CHARLES YC PAK

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Aromatase deficiency causes altered expression of molecules critical for calcium reabsorption in the kidneys of female mice *
    Orhan K Oz
    Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9153, USA
    J Bone Miner Res 22:1893-902. 2007
  2. ncbi request reprint Biochemical profile of idiopathic uric acid nephrolithiasis
    C Y Pak
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    Kidney Int 60:757-61. 2001
  3. ncbi request reprint Predictive value of kidney stone composition in the detection of metabolic abnormalities
    Charles Y C Pak
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    Am J Med 115:26-32. 2003
  4. ncbi request reprint Elucidation of factors determining formation of calcium phosphate stones
    Charles Y C Pak
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8571, USA
    J Urol 172:2267-70. 2004
  5. ncbi request reprint Physicochemical metabolic characteristics for calcium oxalate stone formation in patients with gouty diathesis
    Charles Y C Pak
    Center for Mineral Metabolism and Clinical Research, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    J Urol 173:1606-9. 2005
  6. ncbi request reprint Effect of dietary modification on urinary stone risk factors
    Charles Y C Pak
    Center for Mineral Metabolism and Clinical Research and Department of Urology, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Kidney Int 68:2264-73. 2005
  7. doi request reprint Evidence for metabolic origin of absorptive hypercalciuria Type II
    Charles Y C Pak
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
    Urol Res 39:147-52. 2011
  8. doi request reprint Medical stone management: 35 years of advances
    Charles Y C Pak
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    J Urol 180:813-9. 2008
  9. ncbi request reprint Pharmacotherapy of kidney stones
    Charles Y C Pak
    University of Texas Southwestern Medical Center, Center for Mineral Metabolism and Clinical Research, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
    Expert Opin Pharmacother 9:1509-18. 2008
  10. pmc New methods of assessing crystal growth and saturation of brushite in whole urine: effect of pH, calcium and citrate
    Charles Y C Pak
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    J Urol 180:1532-7. 2008

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Aromatase deficiency causes altered expression of molecules critical for calcium reabsorption in the kidneys of female mice *
    Orhan K Oz
    Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9153, USA
    J Bone Miner Res 22:1893-902. 2007
    ..ArKO mice have hypercalciuria and lower levels of calcium transport proteins, whereas levels of the klotho protein are elevated. Thus, estrogen deficiency is sufficient to cause altered renal calcium handling...
  2. ncbi request reprint Biochemical profile of idiopathic uric acid nephrolithiasis
    C Y Pak
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    Kidney Int 60:757-61. 2001
    ..The control group was composed of 54 with absorptive hypercalciuria and 2 normal subjects, matched with the UA stone group according to age, body mass index, and gender...
  3. ncbi request reprint Predictive value of kidney stone composition in the detection of metabolic abnormalities
    Charles Y C Pak
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    Am J Med 115:26-32. 2003
    ..To determine if kidney stone composition can predict the underlying medical diagnosis, and vice versa...
  4. ncbi request reprint Elucidation of factors determining formation of calcium phosphate stones
    Charles Y C Pak
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8571, USA
    J Urol 172:2267-70. 2004
    ..In this study we compared the effect of the urinary concentration of calcium with that of oxalate on the urinary relative saturation ratio (RSR) of calcium oxalate and brushite in patients with pure or mixed calcium phosphate stones...
  5. ncbi request reprint Physicochemical metabolic characteristics for calcium oxalate stone formation in patients with gouty diathesis
    Charles Y C Pak
    Center for Mineral Metabolism and Clinical Research, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    J Urol 173:1606-9. 2005
    ..We determined why calcium oxalate stones instead of uric acid stones form in some patients with gouty diathesis...
  6. ncbi request reprint Effect of dietary modification on urinary stone risk factors
    Charles Y C Pak
    Center for Mineral Metabolism and Clinical Research and Department of Urology, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Kidney Int 68:2264-73. 2005
    ..This study was undertaken to ascertain the effect of dietary modification on urinary stone risks, and to determine whether the response depends on the prevailing urinary calcium...
  7. doi request reprint Evidence for metabolic origin of absorptive hypercalciuria Type II
    Charles Y C Pak
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
    Urol Res 39:147-52. 2011
    ..In conclusion, AH-II shares with AH-I the same metabolic disturbance(s) stimulating intestinal absorption and renal excretion of calcium but to a lesser degree. Bone might be spared in AH-II...
  8. doi request reprint Medical stone management: 35 years of advances
    Charles Y C Pak
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    J Urol 180:813-9. 2008
    ..The goal of this article is to review the progress made from the perspective of collaborating urologists and urological journals in which the findings were reported...
  9. ncbi request reprint Pharmacotherapy of kidney stones
    Charles Y C Pak
    University of Texas Southwestern Medical Center, Center for Mineral Metabolism and Clinical Research, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
    Expert Opin Pharmacother 9:1509-18. 2008
    ..Kidney stones are associated with various biochemical disturbances in urine. Various drugs and dietary changes have been recommended to halt stone recurrence...
  10. pmc New methods of assessing crystal growth and saturation of brushite in whole urine: effect of pH, calcium and citrate
    Charles Y C Pak
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    J Urol 180:1532-7. 2008
    ..To explore this question new methods for the saturation and crystal growth of brushite were devised that are applicable to whole urine without any computer program...
  11. doi request reprint Comparison of semi-empirical and computer derived methods for estimating urinary saturation of calcium oxalate
    Charles Y C Pak
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    J Urol 182:2951-6. 2009
    ....
  12. ncbi request reprint Medical management of urinary stone disease
    Charles Y C Pak
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Tex 75390 8571, USA
    Nephron Clin Pract 98:c49-53. 2004
    ..In a simple approach, thiazide or indapamide with potassium citrate is recommended for patients with hypercalciuria, and potassium citrate alone for the remaining normocalciuric subjects...
  13. ncbi request reprint Effects of potassium alkali and calcium supplementation on bone turnover in postmenopausal women
    Khashayar Sakhaee
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    J Clin Endocrinol Metab 90:3528-33. 2005
    ..In postmenopausal women, combined treatment with potassium citrate and calcium citrate inhibits bone resorption by providing an alkali load and increasing absorbed calcium...
  14. ncbi request reprint Prevention of spinal bone loss by potassium citrate in cases of calcium urolithiasis
    Charles Y C Pak
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Urol 168:31-4. 2002
    ..We determine if potassium citrate treatment stabilizes spinal bone density among patients with recurrent calcium oxalate nephrolithiasis...
  15. ncbi request reprint Biochemical profile of stone-forming patients with diabetes mellitus
    Charles Y C Pak
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas 75390 8885, USA
    Urology 61:523-7. 2003
    ..To test the hypothesis that stone-forming patients with type II diabetes (DM-II) have a high prevalence of uric acid (UA) stones and present with some of the biochemical features of gouty diathesis (GD)...
  16. ncbi request reprint Effect of high protein diet on stone-forming propensity and bone loss in rats
    Jamshid Amanzadeh
    Center for Mineral Metabolism and Clinical Research and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    Kidney Int 64:2142-9. 2003
    ..The purpose of this study was to create an animal model of animal protein excess and to evaluate the response of kidney and bone to the dietary protein load...
  17. ncbi request reprint Biochemical distinction between hyperuricosuric calcium urolithiasis and gouty diathesis
    Charles Y C Pak
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    Urology 60:789-94. 2002
    ....
  18. ncbi request reprint Prevention of thiazide-induced hypokalemia without magnesium depletion by potassium-magnesium-citrate
    Clarita V Odvina
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8885, USA
    Am J Ther 13:101-8. 2006
    ..Moreover, KCl is devoid of protective action toward crystallization of stone-forming salts...
  19. ncbi request reprint Effect of high and low calcium diets on stone forming risk during liberal oxalate intake
    Edward D Matsumoto
    Department of Urology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Urol 176:132-6. 2006
    ..Recent studies suggest that a high calcium diet protects against calcium oxalate stone formation. We compared the effect of high and low calcium diets on urinary saturation of calcium oxalate during liberal oxalate intake...
  20. ncbi request reprint Biochemical characterization of primary hyperparathyroidism with and without kidney stones
    Clarita V Odvina
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8885, USA
    Urol Res 35:123-8. 2007
    ..Stone-formers with PHPT display exaggerated urinary calcium excretion due to intestinal hyperabsorption of calcium, contributing to a greater enhancement of the saturation of stone-forming calcium salts...
  21. ncbi request reprint Reduction of renal stone risk by potassium-magnesium citrate during 5 weeks of bed rest
    Joseph E Zerwekh
    Center for Mineral Metabolism and Clinical Research, and the Department of Physical Medicine and Rehabilitation, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Urol 177:2179-84. 2007
    ..This study was performed to evaluate the efficacy of potassium alkali as potassium-magnesium citrate in reducing renal stone risk and bone turnover...
  22. ncbi request reprint Pathophysiologic basis for normouricosuric uric acid nephrolithiasis
    Khashayar Sakhaee
    Center of Mineral Metabolism and Clinical Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8891, USA
    Kidney Int 62:971-9. 2002
    ..Patients with uric acid nephrolithaisis have normal acid-base parameters according conventional clinical tests...
  23. doi request reprint Intestinal hyperabsorption of calcium and low bone turnover in hypercalciuric postmenopausal osteoporosis
    Clarita V Odvina
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
    Urol Res 36:233-9. 2008
    ....
  24. ncbi request reprint Severely suppressed bone turnover: a potential complication of alendronate therapy
    Clarita V Odvina
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    J Clin Endocrinol Metab 90:1294-301. 2005
    ..Our observations emphasize the need for increased awareness and monitoring for the potential development of excessive suppression of bone turnover during long-term alendronate therapy...
  25. pmc Biochemical and histological assessment of alkali therapy during high animal protein intake in the rat
    Joseph E Zerwekh
    Department of Internal Medicine, Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8885, USA
    Bone 45:1004-9. 2009
    ..In this animal model of high dietary animal protein intake, the major skeletal effect of alkali therapy is to reduce bone resorption, with little or no effect on bone formation...
  26. ncbi request reprint Identification and characterization of a gene with base substitutions associated with the absorptive hypercalciuria phenotype and low spinal bone density
    Berenice Y Reed
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    J Clin Endocrinol Metab 87:1476-85. 2002
    ..This is the first description of a specific gene defect associated with AH...
  27. ncbi request reprint Long-term combined treatment with thiazide and potassium citrate in nephrolithiasis does not lead to hypokalemia or hypochloremic metabolic alkalosis
    Clarita V Odvina
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, and Department of Veterans Affairs Medical Center, Dallas, Texas 75390 8885, USA
    Kidney Int 63:240-7. 2003
    ..This retrospective analysis was conducted to determine if these two potential complications are encountered in patients on long-term potassium citrate and thiazide therapy...
  28. ncbi request reprint Pathogenesis of hypercalciuric nephrolithiasis
    Joseph E Zerwekh
    Department of Internal Medicine, Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
    Endocrinol Metab Clin North Am 31:869-84. 2002
    ..Such studies have disclosed that hypercalciuria is probably polygenic in nature and will require a concerted effort to better understand the defects while attempting to develop gene-specific countermeasures...
  29. ncbi request reprint Reduction in normalized bone elasticity following long-term bisphosphonate treatment as measured by ultrasound critical angle reflectometry
    Edmond Richer
    Advanced Radiological Sciences Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Osteoporos Int 16:1384-92. 2005
    ..Thus, the material bone quality of cortical and trabecular bone may be impaired following bisphosphonate treatment, as in renal transplantation on steroids...
  30. ncbi request reprint Effect of ascorbic acid consumption on urinary stone risk factors
    Olivier Traxer
    Department of Urology, The University of Texas Southwestern Medical Center, Dallas, 75390 9110, USA
    J Urol 170:397-401. 2003
    ..We evaluated the effect of AA consumption on urinary saturation of calcium oxalate (CaOx) and urinary pH...
  31. ncbi request reprint Etiological role of estrogen status in renal stone formation
    Howard J Heller
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Center for Mineral Metabolism and Clinical Research, USA
    J Urol 168:1923-7. 2002
    ..We examined the contribution of estrogen to kidney stone risk by comparing outpatient evaluations in the 2 genders, and in estrogen treated and untreated postmenopausal women...
  32. ncbi request reprint Stone forming risk of calcium citrate supplementation in healthy postmenopausal women
    Khashayar Sakhaee
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
    J Urol 172:958-61. 2004
    ..We evaluated the effect of calcium citrate supplementation alone or in combination with potassium citrate on the stone forming propensity in healthy postmenopausal women...
  33. ncbi request reprint Rapid Communication: relative effect of urinary calcium and oxalate on saturation of calcium oxalate
    Charles Y C Pak
    Center for Mineral Metabolism and Clinical Research, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 8571, USA
    Kidney Int 66:2032-7. 2004
    ..The study compared the effect of urinary calcium with that of oxalate on urinary saturation [relative saturation ratio (RSR)] of calcium oxalate...
  34. ncbi request reprint Biochemical and physicochemical presentations of patients with brushite stones
    Charles Y C Pak
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    J Urol 171:1046-9. 2004
    ..We determined whether the biochemical and physicochemical backgrounds of patients with brushite stones differ from those with hydroxyapatite and calcium oxalate stones...
  35. pmc Mechanism of urinary calcium regulation by urinary magnesium and pH
    Olivier Bonny
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Am Soc Nephrol 19:1530-7. 2008
    ..In summary, these data are compatible with the hypothesis that urinary magnesium directly inhibits renal calcium absorption, which can be negated by high luminal pH, and that this regulation likely takes place in the distal tubule...
  36. ncbi request reprint Association of urinary pH with body weight in nephrolithiasis
    Naim M Maalouf
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Kidney Int 65:1422-5. 2004
    ..Based on these observations, we hypothesized that urinary pH may be inversely associated to body weight in nephrolithiasis...
  37. pmc Comparison of semi-empirical and computer derived methods for estimating urinary saturation of brushite
    Charles Y C Pak
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Urol 181:1423-8. 2009
    ..To attempt resolution the supersaturation index according to the Joint Expert Speciation System and the relative saturation ratio according to Equil 2 were compared with the semi-empirically derived concentration-to-product ratio...
  38. ncbi request reprint Cloning and characterization of the human soluble adenylyl cyclase
    Weidong Geng
    Center for Mineral Metabolism and Clinical Research, Department of Internal Medicine University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 8885, USA
    Am J Physiol Cell Physiol 288:C1305-16. 2005
    ..In summary, hsAC is a divalent cation and HCO(3)(-) sensor, and its HCO(3)(-) sensitivity is modulated by divalent cations...
  39. ncbi request reprint Effect of dietary calcium on stone forming propensity
    Howard J Heller
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8885, USA
    J Urol 169:470-4. 2003
    ..This metabolic study was designed to elucidate the physiological and physicochemical effects conferring this apparent protection...
  40. ncbi request reprint Cost-effectiveness of medical management strategies for nephrolithiasis
    Yair Lotan
    Department of Urology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Urol 172:2275-81. 2004
    ..We evaluated the cost-effectiveness and stone recurrence rates of common management strategies in stone formers...
  41. ncbi request reprint Effect of low-carbohydrate high-protein diets on acid-base balance, stone-forming propensity, and calcium metabolism
    Shalini T Reddy
    Department of Internal Medicine, Section of General Internal Medicine, The University of Chicago, IL 60637, USA
    Am J Kidney Dis 40:265-74. 2002
    ..Low-carbohydrate high-protein (LCHP) diets are used commonly for weight reduction. This study explores the relationship between such diets and acid-base balance, kidney-stone risk, and calcium and bone metabolism...
  42. ncbi request reprint Effect of cranberry juice consumption on urinary stone risk factors
    Matthew T Gettman
    Department of Urology, Mayo Clinic, Rochester, Minnesota, USA
    J Urol 174:590-4; quiz 801. 2005
    ..We evaluated the effect of cranberry juice on urinary stone risk factors...
  43. ncbi request reprint Urinary reference values for stone risk factors in children
    Kristy M Borawski
    Division of Urology, Duke University Medical Center, Durham, North Carolina, USA
    J Urol 179:290-4; discussion 294. 2008
    ..We measured urinary stone risk factors in healthy children 3 to 18 years old, and sought to determine whether the risk factors are affected by age...