J Palis

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. doi request reprint Primitive erythropoiesis in the mammalian embryo
    James Palis
    University of Rochester Medical Center, Department of Pediatrics, Center for Pediatric Biomedical Research, New York 14642, USA
    Int J Dev Biol 54:1011-8. 2010
  2. pmc Erythropoietin critically regulates the terminal maturation of murine and human primitive erythroblasts
    Jeffrey Malik
    Haematologica 98:1778-87. 2013
  3. pmc Stat and interferon genes identified by network analysis differentially regulate primitive and definitive erythropoiesis
    Emily Greenfest-Allen
    Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA stoec
    BMC Syst Biol 7:38. 2013
  4. ncbi request reprint Yolk-sac hematopoiesis: the first blood cells of mouse and man
    J Palis
    University of Rochester, Department of Pediatrics and Cancer Center, Rochester, NY 14642, USA
    Exp Hematol 29:927-36. 2001
  5. doi request reprint Ontogeny of erythropoiesis
    James Palis
    Department of Pediatrics, University of Rochester Medical Center, Rochester, New York 14642, USA
    Curr Opin Hematol 15:155-61. 2008
  6. ncbi request reprint Erythropoietin-receptor expression and function during the initiation of murine yolk sac erythropoiesis
    J K McGann
    Department of Pediatrics, University of Rochester Medical Center, NY 14642, USA
    Exp Hematol 25:1149-57. 1997
  7. ncbi request reprint Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse
    J Palis
    University of Rochester Medical Center, Department of Pediatrics and Cancer Center, Box 777, Rochester, NY 14642, USA rochester edu
    Development 126:5073-84. 1999
  8. ncbi request reprint Initiation of murine embryonic erythropoiesis: a spatial analysis
    L Silver
    University of Rochester Medical Center, Department of Pediatrics and Cancer Center, NY 14642, USA
    Blood 89:1154-64. 1997
  9. ncbi request reprint Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4
    K E McGrath
    Department of Pediatrics and Cancer Center, University of Rochester Medical Center, Rochester, New York, 14642, USA
    Dev Biol 213:442-56. 1999
  10. ncbi request reprint Subtractive hybridization reveals tissue-specific expression of ahnak during embryonic development
    P D Kingsley
    University of Rochester Medical Center, Department of Pediatrics and Cancer Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Dev Growth Differ 43:133-43. 2001

Collaborators

Detail Information

Publications43

  1. doi request reprint Primitive erythropoiesis in the mammalian embryo
    James Palis
    University of Rochester Medical Center, Department of Pediatrics, Center for Pediatric Biomedical Research, New York 14642, USA
    Int J Dev Biol 54:1011-8. 2010
    ..This surprising finding indicates that the primitive erythroid lineage is indeed mammalian, rather than non-mammalian, in character...
  2. pmc Erythropoietin critically regulates the terminal maturation of murine and human primitive erythroblasts
    Jeffrey Malik
    Haematologica 98:1778-87. 2013
    ..We conclude that erythropoietin plays an evolutionarily conserved role in promoting the proliferation, survival, and appropriate timing of terminal maturation of primitive erythroid precursors. ..
  3. pmc Stat and interferon genes identified by network analysis differentially regulate primitive and definitive erythropoiesis
    Emily Greenfest-Allen
    Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA stoec
    BMC Syst Biol 7:38. 2013
    ..Inferred networks are strongly connected and do not fit a scale-free model, making it difficult to identify essential regulators using the hub-essentiality standard...
  4. ncbi request reprint Yolk-sac hematopoiesis: the first blood cells of mouse and man
    J Palis
    University of Rochester, Department of Pediatrics and Cancer Center, Rochester, NY 14642, USA
    Exp Hematol 29:927-36. 2001
    ..To review the process of blood-cell formation in the murine and human yolk sac...
  5. doi request reprint Ontogeny of erythropoiesis
    James Palis
    Department of Pediatrics, University of Rochester Medical Center, Rochester, New York 14642, USA
    Curr Opin Hematol 15:155-61. 2008
    ....
  6. ncbi request reprint Erythropoietin-receptor expression and function during the initiation of murine yolk sac erythropoiesis
    J K McGann
    Department of Pediatrics, University of Rochester Medical Center, NY 14642, USA
    Exp Hematol 25:1149-57. 1997
    ..These results also suggest that other growth factor signaling cascades are active during the onset of mammalian erythropoiesis...
  7. ncbi request reprint Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse
    J Palis
    University of Rochester Medical Center, Department of Pediatrics and Cancer Center, Box 777, Rochester, NY 14642, USA rochester edu
    Development 126:5073-84. 1999
    ....
  8. ncbi request reprint Initiation of murine embryonic erythropoiesis: a spatial analysis
    L Silver
    University of Rochester Medical Center, Department of Pediatrics and Cancer Center, NY 14642, USA
    Blood 89:1154-64. 1997
    ..During the stages analyzed, tal-1 and rbtn2 expression was also present in posterior embryonic mesoderm, while GATA-1 and GATA-2 expression was evident in extraembryonic tissues of ectodermal origin...
  9. ncbi request reprint Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4
    K E McGrath
    Department of Pediatrics and Cancer Center, University of Rochester Medical Center, Rochester, New York, 14642, USA
    Dev Biol 213:442-56. 1999
    ..Migration occurred with an optimum dose similar to that found for adult hematopoietic cells and was dependent on the presence of SDF-1 in a gradient. This work suggests roles for chemokine signaling in multiple embryogenic events...
  10. ncbi request reprint Subtractive hybridization reveals tissue-specific expression of ahnak during embryonic development
    P D Kingsley
    University of Rochester Medical Center, Department of Pediatrics and Cancer Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Dev Growth Differ 43:133-43. 2001
    ..The potential functions of ahnak are discussed in light of these results...
  11. ncbi request reprint The relationship of CD5+ B lymphocytes to macrophages: insights from normal biphenotypic B/macrophage cells
    M A Borrello
    Vaccinex, Laboratory of Cellular Immunology, Rochester, NY, USA
    Int Rev Immunol 20:137-55. 2001
    ..This review considers normal B/macrophage cell function in an evolutionary context where a primitive, flexible cell type could perform dual roles in adaptive and innate immunity...
  12. ncbi request reprint Expression of homeobox genes, including an insulin promoting factor, in the murine yolk sac at the time of hematopoietic initiation
    K E McGrath
    Department of Pediatrics, University of Rochester Medical Center, NY 14642, USA
    Mol Reprod Dev 48:145-53. 1997
    ..We hypothesize the early expression of insulin in the YS is required for the expansion of insulin responsive cells including primitive erythroblasts...
  13. pmc "Maturational" globin switching in primary primitive erythroid cells
    Paul D Kingsley
    Department of Pediatrics, University of Rochester Medical Center, Center for Pediatric Biomedical Research, Box 703, 601 Elmwood Ave, Rochester, NY 14642, USA
    Blood 107:1665-72. 2006
    ..Globin switching during ontogeny is due not only to the sequential appearance of primitive and definitive lineages but also to changes in globin expression as primitive erythroblasts mature in the bloodstream...
  14. ncbi request reprint Yolk sac-derived primitive erythroblasts enucleate during mammalian embryogenesis
    Paul D Kingsley
    Department of Pediatrics, Center for Human Genetics and Molecular Pediatric Disease, University of Rochester Medical Center, NY 14642, USA
    Blood 104:19-25. 2004
    ..Our studies establish a new paradigm in the understanding of primitive erythropoiesis and support the concept that primitive erythropoiesis in mice shares many similarities with definitive erythropoiesis of mammals...
  15. pmc Spatial and temporal emergence of high proliferative potential hematopoietic precursors during murine embryogenesis
    J Palis
    University of Rochester Medical Center, Department of Pediatrics and Cancer Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 98:4528-33. 2001
    ..Our findings support the hypothesis that definitive but not primitive hematopoietic progenitors originate from yolk sac-derived HPP-CFC during late gastrulation...
  16. ncbi request reprint Developmental expression of extracellular glutathione peroxidase suggests antioxidant roles in deciduum, visceral yolk sac, and skin
    P D Kingsley
    Department of Pediatrics and Cancer Center, University of Rochester Medical Center, New York 14642, USA
    Mol Reprod Dev 49:343-55. 1998
    ..These findings suggest that EGPx may serve a wider antioxidant role than previously recognized in the interstitium of multiple localized tissues, particularly those associated with the active transport of lipids...
  17. pmc Enucleation of primitive erythroid cells generates a transient population of "pyrenocytes" in the mammalian fetus
    Kathleen E McGrath
    University of Rochester Medical Center, Department of Pediatrics, Center for Pediatric Biomedical Research, Rochester, NY 14642, USA
    Blood 111:2409-17. 2008
    ..Continued studies comparing primitive and definitive erythropoiesis will lead to an improved understanding of terminal erythroid maturation...
  18. pmc Multispectral imaging of hematopoietic cells: where flow meets morphology
    Kathleen E McGrath
    University of Rochester Medical Center, Department of Pediatrics, Center for Pediatric Biomedical Research, Box 703, 601 Elmwood Ave, Rochester, NY 14642, United States
    J Immunol Methods 336:91-7. 2008
    ....
  19. pmc Histone hyperacetylation within the beta-globin locus is context-dependent and precedes high-level gene expression
    George Fromm
    Departments of Pediatrics, Center for Pediatric Biomedical Research, University of Rochester Medical Center, Box 703, 601 Elmwood Ave, Rochester, NY14642, USA
    Blood 114:3479-88. 2009
    ..These data narrow the range of possible mechanisms by which hyperacetylated domains form...
  20. ncbi request reprint Circulation is established in a stepwise pattern in the mammalian embryo
    Kathleen E McGrath
    Center for Human Genetics and Molecular Pediatric Diseases, Department of Pediatrics, University of Rochester, NY, USA
    Blood 101:1669-76. 2003
    ..We conclude that a functional vascular system develops gradually and that specialized vascular-hematopoietic environments exist after circulation becomes fully established...
  21. pmc All primitive and definitive hematopoietic progenitor cells emerging before E10 in the mouse embryo are products of the yolk sac
    Christopher T Lux
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis 46202 5254, USA
    Blood 111:3435-8. 2008
    ..Thus, primitive erythroblasts and essentially all definitive HPCs destined to initially seed the fetal liver after E9.5 are generated in the YS between E7.0-E9.5 and are redistributed into the EP via the systemic circulation...
  22. pmc Sox6 directly silences epsilon globin expression in definitive erythropoiesis
    Zanhua Yi
    Department of Pediatrics, University of Arizona, College of Medicine, Tucson, Arizona, USA
    PLoS Genet 2:e14. 2006
    ..Thus, Sox6 regulation of epsilony globin might provide a novel therapeutical target in the treatment of hemoglobinopathies such as sickle cell anemia and thalassemia...
  23. ncbi request reprint Differential gene expression during early murine yolk sac development
    J Palis
    University of Rochester, Department of Pediatrics, New York, USA
    Mol Reprod Dev 42:19-27. 1995
    ..These results are consistent with the hypothesis that at E7.5, the yolk sac endoderm provides differentiated liver-like functions, while the newly developing extraembryonic mesoderm is still a largely undifferentiated tissue...
  24. ncbi request reprint "Liver function tests" are not always tests of liver function
    D N Korones
    Department of Pediatrics, University of Rochester, School of Medicine and Dentistry, Children s Hospital at Strong, New York 14642, USA
    Am J Hematol 66:46-8. 2001
    ..Hematologists/oncologists should consider obtaining a serum CK to rule out muscle disease in patients with unexplained elevations of AST, ALT, and LDH...
  25. ncbi request reprint Hematopoiesis in the yolk sac: more than meets the eye
    Kathleen E McGrath
    Department of Pediatrics and the Center for Pediatric Biomedical Research, University of Rochester Medical Center, Rochester, NY 14642, USA
    Exp Hematol 33:1021-8. 2005
    ....
  26. pmc Primitive erythropoiesis and megakaryopoiesis in the yolk sac are independent of c-myb
    Joanna Tober
    Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Blood 111:2636-9. 2008
    ..5 yolk sac and E11.5 liver. Despite this impaired megakaryocyte potential, c-myb-null fetuses had normal platelet numbers at E12.5 but became thrombocytopenic by E15.5, suggesting that c-myb is required for sustained thrombopoiesis...
  27. pmc The megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesis
    Joanna Tober
    Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, NY 14642, USA
    Blood 109:1433-41. 2007
    ....
  28. ncbi request reprint Analysis of hematopoietic progenitors in the mouse embryo
    James Palis
    Department of Pediatrics, Center for Genetics and Molecular Pediatric Disease, University of Rochester Medical Center, Rochester, NY, USA
    Methods Mol Med 105:289-302. 2005
    ..This chapter describes the methodologies for the culture and identification of unipotential and multipotential hematopoietic progenitors in the mouse embryo...
  29. doi request reprint Ontogeny of erythropoiesis in the mammalian embryo
    Kathleen McGrath
    Department of Pediatrics, Center for Pediatric Biomedical Research, University of Rochester, Rochester, New York 14642, USA
    Curr Top Dev Biol 82:1-22. 2008
    ..Continued comparative studies of primitive and definitive erythropoiesis in mammalian and nonmammalian embryos will lead to an improved understanding of terminal erythroid maturation and globin gene regulation...
  30. pmc Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: dose-response and time-course profiles measured by flow cytometry
    Stephen D Dertinger
    Litron Laboratories, Rochester, NY 14623, USA
    Mutat Res 634:119-25. 2007
    ....
  31. pmc Transient glutathione depletion determines terminal differentiation in HL-60 cells
    Suzanne M Krance
    University of Rochester School of Medicine, Rochester, New York, USA
    Oxid Med Cell Longev 3:53-60. 2010
    ..These findings indicate that intracellular GSH levels are regulated in a complex fashion during HL-60 cell differentiation, and that transient GSH depletion using low doses of CDNB and DEM enhances the differentiation process...
  32. pmc Pig-a mutation: kinetics in rat erythrocytes following exposure to five prototypical mutagens
    Souk Phonethepswath
    Litron Laboratories, Rochester, New York 14623, USA
    Toxicol Sci 114:59-70. 2010
    ..The kinetics and ease of scoring this blood-based endpoint suggest that integration into routine toxicology studies will be feasible...
  33. pmc Foxp3 regulates megakaryopoiesis and platelet function
    Jamie J Bernard
    Department of Environmental Medicine, University of Rochester, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 29:1874-82. 2009
    ..Scurfy mice and some humans with IPEX are also thrombocytopenic. The purpose of this study was to determine whether the absence of functional Foxp3 leads to defects in megakaryocytes and platelets...
  34. ncbi request reprint Haemangioblast commitment is initiated in the primitive streak of the mouse embryo
    Tara L Huber
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York City, New York 10029, USA
    Nature 432:625-30. 2004
    ....
  35. doi request reprint A heme export protein is required for red blood cell differentiation and iron homeostasis
    Siobán B Keel
    Division of Hematology, University of Washington, Seattle, WA 98195, USA
    Science 319:825-8. 2008
    ..Thus, the trafficking of heme, and not just elemental iron, facilitates erythropoiesis and systemic iron balance...
  36. ncbi request reprint Developmental biology: no red cell is an island
    James Palis
    Nature 432:964-5. 2004
  37. ncbi request reprint Onset of cardiac function during early mouse embryogenesis coincides with entry of primitive erythroblasts into the embryo proper
    Rui Ping Ji
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY, USA
    Circ Res 92:133-5. 2003
    ..In situ hybridization revealed an onset of the heartbeat coincident with the appearance of yolk sac-derived erythroblasts in the embryo proper at 5 S. Early maturation of the circulation follows a tightly coordinated program...
  38. ncbi request reprint Lineage analysis of the hemangioblast as defined by FLK1 and SCL expression
    Yun Shin Chung
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Development 129:5511-20. 2002
    ..Replating studies demonstrate that hematopoietic progenitors are enriched within FLK1(+)CD4(+) and FLK1(-)CD4(+) cells, while endothelial cells develop from FLK1(+)CD4(+) and FLK1(+)CD4(-) cell populations...
  39. ncbi request reprint Runx1 is essential for hematopoietic commitment at the hemangioblast stage of development in vitro
    Georges Lacaud
    Carl C Icahn Institute for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Blood 100:458-66. 2002
    ....
  40. pmc The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis
    David G Ransom
    Division of Hematology Oncology, Children s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    PLoS Biol 2:E237. 2004
    ..Our results establish a major role for this transcriptional intermediary factor in the differentiation of hematopoietic cells in vertebrates...
  41. ncbi request reprint Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis
    Rebecca A Wingert
    Stem Cell Program and Division Hematology Oncology Children s Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 436:1035-39. 2005
    ..These findings uncover a connection between haem biosynthesis and Fe-S clusters, indicating that haemoglobin production in the differentiating red cell is regulated through Fe-S cluster assembly...
  42. ncbi request reprint cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes
    Alan J Davidson
    Department of Medicine, Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Nature 425:300-6. 2003
    ..Taken together, these findings demonstrate that cdx4 regulates hox genes and is necessary for the specification of haematopoietic cell fate during vertebrate embryogenesis...

Research Grants30

  1. INITIATION OF MAMMALIAN EMBRYONIC HEMATOPOIESIS
    James Palis; Fiscal Year: 2007
    ..A better understanding of the mechanisms responsible for terminal erythroid maturation will ultimately lead to the efficient and complete ex vivo synthesis of erythrocytes to serve an ever-expanding clinical need for red blood cells. ..
  2. Ontogeny of erythroid lineage differentiation
    James Palis; Fiscal Year: 2009
    ..These studies will improve our understanding of the causes of anemia and will ultimately lead to curative treatments for children and adults with sickle cell disease and thalassemia syndromes. ..
  3. INITIATION OF MAMMALIAN EMBRYONIC HEMATOPOIESIS
    James Palis; Fiscal Year: 2009
    ..A better understanding of the mechanisms responsible for terminal erythroid maturation will ultimately lead to the efficient and complete ex vivo synthesis of erythrocytes to serve an ever-expanding clinical need for red blood cells. ..
  4. Hematopoietic targets of radiation: identification and mitigation
    James Palis; Fiscal Year: 2009
    ..PUBLIC HEALTH STATEMENT: The proposed research is designed to learn which blood cells in the bone marrow are sensitive to radiation and to learn how to protect these cells. ..
  5. Ontogeny of erythroid lineage differentiation
    James Palis; Fiscal Year: 2010
    ..These studies will improve our understanding of the causes of anemia and will ultimately lead to curative treatments for children and adults with sickle cell disease and thalassemia syndromes. ..
  6. INITIATION OF MAMMALIAN EMBRYONIC HEMATOPOIESIS
    James Palis; Fiscal Year: 2010
    ..A better understanding of the mechanisms responsible for terminal erythroid maturation will ultimately lead to the efficient and complete ex vivo synthesis of erythrocytes to serve an ever-expanding clinical need for red blood cells. ..
  7. INITIATION OF MAMMALIAN EMBRYONIC HEMATOPOIESIS
    James Palis; Fiscal Year: 2009
    ..A better understanding of the mechanisms responsible for terminal erythroid maturation will ultimately lead to the efficient and complete ex vivo synthesis of erythrocytes to serve an ever-expanding clinical need for red blood cells. ..
  8. Hematopoietic targets of radiation: identification and mitigation
    James Palis; Fiscal Year: 2010
    ..PUBLIC HEALTH STATEMENT: The proposed research is designed to learn which blood cells in the bone marrow are sensitive to radiation and to learn how to protect these cells. ..
  9. Hematopoietic targets of radiation: identification and mitigation
    James Palis; Fiscal Year: 2009
    ..PUBLIC HEALTH STATEMENT: The proposed research is designed to learn which blood cells in the bone marrow are sensitive to radiation and to learn how to protect these cells. ..
  10. INITIATION OF MAMMALIAN EMBRYONIC HEMATOPOIESIS
    James Palis; Fiscal Year: 2010
    ..A better understanding of the mechanisms responsible for terminal erythroid maturation will ultimately lead to the efficient and complete ex vivo synthesis of erythrocytes to serve an ever-expanding clinical need for red blood cells. ..
  11. Ontogeny of erythroid lineage differentiation
    James Palis; Fiscal Year: 2007
    ..These studies will improve our understanding of the causes of anemia and will ultimately lead to curative treatments for children and adults with sickle cell disease and thalassemia syndromes. ..
  12. Ontogeny of erythroid lineage differentiation
    James Palis; Fiscal Year: 2006
    ..These studies will improve our understanding of the causes of anemia and will ultimately lead to curative treatments for children and adults with sickle cell disease and thalassemia syndromes. ..
  13. INITIATION OF MAMMALIAN EMBRYONIC HEMATOPOIESIS
    James Palis; Fiscal Year: 1999
    ....
  14. Embryonic hematopoietic stem cell origin and ontogeny
    James Palis; Fiscal Year: 2001
    ..A better understanding of the initiation of mammalian hematopoiesis will provide insights into the ontogeny, regulation and expansion of HSCs, as well as the origin of leukemias and bone marrow failure syndromes. ..
  15. INITIATION OF MAMMALIAN EMBRYONIC HEMATOPOIESIS
    James Palis; Fiscal Year: 2001
    ....
  16. INITIATION OF MAMMALIAN EMBRYONIC HEMATOPOIESIS
    James Palis; Fiscal Year: 2002
    ....
  17. Embryonic hematopoietic stem cell origin and ontogeny
    James Palis; Fiscal Year: 2002
    ..A better understanding of the initiation of mammalian hematopoiesis will provide insights into the ontogeny, regulation and expansion of HSCs, as well as the origin of leukemias and bone marrow failure syndromes. ..
  18. Embryonic hematopoietic stem cell origin and ontogeny
    James Palis; Fiscal Year: 2003
    ..A better understanding of the initiation of mammalian hematopoiesis will provide insights into the ontogeny, regulation and expansion of HSCs, as well as the origin of leukemias and bone marrow failure syndromes. ..
  19. Initiation of Mammalian Yolk Sac Hematopoiesis
    James Palis; Fiscal Year: 2003
    ..This will ultimately lead to improvements in bone marrow transplantation for the curative treatment of congenital anemias, genetic diseases and several forms of childhood and adult cancers. ..
  20. Embryonic hematopoietic stem cell origin and ontogeny
    James Palis; Fiscal Year: 2004
    ..A better understanding of the initiation of mammalian hematopoiesis will provide insights into the ontogeny, regulation and expansion of HSCs, as well as the origin of leukemias and bone marrow failure syndromes. ..
  21. Embryonic hematopoietic stem cell origin and ontogeny
    James Palis; Fiscal Year: 2003
    ..A better understanding of the initiation of mammalian hematopoiesis will provide insights into the ontogeny, regulation and expansion of HSCs, as well as the origin of leukemias and bone marrow failure syndromes. ..
  22. Initiation of Embryonic Hematopoiesis
    James Palis; Fiscal Year: 2004
    ..Furthermore, a better understanding of the initiation of mammalian hematopoiesis will provide insights into the origin of hematopoietic stem cells and the development of leukemias and marrow failure syndromes. ..
  23. Initiation of Mammalian Yolk Sac Hematopoiesis
    James Palis; Fiscal Year: 2006
    ..This will ultimately lead to improvements in bone marrow transplantation for the curative treatment of congenital anemias, genetic diseases and several forms of childhood and adult cancers. ..
  24. Hematopoietic targets of radiation: identification and mitigation
    James Palis; Fiscal Year: 2010
    ..PUBLIC HEALTH STATEMENT: The proposed research is designed to learn which blood cells in the bone marrow are sensitive to radiation and to learn how to protect these cells. ..