Ann C Palmenberg
Affiliation: University of Wisconsin
Basta H, Palmenberg A. AMP-activated protein kinase phosphorylates EMCV, TMEV and SafV leader proteins at different sites. Virology. 2014;462-463:236-40 pubmed publisher
..In both cases, recombinant AMP-activated kinase (AMPK) was reactive with the proteins at these sites, and also with LE, modifying the same residue recognized by CK2. ..
Petty R, Basta H, Bacot Davis V, Brown B, Palmenberg A. Binding interactions between the encephalomyocarditis virus leader and protein 2A. J Virol. 2014;88:13503-9 pubmed publisher
Palmenberg A, Gern J. Classification and evolution of human rhinoviruses. Methods Mol Biol. 2015;1221:1-10 pubmed publisher
..Currently, three species, the RV-A, RV-B, and RV-C, are recognized. Of these, the RV-C, discovered in 2006, are the most unusual in terms of capsid structure, receptor use, and association with severe disease in children. ..
Bacot Davis V, Ciomperlik J, Basta H, Cornilescu C, Palmenberg A. Solution structures of Mengovirus Leader protein, its phosphorylated derivatives, and in complex with nuclear transport regulatory protein, RanGTPase. Proc Natl Acad Sci U S A. 2014;111:15792-7 pubmed publisher
Ciomperlik J, Basta H, Palmenberg A. Three cardiovirus Leader proteins equivalently inhibit four different nucleocytoplasmic trafficking pathways. Virology. 2015;484:194-202 pubmed publisher
..The Leader phosphorylation cascade was not effective against recombinant Nup proteins. The findings support a model of Leader-dependent Nup phosphorylation with the purpose of disrupting Nup-transportin interactions. ..
Ciomperlik J, Basta H, Palmenberg A. Cardiovirus Leader proteins bind exportins: Implications for virus replication and nucleocytoplasmic trafficking inhibition. Virology. 2016;487:19-26 pubmed publisher
..The involvement of exportins in this mechanism is important to viral replication and the observation of trafficking inhibition by LE. ..
Palmenberg A. The Language of Life. Annu Rev Virol. 2016;3:1-28 pubmed
..If there is any unity to this, it would be a pursuit of the language of life, or sequence analysis, as taught to us by natural selection. The intent here is not a legacy but an example. Science is a beautiful fate. ..
Palmenberg A. Rhinovirus C, Asthma, and Cell Surface Expression of Virus Receptor CDHR3. J Virol. 2017;91: pubmed publisher
..Selective pressure favoring the Cys529 codon may have coemerged with the evolution of RV-C and helped shape modern human genomes against the virus-susceptible, albeit ancestral Tyr529. ..
Watters K, Inankur B, Gardiner J, Warrick J, Sherer N, Yin J, et al
. Differential Disruption of Nucleocytoplasmic Trafficking Pathways by Rhinovirus 2A Proteases. J Virol. 2017;91: pubmed publisher
..The importance of this finding is that it provides a mechanistic explanation for how different types (strains) of rhinoviruses may elicit different cell responses that directly or indirectly lead to distinct disease phenotypes. ..