Frank Pajonk

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Tumor cells with low proteasome subunit expression predict overall survival in head and neck cancer patients
    Chann Lagadec
    Department of Radiation Oncology, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095, USA
    BMC Cancer 14:152. 2014
  2. pmc Characterization of the stem cell niche and its importance in radiobiological response
    Frank Pajonk
    Department of Radiation Oncology, David Geffen School of Medicine, UCLA, Los Angeles, CA Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA Electronic address
    Semin Radiat Oncol 23:237-41. 2013
  3. pmc Anthracyclines, proteasome activity and multi-drug-resistance
    Mirela R Fekete
    Department of Neurology, Bürgerhospital, Tunzhofer Str 14 16, 70191 Stuttgart, Germany
    BMC Cancer 5:114. 2005
  4. pmc Radiation resistance of cancer stem cells: the 4 R's of radiobiology revisited
    Frank Pajonk
    Department of Radiation Oncology, Division of Molecular and Cellular Oncology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Stem Cells 28:639-48. 2010
  5. pmc The proteasome inhibitor MG-132 protects hypoxic SiHa cervical carcinoma cells after cyclic hypoxia/reoxygenation from ionizing radiation
    Frank Pajonk
    Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1714, USA
    Neoplasia 8:1037-41. 2006
  6. pmc The effects of tea extracts on proinflammatory signaling
    Frank Pajonk
    Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1714, USA
    BMC Med 4:28. 2006
  7. pmc Survival and self-renewing capacity of breast cancer initiating cells during fractionated radiation treatment
    Chann Lagadec
    Division of Molecular and Cellular Oncology, Department of Radiation Oncology, David Geffen School of Medicine at University of California, Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1714, USA
    Breast Cancer Res 12:R13. 2010
  8. pmc The proteasome inhibitor MG-132 sensitizes PC-3 prostate cancer cells to ionizing radiation by a DNA-PK-independent mechanism
    Frank Pajonk
    Department of Radiation Oncology, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA90095 1714, USA
    BMC Cancer 5:76. 2005
  9. pmc In vivo imaging, tracking, and targeting of cancer stem cells
    Erina Vlashi
    Division of Molecular and Cellular Oncology, Department of Radiation Oncology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095 1714, USA
    J Natl Cancer Inst 101:350-9. 2009
  10. pmc Radioresistance of prostate cancer cells with low proteasome activity
    Lorenza Della Donna
    Department of Radiation Oncology, David Geffen School of Medicine at UCLA, 10833 LeConte Ave, Los Angeles, CA 90095 1714, USA
    Prostate 72:868-74. 2012

Research Grants

  1. The 26S Proteasome in Cancer Stem Cells
    Frank Pajonk; Fiscal Year: 2010

Collaborators

Detail Information

Publications31

  1. doi request reprint Tumor cells with low proteasome subunit expression predict overall survival in head and neck cancer patients
    Chann Lagadec
    Department of Radiation Oncology, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095, USA
    BMC Cancer 14:152. 2014
    ..The objective of this study was to investigate if head and neck squamous cell carcinoma (HNSCC) also contain cancer stem cells that can be identified by low 26S proteasome activity and if their presence correlates to clinical outcome...
  2. pmc Characterization of the stem cell niche and its importance in radiobiological response
    Frank Pajonk
    Department of Radiation Oncology, David Geffen School of Medicine, UCLA, Los Angeles, CA Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA Electronic address
    Semin Radiat Oncol 23:237-41. 2013
    ..In this review, we highlight some of the best-characterized aspects of normal tissue stem cells, cancer stem cells, and their niches in the bone marrow, gut, and brain, as well as their responses to ionizing radiation...
  3. pmc Anthracyclines, proteasome activity and multi-drug-resistance
    Mirela R Fekete
    Department of Neurology, Bürgerhospital, Tunzhofer Str 14 16, 70191 Stuttgart, Germany
    BMC Cancer 5:114. 2005
    ..Observations that cyclosporin A, and certain other substances, inhibit both the proteasome and P-glycoprotein led us to investigate whether anthracyclines, well known substrates of P-gp, also inhibit the function of the proteasome...
  4. pmc Radiation resistance of cancer stem cells: the 4 R's of radiobiology revisited
    Frank Pajonk
    Department of Radiation Oncology, Division of Molecular and Cellular Oncology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Stem Cells 28:639-48. 2010
    ..We relate recent findings on CSCs to these four phenomena and discuss possible consequences...
  5. pmc The proteasome inhibitor MG-132 protects hypoxic SiHa cervical carcinoma cells after cyclic hypoxia/reoxygenation from ionizing radiation
    Frank Pajonk
    Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1714, USA
    Neoplasia 8:1037-41. 2006
    ..This study was designed to determine how varying cycles of hypoxia/reoxygenation affect the response of cervical carcinoma cells irradiated under oxic and hypoxic conditions and whether this could be modulated by proteasome inhibition...
  6. pmc The effects of tea extracts on proinflammatory signaling
    Frank Pajonk
    Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1714, USA
    BMC Med 4:28. 2006
    ..We investigated the underlying molecular mechanisms and compared effects of tea extracts with the effects of epigallocatechin-gallate, the proposed most-active moiety of green tea...
  7. pmc Survival and self-renewing capacity of breast cancer initiating cells during fractionated radiation treatment
    Chann Lagadec
    Division of Molecular and Cellular Oncology, Department of Radiation Oncology, David Geffen School of Medicine at University of California, Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1714, USA
    Breast Cancer Res 12:R13. 2010
    ..We hypothesized that CICs, in contrast to their non-tumorigenic counterparts, not only survive fractions of ionizing radiation but also retain the CIC phenotype as defined by operational means...
  8. pmc The proteasome inhibitor MG-132 sensitizes PC-3 prostate cancer cells to ionizing radiation by a DNA-PK-independent mechanism
    Frank Pajonk
    Department of Radiation Oncology, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA90095 1714, USA
    BMC Cancer 5:76. 2005
    ....
  9. pmc In vivo imaging, tracking, and targeting of cancer stem cells
    Erina Vlashi
    Division of Molecular and Cellular Oncology, Department of Radiation Oncology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095 1714, USA
    J Natl Cancer Inst 101:350-9. 2009
    ..The 26S proteasome is the main regulator of many processes within a proliferating cell, and its activity may be altered depending on the phenotype of a cell...
  10. pmc Radioresistance of prostate cancer cells with low proteasome activity
    Lorenza Della Donna
    Department of Radiation Oncology, David Geffen School of Medicine at UCLA, 10833 LeConte Ave, Los Angeles, CA 90095 1714, USA
    Prostate 72:868-74. 2012
    ..Proteasome inhibitors have been suggested as promising new agents against solid tumors including prostate cancer but initial results from clinical trials are disappointing...
  11. ncbi request reprint A sense of danger from radiation
    William H McBride
    Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1714, USA
    Radiat Res 162:1-19. 2004
    ..This article focuses on how normal tissues and tumors sense and respond to danger from ionizing radiation, on the nature of the signals that are sent, and on the impact on the eventual consequences of exposure...
  12. pmc Effects of recombinant erythropoietin on breast cancer-initiating cells
    Tiffany M Phillips
    Department of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, 10833 LeConte Ave, Los Angeles, CA 90095 1714, USA
    Neoplasia 9:1122-9. 2007
    ..Cancer recurrence is thought to rely on the proliferation of cancer initiating cells (CICs). In breast cancer, CICs can be identified by phenotypic markers and their fate is controlled by the Notch pathway...
  13. pmc Metabolic state of glioma stem cells and nontumorigenic cells
    Erina Vlashi
    Department of Radiation Oncology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 108:16062-7. 2011
    ..We conclude that GSCs rely mainly on oxidative phosphorylation. However, if challenged, they can use additional metabolic pathways. Therefore, targeting glycolysis in glioma may spare GSCs...
  14. pmc Radiation-induced Notch signaling in breast cancer stem cells
    Chann Lagadec
    Department of Radiation Oncology, David Geffen School of Medicine at University of California, Los Angeles UCLA, Los Angeles, California
    Int J Radiat Oncol Biol Phys 87:609-18. 2013
    ..To explore patterns of Notch receptor and ligand expression in response to radiation that could be crucial in defining optimal dosing schemes for γ-secretase inhibitors if combined with radiation...
  15. pmc Radiation-induced reprogramming of breast cancer cells
    Chann Lagadec
    Department of Radiation Oncology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1714, USA
    Stem Cells 30:833-44. 2012
    ..We conclude that radiation may induce a BCSC phenotype in differentiated breast cancer cells and that this mechanism contributes to increased BCSC numbers seen after classic anticancer treatment...
  16. pmc Oxygen levels do not determine radiation survival of breast cancer stem cells
    Chann Lagadec
    Department of Radiation Oncology, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e34545. 2012
    ..We conclude that because BCSCs are protected from radiation through high expression levels of free radical scavengers, hypoxia does not lead to additional radioprotection of BCSCs...
  17. doi request reprint The RNA-binding protein Musashi-1 regulates proteasome subunit expression in breast cancer- and glioma-initiating cells
    Chann Lagadec
    Department of Radiation Oncology, David Geffen School of Medicine and, University of California Los Angeles, California, USA
    Stem Cells 32:135-44. 2014
    ....
  18. pmc Differential Effects of the Proteasome Inhibitor NPI-0052 against Glioma Cells
    Erina Vlashi
    Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Transl Oncol 3:50-5. 2010
    ..We conclude that NPI-0052 is not a suitable drug for the treatment of malignant gliomas despite its efficacy in other cancer types...
  19. pmc Radiation responses of cancer stem cells
    Erina Vlashi
    Division of Molecular and Cellular Oncology, Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1714, USA
    J Cell Biochem 108:339-42. 2009
    ..This is particularly true for biological targeting of cancer for enhanced radiotherapeutic benefit, which must consider whether the unique properties of this subpopulation allow it to avoid such therapies...
  20. ncbi request reprint The role of the ubiquitin/proteasome system in cellular responses to radiation
    William H McBride
    Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Oncogene 22:5755-73. 2003
    ..In addition, other drugs in common clinical use have been shown to affect proteasome function, and their activities may be valuably reconsidered from this perspective...
  21. ncbi request reprint The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation
    Tiffany M Phillips
    Department of Radiation Oncology, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095 1714, USA
    J Natl Cancer Inst 98:1777-85. 2006
    ..Cancer-initiating cells can now be prospectively isolated from breast cancer cell lines and tumor samples and propagated as mammospheres in vitro under serum-free conditions...
  22. ncbi request reprint Hyperthermia-induced proteasome inhibition and loss of androgen receptor expression in human prostate cancer cells
    Frank Pajonk
    Department of Radiation Oncology, Experimental Division, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1714, USA
    Cancer Res 65:4836-43. 2005
    ..Hyperthermia abrogates AR expression in androgen-dependent cells and might thus promote malignant progression of prostate cancer...
  23. pmc Irradiation of the potential cancer stem cell niches in the adult brain improves progression-free survival of patients with malignant glioma
    Patrick Evers
    Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    BMC Cancer 10:384. 2010
    ..This suggests that the NSC niches in the brain may harbor cancer stem cells (CSCs), Thus providing novel therapy targets. We hypothesize that higher radiation doses to these NSC niches improve patient survival by eradicating CSCs...
  24. ncbi request reprint NF-kappa B, cytokines, proteasomes, and low-dose radiation exposure
    William H McBride
    Roy E Coats Laboratories, Department of Radiation Oncology, University of California Los Angeles, Los Angeles, CA 90064, USA
    Mil Med 167:66-7. 2002
    ..These pathways are relevant to low-dose radiation effects, adaptive responses, and carcinogenesis...
  25. pmc Targeted elimination of breast cancer cells with low proteasome activity is sufficient for tumor regression
    Erina Vlashi
    Department of Radiation Oncology, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA, 90095 1714, USA
    Breast Cancer Res Treat 141:197-203. 2013
    ..We conclude that specific targeting of BCSCs could be a useful strategy to improve treatment outcome. ..
  26. pmc National Institutes of Health funding in radiation oncology: a snapshot
    Michael Steinberg
    Department of Radiation Oncology, David Geffen School of Medicine at University of California, Los Angeles UCLA, Los Angeles, California, USA
    Int J Radiat Oncol Biol Phys 86:234-40. 2013
    ..Our data suggest that the field of radiation oncology is underfunded by the NIH and that the current level of support does not match the relevance of radiation oncology for cancer patients or the potential of its academic work force...
  27. ncbi request reprint The human immunodeficiency virus (HIV)-1 protease inhibitor saquinavir inhibits proteasome function and causes apoptosis and radiosensitization in non-HIV-associated human cancer cells
    Frank Pajonk
    Department of Radiation Therapy, Radiological University Clinic, Hugstetter Strasse 55, 79106 Freiburg i Brsg, Germany
    Cancer Res 62:5230-5. 2002
    ..Because saquinavir induced apoptosis in human cancer cells, HIV-I protease inhibitors might become a new class of cytotoxic drugs, alone or in combination with radiation or chemotherapy...
  28. ncbi request reprint The erythropoietin-receptor pathway modulates survival of cancer cells
    Frank Pajonk
    Clinical and Experimental Radiation Biology Research Section, Department of Radiation Therapy, Radiological University Clinic, Robert Koch Str 3, 79106 Freiburg i Brsg, Germany
    Oncogene 23:8987-91. 2004
    ..As most human tumors express erythropoietin receptor, we advocate a restricted use erythropoietin to patients suffering from erythropoietin-receptor-expressing cancers...
  29. ncbi request reprint N-acetyl-L-cysteine inhibits 26S proteasome function: implications for effects on NF-kappaB activation
    Frank Pajonk
    Department of Radiation Therapy, Radiological University Clinic Freiburg, Hugstetter Strasse 55, 79106 Freiburg im Breisgau, Germany
    Free Radic Biol Med 32:536-43. 2002
    ....
  30. ncbi request reprint Vitiligo at the sites of irradiation in a patient with Hodgkin's disease
    Frank Pajonk
    Department of Radiation Therapy, Radiological University Clinic, Freiburg Br, Germany
    Strahlenther Onkol 178:159-62. 2002
    ..Current hypotheses discuss autoimmune, autotoxic and neuronal mechanisms. Here we report the case of radiation-induced depigmentation of the skin of a patient with Hodgkin's disease and 25-year history of vitiligo...
  31. ncbi request reprint Do erythropoietin receptors on cancer cells explain unexpected clinical findings?
    Michael Henke
    Klinik fur Strahlenheilkunde, Universitatsklinikum, Robert Koch Strasse, 3 D 79106, Freiburg, Germany
    J Clin Oncol 24:4708-13. 2006
    ..Recent reports suggest that cancer control may worsen if erythropoietin is administered. We investigated whether erythropoietin receptor expression on cancer cells may correlate with this unexpected finding...

Research Grants2

  1. The 26S Proteasome in Cancer Stem Cells
    Frank Pajonk; Fiscal Year: 2010
    ....