SUBBA PALLI

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. pmc Juvenile hormone and insulin regulate trehalose homeostasis in the red flour beetle, Tribolium castaneum
    Jingjing Xu
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, KY, USA
    PLoS Genet 9:e1003535. 2013
  2. pmc Bed bugs evolved unique adaptive strategy to resist pyrethroid insecticides
    Fang Zhu
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, KY 40546, USA
    Sci Rep 3:1456. 2013
  3. pmc RNA interference of NADPH-cytochrome P450 reductase results in reduced insecticide resistance in the bed bug, Cimex lectularius
    Fang Zhu
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS ONE 7:e31037. 2012
  4. pmc Integrated analysis of cytochrome P450 gene superfamily in the red flour beetle, Tribolium castaneum
    Fang Zhu
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, KY 40546, USA
    BMC Genomics 14:174. 2013
  5. pmc Large-scale RNAi screen of G protein-coupled receptors involved in larval growth, molting and metamorphosis in the red flour beetle
    Hua Bai
    Department of Entomology, S 225 Agriculture Science Bldg, N, University of Kentucky, Lexington, KY 40546, USA
    BMC Genomics 12:388. 2011
  6. ncbi request reprint Improved ecdysone receptor-based inducible gene regulation system
    Subba R Palli
    Department of Entomology, College of Agriculture, University of Kentucky, KY 40546, USA
    Eur J Biochem 270:1308-15. 2003
  7. ncbi request reprint The influence of heterodimer partner ultraspiracle/retinoid X receptor on the function of ecdysone receptor
    Subba R Palli
    Department of Entomology, University of Kentucky, Lexington, KY 40546, USA
    FEBS J 272:5979-90. 2005
  8. ncbi request reprint Biochemical mode of action and differential activity of new ecdysone agonists against mosquitoes and moths
    S R Palli
    Department of Entomology, S225 Agricultural Science Center, College of Agriculture, University of Kentucky, Lexington, KY 40546, USA
    Arch Insect Biochem Physiol 58:234-42. 2005
  9. ncbi request reprint Functional characterization of ecdysone receptor gene switches in mammalian cells
    Siva K Panguluri
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, KY 40546, USA
    FEBS J 273:5550-63. 2006
  10. ncbi request reprint Effect of ecdysone receptor gene switch ligands on endogenous gene expression in 293 cells
    Siva K Panguluri
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, KY 40546, USA
    FEBS J 274:5669-89. 2007

Research Grants

  1. Molecular Analysis of Juvenile Hormone Action
    SUBBA PALLI; Fiscal Year: 2006
  2. Molecular Analysis of Juvenile Hormone Action
    SUBBA PALLI; Fiscal Year: 2007
  3. Molecular Analysis of Juvenile Hormone Action
    SUBBA PALLI; Fiscal Year: 2009
  4. Molecular Analysis of Juvenile Hormone Action
    Subba R Palli; Fiscal Year: 2010

Collaborators

Detail Information

Publications32

  1. pmc Juvenile hormone and insulin regulate trehalose homeostasis in the red flour beetle, Tribolium castaneum
    Jingjing Xu
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, KY, USA
    PLoS Genet 9:e1003535. 2013
    ..More importantly, JH regulates trehalose homeostasis, including trehalose transport and metabolism, and controls utilization of stored nutrients in starved adults...
  2. pmc Bed bugs evolved unique adaptive strategy to resist pyrethroid insecticides
    Fang Zhu
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, KY 40546, USA
    Sci Rep 3:1456. 2013
    ..Understanding the complexity of adaptive strategies employed by bed bugs will help in designing the most effective and sustainable bed bug control methods...
  3. pmc RNA interference of NADPH-cytochrome P450 reductase results in reduced insecticide resistance in the bed bug, Cimex lectularius
    Fang Zhu
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS ONE 7:e31037. 2012
    ....
  4. pmc Integrated analysis of cytochrome P450 gene superfamily in the red flour beetle, Tribolium castaneum
    Fang Zhu
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, KY 40546, USA
    BMC Genomics 14:174. 2013
    ..castaneum CYPs with genes in other insect species, investigated the CYP6BQ gene cluster organization, function and evolution, as well as examined the mitochondrial CYPs gene expression patterns and intron-exon organization...
  5. pmc Large-scale RNAi screen of G protein-coupled receptors involved in larval growth, molting and metamorphosis in the red flour beetle
    Hua Bai
    Department of Entomology, S 225 Agriculture Science Bldg, N, University of Kentucky, Lexington, KY 40546, USA
    BMC Genomics 12:388. 2011
    ..In this study, we employed functional genomics methods and used the red flour beetle, Tribolium castaneum, as a model system to study the physiological roles of GPCRs during the larval growth, molting and metamorphosis...
  6. ncbi request reprint Improved ecdysone receptor-based inducible gene regulation system
    Subba R Palli
    Department of Entomology, College of Agriculture, University of Kentucky, KY 40546, USA
    Eur J Biochem 270:1308-15. 2003
    ..Withdrawal of the ligand resulted in 50% and 80% reduction in reporter gene activity by 12 h and 24 h, respectively...
  7. ncbi request reprint The influence of heterodimer partner ultraspiracle/retinoid X receptor on the function of ecdysone receptor
    Subba R Palli
    Department of Entomology, University of Kentucky, Lexington, KY 40546, USA
    FEBS J 272:5979-90. 2005
    ..The EcR:Lm-HsRXR chimera heterodimer, but not the EcR:HsRXR heterodimer, supported ligand-dependent induction of reporter gene in a C57BL/6 mouse model...
  8. ncbi request reprint Biochemical mode of action and differential activity of new ecdysone agonists against mosquitoes and moths
    S R Palli
    Department of Entomology, S225 Agricultural Science Center, College of Agriculture, University of Kentucky, Lexington, KY 40546, USA
    Arch Insect Biochem Physiol 58:234-42. 2005
    ..These compounds showed higher activity in A. aegypti when compared to their activity in H. virescens. These data show that the THQ ligands are a new class of non-steroidal ecdysone agonists with preferential activity against mosquitoes...
  9. ncbi request reprint Functional characterization of ecdysone receptor gene switches in mammalian cells
    Siva K Panguluri
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, KY 40546, USA
    FEBS J 273:5550-63. 2006
    ....
  10. ncbi request reprint Effect of ecdysone receptor gene switch ligands on endogenous gene expression in 293 cells
    Siva K Panguluri
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, KY 40546, USA
    FEBS J 274:5669-89. 2007
    ....
  11. doi request reprint Proliferation and differentiation of intestinal stem cells during metamorphosis of the red flour beetle, Tribolium castaneum
    R Parthasarathy
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, Kentucky 40546, USA
    Dev Dyn 237:893-908. 2008
    ..These data show that the proliferation of ISCs is under both developmental and endocrine regulation...
  12. ncbi request reprint Improvement of a monopartite ecdysone receptor gene switch and demonstration of its utility in regulation of transgene expression in plants
    Venkata S Tavva
    Department of Entomology, University of Kentucky, Lexington, KY 40546 0091, USA
    FEBS J 275:2161-76. 2008
    ..In addition, the affected plants recovered after withdrawal of the ligand, demonstrating the utility of this gene switch in regulating the expression of critical transgenes in plants...
  13. pmc Hormonal regulation of the humoral innate immune response in Drosophila melanogaster
    Thomas Flatt
    Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    J Exp Biol 211:2712-24. 2008
    ..Our results suggest that 20E and JH play major roles in the regulation of gene expression in response to immune challenge...
  14. ncbi request reprint Crustacean retinoid-X receptor isoforms: distinctive DNA binding and receptor-receptor interaction with a cognate ecdysteroid receptor
    Xiaohui Wu
    Department of Zoology, University of Oklahoma, Norman, OK 73019, USA
    Mol Cell Endocrinol 218:21-38. 2004
    ..Transactivation studies using a hybrid UpEcR ligand-binding domain construct and UpRXR (+/-33) ligand-binding domain constructs also showed that the 33-aa insertion was indispensable in mediating ecdysteroid stimulated transactivation...
  15. ncbi request reprint Highly flexible ligand binding pocket of ecdysone receptor: a single amino acid change leads to discrimination between two groups of nonsteroidal ecdysone agonists
    Mohan B Kumar
    RheoGene Inc, Norristown, Pennsylvania 19403, USA
    J Biol Chem 279:27211-8. 2004
    ..The CfEcR and its V128F/A110P mutant were used to demonstrate simultaneous regulation of two reporter genes using THQ and DAH ligands...
  16. ncbi request reprint The acidic activation domains of the baculovirus transactivators IE1 and IE0 are functional for transcriptional activation in both insect and mammalian cells
    Xiaojiang Dai
    Pacific Agri Food Research Centre, Agriculture and Agri Food Canada, Summerland, BC, Canada V0H 1Z0
    J Gen Virol 85:573-82. 2004
    ..These results show that the baculovirus AADs are functional for transcriptional activation in mammalian cells and that AcMNPV AADs generally appear to be more potent than OpMNPV AADs in both insect and mammalian cells...
  17. ncbi request reprint Identification and characterization of a juvenile hormone (JH) response region in the JH esterase gene from the spruce budworm, Choristoneura fumiferana
    Damodar R Kethidi
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, KY 40546, USA
    J Biol Chem 279:19634-42. 2004
    ..These results suggest that the 30-bp JHRE identified in the Cfjhe gene promoter is sufficient to support JH induction and 20E suppression of the Cfjhe gene...
  18. ncbi request reprint Applications of EcR gene switch technology in functional genomics
    Venkata S Tavva
    Department of Entomology, University of Kentucky, Lexington, KY 40546 0091, USA
    Arch Insect Biochem Physiol 65:164-79. 2007
    ....
  19. ncbi request reprint Development of a tightly regulated and highly inducible ecdysone receptor gene switch for plants through the use of retinoid X receptor chimeras
    Venkata S Tavva
    Plant and Soil Sciences Department, University of Kentucky, 1405 Veterans Road, Lexington, KY 40546 0312, USA
    Transgenic Res 16:599-612. 2007
    ..The new CfEcR two-hybrid gene switch that uses the RXR CH9 as a partner in inducing reporter gene expression provides an efficient, ligand-sensitive and tightly regulated gene switch for plants...
  20. ncbi request reprint Stage- and cell-specific expression of ecdysone receptors and ecdysone-induced transcription factors during midgut remodeling in the yellow fever mosquito, Aedes aegypti
    R Parthasarathy
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, KY 40546, USA
    J Insect Physiol 53:216-29. 2007
    ....
  21. ncbi request reprint Heterodimerization of ecdysone receptor and ultraspiracle on symmetric and asymmetric response elements
    Srini C Perera
    Great Lakes Forestry Centre, Canadian Forestry Service, Sault Ste Marie, Ontario, Canada
    Arch Insect Biochem Physiol 60:55-70. 2005
    ..We conclude that the use of heterodimerization interfaces present in CD and E domains of EcR/USP depends on the nature of response elements they bind to...
  22. ncbi request reprint Ecdysteroid receptors and their applications in agriculture and medicine
    Subba R Palli
    Department of Entomology, College of Agriculture, University of Kentucky Lexington, Kentucky 40546, USA
    Vitam Horm 73:59-100. 2005
  23. ncbi request reprint Ecdysteroid titers and developmental expression of ecdysteroid-regulated genes during metamorphosis of the yellow fever mosquito, Aedes aegypti (Diptera: Culicidae)
    Venu M Margam
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, KY 40546, USA
    J Insect Physiol 52:558-68. 2006
    ..These data which describe the relationship between ecdysteroid titers and mRNA levels of Ae. aegypti ecdysteroid-regulated genes lay a solid foundation for future studies on the hormonal regulation of development in mosquitoes...
  24. ncbi request reprint Development of a methoxyfenozide-responsive gene switch for applications in plants
    Venkata S Tavva
    Plant and Soil Sciences Department, 1405 Veterans Road, University of Kentucky, Lexington, KY 40546 0312, USA
    Plant J 45:457-69. 2006
    ..The sensitivity of the CfEcR + LmRXR two-hybrid switch was 25 to 625 times greater than the monopartate gene switch, depending on the plant species tested...
  25. ncbi request reprint Protein kinase C mediated phosphorylation blocks juvenile hormone action
    Damu R Kethidi
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, KY 40546, USA
    Mol Cell Endocrinol 247:127-34. 2006
    ..These data suggest that protein kinase C mediated phosphorylation prevents binding of nuclear proteins to juvenile hormone responsive promoters resulting in suppression of JH action...
  26. ncbi request reprint Developmental and hormonal regulation of midgut remodeling in a lepidopteran insect, Heliothis virescens
    R Parthasarathy
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, KY 40546, USA
    Mech Dev 124:23-34. 2007
    ..aegypti where JHA uncouples midgut remodeling from metamorphosis...
  27. ncbi request reprint Developmental and hormonal regulation of juvenile hormone esterase gene in Drosophila melanogaster
    Damu R Kethidi
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, 40546, USA
    J Insect Physiol 51:393-400. 2005
    ..20-hydroxyecdysone induced DHR3 mRNA and suppressed JH III induction of DmJhe mRNA. These studies show that the expression of jhe in D. melanogaster is regulated by both JH and 20E...
  28. pmc bHLH-PAS family transcription factor methoprene-tolerant plays a key role in JH action in preventing the premature development of adult structures during larval-pupal metamorphosis
    R Parthasarathy
    Department of Entomology, College of Agriculture, University of Kentucky, S225 Ag Science N, Lexington, KY 40546, USA
    Mech Dev 125:601-16. 2008
    ....
  29. ncbi request reprint Mechanisms of midgut remodeling: juvenile hormone analog methoprene blocks midgut metamorphosis by modulating ecdysone action
    Yu Wu
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, KY 40546, USA
    Mech Dev 123:530-47. 2006
    ..Thus, JH analog, methoprene acts on Ae. aegypti by interfering with the expression of genes involved in 20E action resulting in a block in midgut remodeling and death during pupal stage...
  30. pmc Transcription factor broad suppresses precocious development of adult structures during larval-pupal metamorphosis in the red flour beetle, Tribolium castaneum
    R Parthasarathy
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, KY 40546, United States
    Mech Dev 125:299-313. 2008
    ..These data suggest that the expression of Tcbr during the final instar larval stage promotes pupal program while suppressing the larval and adult programs ensuring a transitory pupal stage in holometabolous insects...
  31. pmc Identification and characterization of a juvenile hormone response element and its binding proteins
    Yiping Li
    Department of Entomology, University of Kentucky, Lexington, KY 40546, USA
    J Biol Chem 282:37605-17. 2007
    ....
  32. ncbi request reprint Tight transcriptional regulation of foreign genes in insect cells using an ecdysone receptor-based inducible system
    Xiaojiang Dai
    Pacific Agri Food Research Centre, Agriculture and Agri Food Canada, Summerland, BC, Canada V0H 1Z0
    Protein Expr Purif 42:236-45. 2005
    ..This system will therefore be a very useful tool for biotechnology applications expressing highly toxic proteins in insect cells and for studying the functional genomics of insects and microorganisms that infect them...

Research Grants5

  1. Molecular Analysis of Juvenile Hormone Action
    SUBBA PALLI; Fiscal Year: 2006
    ..The receptors can also be used in medicine by developing gene switches for various applications such as gene therapy, drug discovery and therapeutic protein production. ..
  2. Molecular Analysis of Juvenile Hormone Action
    SUBBA PALLI; Fiscal Year: 2007
    ..The receptors can also be used in medicine by developing gene switches for various applications such as gene therapy, drug discovery and therapeutic protein production. ..
  3. Molecular Analysis of Juvenile Hormone Action
    SUBBA PALLI; Fiscal Year: 2009
    ..The receptors can also be used in medicine by developing gene switches for various applications such as gene therapy, drug discovery and therapeutic protein production. ..
  4. Molecular Analysis of Juvenile Hormone Action
    Subba R Palli; Fiscal Year: 2010
    ....