Pajor A, de Oliveira C, Song K, Huard K, Shanmugasundaram V, Erion D. Molecular Basis for Inhibition of the Na+/Citrate Transporter NaCT (SLC13A5) by Dicarboxylate Inhibitors. Mol Pharmacol. 2016;90:755-765 pubmed
..These findings should provide a basis for future drug design of SLC13 inhibitors. ..
Pajor A, Sun N. Single nucleotide polymorphisms in the human Na+-dicarboxylate cotransporter affect transport activity and protein expression. Am J Physiol Renal Physiol. 2010;299:F704-11 pubmed publisher
..All of these mutations are predicted to decrease transport activity in vivo, which would result in decreased intestinal and renal absorption of citric acid cycle intermediates. ..
Pajor A, Sun N, Joshi A, Randolph K. Transmembrane helix 7 in the Na+/dicarboxylate cotransporter 1 is an outer helix that contains residues critical for function. Biochim Biophys Acta. 2011;1808:1454-61 pubmed publisher
..However, most of TM7 does not appear to be accessible to the extracellular fluid and is likely to be an outer helix in contact with the lipid bilayer. ..
Pajor A, Sun N, Leung A. Functional characterization of SdcF from Bacillus licheniformis, a homolog of the SLC13 Na?/dicarboxylate transporters. J Membr Biol. 2013;246:705-15 pubmed publisher
..We conclude that SdcF is a secondary active transporter for four- and five-carbon dicarboxylates that can use Na? or Li? as a driving cation...
Pajor A. Sodium-coupled dicarboxylate and citrate transporters from the SLC13 family. Pflugers Arch. 2014;466:119-30 pubmed publisher
..This review summarizes current knowledge of the structure, function, and regulation of the di- and tricarboxylate transporters of the SLC13 family. ..