Research Topics
| CHARLES YC PAKSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
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Detail Information
Publications
Aromatase deficiency causes altered expression of molecules critical for calcium reabsorption in the kidneys of female mice *Orhan K Oz
Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9153, USA
J Bone Miner Res 22:1893-902. 2007..ArKO mice have hypercalciuria and lower levels of calcium transport proteins, whereas levels of the klotho protein are elevated. Thus, estrogen deficiency is sufficient to cause altered renal calcium handling...- Biochemical profile of idiopathic uric acid nephrolithiasisC Y Pak
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
Kidney Int 60:757-61. 2001..The control group was composed of 54 with absorptive hypercalciuria and 2 normal subjects, matched with the UA stone group according to age, body mass index, and gender... - Predictive value of kidney stone composition in the detection of metabolic abnormalitiesCharles Y C Pak
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
Am J Med 115:26-32. 2003..To determine if kidney stone composition can predict the underlying medical diagnosis, and vice versa... - Elucidation of factors determining formation of calcium phosphate stonesCharles Y C Pak
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8571, USA
J Urol 172:2267-70. 2004..In this study we compared the effect of the urinary concentration of calcium with that of oxalate on the urinary relative saturation ratio (RSR) of calcium oxalate and brushite in patients with pure or mixed calcium phosphate stones... - Physicochemical metabolic characteristics for calcium oxalate stone formation in patients with gouty diathesisCharles Y C Pak
Center for Mineral Metabolism and Clinical Research, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
J Urol 173:1606-9. 2005..We determined why calcium oxalate stones instead of uric acid stones form in some patients with gouty diathesis... - Effect of dietary modification on urinary stone risk factorsCharles Y C Pak
Center for Mineral Metabolism and Clinical Research and Department of Urology, University of Texas Southwestern Medical Center, Dallas, 75390, USA
Kidney Int 68:2264-73. 2005..This study was undertaken to ascertain the effect of dietary modification on urinary stone risks, and to determine whether the response depends on the prevailing urinary calcium... 
Evidence for metabolic origin of absorptive hypercalciuria Type IICharles Y C Pak
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
Urol Res 39:147-52. 2011..In conclusion, AH-II shares with AH-I the same metabolic disturbance(s) stimulating intestinal absorption and renal excretion of calcium but to a lesser degree. Bone might be spared in AH-II...- Medical stone management: 35 years of advancesCharles Y C Pak
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
J Urol 180:813-9. 2008..The goal of this article is to review the progress made from the perspective of collaborating urologists and urological journals in which the findings were reported... - Pharmacotherapy of kidney stonesCharles Y C Pak
University of Texas Southwestern Medical Center, Center for Mineral Metabolism and Clinical Research, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
Expert Opin Pharmacother 9:1509-18. 2008..Kidney stones are associated with various biochemical disturbances in urine. Various drugs and dietary changes have been recommended to halt stone recurrence... 
New methods of assessing crystal growth and saturation of brushite in whole urine: effect of pH, calcium and citrateCharles Y C Pak
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
J Urol 180:1532-7. 2008..To explore this question new methods for the saturation and crystal growth of brushite were devised that are applicable to whole urine without any computer program...- Comparison of semi-empirical and computer derived methods for estimating urinary saturation of calcium oxalateCharles Y C Pak
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
J Urol 182:2951-6. 2009.... - Medical management of urinary stone diseaseCharles Y C Pak
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Tex 75390 8571, USA
Nephron Clin Pract 98:c49-53. 2004..In a simple approach, thiazide or indapamide with potassium citrate is recommended for patients with hypercalciuria, and potassium citrate alone for the remaining normocalciuric subjects... - Effects of potassium alkali and calcium supplementation on bone turnover in postmenopausal womenKhashayar Sakhaee
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
J Clin Endocrinol Metab 90:3528-33. 2005..In postmenopausal women, combined treatment with potassium citrate and calcium citrate inhibits bone resorption by providing an alkali load and increasing absorbed calcium... - Prevention of spinal bone loss by potassium citrate in cases of calcium urolithiasisCharles Y C Pak
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA
J Urol 168:31-4. 2002..CONCLUSIONS: Potassium citrate, a commonly used drug for the prevention of recurrent nephrolithiasis, may avert age dependent bone loss. Spinal bone density increased in most patients when it normally decreases... - Biochemical profile of stone-forming patients with diabetes mellitusCharles Y C Pak
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas 75390-8885, USA
Urology 61:523-7. 2003..Diabetic patients with UA stones share a key feature of those with GD, namely the passage of unusually acid urine, but not the low fractional excretion of urate... - Effect of high protein diet on stone-forming propensity and bone loss in ratsJamshid Amanzadeh
Center for Mineral Metabolism and Clinical Research and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8885, USA
Kidney Int 64:2142-9. 2003..Hypocitraturia is probably renal in origin. This rat model will be useful in elucidating the mechanisms by which high protein intake increases the risk of nephrolithiasis and bone loss in human beings... - Biochemical distinction between hyperuricosuric calcium urolithiasis and gouty diathesisCharles Y C Pak
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8885, USA
Urology 60:789-94. 2002..The varying biochemical and physicochemical presentations of the two conditions can be ascribed to overindulgence with purine-rich foods in those with HUCU and underlying primary gout in those with GD... - Prevention of thiazide-induced hypokalemia without magnesium depletion by potassium-magnesium-citrateClarita V Odvina
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8885, USA
Am J Ther 13:101-8. 2006..Moreover, KCl is devoid of protective action toward crystallization of stone-forming salts... - Effect of high and low calcium diets on stone forming risk during liberal oxalate intakeEdward D Matsumoto
Department of Urology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
J Urol 176:132-6. 2006..A high calcium diet during liberal oxalate intake may pose an increased risk of calcium oxalate stone formation... - Biochemical characterization of primary hyperparathyroidism with and without kidney stonesClarita V Odvina
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8885, USA
Urol Res 35:123-8. 2007..Stone-formers with PHPT display exaggerated urinary calcium excretion due to intestinal hyperabsorption of calcium, contributing to a greater enhancement of the saturation of stone-forming calcium salts... - Reduction of renal stone risk by potassium-magnesium citrate during 5 weeks of bed restJoseph E Zerwekh
Center for Mineral Metabolism and Clinical Research, and the Department of Physical Medicine and Rehabilitation, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
J Urol 177:2179-84. 2007..This study was performed to evaluate the efficacy of potassium alkali as potassium-magnesium citrate in reducing renal stone risk and bone turnover... - Pathophysiologic basis for normouricosuric uric acid nephrolithiasisKhashayar Sakhaee
Center of Mineral Metabolism and Clinical Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8891, USA
Kidney Int 62:971-9. 2002..Although net acid excretion is maintained at the expense of increased titratable acidity and to some degree hypocitraturia, the compromise is acid urine pH and may result in uric acid nephrolithiasis... - Intestinal hyperabsorption of calcium and low bone turnover in hypercalciuric postmenopausal osteoporosisClarita V Odvina
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
Urol Res 36:233-9. 2008.... - Severely suppressed bone turnover: a potential complication of alendronate therapyClarita V Odvina
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
J Clin Endocrinol Metab 90:1294-301. 2005..Our observations emphasize the need for increased awareness and monitoring for the potential development of excessive suppression of bone turnover during long-term alendronate therapy... - Biochemical and histological assessment of alkali therapy during high animal protein intake in the ratJoseph E Zerwekh
Department of Internal Medicine, Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8885, USA
Bone 45:1004-9. 2009..In this animal model of high dietary animal protein intake, the major skeletal effect of alkali therapy is to reduce bone resorption, with little or no effect on bone formation... - Identification and characterization of a gene with base substitutions associated with the absorptive hypercalciuria phenotype and low spinal bone densityBerenice Y Reed
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
J Clin Endocrinol Metab 87:1476-85. 2002..This is the first description of a specific gene defect associated with AH... - Long-term combined treatment with thiazide and potassium citrate in nephrolithiasis does not lead to hypokalemia or hypochloremic metabolic alkalosisClarita V Odvina
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, and Department of Veterans Affairs Medical Center, Dallas, Texas 75390 8885, USA
Kidney Int 63:240-7. 2003..This retrospective analysis was conducted to determine if these two potential complications are encountered in patients on long-term potassium citrate and thiazide therapy... - Pathogenesis of hypercalciuric nephrolithiasisJoseph E Zerwekh
Department of Internal Medicine, Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
Endocrinol Metab Clin North Am 31:869-84. 2002..Such studies have disclosed that hypercalciuria is probably polygenic in nature and will require a concerted effort to better understand the defects while attempting to develop gene-specific countermeasures... - Reduction in normalized bone elasticity following long-term bisphosphonate treatment as measured by ultrasound critical angle reflectometryEdmond Richer
Advanced Radiological Sciences Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Osteoporos Int 16:1384-92. 2005..Thus, the material bone quality of cortical and trabecular bone may be impaired following bisphosphonate treatment, as in renal transplantation on steroids... - Effect of ascorbic acid consumption on urinary stone risk factorsOlivier Traxer
Department of Urology, The University of Texas Southwestern Medical Center, Dallas, 75390-9110, USA
J Urol 170:397-401. 2003..Stone formers respond no differently to AA than normal subjects. We recommend limiting AA use to less than 2 gm daily in CaOx stone formers... - Etiological role of estrogen status in renal stone formationHoward J Heller
Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Center for Mineral Metabolism and Clinical Research, USA
J Urol 168:1923-7. 2002..Estrogen treatment may decrease the risk of stone recurrence in postmenopausal women by lowering urinary calcium and calcium oxalate saturation... - Stone forming risk of calcium citrate supplementation in healthy postmenopausal womenKhashayar Sakhaee
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
J Urol 172:958-61. 2004..We evaluated the effect of calcium citrate supplementation alone or in combination with potassium citrate on the stone forming propensity in healthy postmenopausal women... - Rapid Communication: relative effect of urinary calcium and oxalate on saturation of calcium oxalateCharles Y C Pak
Center for Mineral Metabolism and Clinical Research, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 8571, USA
Kidney Int 66:2032-7. 2004..The study compared the effect of urinary calcium with that of oxalate on urinary saturation [relative saturation ratio (RSR)] of calcium oxalate... - Biochemical and physicochemical presentations of patients with brushite stonesCharles Y C Pak
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8885, USA
J Urol 171:1046-9. 2004.... - Mechanism of urinary calcium regulation by urinary magnesium and pHOlivier Bonny
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
J Am Soc Nephrol 19:1530-7. 2008..In summary, these data are compatible with the hypothesis that urinary magnesium directly inhibits renal calcium absorption, which can be negated by high luminal pH, and that this regulation likely takes place in the distal tubule... - Association of urinary pH with body weight in nephrolithiasisNaim M Maalouf
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Kidney Int 65:1422-5. 2004..The results confirm the previously proposed scheme that obesity may sometimes cause uric acid nephrolithiasis by producing excessively acid urine due to insulin resistance... - Comparison of semi-empirical and computer derived methods for estimating urinary saturation of brushiteCharles Y C Pak
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA
J Urol 181:1423-8. 2009..To attempt resolution the supersaturation index according to the Joint Expert Speciation System and the relative saturation ratio according to Equil 2 were compared with the semi-empirically derived concentration-to-product ratio... - Cloning and characterization of the human soluble adenylyl cyclaseWeidong Geng
Center for Mineral Metabolism and Clinical Research, Department of Internal Medicine. University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390-8885, USA
Am J Physiol Cell Physiol 288:C1305-16. 2005..In summary, hsAC is a divalent cation and HCO(3)(-) sensor, and its HCO(3)(-) sensitivity is modulated by divalent cations... - Effect of dietary calcium on stone forming propensityHoward J Heller
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8885, USA
J Urol 169:470-4. 2003..However, high calcium intake alone, without concomitant changes in the diet, poses a modest risk for calcium stone formation... - Cost-effectiveness of medical management strategies for nephrolithiasisYair Lotan
Department of Urology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Urol 172:2275-81. 2004..Modified SMEM and empiric therapy yield the same cost and efficacy as treatments that follow comprehensive evaluation. However, modified SMEM may be advantageous because it offers useful additional medical information... - Effect of low-carbohydrate high-protein diets on acid-base balance, stone-forming propensity, and calcium metabolismShalini T Reddy
Department of Internal Medicine, Section of General Internal Medicine, The University of Chicago, IL 60637, USA
Am J Kidney Dis 40:265-74. 2002..Low-carbohydrate high-protein (LCHP) diets are used commonly for weight reduction. This study explores the relationship between such diets and acid-base balance, kidney-stone risk, and calcium and bone metabolism... - Effect of cranberry juice consumption on urinary stone risk factorsMatthew T Gettman
Department of Urology, Mayo Clinic, Rochester, Minnesota, USA
J Urol 174:590-4; quiz 801. 2005..Overall CBJ increases the risk of calcium oxalate and uric acid stone formation but decreases the risk of brushite stones... - Urinary reference values for stone risk factors in childrenKristy M Borawski
Division of Urology, Duke University Medical Center, Durham, North Carolina, USA
J Urol 179:290-4; discussion 294. 2008..We measured urinary stone risk factors in healthy children 3 to 18 years old, and sought to determine whether the risk factors are affected by age...