Paivi Pajukanta

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc A nonsynonymous SNP within PCDH15 is associated with lipid traits in familial combined hyperlipidemia
    Adriana Huertas-Vazquez
    Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Hum Genet 127:83-9. 2010
  2. pmc Adipose co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes
    Blake E Haas
    Department of Human Genetics, Gonda Center, Los Angeles, California, 90095 7088, USA
    BMC Med Genomics 5:61. 2012
  3. doi request reprint Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci
    Daphna Weissglas-Volkov
    Department of Human Genetics, David Geffen School of Medicine at UCLA, Gonda Center, Room 6335B, 695 Charles E Young Drive South, Los Angeles, CA 90095 7088, USA
    J Med Genet 50:298-308. 2013
  4. pmc Do DNA sequence variants in ABCA1 contribute to HDL cholesterol levels in the general population?
    Paivi Pajukanta
    Department of Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, California 90095 7088, USA
    J Clin Invest 114:1244-7. 2004
  5. ncbi request reprint Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1)
    Paivi Pajukanta
    Department of Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California 90095 7088, USA
    Nat Genet 36:371-6. 2004
  6. pmc Combined analysis of genome scans of dutch and finnish families reveals a susceptibility locus for high-density lipoprotein cholesterol on chromosome 16q
    Paivi Pajukanta
    Department of Human Genetics, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095, USA
    Am J Hum Genet 72:903-17. 2003
  7. pmc Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples
    Daphna Weissglas-Volkov
    Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7088, USA
    Circ Cardiovasc Genet 3:31-8. 2010
  8. pmc Identification of two common variants contributing to serum apolipoprotein B levels in Mexicans
    Daphna Weissglas-Volkov
    Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095 7088, USA
    Arterioscler Thromb Vasc Biol 30:353-9. 2010
  9. pmc Evidence of how rs7575840 influences apolipoprotein B-containing lipid particles
    Blake E Haas
    Department of Human Genetics, David Geffen School of Medicine at the University of California, Los Angeles, Gonda Center, Rm 6335B, 695 Charles E Young Dr S, Los Angeles, CA 90095 7088, USA
    Arterioscler Thromb Vasc Biol 31:1201-7. 2011
  10. ncbi request reprint USF1 contributes to high serum lipid levels in Dutch FCHL families and U.S. whites with coronary artery disease
    Jenny C Lee
    Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Arterioscler Thromb Vasc Biol 27:2222-7. 2007

Collaborators

Detail Information

Publications31

  1. pmc A nonsynonymous SNP within PCDH15 is associated with lipid traits in familial combined hyperlipidemia
    Adriana Huertas-Vazquez
    Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Hum Genet 127:83-9. 2010
    ..013 and P = 0.044, respectively). Our study suggests that PCDH15 is associated with lipid abnormalities...
  2. pmc Adipose co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes
    Blake E Haas
    Department of Human Genetics, Gonda Center, Los Angeles, California, 90095 7088, USA
    BMC Med Genomics 5:61. 2012
    ..Fat is stored in the form of TGs in human adipose tissue. We hypothesized that gene co-expression networks in human adipose tissue may be correlated with serum TG levels and help reveal novel genes involved in TG regulation...
  3. doi request reprint Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci
    Daphna Weissglas-Volkov
    Department of Human Genetics, David Geffen School of Medicine at UCLA, Gonda Center, Room 6335B, 695 Charles E Young Drive South, Los Angeles, CA 90095 7088, USA
    J Med Genet 50:298-308. 2013
    ..Yet, these populations remain underinvestigated by genomic studies, and to date, no genome-wide association (GWA) studies have been reported for lipids in these rapidly expanding populations...
  4. pmc Do DNA sequence variants in ABCA1 contribute to HDL cholesterol levels in the general population?
    Paivi Pajukanta
    Department of Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, California 90095 7088, USA
    J Clin Invest 114:1244-7. 2004
    ..A new study provides genetic evidence supporting this hypothesis...
  5. ncbi request reprint Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1)
    Paivi Pajukanta
    Department of Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California 90095 7088, USA
    Nat Genet 36:371-6. 2004
    ..USF1 encodes a transcription factor known to regulate several genes of glucose and lipid metabolism...
  6. pmc Combined analysis of genome scans of dutch and finnish families reveals a susceptibility locus for high-density lipoprotein cholesterol on chromosome 16q
    Paivi Pajukanta
    Department of Human Genetics, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095, USA
    Am J Hum Genet 72:903-17. 2003
    ..1 region, we investigated a novel functional and positional candidate gene, helix/forkhead transcription factor (FOXC2), by sequencing and by genotyping of two single-nucleotide polymorphisms in the families...
  7. pmc Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples
    Daphna Weissglas-Volkov
    Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7088, USA
    Circ Cardiovasc Genet 3:31-8. 2010
    ....
  8. pmc Identification of two common variants contributing to serum apolipoprotein B levels in Mexicans
    Daphna Weissglas-Volkov
    Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095 7088, USA
    Arterioscler Thromb Vasc Biol 30:353-9. 2010
    ..This study attempted to determine these genetic factors...
  9. pmc Evidence of how rs7575840 influences apolipoprotein B-containing lipid particles
    Blake E Haas
    Department of Human Genetics, David Geffen School of Medicine at the University of California, Los Angeles, Gonda Center, Rm 6335B, 695 Charles E Young Dr S, Los Angeles, CA 90095 7088, USA
    Arterioscler Thromb Vasc Biol 31:1201-7. 2011
    ..5 kb upstream of APOB, has remained unknown. Our objective was to investigate rs7575840 for association with refined apoB-containing lipid particles, for replication in a Mexican population, and for its underlying functional mechanism...
  10. ncbi request reprint USF1 contributes to high serum lipid levels in Dutch FCHL families and U.S. whites with coronary artery disease
    Jenny C Lee
    Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Arterioscler Thromb Vasc Biol 27:2222-7. 2007
    ..Here we examined the previously associated rs3737787 SNP in extended Dutch FCHL families (n=532) and in a cohort of US subjects who underwent diagnostic coronary angiography (n=1533)...
  11. pmc Galanin preproprotein is associated with elevated plasma triglycerides
    Christopher L Plaisier
    Department of Human Genetics, David Geffen School of Medicine at UCLA, Gonda Center, 695 Charles E Young Drive South, Los Angeles, CA 90095 7088, USA
    Arterioscler Thromb Vasc Biol 29:147-52. 2009
    ..We hypothesized that variation in the galanin preproprotein (GAL) gene may contribute to hypertriglyceridemia (HTG) in humans...
  12. ncbi request reprint Association of the APOLIPOPROTEIN A1/C3/A4/A5 gene cluster with triglyceride levels and LDL particle size in familial combined hyperlipidemia
    Rebecca Mar
    Department of Human Genetics, University of California, Los Angeles, USA
    Circ Res 94:993-9. 2004
    ....
  13. pmc A systems genetics approach implicates USF1, FADS3, and other causal candidate genes for familial combined hyperlipidemia
    Christopher L Plaisier
    Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
    PLoS Genet 5:e1000642. 2009
    ..We then provide evidence from two independent datasets supporting FADS3 as a causal gene for FCHL and elevated TGs in Mexicans...
  14. ncbi request reprint Common hepatic nuclear factor-4alpha variants are associated with high serum lipid levels and the metabolic syndrome
    Daphna Weissglas-Volkov
    UCLA, Department of Human Genetics, Gonda Neuroscience and Genetics Research Center, 695 Charles E Young Dr South, Los Angeles, CA 90095 7088, USA
    Diabetes 55:1970-7. 2006
    ..005 for total cholesterol and 0.006 for triglycerides). In conclusion, we show for the first time that common HNF4A variants are associated with high serum lipid levels and the metabolic syndrome...
  15. pmc WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels
    Jenny C Lee
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Am J Hum Genet 83:180-92. 2008
    ..In conclusion, analyses of 9,798 subjects show significant association between HDL-C and a WWOX variant with an allele-specific cis-regulatory function...
  16. pmc Estimating ethnic admixture from pedigree data
    Janet S Sinsheimer
    Department of Human Genetics, The University of California, Los Angeles, CA 90095, USA
    Am J Hum Genet 82:748-55. 2008
    ..The utility of the method is demonstrated on simulated data and a real data example involving Mexican families of mixed Amerindian and Spanish ancestry...
  17. ncbi request reprint Locus for elevated apolipoprotein B levels on chromosome 1p31 in families with familial combined hyperlipidemia
    Hooman Allayee
    Department of Human Genetics, Gonda Genetics Research Center, University of California, Los Angeles 90095, USA
    Circ Res 90:926-31. 2002
    ..This is one of the first loci identified for apoB levels in humans and is the second major locus implicated in the genetic etiology of FCH...
  18. pmc Upstream transcription factor 1 influences plasma lipid and metabolic traits in mice
    Sulin Wu
    Department of Human Genetics, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
    Hum Mol Genet 19:597-608. 2010
    ..In all three mouse model settings, notable sex specificity was observed, consistent with human studies showing differences in association with USF1 gene polymorphisms between sexes...
  19. pmc Association of stearoyl-CoA desaturase 1 activity with familial combined hyperlipidemia
    Rebecca Mar-Heyming
    Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Arterioscler Thromb Vasc Biol 28:1193-9. 2008
    ..We used the fatty acid desaturation index (the plasma ratio of 18:1/18:0) as a marker of SCD1 activity to investigate the relationship of SCD1 to familial combined hyperlipidemia (FCHL)...
  20. ncbi request reprint Unraveling the complex genetics of familial combined hyperlipidemia
    Elina Suviolahti
    Department of Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90095 7088, USA
    Ann Med 38:337-51. 2006
    ..This finding has now been replicated in independent FCHL samples. However, the total number of variants, the risk related to each variant and their relative contributions to the disease susceptibility are not known yet...
  21. pmc Transgenic expression and genetic variation of Lmf1 affect LPL activity in mice and humans
    Maryam Hosseini
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Arterioscler Thromb Vasc Biol 32:1204-10. 2012
    ..The objective of this study is to investigate whether, beyond its role as a required factor in lipase maturation, variation in Lmf1 expression is sufficient to modulate LPL activity in vivo...
  22. pmc The N342S MYLIP polymorphism is associated with high total cholesterol and increased LDL receptor degradation in humans
    Daphna Weissglas-Volkov
    Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 7088, USA
    J Clin Invest 121:3062-71. 2011
    ..Our findings suggest that modulation of MYLIP activity can affect LDL-C levels and that pharmacologic inhibition of MYLIP activity might be a useful strategy in the treatment of dyslipidemia and ASCVD...
  23. pmc Exome sequencing identifies 2 rare variants for low high-density lipoprotein cholesterol in an extended family
    M V Prasad Linga Reddy
    Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Circ Cardiovasc Genet 5:538-46. 2012
    ..Less is known about its feasibility to identify genes for complex traits. We used exome sequencing to search for rare variants responsible for a complex trait, low levels of serum high-density lipoprotein cholesterol (HDL-C)...
  24. pmc Association testing in a linked region using large pedigrees
    Rita M Cantor
    Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 7088, USA
    Am J Hum Genet 76:538-42. 2005
    ..For the test results to be valid, good estimates of haplotype frequencies must be used in the analysis...
  25. pmc Genome scans provide evidence for low-HDL-C loci on chromosomes 8q23, 16q24.1-24.2, and 20q13.11 in Finnish families
    Aino Soro
    Department of Human Genetics, Gonda Neuroscience and Genetics Research Center, University of California, Los Angeles, CA 90095 7088, USA
    Am J Hum Genet 70:1333-40. 2002
    ..11, the latter representing a recently characterized region for type 2 diabetes. Besides these three loci, loci on chromosomes 2p and 3p showed linkage in the families with low HDL-C and a locus on 2ptel in the families with FCHL...
  26. pmc The SLC6A14 gene shows evidence of association with obesity
    Elina Suviolahti
    Department of Human Genetics, University of California, Los Angeles, USA
    J Clin Invest 112:1762-72. 2003
    ..003). The SLC6A14 gene is an interesting novel candidate for obesity because it encodes an amino acid transporter, which potentially regulates tryptophan availability for serotonin synthesis and thus possibly affects appetite control...
  27. pmc Merging microsatellite data: enhanced methodology and software to combine genotype data for linkage and association analysis
    Angela P Presson
    Department of Human Genetics, University of California, Los Angeles, CA 90095, USA
    BMC Bioinformatics 9:317. 2008
    ..A consequence of such alignments is that codominant genotypes must often be analyzed as phenotypes. In this paper we describe several extensions that are implemented in MicroMerge version 2 (v2)...
  28. ncbi request reprint Familial combined hyperlipidemia: upstream transcription factor 1 and beyond
    Jenny C Lee
    Department of Human Genetics bDepartment of Medicine Division of Cardiology, University of California Los Angeles, Los Angeles, California 90095, USA
    Curr Opin Lipidol 17:101-9. 2006
    ..Aiming beyond upstream transcription factor 1, we also evaluate novel strategies that have made it possible to globally examine the genome and the transcriptome...
  29. ncbi request reprint Genetics of atherosclerosis
    Aldons J Lusis
    Department of 1Human Genetics, University of California, Los Angeles, California 90095, USA
    Annu Rev Genomics Hum Genet 5:189-218. 2004
    ..Successful discovery of these genetic factors will require using complementary approaches with animal models, large-scale human genetic studies, and functional experiments. This review emphasizes the common, complex forms of CAD...
  30. pmc Genetic causes of high and low serum HDL-cholesterol
    Daphna Weissglas-Volkov
    Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Lipid Res 51:2032-57. 2010
    ....
  31. ncbi request reprint Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia
    Miklos Peterfy
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Nat Genet 39:1483-7. 2007
    ..Thus, through its profound effect on lipase activity, LMF1 emerges as an important candidate gene in hypertriglyceridemia...

Research Grants6

  1. Genetic susceptibility to Common Lipid Disorders in Mexico
    Paivi Pajukanta; Fiscal Year: 2007
    ..In Specific Aim 2, we will investigate USF1, HNF4A and the chromosomal loci implicated in the genome scan to characterize the DNA variants conferring the susceptibility to FCHL in Mexicans. ..
  2. Genetic susceptibility to Common Lipid Disorders in Mexico
    Paivi Pajukanta; Fiscal Year: 2009
    ..In Specific Aim 2, we will investigate USF1, HNF4A and the chromosomal loci implicated in the genome scan to characterize the DNA variants conferring the susceptibility to FCHL in Mexicans. ..
  3. Genetics of high serum triglycerides and related metabolic traits in Mexicans
    Paivi Pajukanta; Fiscal Year: 2010
    ....