Affiliation: University of Chicago
- Practical considerations regarding the use of genotype and pedigree data to model relatedness in the context of genome-wide association studiesRiyan Cheng
Department of Human Genetics, The University of Chicago, Illinois 60637
G3 (Bethesda) 3:1861-7. 2013....
- Assessment of behaviors modeling aspects of schizophrenia in Csmd1 mutant miceMargaret G Distler
Department of Pathology, University of Chicago, Chicago, Illinois, United States of America
PLoS ONE 7:e51235. 2012..Nevertheless, future studies should consider alternative mouse models including gain-of-function mutations, and loss-of-function mutations that target alternative transcripts of Csmd1...
- Role of Glyoxalase 1 (Glo1) and methylglyoxal (MG) in behavior: recent advances and mechanistic insightsMargaret G Distler
Department of Pathology, University of Chicago Chicago, IL, USA
Front Genet 3:250. 2012..This review highlights GLO1's association with behavioral phenotypes, describes recent discoveries that have elucidated the underlying mechanisms, and identifies opportunities for future research...
- Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13)Amy B Hart
Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
PLoS ONE 7:e42646. 2012..Our approach provides a case study for analysis of high-dimensional intermediate pharmacogenomic phenotypes, which may be more tractable than clinical diagnoses...
- Methamphetamine-induced conditioned place preference in LG/J and SM/J mouse strains and an F45/F46 advanced intercross lineCamron D Bryant
Department of Human Genetics, The University of Chicago, Chicago, IL, USA
Front Genet 3:126. 2012..The use of highly recombinant genetic populations like AIL should facilitate the identification of these genes and may have implications for understanding psychostimulant abuse in humans...
- A common and unstable copy number variant is associated with differences in Glo1 expression and anxiety-like behaviorRichard Williams
Committee on Computational Neuroscience, University of Chicago, Chicago, Illinois, United States of America
PLoS ONE 4:e4649. 2009..Finally, these data provide an example of biologically significant phenotypic variability in model organisms that can be attributed to CNVs...
- Translational genetic approaches to substance use disorders: bridging the gap between mice and humansAbraham A Palmer
Department of Human Genetics, The University of Chicago, Chicago, IL 60637, USA
Hum Genet 131:931-9. 2012..We hope these examples illustrate how novel biological insights about the effect of genes on substance use disorders can be obtained when mouse and human genetic studies are successfully integrated...
- QTLRel: an R package for genome-wide association studies in which relatedness is a concernRiyan Cheng
Department of Human Genetics, The University of Chicago, IL 60637, USA
BMC Genet 12:66. 2011..We have developed an R package, QTLRel, to enable more flexible modeling of genetic relatedness as well as covariates and non-genetic variance components...
- Prenatal protein deprivation alters dopamine-mediated behaviors and dopaminergic and glutamatergic receptor bindingAbraham A Palmer
Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
Brain Res 1237:62-74. 2008....
- Sensitivity to the locomotor-stimulant effects of ethanol and allopregnanolone: a quantitative trait locus study of common genetic influenceA A Palmer
Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
Genes Brain Behav 5:506-17. 2006..These results confirm the presence of QTL for ethanol and allopregnanolone sensitivity in a common region of chromosome 2 and suggest possible pleiotropic genetic influence on sensitivity to these drugs...
- A major QTL on chromosome 11 influences psychostimulant and opioid sensitivity in miceC D Bryant
Department of Human Genetics, University of Chicago, Chicago, IL, USA
Genes Brain Behav 8:795-805. 2009..Identification of the genes underlying QTLs for response to psychostimulants and opioids may provide insights about genetic factors that modulate sensitivity to drugs of abuse...
- Sensitivity to the locomotor stimulant effects of ethanol and allopregnanolone is influenced by common genesAbraham A Palmer
Portland Alcohol Research Center, Oregon Health and Science University, USA
Behav Neurosci 116:126-37. 2002..FAST mice were more sensitive to the stimulant effects of allopregnanolone compared with SLOW mice. These data suggest that sensitivity to the locomotor stimulant effects of these drugs is influenced by common genes...
- Gene expression differences in mice divergently selected for methamphetamine sensitivityAbraham A Palmer
Columbia Genome Center, Columbia University, 1150 St Nicholas Ave, New York, New York 10032, USA
Mamm Genome 16:291-305. 2005..The identified genes provide excellent candidates for future hypothesis-driven studies, translational genetic studies, and pharmacological interventions...
- Inappropriate choice of the experimental unit leads to a dramatic overestimation of the significance of quantitative trait loci for prepulse inhibition and startle response in recombinant congenic miceAbraham A Palmer
Neuropsychopharmacology 28:818; author reply 819. 2003
- Effects of a Drd2 deletion mutation on ethanol-induced locomotor stimulation and sensitization suggest a role for epistasisAbraham A Palmer
Veterans Affairs Medical Center, Research Service, Portland, Oregon 97239, USA
Behav Genet 33:311-24. 2003..The impact of the Drd2 null mutation on a subset of ethanol-related behavioral traits is subject to epistatic influences...
- Corticotropin-releasing factor overexpression decreases ethanol drinking and increases sensitivity to the sedative effects of ethanolAbraham A Palmer
Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 Sam Jackson Park Road, Portland, OR 97239, USA
Psychopharmacology (Berl) 176:386-97. 2004..Corticotropin-releasing factor (CRF) may play a significant role in drug and alcohol abuse...
- Rapid selection response for contextual fear conditioning in a cross between C57BL/6J and A/J: behavioral, QTL and gene expression analysisChristine A Ponder
Department of Genetics, Rockefeller University, 1230 York Ave, P O Box 288, New York, NY10065, USA
Behav Genet 38:277-91. 2008..We used Affymetrix microarrays to identify many differentially expressed genes in the amygdala and hippocampus of the selected lines. We conclude that tyr is one of many alleles that influence fear conditioning...
- Forward, relaxed, and reverse selection for reduced and enhanced sensitivity to ethanol's locomotor stimulant effects in miceTamara J Phillips
Department of Veterans Affairs Medical Center, Portland, Oregon 97201, USA
Alcohol Clin Exp Res 26:593-602. 2002....
- Initial sensitivity, tolerance and cross-tolerance to allopregnanolone- and ethanol-induced hypothermia in selected mouse linesAbraham A Palmer
Portland Alcohol Research Center, Portland, OR 97201, USA
Psychopharmacology (Berl) 162:313-22. 2002..We also postulated that tolerance would develop to these two drugs by similar mechanisms, such that tolerance to one would impart cross-tolerance to the other...
- Effect of forward and reverse selection for ethanol-induced locomotor response on other measures of ethanol sensitivityAbraham A Palmer
Portland Alcohol Research Center and Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
Alcohol Clin Exp Res 26:1322-9. 2002..The reverse-selected lines, named r-FAST and r-SLOW, were virtually equally sensitive to the stimulant effects of the selection dose of ethanol after 16 generations of reverse selection...
- Identification of quantitative trait loci for prepulse inhibition in ratsAbraham A Palmer
Department of Pharmacology, University of California San Diego, La Jolla 92093, USA
Psychopharmacology (Berl) 165:270-9. 2003..Deficient prepulse inhibition (PPI) of the startle response has shown promise as an endophenotype for schizophrenia, as well as several other psychiatric disorders...
- Locomotor activity responses to ethanol, other alcohols, and GABA-A acting compounds in forward- and reverse-selected FAST and SLOW mouse linesAbraham A Palmer
Portland Alcohol Research Center, Portland, Oregon, USA
Behav Neurosci 116:958-67. 2002..Results support an effect of selection for ethanol sensitivity on allosteric modulation of the GABA-A receptor...
- Significance thresholds for quantitative trait locus mapping under selective genotypingAni Manichaikul
Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland 21205, USA
Genetics 177:1963-6. 2007..A stratified permutation test should be used, with phenotypes shuffled separately within the genotyped and ungenotyped individuals...
- A genomewide screen of 345 families for autism-susceptibility lociAmanda L Yonan
Department of Genetics and Development and Columbia Genome Center, Columbia University, New York, NY 10032, USA
Am J Hum Genet 73:886-97. 2003....
- Reverse selection for differential response to the locomotor stimulant effects of ethanol provides evidence for pleiotropic genetic influence on locomotor response to other drugs of abuseHadley C Bergstrom
Department of Veterans Affairs Medical Center, Research Service, Portland, Oregon 97239, USA
Alcohol Clin Exp Res 27:1535-47. 2003..These lines are well suited for asking whether the same alleles that influence sensitivity to ethanol are also responsible for these later arising differences in drug sensitivity...
- The nature and identification of quantitative trait loci: a community's viewOduola Abiola
Nat Rev Genet 4:911-6. 2003..Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?..
- Use of chromosome substitution strains to identify seizure susceptibility loci in miceMelodie R Winawer
Department of Neurology, Columbia University, New York, NY 10032, USA
Mamm Genome 18:23-31. 2007..CSS mapping suggests seizure susceptibility loci on mouse Chromosomes 10 and 18. This approach provides a framework for identifying potentially novel homologous candidate genes for human temporal lobe epilepsy...
- Translational Genetic Study of Fear and AnxietyABRAHAM PALMER; Fiscal Year: 2007..This training program will prepare the candidate for an academic career focused on the use of endophenotypes, animal models and bioinformatics to elucidate the genetic basis of psychiatric disease. [unreadable] [unreadable]..