ABRAHAM PALMER

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. pmc Practical considerations regarding the use of genotype and pedigree data to model relatedness in the context of genome-wide association studies
    Riyan Cheng
    Department of Human Genetics, The University of Chicago, Illinois 60637
    G3 (Bethesda) 3:1861-7. 2013
  2. pmc Assessment of behaviors modeling aspects of schizophrenia in Csmd1 mutant mice
    Margaret G Distler
    Department of Pathology, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 7:e51235. 2012
  3. pmc Role of Glyoxalase 1 (Glo1) and methylglyoxal (MG) in behavior: recent advances and mechanistic insights
    Margaret G Distler
    Department of Pathology, University of Chicago Chicago, IL, USA
    Front Genet 3:250. 2012
  4. pmc Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13)
    Amy B Hart
    Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 7:e42646. 2012
  5. pmc Methamphetamine-induced conditioned place preference in LG/J and SM/J mouse strains and an F45/F46 advanced intercross line
    Camron D Bryant
    Department of Human Genetics, The University of Chicago, Chicago, IL, USA
    Front Genet 3:126. 2012
  6. pmc A common and unstable copy number variant is associated with differences in Glo1 expression and anxiety-like behavior
    Richard Williams
    Committee on Computational Neuroscience, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 4:e4649. 2009
  7. pmc Translational genetic approaches to substance use disorders: bridging the gap between mice and humans
    Abraham A Palmer
    Department of Human Genetics, The University of Chicago, Chicago, IL 60637, USA
    Hum Genet 131:931-9. 2012
  8. pmc QTLRel: an R package for genome-wide association studies in which relatedness is a concern
    Riyan Cheng
    Department of Human Genetics, The University of Chicago, IL 60637, USA
    BMC Genet 12:66. 2011
  9. pmc Prenatal protein deprivation alters dopamine-mediated behaviors and dopaminergic and glutamatergic receptor binding
    Abraham A Palmer
    Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Brain Res 1237:62-74. 2008
  10. ncbi request reprint Sensitivity to the locomotor-stimulant effects of ethanol and allopregnanolone: a quantitative trait locus study of common genetic influence
    A A Palmer
    Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Genes Brain Behav 5:506-17. 2006

Collaborators

Detail Information

Publications28

  1. pmc Practical considerations regarding the use of genotype and pedigree data to model relatedness in the context of genome-wide association studies
    Riyan Cheng
    Department of Human Genetics, The University of Chicago, Illinois 60637
    G3 (Bethesda) 3:1861-7. 2013
    ....
  2. pmc Assessment of behaviors modeling aspects of schizophrenia in Csmd1 mutant mice
    Margaret G Distler
    Department of Pathology, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 7:e51235. 2012
    ..Nevertheless, future studies should consider alternative mouse models including gain-of-function mutations, and loss-of-function mutations that target alternative transcripts of Csmd1...
  3. pmc Role of Glyoxalase 1 (Glo1) and methylglyoxal (MG) in behavior: recent advances and mechanistic insights
    Margaret G Distler
    Department of Pathology, University of Chicago Chicago, IL, USA
    Front Genet 3:250. 2012
    ..This review highlights GLO1's association with behavioral phenotypes, describes recent discoveries that have elucidated the underlying mechanisms, and identifies opportunities for future research...
  4. pmc Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13)
    Amy B Hart
    Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 7:e42646. 2012
    ..Our approach provides a case study for analysis of high-dimensional intermediate pharmacogenomic phenotypes, which may be more tractable than clinical diagnoses...
  5. pmc Methamphetamine-induced conditioned place preference in LG/J and SM/J mouse strains and an F45/F46 advanced intercross line
    Camron D Bryant
    Department of Human Genetics, The University of Chicago, Chicago, IL, USA
    Front Genet 3:126. 2012
    ..The use of highly recombinant genetic populations like AIL should facilitate the identification of these genes and may have implications for understanding psychostimulant abuse in humans...
  6. pmc A common and unstable copy number variant is associated with differences in Glo1 expression and anxiety-like behavior
    Richard Williams
    Committee on Computational Neuroscience, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 4:e4649. 2009
    ..Finally, these data provide an example of biologically significant phenotypic variability in model organisms that can be attributed to CNVs...
  7. pmc Translational genetic approaches to substance use disorders: bridging the gap between mice and humans
    Abraham A Palmer
    Department of Human Genetics, The University of Chicago, Chicago, IL 60637, USA
    Hum Genet 131:931-9. 2012
    ..We hope these examples illustrate how novel biological insights about the effect of genes on substance use disorders can be obtained when mouse and human genetic studies are successfully integrated...
  8. pmc QTLRel: an R package for genome-wide association studies in which relatedness is a concern
    Riyan Cheng
    Department of Human Genetics, The University of Chicago, IL 60637, USA
    BMC Genet 12:66. 2011
    ..We have developed an R package, QTLRel, to enable more flexible modeling of genetic relatedness as well as covariates and non-genetic variance components...
  9. pmc Prenatal protein deprivation alters dopamine-mediated behaviors and dopaminergic and glutamatergic receptor binding
    Abraham A Palmer
    Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Brain Res 1237:62-74. 2008
    ....
  10. ncbi request reprint Sensitivity to the locomotor-stimulant effects of ethanol and allopregnanolone: a quantitative trait locus study of common genetic influence
    A A Palmer
    Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Genes Brain Behav 5:506-17. 2006
    ..These results confirm the presence of QTL for ethanol and allopregnanolone sensitivity in a common region of chromosome 2 and suggest possible pleiotropic genetic influence on sensitivity to these drugs...
  11. pmc A major QTL on chromosome 11 influences psychostimulant and opioid sensitivity in mice
    C D Bryant
    Department of Human Genetics, University of Chicago, Chicago, IL, USA
    Genes Brain Behav 8:795-805. 2009
    ..Identification of the genes underlying QTLs for response to psychostimulants and opioids may provide insights about genetic factors that modulate sensitivity to drugs of abuse...
  12. ncbi request reprint Sensitivity to the locomotor stimulant effects of ethanol and allopregnanolone is influenced by common genes
    Abraham A Palmer
    Portland Alcohol Research Center, Oregon Health and Science University, USA
    Behav Neurosci 116:126-37. 2002
    ..FAST mice were more sensitive to the stimulant effects of allopregnanolone compared with SLOW mice. These data suggest that sensitivity to the locomotor stimulant effects of these drugs is influenced by common genes...
  13. ncbi request reprint Gene expression differences in mice divergently selected for methamphetamine sensitivity
    Abraham A Palmer
    Columbia Genome Center, Columbia University, 1150 St Nicholas Ave, New York, New York 10032, USA
    Mamm Genome 16:291-305. 2005
    ..The identified genes provide excellent candidates for future hypothesis-driven studies, translational genetic studies, and pharmacological interventions...
  14. ncbi request reprint Inappropriate choice of the experimental unit leads to a dramatic overestimation of the significance of quantitative trait loci for prepulse inhibition and startle response in recombinant congenic mice
    Abraham A Palmer
    Neuropsychopharmacology 28:818; author reply 819. 2003
  15. ncbi request reprint Effects of a Drd2 deletion mutation on ethanol-induced locomotor stimulation and sensitization suggest a role for epistasis
    Abraham A Palmer
    Veterans Affairs Medical Center, Research Service, Portland, Oregon 97239, USA
    Behav Genet 33:311-24. 2003
    ..The impact of the Drd2 null mutation on a subset of ethanol-related behavioral traits is subject to epistatic influences...
  16. ncbi request reprint Corticotropin-releasing factor overexpression decreases ethanol drinking and increases sensitivity to the sedative effects of ethanol
    Abraham A Palmer
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 Sam Jackson Park Road, Portland, OR 97239, USA
    Psychopharmacology (Berl) 176:386-97. 2004
    ..Corticotropin-releasing factor (CRF) may play a significant role in drug and alcohol abuse...
  17. doi request reprint Rapid selection response for contextual fear conditioning in a cross between C57BL/6J and A/J: behavioral, QTL and gene expression analysis
    Christine A Ponder
    Department of Genetics, Rockefeller University, 1230 York Ave, P O Box 288, New York, NY10065, USA
    Behav Genet 38:277-91. 2008
    ..We used Affymetrix microarrays to identify many differentially expressed genes in the amygdala and hippocampus of the selected lines. We conclude that tyr is one of many alleles that influence fear conditioning...
  18. ncbi request reprint Forward, relaxed, and reverse selection for reduced and enhanced sensitivity to ethanol's locomotor stimulant effects in mice
    Tamara J Phillips
    Department of Veterans Affairs Medical Center, Portland, Oregon 97201, USA
    Alcohol Clin Exp Res 26:593-602. 2002
    ....
  19. ncbi request reprint Initial sensitivity, tolerance and cross-tolerance to allopregnanolone- and ethanol-induced hypothermia in selected mouse lines
    Abraham A Palmer
    Portland Alcohol Research Center, Portland, OR 97201, USA
    Psychopharmacology (Berl) 162:313-22. 2002
    ..We also postulated that tolerance would develop to these two drugs by similar mechanisms, such that tolerance to one would impart cross-tolerance to the other...
  20. ncbi request reprint Effect of forward and reverse selection for ethanol-induced locomotor response on other measures of ethanol sensitivity
    Abraham A Palmer
    Portland Alcohol Research Center and Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
    Alcohol Clin Exp Res 26:1322-9. 2002
    ..The reverse-selected lines, named r-FAST and r-SLOW, were virtually equally sensitive to the stimulant effects of the selection dose of ethanol after 16 generations of reverse selection...
  21. ncbi request reprint Identification of quantitative trait loci for prepulse inhibition in rats
    Abraham A Palmer
    Department of Pharmacology, University of California San Diego, La Jolla 92093, USA
    Psychopharmacology (Berl) 165:270-9. 2003
    ..Deficient prepulse inhibition (PPI) of the startle response has shown promise as an endophenotype for schizophrenia, as well as several other psychiatric disorders...
  22. ncbi request reprint Locomotor activity responses to ethanol, other alcohols, and GABA-A acting compounds in forward- and reverse-selected FAST and SLOW mouse lines
    Abraham A Palmer
    Portland Alcohol Research Center, Portland, Oregon, USA
    Behav Neurosci 116:958-67. 2002
    ..Results support an effect of selection for ethanol sensitivity on allosteric modulation of the GABA-A receptor...
  23. pmc Significance thresholds for quantitative trait locus mapping under selective genotyping
    Ani Manichaikul
    Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Genetics 177:1963-6. 2007
    ..A stratified permutation test should be used, with phenotypes shuffled separately within the genotyped and ungenotyped individuals...
  24. pmc A genomewide screen of 345 families for autism-susceptibility loci
    Amanda L Yonan
    Department of Genetics and Development and Columbia Genome Center, Columbia University, New York, NY 10032, USA
    Am J Hum Genet 73:886-97. 2003
    ....
  25. ncbi request reprint Reverse selection for differential response to the locomotor stimulant effects of ethanol provides evidence for pleiotropic genetic influence on locomotor response to other drugs of abuse
    Hadley C Bergstrom
    Department of Veterans Affairs Medical Center, Research Service, Portland, Oregon 97239, USA
    Alcohol Clin Exp Res 27:1535-47. 2003
    ..These lines are well suited for asking whether the same alleles that influence sensitivity to ethanol are also responsible for these later arising differences in drug sensitivity...
  26. pmc The nature and identification of quantitative trait loci: a community's view
    Oduola Abiola
    Nat Rev Genet 4:911-6. 2003
    ..Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?..
  27. pmc Use of chromosome substitution strains to identify seizure susceptibility loci in mice
    Melodie R Winawer
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Mamm Genome 18:23-31. 2007
    ..CSS mapping suggests seizure susceptibility loci on mouse Chromosomes 10 and 18. This approach provides a framework for identifying potentially novel homologous candidate genes for human temporal lobe epilepsy...

Research Grants15

  1. Mouse QTL and Human Association Study of Methamphetamine Sensitivity
    ABRAHAM PALMER; Fiscal Year: 2006
    ..Identification of these genes may be useful for developing new therapeutic strategies to treat or prevent drug abuse and addiction. ..
  2. Mouse QTL and Human Association Study of Methamphetamine Sensitivity
    ABRAHAM PALMER; Fiscal Year: 2009
    ..Identification of these genes may be useful for developing new therapeutic strategies to treat or prevent drug abuse and addiction. ..
  3. Mouse QTL and Human Association Study of Methamphetamine Sensitivity
    Abraham A Palmer; Fiscal Year: 2010
    ..Identification of these genes may be useful for developing new therapeutic strategies to treat or prevent drug abuse and addiction. ..
  4. FINDING GENES THAT CAUSE QLT FOR FEAR LEARNING AND ANXIETY
    Abraham A Palmer; Fiscal Year: 2010
    ..These genes will later be examined in humans and will advance both diagnosis of anxiety disorders and the development of new and more effective treatments for normal and pathological anxiety. ..
  5. FINDING GENES THAT CAUSE QLT FOR FEAR LEARNING AND ANXIETY
    ABRAHAM PALMER; Fiscal Year: 2009
    ..These genes will later be examined in humans and will advance both diagnosis of anxiety disorders and the development of new and more effective treatments for normal and pathological anxiety. ..
  6. Mouse QTL and Human Association Study of Methamphetamine Sensitivity
    ABRAHAM PALMER; Fiscal Year: 2009
    ..Identification of these genes may be useful for developing new therapeutic strategies to treat or prevent drug abuse and addiction. ..
  7. Mouse QTL and Human Association Study of Methamphetamine Sensitivity
    ABRAHAM PALMER; Fiscal Year: 2009
    ..Identification of these genes may be useful for developing new therapeutic strategies to treat or prevent drug abuse and addiction. ..
  8. FINDING GENES THAT CAUSE QLT FOR FEAR LEARNING AND ANXIETY
    ABRAHAM PALMER; Fiscal Year: 2009
    ..These genes will later be examined in humans and will advance both diagnosis of anxiety disorders and the development of new and more effective treatments for normal and pathological anxiety. ..
  9. Mouse QTL and Human Association Study of Methamphetamine Sensitivity
    ABRAHAM PALMER; Fiscal Year: 2007
    ..Identification of these genes may be useful for developing new therapeutic strategies to treat or prevent drug abuse and addiction. ..
  10. Translational Genetic Study of Fear and Anxiety
    ABRAHAM PALMER; Fiscal Year: 2007
    ..This training program will prepare the candidate for an academic career focused on the use of endophenotypes, animal models and bioinformatics to elucidate the genetic basis of psychiatric disease. ..
  11. FINDING GENES THAT CAUSE QLT FOR FEAR LEARNING AND ANXIETY
    ABRAHAM PALMER; Fiscal Year: 2007
    ..These genes will later be examined in humans and will advance both diagnosis of anxiety disorders and the development of new and more effective treatments for normal and pathological anxiety. ..
  12. Mouse QTL and Human Association Study of Methamphetamine Sensitivity
    Abraham A Palmer; Fiscal Year: 2010
    ..Identification of these genes may be useful for developing new therapeutic strategies to treat or prevent drug abuse and addiction. ..