+ on these mechanisms are now underway... - Reduced cross-bridge dependent stiffness of skinned myocardium from mice lacking cardiac myosin binding protein-CBradley M Palmer
Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
Mol Cell Biochem 263:73-80. 2004.... - The essential light chain N-terminal extension alters force and fiber kinetics in mouse cardiac muscleMark S Miller
Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont 05405, USA
J Biol Chem 280:34427-34. 2005..Our results strongly suggest that an interaction between residues 5-14 of the ELC N terminus and the C-terminal residues of actin enhances cardiac performance... - Mechanisms underlying skeletal muscle weakness in human heart failure: alterations in single fiber myosin protein content and functionMark S Miller
Departments of Molecular Physiology and Biophysics and Medicine, University of Vermont, College of Medicine, Burlington, VT, USA
Circ Heart Fail 2:700-6. 2009..Patients with chronic heart failure (HF) frequently experience skeletal muscle weakness that limits physical function. The mechanisms underlying muscle weakness, however, have not been clearly defined... - Thick-to-thin filament surface distance modulates cross-bridge kinetics in Drosophila flight muscleBertrand C W Tanner
Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont, USA
Biophys J 103:1275-84. 2012..Together, these structural changes may provide a mechanism for altering cross-bridge performance throughout a contraction-relaxation cycle... - Effects of cardiac myosin isoform variation on myofilament function and crossbridge kinetics in transgenic rabbitsTakeki Suzuki
Department of Medicine, Cardiology Unit, Fletcher Allen Health Care, Burlington, VT 05401, USA
Circ Heart Fail 2:334-41. 2009..This study was undertaken to identify a myofilament-based mechanism underlying tachycardia-induced cardiomyopathy protection and to extrapolate the impact of MHC isoform variation on myofilament function in human hearts... - Erythropoietin induces positive inotropic and lusitropic effects in murine and human myocardiumDavid Hefer
The Department of Medicine Cardiac Unit, University of Vermont, College of Medicine, Burlington, VT, USA
J Mol Cell Cardiol 52:256-63. 2012..These effects are mediated through PI3-K and PKCε isoform signaling to directly affect both calcium release dynamics and myofilament function... - Two-state model of acto-myosin attachment-detachment predicts C-process of sinusoidal analysisBradley M Palmer
Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont, USA
Biophys J 93:760-9. 2007..Experimental results from activated cardiac muscle examined at different temperatures and containing predominately alpha- or beta-myosin heavy chain isoforms were found to be consistent with the above interpretation... - Cardiac myosin binding protein-C is essential for thick-filament stability and flexural rigidityLori R Nyland
Department of Biology, University of Vermont, Burlington, Vermont 05405, USA
Biophys J 96:3273-80. 2009..These results provide what we consider a new understanding for the critical role of cMyBP-C in defining normal cardiac output by sustaining force and muscle stiffness... - Myosin cross-bridge dynamics in patients with hypertension and concentric left ventricular remodelingCameron Donaldson
Cardiology Unit, University of Vermont, Burlington, VT, USA
Circ Heart Fail 5:803-11. 2012..HTN and concentric remodeling are also common precursors to heart failure with a preserved ejection fraction. It is not known whether the myofilament contributes to diastolic dysfunction in patients with concentric remodeling... - Chronic heart failure decreases cross-bridge kinetics in single skeletal muscle fibres from humansMark S Miller
Department of Molecular Physiology, University of Vermont, Burlington, VT 05405, USA
J Physiol 588:4039-53. 2010..Additionally, we uncovered a unique kinetic property of MHC I fibres, a potential indication of two distinct populations of cross-bridges, which may have important physiological consequences... - Cardiac myosin isoforms exhibit differential rates of MgADP release and MgATP binding detected by myocardial viscoelasticityYuan Wang
Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
J Mol Cell Cardiol 54:1-8. 2013.... - Role of cardiac myosin binding protein C in sustaining left ventricular systolic stiffeningBradley M Palmer
Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
Circ Res 94:1249-55. 2004..Abnormal sarcomere shortening velocity and abbreviated muscle stiffening may underlie development of cardiac dysfunction associated with deficient incorporation of cMyBP-C... - Thick filament proteins and performance in human heart failureBradley M Palmer
Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
Heart Fail Rev 10:187-97. 2005.... - Effect of heart failure on skeletal muscle myofibrillar protein content, isoform expression and calcium sensitivityMichael J Toth
Department of Medicine, University of Vermont, Burlington, VT 05405, United States
Int J Cardiol 107:211-9. 2006..To address this issue, we examined the effect of heart failure on skeletal muscle myofibrillar protein content, isoform distribution and Ca2+ sensitivity... - Acto-myosin crossbridge kinetics in humans with coronary artery disease: influence of sex and diabetes mellitusNaomi K Fukagawa
Department of Medicine, University of Vermont College of Medicine, 89 Beaumont Avenue, Given C 207, Burlington, VT 05405 0068, USA
J Mol Cell Cardiol 39:743-53. 2005..These sex-related differences were absent in DM, suggesting that differences in the properties of cardiac muscle contribute to reported sex differences in the incidence and mortality of HF in DM... - Differential cross-bridge kinetics of FHC myosin mutations R403Q and R453C in heterozygous mouse myocardiumBradley M Palmer
Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
Am J Physiol Heart Circ Physiol 287:H91-9. 2004.... - Tachycardia-induced diastolic dysfunction and resting tone in myocardium from patients with a normal ejection fractionDonald E Selby
Cardiology Division and Department of Physiology, University of Vermont College of Medicine, Burlington, Vermont 05401, USA
J Am Coll Cardiol 58:147-54. 2011..The purpose of this study is to evaluate tachycardia-induced relaxation abnormalities in myocardium from patients with a normal ejection fraction... - Intracellular distributions of essential elements in cardiomyocytesBradley M Palmer
Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, 05405, USA
J Struct Biol 155:12-21. 2006.... - Resistance training alters skeletal muscle structure and function in human heart failure: effects at the tissue, cellular and molecular levelsMichael J Toth
Health Science Research Facility 126B, 149 Beaumont Ave, University of Vermont, Burlington, VT 05405, USA
J Physiol 590:1243-59. 2012..More broadly, these data highlight novel cellular and molecular adaptations in muscle structure and function that contribute to the resistance-trained phenotype... - Measuring myosin cross-bridge attachment time in activated muscle fibers using stochastic vs. sinusoidal length perturbation analysisBertrand C W Tanner
Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont, USA
J Appl Physiol 110:1101-8. 2011..This study demonstrates that white noise analysis can detect underlying molecular processes associated with dynamic muscle contraction comparable to sinusoidal analysis, but in a fraction of the time... - A strain-dependency of Myosin off-rate must be sensitive to frequency to predict the B-process of sinusoidal analysisBradley M Palmer
Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
Adv Exp Med Biol 682:57-75. 2010.... - Cardiomyocyte function associated with hyperactivity and/or hypertension in genetic models of LV hypertrophyBradley M Palmer
Dept of Molecular Physiology and Biophysics, Univ of Vermont, Burlington, VT 05405, USA
Am J Physiol Heart Circ Physiol 290:H463-73. 2006.... - Fibroblast cytoskeletal remodeling contributes to connective tissue tensionHelene M Langevin
Department of Neurology, University of Vermont, Burlington, Vermont 05405, USA
J Cell Physiol 226:1166-75. 2011.... - Effects of testosterone on cardiomyocyte calcium homeostasis and contractile function in female ratsRonald D Beesley
Department of Obstetrics and Gynecology, University of Vermont College of Medicine, Burlington, VT, USA
Exp Physiol 98:161-71. 2013..Our results argue against acute or chronic effects of T on cardiomyocyte shortening dynamics, calcium cycling or myosin heavy chain expression, arguing against any direct effect of T on cardiomyocyte function in adult females...